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Kasey Lyn Couts

TitleAsst Professor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-MED
Email

    Collapse Biography 
    Collapse education and training
    Valparaiso University, Valparaiso, INB.S.05/2004Biochemistry
    University of Colorado- Boulder, Boulder, COPh.D.12/2010Biochemistry

    Collapse Overview 
    Collapse overview
    My research interests are primarily focused on understanding the development and pathobiology underlying rare melanomas (such as mucosal, acral, and ocular melanomas) in order to 1) identify risk factors to improve prevention and early detection, 2) develop novel tumor/blood diagnostics for rare melanoma subtypes, 3) establish methods for halting progression and eliminating micro-metastatic disease, and 4) improve efficacy of current therapies (targeted and immunotherapies) and develop new treatment modalities which are effective for rare melanoma patients.

    Collapse Research 
    Collapse research activities and funding
         (Kasey Couts)Jul 1, 2019 - Jun 30, 2022
    Patten-Davis Foundation
    CU Center for Rare Melanomas
    Role Description: Establish a first-of-its-kind joint research and clinical center for improving care of patients with rare, non-UV associated melanomas.
    Role: Co-Director
         (Kasey Couts)Mar 1, 2019 - Feb 28, 2020
    CCTSI
    The role of BRAF fusions in melanoma anti-tumor immune responses
    Role Description: Determine how BRAF fusions promote anti-tumor immunotherapy responses in melanoma patients.
    Role: Principle Investigator
         (Kasey Couts)Jan 1, 2018 - Dec 31, 2018
    American Cancer Society Institutional Seed Grant
    Targeting cell cycle structural variants in acral and mucosal melanomas
    Role Description: Investigate cell cycle structural variants and cell cycle based therapies in acral and mucosal melanomas.
    Role: Principle Investigator
         (Kasey Couts)Jul 1, 2017 - Dec 31, 2018
    Cancer League of Colorado
    Improving targeted therapy in melanomas with BRAF fusions
    Role Description: Test novel combinatorial treatment strategies for BRAF fusions.
    Role: Principle Investigator
         (Kasey Couts)Apr 1, 2016 - Mar 31, 2017
    CCTSI
    Activating gene fusions as targets in malignant melanoma
    Role Description: Characterize gene fusions in pan-negative melanomas using melanoma PDX models.
    Role: Principle Investigator
         (Kasey Couts)Jan 1, 2016 - Jun 1, 2017
    Paul R. Ohara II Seed Grant Award
    Gene fusions as actionable therapeutic targets in acral lentiginous melanomas
    Role Description: Characterize and test efficacy of targeted inhibitors for gene fusions in acral melanomas.
    Role: Principle Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Turner JA, Paton EL, Van Gulick R, Stefanoni D, Cendali F, Reisz J, Tobin RP, McCarter M, D'Alessandro A, Torres RM, Robinson WA, Couts KL, Schlaepfer IR. BRAF Modulates Lipid Use and Accumulation. Cancers (Basel). 2022 Apr 23; 14(9). PMID: 35565240.
      View in: PubMed
    2. Vorwald VM, Davis DM, Van Gulick RJ, Torphy RJ, Borgers JS, Klarquist J, Couts KL, Amato CM, Cogswell DT, Fujita M, Castleman MJ, Davis T, Lozupone C, Medina TM, Robinson WA, Gapin L, McCarter MD, Tobin RP. Circulating CD8+ mucosal-associated invariant T cells correlate with improved treatment responses and overall survival in anti-PD-1-treated melanoma patients. Clin Transl Immunology. 2022; 11(1):e1367. PMID: 35028137.
      View in: PubMed
    3. Mukherjee N, Dart CR, Amato CM, Honig-Frand A, Lambert JR, Lambert KA, Robinson WA, Tobin RP, McCarter MD, Couts KL, Fujita M, Norris DA, Shellman YG. Expression Differences in BCL2 Family Members between Uveal and Cutaneous Melanomas Account for Varying Sensitivity to BH3 Mimetics. J Invest Dermatol. 2022 Jul; 142(7):1912-1922.e7. PMID: 34942200.
      View in: PubMed
    4. Dart CR, Mukherjee N, Amato CM, Goulding A, MacBeth M, Van Gulick R, Couts KL, Lambert JR, Norris DA, Robinson WA, Shellman YG. A Novel Regimen for Treating Melanoma: MCL1 Inhibitors and Azacitidine. Pharmaceuticals (Basel). 2021 Jul 30; 14(8). PMID: 34451846.
      View in: PubMed
    5. Holman BN, Van Gulick RJ, Amato CM, MacBeth ML, Davies KD, Aisner DL, Robinson WA, Couts KL. Clinical and molecular features of subungual melanomas are site-specific and distinct from acral melanomas. Melanoma Res. 2020 12; 30(6):562-573. PMID: 33156595.
      View in: PubMed
    6. Tobin RP, Jordan KR, Kapoor P, Spongberg E, Davis D, Vorwald VM, Couts KL, Gao D, Smith DE, Borgers JSW, Robinson S, Amato C, Gonzalez R, Lewis KD, Robinson WA, Borges VF, McCarter MD. IL-6 and IL-8 Are Linked With Myeloid-Derived Suppressor Cell Accumulation and Correlate With Poor Clinical Outcomes in Melanoma Patients. Front Oncol. 2019; 9:1223. PMID: 31781510.
      View in: PubMed
    7. Mukherjee N, Strosnider A, Vagher B, Lambert KA, Slaven S, Robinson WA, Amato CM, Couts KL, Bemis JGT, Turner JA, Norris DA, Shellman YG. BH3 mimetics induce apoptosis independent of DRP-1 in melanoma. Cell Death Dis. 2018 09 05; 9(9):907. PMID: 30185782.
      View in: PubMed
    8. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 30254212.
      View in: PubMed
    9. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 32071067.
      View in: PubMed
    10. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 32513939.
      View in: PubMed
    11. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 34348236.
      View in: PubMed
    12. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 19362540.
      View in: PubMed
    13. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 19483722.
      View in: PubMed
    14. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 27864876.
      View in: PubMed
    15. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 35172482.
      View in: PubMed
    16. Couts KL, Bemis J, Turner JA, Bagby SM, Murphy D, Christiansen J, Hintzsche JD, Le A, Pitts TM, Wells K, Applegate A, Amato C, Multani P, Chow-Maneval E, Tentler JJ, Shellman YG, Rioth MJ, Tan AC, Gonzalez R, Medina T, Doebele RC, Robinson WA. ALK Inhibitor Response in Melanomas Expressing EML4-ALK Fusions and Alternate ALK Isoforms. Mol Cancer Ther. 2018 01; 17(1):222-231. PMID: 29054983.
      View in: PubMed
    17. Hintzsche JD, Gorden NT, Amato CM, Kim J, Wuensch KE, Robinson SE, Applegate AJ, Couts KL, Medina TM, Wells KR, Wisell JA, McCarter MD, Box NF, Shellman YG, Gonzalez RC, Lewis KD, Tentler JJ, Tan AC, Robinson WA. Whole-exome sequencing identifies recurrent SF3B1 R625 mutation and comutation of NF1 and KIT in mucosal melanoma. Melanoma Res. 2017 06; 27(3):189-199. PMID: 28296713.
      View in: PubMed
    18. Nguyen N, Couts KL, Luo Y, Fujita M. Understanding melanoma stem cells. Melanoma Manag. 2015; 2(2):179-188. PMID: 26594315.
      View in: PubMed
    19. Lee T, Wang N, Houel S, Couts K, Old W, Ahn N. Dosage and temporal thresholds in microRNA proteomics. Mol Cell Proteomics. 2015 Feb; 14(2):289-302. PMID: 25467838.
      View in: PubMed
    20. Couts KL, Anderson EM, Gross MM, Sullivan K, Ahn NG. Oncogenic B-Raf signaling in melanoma cells controls a network of microRNAs with combinatorial functions. Oncogene. 2013 Apr 11; 32(15):1959-70. PMID: 22751131.
      View in: PubMed
    21. Roberts EC, Hammond K, Traish AM, Resing KA, Ahn NG. Identification of G2/M targets for the MAP kinase pathway by functional proteomics. Proteomics. 2006 Aug; 6(16):4541-53. PMID: 16858730.
      View in: PubMed
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