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Simona Zarini

TitleInstructor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-MED
Phone303/724-3968

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Fridman V, Zarini S, Sillau S, Harrison K, Bergman BC, Feldman EL, Reusch JEB, Callaghan BC. Altered plasma serine and 1-deoxydihydroceramide profiles are associated with diabetic neuropathy in type 2 diabetes and obesity. J Diabetes Complications. 2021 Apr; 35(4):107852. PMID: 33485750.
      View in: PubMed
    2. Kahn D, Perreault L, Macias E, Zarini S, Newsom SA, Strauss A, Kerege A, Harrison K, Snell-Bergeon J, Bergman BC. Subcellular localisation and composition of intramuscular triacylglycerol influence insulin sensitivity in humans. Diabetologia. 2021 Jan; 64(1):168-180. PMID: 33128577.
      View in: PubMed
    3. Shook BA, Wasko RR, Mano O, Rutenberg-Schoenberg M, Rudolph MC, Zirak B, Rivera-Gonzalez GC, López-Giráldez F, Zarini S, Rezza A, Clark DA, Rendl M, Rosenblum MD, Gerstein MB, Horsley V. Dermal Adipocyte Lipolysis and Myofibroblast Conversion Are Required for Efficient Skin Repair. Cell Stem Cell. 2020 06 04; 26(6):880-895.e6. PMID: 32302523.
      View in: PubMed
    4. Bapputty R, Talahalli R, Zarini S, Samuels I, Murphy R, Gubitosi-Klug R. Montelukast Prevents Early Diabetic Retinopathy in Mice. Diabetes. 2019 10; 68(10):2004-2015. PMID: 31350303.
      View in: PubMed
    5. Sachs S, Zarini S, Kahn DE, Harrison KA, Perreault L, Phang T, Newsom SA, Strauss A, Kerege A, Schoen JA, Bessesen DH, Schwarzmayr T, Graf E, Lutter D, Krumsiek J, Hofmann SM, Bergman BC. Intermuscular adipose tissue directly modulates skeletal muscle insulin sensitivity in humans. Am J Physiol Endocrinol Metab. 2019 05 01; 316(5):E866-E879. PMID: 30620635.
      View in: PubMed
    6. Zarini S, Barkley RM, Gijón MA, Murphy RC. Overview of Lipid Mass Spectrometry and Lipidomics. Methods Mol Biol. 2019; 1978:81-105. PMID: 31119658.
      View in: PubMed
    7. Okuno T, Gijón MA, Zarini S, Martin SA, Barkley RM, Johnson CA, Ohba M, Yokomizo T, Murphy RC. Altered eicosanoid production and phospholipid remodeling during cell culture. J Lipid Res. 2018 03; 59(3):542-549. PMID: 29353239.
      View in: PubMed
    8. Sorgi CA, Zarini S, Martin SA, Sanchez RL, Scandiuzzi RF, Gijón MA, Guijas C, Flamand N, Murphy RC, Faccioli LH. Dormant 5-lipoxygenase in inflammatory macrophages is triggered by exogenous arachidonic acid. Sci Rep. 2017 09 08; 7(1):10981. PMID: 28887514.
      View in: PubMed
    9. Turcotte C, Zarini S, Jean S, Martin C, Murphy RC, Marsolais D, Laviolette M, Blanchet MR, Flamand N. The Endocannabinoid Metabolite Prostaglandin E2 (PGE2)-Glycerol Inhibits Human Neutrophil Functions: Involvement of Its Hydrolysis into PGE2 and EP Receptors. J Immunol. 2017 04 15; 198(8):3255-3263. PMID: 28258202.
      View in: PubMed
    10. Portillo JA, Schwartz I, Zarini S, Bapputty R, Kern TS, Gubitosi-Klug RA, Murphy RC, Subauste MC, Subauste CS. Proinflammatory responses induced by CD40 in retinal endothelial and Müller cells are inhibited by blocking CD40-Traf2,3 or CD40-Traf6 signaling. Invest Ophthalmol Vis Sci. 2014 Dec 04; 55(12):8590-7. PMID: 25477319.
      View in: PubMed
    11. Montrose DC, Nakanishi M, Murphy RC, Zarini S, McAleer JP, Vella AT, Rosenberg DW. The role of PGE2 in intestinal inflammation and tumorigenesis. Prostaglandins Other Lipid Mediat. 2015 Jan-Mar; 116-117:26-36. PMID: 25460828.
      View in: PubMed
    12. Zarini S, Hankin JA, Murphy RC, Gijón MA. Lysophospholipid acyltransferases and eicosanoid biosynthesis in zebrafish myeloid cells. Prostaglandins Other Lipid Mediat. 2014 Oct; 113-115:52-61. PMID: 25175316.
      View in: PubMed
    13. Talahalli R, Zarini S, Tang J, Li G, Murphy R, Kern TS, Gubitosi-Klug RA. Leukocytes regulate retinal capillary degeneration in the diabetic mouse via generation of leukotrienes. J Leukoc Biol. 2013 Jan; 93(1):135-43. PMID: 23108096.
      View in: PubMed
    14. Eun JC, Moore EE, Mauchley DC, Johnson CA, Meng X, Banerjee A, Wohlauer MV, Zarini S, Gijón MA, Murphy RC. The 5-lipoxygenase pathway is required for acute lung injury following hemorrhagic shock. Shock. 2012 Jun; 37(6):599-604. PMID: 22392149.
      View in: PubMed
    15. Mulligan CM, Sparagna GC, Le CH, De Mooy AB, Routh MA, Holmes MG, Hickson-Bick DL, Zarini S, Murphy RC, Xu FY, Hatch GM, McCune SA, Moore RL, Chicco AJ. Dietary linoleate preserves cardiolipin and attenuates mitochondrial dysfunction in the failing rat heart. Cardiovasc Res. 2012 Jun 01; 94(3):460-8. PMID: 22411972.
      View in: PubMed
    16. Barajas-Espinosa A, Ni NC, Yan D, Zarini S, Murphy RC, Funk CD. The cysteinyl leukotriene 2 receptor mediates retinal edema and pathological neovascularization in a murine model of oxygen-induced retinopathy. FASEB J. 2012 Mar; 26(3):1100-9. PMID: 22131271.
      View in: PubMed
    17. Kandasamy P, Zarini S, Chan ED, Leslie CC, Murphy RC, Voelker DR. Pulmonary surfactant phosphatidylglycerol inhibits Mycoplasma pneumoniae-stimulated eicosanoid production from human and mouse macrophages. J Biol Chem. 2011 Mar 11; 286(10):7841-7853. PMID: 21205826.
      View in: PubMed
    18. Chen M, Lam BK, Luster AD, Zarini S, Murphy RC, Bair AM, Soberman RJ, Lee DM. Joint tissues amplify inflammation and alter their invasive behavior via leukotriene B4 in experimental inflammatory arthritis. J Immunol. 2010 Nov 01; 185(9):5503-11. PMID: 20876351.
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    19. Montrose DC, Kadaveru K, Ilsley JN, Root SH, Rajan TV, Ramesh M, Nichols FC, Liang BT, Sonin D, Hand AR, Zarini S, Murphy RC, Belinsky GS, Nakanishi M, Rosenberg DW. cPLA2 is protective against COX inhibitor-induced intestinal damage. Toxicol Sci. 2010 Sep; 117(1):122-32. PMID: 20562220.
      View in: PubMed
    20. Talahalli R, Zarini S, Sheibani N, Murphy RC, Gubitosi-Klug RA. Increased synthesis of leukotrienes in the mouse model of diabetic retinopathy. Invest Ophthalmol Vis Sci. 2010 Mar; 51(3):1699-708. PMID: 19834040.
      View in: PubMed
    21. Zarini S, Gijón MA, Ransome AE, Murphy RC, Sala A. Transcellular biosynthesis of cysteinyl leukotrienes in vivo during mouse peritoneal inflammation. Proc Natl Acad Sci U S A. 2009 May 19; 106(20):8296-301. PMID: 19416808.
      View in: PubMed
    22. Gijón MA, Riekhof WR, Zarini S, Murphy RC, Voelker DR. Lysophospholipid acyltransferases and arachidonate recycling in human neutrophils. J Biol Chem. 2008 Oct 31; 283(44):30235-45. PMID: 18772128.
      View in: PubMed
    23. Riekhof WR, Wu J, Gijón MA, Zarini S, Murphy RC, Voelker DR. Lysophosphatidylcholine metabolism in Saccharomyces cerevisiae: the role of P-type ATPases in transport and a broad specificity acyltransferase in acylation. J Biol Chem. 2007 Dec 21; 282(51):36853-61. PMID: 17951629.
      View in: PubMed
    24. Farias SE, Zarini S, Precht T, Murphy RC, Heidenreich KA. Transcellular biosynthesis of cysteinyl leukotrienes in rat neuronal and glial cells. J Neurochem. 2007 Nov; 103(4):1310-8. PMID: 17711426.
      View in: PubMed
    25. Gijón MA, Zarini S, Murphy RC. Biosynthesis of eicosanoids and transcellular metabolism of leukotrienes in murine bone marrow cells. J Lipid Res. 2007 Mar; 48(3):716-25. PMID: 17179116.
      View in: PubMed
    26. Zarini S, Gijón MA, Folco G, Murphy RC. Effect of arachidonic acid reacylation on leukotriene biosynthesis in human neutrophils stimulated with granulocyte-macrophage colony-stimulating factor and formyl-methionyl-leucyl-phenylalanine. J Biol Chem. 2006 Apr 14; 281(15):10134-42. PMID: 16495221.
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    27. Murphy RC, Barkley RM, Zemski Berry K, Hankin J, Harrison K, Johnson C, Krank J, McAnoy A, Uhlson C, Zarini S. Electrospray ionization and tandem mass spectrometry of eicosanoids. Anal Biochem. 2005 Nov 01; 346(1):1-42. PMID: 15961057.
      View in: PubMed
    28. Nick JA, Coldren CD, Geraci MW, Poch KR, Fouty BW, O'Brien J, Gruber M, Zarini S, Murphy RC, Kuhn K, Richter D, Kast KR, Abraham E. Recombinant human activated protein C reduces human endotoxin-induced pulmonary inflammation via inhibition of neutrophil chemotaxis. Blood. 2004 Dec 15; 104(13):3878-85. PMID: 15339848.
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    29. Taube C, Wei X, Swasey CH, Joetham A, Zarini S, Lively T, Takeda K, Loader J, Miyahara N, Kodama T, Shultz LD, Donaldson DD, Hamelmann EH, Dakhama A, Gelfand EW. Mast cells, Fc epsilon RI, and IL-13 are required for development of airway hyperresponsiveness after aerosolized allergen exposure in the absence of adjuvant. J Immunol. 2004 May 15; 172(10):6398-406. PMID: 15128831.
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    30. Di Gennaro A, Carnini C, Buccellati C, Ballerio R, Zarini S, Fumagalli F, Viappiani S, Librizzi L, Hernandez A, Murphy RC, Constantin G, De Curtis M, Folco G, Sala A. Cysteinyl-leukotrienes receptor activation in brain inflammatory reactions and cerebral edema formation: a role for transcellular biosynthesis of cysteinyl-leukotrienes. FASEB J. 2004 May; 18(7):842-4. PMID: 15001558.
      View in: PubMed
    31. Borovsky D, Meola SM. Biochemical and cytoimmunological evidence for the control of Aedes aegypti larval trypsin with Aea-TMOF. Arch Insect Biochem Physiol. 2004 Mar; 55(3):124-39. PMID: 24284026.
      View in: PubMed
    32. Tedeschi A, Ciceri P, Zarini S, Lorini M, Di Donato M, Nicosia S, Miadonna A, Sala A. Role of sodium in intracellular calcium elevation and leukotriene B4 formation by receptor-mediated activation of human neutrophils. Biochem Pharmacol. 2004 Jan 15; 67(2):385-93. PMID: 14698050.
      View in: PubMed
    33. Zarini S, Murphy RC. Biosynthesis of 5-oxo-6,8,11,14-eicosatetraenoic acid from 5-hydroperoxyeicosatetraenoic acid in the murine macrophage. J Biol Chem. 2003 Mar 28; 278(13):11190-6. PMID: 12547823.
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    34. Murphy RC, Zarini S. Glutathione adducts of oxyeicosanoids. Prostaglandins Other Lipid Mediat. 2002 Aug; 68-69:471-82. PMID: 12432937.
      View in: PubMed
    35. Centanni S, Santus P, Di Marco F, Fumagalli F, Zarini S, Sala A. The potential role of tocopherol in asthma and allergies: modification of the leukotriene pathway. BioDrugs. 2001; 15(2):81-6. PMID: 11437677.
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    36. Bonazzi A, Bolla M, Buccellati C, Hernandez A, Zarini S, Viganò T, Fumagalli F, Viappiani S, Ravasi S, Zannini P, Chiesa G, Folco G, Sala A. Effect of endogenous and exogenous prostaglandin E(2) on interleukin-1 beta-induced cyclooxygenase-2 expression in human airway smooth-muscle cells. Am J Respir Crit Care Med. 2000 Dec; 162(6):2272-7. PMID: 11112151.
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    37. Profita M, Sala A, Riccobono L, Pace E, Paternò A, Zarini S, Siena L, Mirabella A, Bonsignore G, Vignola AM. 15(S)-HETE modulates LTB(4) production and neutrophil chemotaxis in chronic bronchitis. . 2000 Oct; 279(4):C1249-58. PMID: 11003605.
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    38. Vidal A, Durand T, Vidal JP, Rossi JC, Ravasi S, Zarini S, Sala A. Synthesis of 19-[(2-azido-5-iodo)-benzoyloxy]-LTA4 and enzymatic conversion to the LTC4 analogue. Bioorg Med Chem Lett. 2000 Apr 03; 10(7):665-8. PMID: 10762049.
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    39. Sala A, Zarini S, Folco G, Murphy RC, Henson PM. Differential metabolism of exogenous and endogenous arachidonic acid in human neutrophils. J Biol Chem. 1999 Oct 01; 274(40):28264-9. PMID: 10497182.
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    40. Visioli F, Romani A, Mulinacci N, Zarini S, Conte D, Vincieri FF, Galli C. Antioxidant and other biological activities of olive mill waste waters. J Agric Food Chem. 1999 Aug; 47(8):3397-401. PMID: 10552663.
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    41. Sala A, Zarini S, Bolla M. Leukotrienes: lipid bioeffectors of inflammatory reactions. Biochemistry (Mosc). 1998 Jan; 63(1):84-92. PMID: 9526099.
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    42. Sala A, Buccellati C, Zarini S, Bolla M, Bonazzi A, Folco GC. The polymorphonuclear leukocyte: a cell tuned for transcellular biosynthesis of cys-leukotrienes. J Physiol Pharmacol. 1997 Dec; 48(4):665-73. PMID: 9444615.
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    43. Sala A, Garcia M, Zarini S, Rossi JC, Folco G, Durand T. 14,15-Dehydroleukotriene A4: a specific substrate for leukotriene C4 synthase. Biochem J. 1997 Nov 15; 328 ( Pt 1):225-9. PMID: 9359857.
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    44. Sala A, Bolla M, Zarini S, Müller-Peddinghaus R, Folco G. Release of leukotriene A4 versus leukotriene B4 from human polymorphonuclear leukocytes. J Biol Chem. 1996 Jul 26; 271(30):17944-8. PMID: 8663438.
      View in: PubMed
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