My research program is focused on the interdisciplinary science of health behavior change, the process of using psychological interventions to improve behaviors related to disease prevention and self-management. In 2018 I developed a novel theory to explain a variety of health behaviors and health decision-making scenarios based on the interaction of two distinct neurocognitive systems: See my website at http://2mindstheory.org. Within this broad area, I have focused particularly on the use of motivational interviewing (MI) to improve patients’ and families’ self-management of various chronic illnesses, and in the use of technology to assess patients’ day-by-day experiences and behaviors related to adherence. This work builds on my training as a clinical psychologist and psychotherapy researcher, and on my professional experience designing and evaluating telehealth nurse counseling interventions. My early research studying nurse-delivered counseling to support patient self-management was featured in a 2006 invited chapter for the book Promoting Treatment Adherence: A Practical Handbook for Health Care Practitioners (Sage: Thousand Oaks, CA) and in a 2010 invited state-of-the-science address at the Western Institute of Nursing Research (WIN) conference. As co-PI on an industry-funded study from 2012-2015, I developed counseling protocols for in-person MI counseling by glaucoma educators, demonstrated treatment fidelity, and tested adherence results in a multi-site randomized controlled trial. I have also provided MI training in studies to improve oral health care and reduce pediatric obesity among Head Start children, studies of physical therapy outcomes, and studies of screening and brief interventions for substance use disorders. I was PI on an NIH-funded R21 grant to study HIV medication adherence using smartphone technology, and on a pilot study of brief smartphone-delivered tailored messages to improve adherence. I currently lead an interprofessional training team that teaches MI in HIV care, and I collaborate on studies of opioid treatment in rural clinics and technology-delivered screening and brief interventions for pregnant women. In many of these studies I have supervised the work of other MI trainers and evaluated patients’ daily behaviors over time using monitoring technologies.