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Eva Grayck

TitleProfessor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-PEDS

    Collapse Research 
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    K08HL070088     (GRAYCK, EVA NOZIK)Apr 3, 2002 - Mar 31, 2008
    NIH/NHLBI
    S-nitrosylation of A -adrenergic receptors inthe lung
    Role: Principal Investigator

    R01HL086680     (GRAYCK, EVA NOZIK)Dec 1, 2006 - Jul 31, 2018
    NIH/NHLBI
    Impact of Insufficient Vascular EC-SOD in Pulmonary Hypertension
    Role: Principal Investigator

    R03HL110783     (GRAYCK, EVA NOZIK)Sep 23, 2011 - Jul 31, 2014
    NIH/NHLBI
    DNA methylation of extracellular superoxide dismutase in pulmonary hypertension
    Role: Principal Investigator

    R01HL119533     (GRAYCK, EVA NOZIK)Sep 1, 2014 - Jun 30, 2018
    NIH/NHLBI
    miRNA Regulation of Vascular Permeability and Inflammation in the Lung Injury
    Role: Principal Investigator

    R35HL139726     (GRAYCK, EVA NOZIK)Jun 1, 2018 - May 31, 2025
    NIH/NHLBI
    SOD3 regulation of redox sensitive signaling in pulmonary vascular diseases
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Patil MA, Upadhyay AK, Hernandez-Lagunas L, Good R, Carpenter TC, Sucharov CC, Nozik-Grayck E, Kompella UB. Targeted delivery of YSA-functionalized and non-functionalized polymeric nanoparticles to injured pulmonary vasculature. Artif Cells Nanomed Biotechnol. 2018 Nov 19; 1-8. PMID: 30450979.
      View in: PubMed
    2. Rashid J, Nozik-Grayck E, McMurtry IF, Stenmark KR, Ahsan F. Inhaled combination of sildenafil and rosiglitazone improves pulmonary hemodynamics, cardiac function, and arterial remodeling. Am J Physiol Lung Cell Mol Physiol. 2019 Jan 01; 316(1):L119-L130. PMID: 30307312.
      View in: PubMed
    3. Garcia AM, Allawzi A, Tatman P, Hernandez-Lagunas L, Swain K, Mouradian G, Bowler R, Karimpour-Fard A, Sucharov CC, Nozik-Grayck E. R213G polymorphism in SOD3 protects against bleomycin-induced inflammation and attenuates induction of proinflammatory pathways. Physiol Genomics. 2018 Sep 01; 50(9):807-816. PMID: 30004839.
      View in: PubMed
    4. Ferguson SK, Redinius K, Yalamanoglu A, Harral JW, Hyen Baek J, Pak D, Loomis Z, Hassell D, Eigenberger P, Nozik-Grayck E, Nuss R, Hassell K, Stenmark KR, Buehler PW, Irwin DC. Effects of living at moderate altitude on pulmonary vascular function and exercise capacity in mice with sickle cell anaemia. J Physiol. 2018 Jun 21. PMID: 29931797.
      View in: PubMed
    5. Ni K, Gill A, Tseng V, Mikosz AM, Koike K, Beatman EL, Xu CY, Cao D, Gally F, Mould KJ, Serban KA, Schweitzer KS, March KL, Janssen WJ, Nozik-Grayck E, Garantziotis S, Petrache I. Rapid clearance of heavy chain-modified hyaluronan during resolving acute lung injury. Respir Res. 2018 05 31; 19(1):107. PMID: 29855321.
      View in: PubMed
    6. Rashid J, Alobaida A, Al-Hilal TA, Hammouda S, McMurtry IF, Nozik-Grayck E, Stenmark KR, Ahsan F. Repurposing rosiglitazone, a PPAR-? agonist and oral antidiabetic, as an inhaled formulation, for the treatment of PAH. J Control Release. 2018 Jun 28; 280:113-123. PMID: 29723610.
      View in: PubMed
    7. Delaney C, Sherlock L, Fisher S, Maltzahn J, Wright C, Nozik-Grayck E. Serotonin 2A receptor inhibition protects against the development of pulmonary hypertension and pulmonary vascular remodeling in neonatal mice. Am J Physiol Lung Cell Mol Physiol. 2018 05 01; 314(5):L871-L881. PMID: 29345193.
      View in: PubMed
    8. Gupta N, Rashid J, Nozik-Grayck E, McMurtry IF, Stenmark KR, Ahsan F. Cocktail of Superoxide Dismutase and Fasudil Encapsulated in Targeted Liposomes Slows PAH Progression at a Reduced Dosing Frequency. Mol Pharm. 2017 03 06; 14(3):830-841. PMID: 28165252.
      View in: PubMed
    9. Rashid J, Patel B, Nozik-Grayck E, McMurtry IF, Stenmark KR, Ahsan F. Inhaled sildenafil as an alternative to oral sildenafil in the treatment of pulmonary arterial hypertension (PAH). J Control Release. 2017 03 28; 250:96-106. PMID: 28185800.
      View in: PubMed
    10. Loomis Z, Eigenberger P, Redinius K, Lisk C, Karoor V, Nozik-Grayck E, Ferguson SK, Hassell K, Nuss R, Stenmark K, Buehler P, Irwin DC. Hemoglobin induced cell trauma indirectly influences endothelial TLR9 activity resulting in pulmonary vascular smooth muscle cell activation. PLoS One. 2017; 12(2):e0171219. PMID: 28152051.
      View in: PubMed
    11. Nozik-Grayck E, Woods C, Stearman RS, Venkataraman S, Ferguson BS, Swain K, Bowler RP, Geraci MW, Ihida-Stansbury K, Stenmark KR, McKinsey TA, Domann FE. Histone deacetylation contributes to low extracellular superoxide dismutase expression in human idiopathic pulmonary arterial hypertension. Am J Physiol Lung Cell Mol Physiol. 2016 07 01; 311(1):L124-34. PMID: 27233998.
      View in: PubMed
    12. Delaney C, Wright RH, Tang JR, Woods C, Villegas L, Sherlock L, Savani RC, Abman SH, Nozik-Grayck E. Lack of EC-SOD worsens alveolar and vascular development in a neonatal mouse model of bleomycin-induced bronchopulmonary dysplasia and pulmonary hypertension. Pediatr Res. 2015 Dec; 78(6):634-40. PMID: 26322414.
      View in: PubMed
    13. Irwin DC, Baek JH, Hassell K, Nuss R, Eigenberger P, Lisk C, Loomis Z, Maltzahn J, Stenmark KR, Nozik-Grayck E, Buehler PW. Hemoglobin-induced lung vascular oxidation, inflammation, and remodeling contribute to the progression of hypoxic pulmonary hypertension and is attenuated in rats with repeated-dose haptoglobin administration. Free Radic Biol Med. 2015 May; 82:50-62. PMID: 25656991; PMCID: PMC4387123.
    14. Acker SN, Seedorf GJ, Abman SH, Nozik-Grayck E, Kuhn K, Partrick DA, Gien J. Altered pulmonary artery endothelial-smooth muscle cell interactions in experimental congenital diaphragmatic hernia. Pediatr Res. 2015 Apr; 77(4):511-9. PMID: 25580737; PMCID: PMC4363155.
    15. Nahar K, Absar S, Gupta N, Kotamraju VR, McMurtry IF, Oka M, Komatsu M, Nozik-Grayck E, Ahsan F. Peptide-coated liposomal fasudil enhances site specific vasodilation in pulmonary arterial hypertension. Mol Pharm. 2014 Dec 01; 11(12):4374-84. PMID: 25333706.
      View in: PubMed
    16. Nozik-Grayck E, Woods C, Taylor JM, Benninger RK, Johnson RD, Villegas LR, Stenmark KR, Harrison DG, Majka SM, Irwin D, Farrow KN. Selective depletion of vascular EC-SOD augments chronic hypoxic pulmonary hypertension. Am J Physiol Lung Cell Mol Physiol. 2014 Dec 01; 307(11):L868-76. PMID: 25326578; PMCID: PMC4254965.
    17. Marriott S, Baskir RS, Gaskill C, Menon S, Carrier EJ, Williams J, Talati M, Helm K, Alford CE, Kropski JA, Loyd J, Wheeler L, Johnson J, Austin E, Nozik-Grayck E, Meyrick B, West JD, Klemm DJ, Majka SM. ABCG2pos lung mesenchymal stem cells are a novel pericyte subpopulation that contributes to fibrotic remodeling. Am J Physiol Cell Physiol. 2014 Oct 15; 307(8):C684-98. PMID: 25122876; PMCID: PMC4200000.
    18. Villegas L, Stidham T, Nozik-Grayck E. Oxidative Stress and Therapeutic Development in Lung Diseases. J Pulm Respir Med. 2014 Aug; 4(4). PMID: 27019769.
      View in: PubMed
    19. Lisk C, Kominsky D, Ehrentraut S, Bonaventura J, Nuss R, Hassell K, Nozik-Grayck E, Irwin DC. Hemoglobin-induced endothelial cell permeability is controlled, in part, via a myeloid differentiation primary response gene-88-dependent signaling mechanism. Am J Respir Cell Mol Biol. 2013 Oct; 49(4):619-26. PMID: 23713977.
      View in: PubMed
    20. Lisk C, McCord J, Bose S, Sullivan T, Loomis Z, Nozik-Grayck E, Schroeder T, Hamilton K, Irwin DC. Nrf2 activation: a potential strategy for the prevention of acute mountain sickness. Free Radic Biol Med. 2013 Oct; 63:264-73. PMID: 23722164; PMCID: PMC4130652.
    21. Gupta V, Gupta N, Shaik IH, Mehvar R, Nozik-Grayck E, McMurtry IF, Oka M, Komatsu M, Ahsan F. Inhaled PLGA particles of prostaglandin E1 ameliorate symptoms and progression of pulmonary hypertension at a reduced dosing frequency. Mol Pharm. 2013 May 06; 10(5):1655-67. PMID: 23485062.
      View in: PubMed
    22. Tang JR, Michaelis KA, Nozik-Grayck E, Seedorf GJ, Hartman-Filson M, Abman SH, Wright CJ. The NF-?B inhibitory proteins I?Ba and I?Bß mediate disparate responses to inflammation in fetal pulmonary endothelial cells. J Immunol. 2013 Mar 15; 190(6):2913-23. PMID: 23418625; PMCID: PMC3594141.
    23. Villegas LR, Kluck D, Field C, Oberley-Deegan RE, Woods C, Yeager ME, El Kasmi KC, Savani RC, Bowler RP, Nozik-Grayck E. Superoxide dismutase mimetic, MnTE-2-PyP, attenuates chronic hypoxia-induced pulmonary hypertension, pulmonary vascular remodeling, and activation of the NALP3 inflammasome. Antioxid Redox Signal. 2013 May 10; 18(14):1753-64. PMID: 23240585; PMCID: PMC3619229.
    24. Gupta V, Gupta N, Shaik IH, Mehvar R, McMurtry IF, Oka M, Nozik-Grayck E, Komatsu M, Ahsan F. Liposomal fasudil, a rho-kinase inhibitor, for prolonged pulmonary preferential vasodilation in pulmonary arterial hypertension. J Control Release. 2013 Apr 28; 167(2):189-99. PMID: 23353807.
      View in: PubMed
    25. Chow K, Fessel JP, Schmidt EP, Gaskill C, Alvarez D, Graham B, Harrison DG, Wagner DH, Nozik-Grayck E, West JD, Klemm DJ, Majka SM. Dysfunctional resident lung mesenchymal stem cells contribute to pulmonary microvascular remodeling. Pulm Circ. 2013 Jan; 3(1):31-49. PMID: 23662173; PMCID: PMC3641738.
    26. Stenmark KR, Yeager ME, El Kasmi KC, Nozik-Grayck E, Gerasimovskaya EV, Li M, Riddle SR, Frid MG. The adventitia: essential regulator of vascular wall structure and function. Annu Rev Physiol. 2013; 75:23-47. PMID: 23216413; PMCID: PMC3762248.
    27. Buehler PW, Baek JH, Lisk C, Connor I, Sullivan T, Kominsky D, Majka S, Stenmark KR, Nozik-Grayck E, Bonaventura J, Irwin DC. Free hemoglobin induction of pulmonary vascular disease: evidence for an inflammatory mechanism. Am J Physiol Lung Cell Mol Physiol. 2012 Aug 15; 303(4):L312-26. PMID: 22728465.
      View in: PubMed
    28. Hartney T, Birari R, Venkataraman S, Villegas L, Martinez M, Black SM, Stenmark KR, Nozik-Grayck E. Xanthine oxidase-derived ROS upregulate Egr-1 via ERK1/2 in PA smooth muscle cells; model to test impact of extracellular ROS in chronic hypoxia. PLoS One. 2011; 6(11):e27531. PMID: 22140445; PMCID: PMC3225357.
    29. Majka S, Hagen M, Blackwell T, Harral J, Johnson JA, Gendron R, Paradis H, Crona D, Loyd JE, Nozik-Grayck E, Stenmark KR, West J. Physiologic and molecular consequences of endothelial Bmpr2 mutation. Respir Res. 2011 Jun 22; 12:84. PMID: 21696628; PMCID: PMC3141420.
    30. Jun D, Garat C, West J, Thorn N, Chow K, Cleaver T, Sullivan T, Torchia EC, Childs C, Shade T, Tadjali M, Lara A, Nozik-Grayck E, Malkoski S, Sorrentino B, Meyrick B, Klemm D, Rojas M, Wagner DH, Majka SM. The pathology of bleomycin-induced fibrosis is associated with loss of resident lung mesenchymal stem cells that regulate effector T-cell proliferation. Stem Cells. 2011 Apr; 29(4):725-35. PMID: 21312316.
      View in: PubMed
    31. Goodman DM, Winkler MK, Fiser RT, Abd-Allah S, Mathur M, Rivero N, Weiss IK, Peterson B, Cornfield DN, Mink R, Nozik Grayck E, McCabe ME, Schuette J, Nares MA, Totapally B, Petrillo-Albarano T, Wolfson RK, Moreland JG, Potter KE, Fackler J, Garber N, Burns JP, Shanley TP, Lieh-Lai MW, Steiner M, Tieves KS, Goldsmith M, Asuncion A, Ross SL, Howell JD, Biagas K, Ognibene K, Joshi P, Rubenstein JS, Kocis KC, Cheifetz IM, Turner DA, Doughty L, Hall MW, Mason K, Penfil S, Morrison W, Hoehn KS, Watson RS, Garcia RL, Storgion SA, Fleming GM, Castillo L, Tcharmtchi MH, Taylor RP, Ul Haque I, Crain N, Baden HP, Lee KJ. The Accreditation Council for Graduate Medical Education proposed work hour regulations. Pediatr Crit Care Med. 2011 Jan; 12(1):120-1. PMID: 21209582.
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    32. Stenmark KR, Nozik-Grayck E, Gerasimovskaya E, Anwar A, Li M, Riddle S, Frid M. The adventitia: Essential role in pulmonary vascular remodeling. Compr Physiol. 2011 Jan; 1(1):141-61. PMID: 23737168; PMCID: PMC4169049.
    33. Gupta VK, Grayck EN, Cheifetz IM. Heliox administration during high-frequency jet ventilation augments carbon dioxide clearance. Respir Care. 2004 Sep; 49(9):1038-44. PMID: 15329176.
      View in: PubMed
    34. Kantrow SP, Huang YC, Whorton AR, Grayck EN, Knight JM, Millington DS, Piantadosi CA. Hypoxia inhibits nitric oxide synthesis in isolated rabbit lung. Am J Physiol. 1997 Jun; 272(6 Pt 1):L1167-73. PMID: 9227519.
      View in: PubMed
    35. Grayck EN, Meliones JN, Kern FH, Hansell DR, Ungerleider RM, Greeley WJ. Elevated serum lactate correlates with intracranial hemorrhage in neonates treated with extracorporeal life support. Pediatrics. 1995 Nov; 96(5 Pt 1):914-7. PMID: 7478835.
      View in: PubMed
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