 Kasey Lyn Couts
| Title | Asst Professor-Research |
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| Institution | University of Colorado Denver - Anschutz Medical Campus |
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| Department | SOM-MED |
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| Phone | 303/724-4037 |
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| Email |  |
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 Biography | Valparaiso University, Valparaiso, IN | B.S. | 05/2004 | Biochemistry | | University of Colorado- Boulder, Boulder, CO | Ph.D. | 12/2010 | Biochemistry |
Overview My research interests are primarily focused on understanding the development and pathobiology underlying rare melanomas (such as mucosal, acral, and ocular melanomas) in order to 1) identify risk factors to improve prevention and early detection, 2) develop novel tumor/blood diagnostics for rare melanoma subtypes, 3) establish methods for halting progression and eliminating micro-metastatic disease, and 4) improve efficacy of current therapies (targeted and immunotherapies) and develop new treatment modalities which are effective for rare melanoma patients.
Research (Kasey Couts)Jan 1, 2016 - Jun 1, 2017 Paul R. Ohara II Seed Grant Award
Gene fusions as actionable therapeutic targets in acral lentiginous melanomas
Role Description: Characterize and test efficacy of targeted inhibitors for gene fusions in acral melanomas.
Role: Principle Investigator |
| (Kasey Couts)Apr 1, 2016 - Mar 31, 2017 CCTSI
Activating gene fusions as targets in malignant melanoma
Role Description: Characterize gene fusions in pan-negative melanomas using melanoma PDX models.
Role: Principle Investigator |
| (Kasey Couts)Jul 1, 2017 - Dec 31, 2018 Cancer League of Colorado
Improving targeted therapy in melanomas with BRAF fusions
Role Description: Test novel combinatorial treatment strategies for BRAF fusions.
Role: Principle Investigator |
| (Kasey Couts)Jan 1, 2018 - Dec 31, 2018 American Cancer Society Institutional Seed Grant
Targeting cell cycle structural variants in acral and mucosal melanomas
Role Description: Investigate cell cycle structural variants and cell cycle based therapies in acral and mucosal melanomas.
Role: Principle Investigator |
| (Kasey Couts)Mar 1, 2019 - Feb 28, 2020 CCTSI
The role of BRAF fusions in melanoma anti-tumor immune responses
Role Description: Determine how BRAF fusions promote anti-tumor immunotherapy responses in melanoma patients.
Role: Principle Investigator |
| (Kasey Couts)Jul 1, 2019 - Jun 30, 2022 Patten-Davis Foundation
CU Center for Rare Melanomas
Role Description: Establish a first-of-its-kind joint research and clinical center for improving care of patients with rare, non-UV associated melanomas.
Role: Co-Director |
Bibliographic
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Holman BN, Van Gulick RJ, Amato CM, MacBeth ML, Davies KD, Aisner DL, Robinson WA, Couts KL. Clinical and molecular features of subungual melanomas are site-specific and distinct from acral melanomas. Melanoma Res. 2020 12; 30(6):562-573. PMID: 33156595.
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Mukherjee N, Skees J, Todd KJ, West DA, Lambert KA, Robinson WA, Amato CM, Couts KL, Van Gulick R, MacBeth M, Nassar K, Tan AC, Zhai Z, Fujita M, Bagby SM, Dart CR, Lambert JR, Norris DA, Shellman YG. MCL1 inhibitors S63845/MIK665 plus Navitoclax synergistically kill difficult-to-treat melanoma cells. Cell Death Dis. 2020 06 08; 11(6):443. PMID: 32513939.
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Borgers JSW, Tobin RP, Vorwald VM, Smith JM, Davis DM, Kimball AK, Clambey ET, Couts KL, McWilliams JA, Jordan KR, Torphy RJ, Schulick R, McCarter MD. High-Dimensional Analysis of Postsplenectomy Peripheral Immune Cell Changes. Immunohorizons. 2020 02 18; 4(2):82-92. PMID: 32071067.
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Tobin RP, Jordan KR, Kapoor P, Spongberg E, Davis D, Vorwald VM, Couts KL, Gao D, Smith DE, Borgers JSW, Robinson S, Amato C, Gonzalez R, Lewis KD, Robinson WA, Borges VF, McCarter MD. IL-6 and IL-8 Are Linked With Myeloid-Derived Suppressor Cell Accumulation and Correlate With Poor Clinical Outcomes in Melanoma Patients. Front Oncol. 2019; 9:1223. PMID: 31781510.
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Turner JA, Bemis JGT, Bagby SM, Capasso A, Yacob BW, Chimed TS, Van Gulick R, Lee H, Tobin R, Tentler JJ, Pitts T, McCarter M, Robinson WA, Couts KL. BRAF fusions identified in melanomas have variable treatment responses and phenotypes. Oncogene. 2019 02; 38(8):1296-1308. PMID: 30254212.
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Mukherjee N, Strosnider A, Vagher B, Lambert KA, Slaven S, Robinson WA, Amato CM, Couts KL, Bemis JGT, Turner JA, Norris DA, Shellman YG. BH3 mimetics induce apoptosis independent of DRP-1 in melanoma. Cell Death Dis. 2018 09 05; 9(9):907. PMID: 30185782.
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Couts KL, Bemis J, Turner JA, Bagby SM, Murphy D, Christiansen J, Hintzsche JD, Le A, Pitts TM, Wells K, Applegate A, Amato C, Multani P, Chow-Maneval E, Tentler JJ, Shellman YG, Rioth MJ, Tan AC, Gonzalez R, Medina T, Doebele RC, Robinson WA. ALK Inhibitor Response in Melanomas Expressing EML4-ALK Fusions and Alternate ALK Isoforms. Mol Cancer Ther. 2018 01; 17(1):222-231. PMID: 29054983.
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Hintzsche JD, Gorden NT, Amato CM, Kim J, Wuensch KE, Robinson SE, Applegate AJ, Couts KL, Medina TM, Wells KR, Wisell JA, McCarter MD, Box NF, Shellman YG, Gonzalez RC, Lewis KD, Tentler JJ, Tan AC, Robinson WA. Whole-exome sequencing identifies recurrent SF3B1 R625 mutation and comutation of NF1 and KIT in mucosal melanoma. Melanoma Res. 2017 06; 27(3):189-199. PMID: 28296713.
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Turner J, Couts K, Sheren J, Saichaemchan S, Ariyawutyakorn W, Avolio I, Cabral E, Glogowska M, Amato C, Robinson S, Hintzsche J, Applegate A, Seelenfreund E, Gonzalez R, Wells K, Bagby S, Tentler J, Tan AC, Wisell J, Varella-Garcia M, Robinson W. Kinase gene fusions in defined subsets of melanoma. Pigment Cell Melanoma Res. 2017 01; 30(1):53-62. PMID: 27864876.
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Nguyen N, Couts KL, Luo Y, Fujita M. Understanding melanoma stem cells. Melanoma Manag. 2015; 2(2):179-188. PMID: 26594315.
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Lee T, Wang N, Houel S, Couts K, Old W, Ahn N. Dosage and temporal thresholds in microRNA proteomics. Mol Cell Proteomics. 2015 Feb; 14(2):289-302. PMID: 25467838.
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Couts KL, Anderson EM, Gross MM, Sullivan K, Ahn NG. Oncogenic B-Raf signaling in melanoma cells controls a network of microRNAs with combinatorial functions. Oncogene. 2013 Apr 11; 32(15):1959-70. PMID: 22751131.
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Argast GM, Croy CH, Couts KL, Zhang Z, Litman E, Chan DC, Ahn NG. Plexin B1 is repressed by oncogenic B-Raf signaling and functions as a tumor suppressor in melanoma cells. Oncogene. 2009 Jul 30; 28(30):2697-709. PMID: 19483722.
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Old WM, Shabb JB, Houel S, Wang H, Couts KL, Yen CY, Litman ES, Croy CH, Meyer-Arendt K, Miranda JG, Brown RA, Witze ES, Schweppe RE, Resing KA, Ahn NG. Functional proteomics identifies targets of phosphorylation by B-Raf signaling in melanoma. Mol Cell. 2009 Apr 10; 34(1):115-31. PMID: 19362540.
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Roberts EC, Hammond K, Traish AM, Resing KA, Ahn NG. Identification of G2/M targets for the MAP kinase pathway by functional proteomics. Proteomics. 2006 Aug; 6(16):4541-53. PMID: 16858730.
This graph shows the total number of publications by year, by first, middle/unknown, or last author.
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| Year | Publications |
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| 2006 | 1 | | 2009 | 2 | | 2012 | 1 | | 2014 | 1 | | 2015 | 1 | | 2017 | 3 | | 2018 | 2 | | 2019 | 1 | | 2020 | 3 | | 2021 | 2 |
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