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Joseph T Sakai

TitleAssociate Professor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-PSYCH
Phone303/724-3182

    Collapse Research 
    Collapse research activities and funding
    K08DA016314     (SAKAI, JOSEPH T)Sep 15, 2004 - Aug 31, 2010
    NIH/NIDA
    Asian Teens, substance dependence and conduct disorder
    Role: Principal Investigator

    R25DA033219     (HOPFER, CHRISTIAN J)Apr 1, 2012 - Mar 31, 2018
    NIH/NIDA
    Substance Use Disorder Research Training for Medical Students
    Role: Co-Principal Investigator

    R01DA031761     (SAKAI, JOSEPH T)Apr 15, 2012 - Feb 28, 2016
    NIH/NIDA
    Adolescents with Substance and Conduct Problems: Imaging Callous-Unemotionality
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Crowley TJ, Dalwani MS, Sakai JT, Raymond KM, McWilliams SK, Banich MT, Mikulich-Gilbertson SK. Children's brain activation during risky decision-making: A contributor to substance problems? Drug Alcohol Depend. 2017 Jun 04; 178:57-65. PMID: 28641131.
      View in: PubMed
    2. Sakai JT, Dalwani MS, Mikulich-Gilbertson SK, Raymond K, McWilliams S, Tanabe J, Rojas D, Regner M, Banich MT, Crowley TJ. Imaging decision about whether to benefit self by harming others: Adolescents with conduct and substance problems, with or without callous-unemotionality, or developing typically. Psychiatry Res. 2017 May 30; 263:103-112. PMID: 28371655.
      View in: PubMed
    3. Boulos PK, Dalwani MS, Tanabe J, Mikulich-Gilbertson SK, Banich MT, Crowley TJ, Sakai JT. Brain Cortical Thickness Differences in Adolescent Females with Substance Use Disorders. PLoS One. 2016; 11(4):e0152983. PMID: 27049765; PMCID: PMC4822952.
    4. Sakai JT, Dalwani MS, Mikulich-Gilbertson SK, McWilliams SK, Raymond KM, Crowley TJ. A Behavioral Measure of Costly Helping: Replicating and Extending the Association with Callous Unemotional Traits in Male Adolescents. PLoS One. 2016; 11(3):e0151678. PMID: 26977935; PMCID: PMC4792436.
    5. Coors ME, Raymond KM, Hopfer CJ, Sakai J, McWilliams SK, Young S, Mikulich-Gilbertson SK. Adolescents with substance use disorder and assent/consent: Empirical data on understanding biobank risks in genomic research. Drug Alcohol Depend. 2016 Feb 01; 159:267-71. PMID: 26774949; PMCID: PMC4745974 [Available on 02/01/17].
    6. Crowley TJ, Dalwani MS, Mikulich-Gilbertson SK, Young SE, Sakai JT, Raymond KM, McWilliams SK, Roark MJ, Banich MT. Adolescents' Neural Processing of Risky Decisions: Effects of Sex and Behavioral Disinhibition. PLoS One. 2015; 10(7):e0132322. PMID: 26176860; PMCID: PMC4503769.
    7. Regner MF, Dalwani M, Yamamoto D, Perry RI, Sakai JT, Honce JM, Tanabe J. Sex Differences in Gray Matter Changes and Brain-Behavior Relationships in Patients with Stimulant Dependence. Radiology. 2015 Dec; 277(3):801-12. PMID: 26133201; PMCID: PMC4666349 [Available on 12/01/16].
    8. Krmpotich T, Mikulich-Gilbertson S, Sakai J, Thompson L, Banich MT, Tanabe J. Impaired Decision-Making, Higher Impulsivity, and Drug Severity in Substance Dependence and Pathological Gambling. J Addict Med. 2015 Jul-Aug; 9(4):273-80. PMID: 25918968; PMCID: PMC4523448.
    9. Dalwani MS, McMahon MA, Mikulich-Gilbertson SK, Young SE, Regner MF, Raymond KM, McWilliams SK, Banich MT, Tanabe JL, Crowley TJ, Sakai JT. Female adolescents with severe substance and conduct problems have substantially less brain gray matter volume. PLoS One. 2015; 10(5):e0126368. PMID: 26000879; PMCID: PMC4441424.
    10. Chumachenko SY, Sakai JT, Dalwani MS, Mikulich-Gilbertson SK, Dunn R, Tanabe J, Young S, McWilliams SK, Banich MT, Crowley TJ. Brain cortical thickness in male adolescents with serious substance use and conduct problems. Am J Drug Alcohol Abuse. 2015; 41(5):414-24. PMID: 26337200; PMCID: PMC4900688.
    11. Schuermeyer J, Salomonsen-Sautel S, Price RK, Balan S, Thurstone C, Min SJ, Sakai JT. Temporal trends in marijuana attitudes, availability and use in Colorado compared to non-medical marijuana states: 2003-11. Drug Alcohol Depend. 2014 Jul 01; 140:145-55. PMID: 24837585; PMCID: PMC4161452.
    12. Salomonsen-Sautel S, Min SJ, Sakai JT, Thurstone C, Hopfer C. Trends in fatal motor vehicle crashes before and after marijuana commercialization in Colorado. Drug Alcohol Depend. 2014 Jul 01; 140:137-44. PMID: 24831752; PMCID: PMC4068732.
    13. Melroy WE, Stephens SH, Sakai JT, Kamens HM, McQueen MB, Corley RP, Stallings MC, Hopfer CJ, Krauter KS, Brown SA, Hewitt JK, Ehringer MA. Examination of genetic variation in GABRA2 with conduct disorder and alcohol abuse and dependence in a longitudinal study. Behav Genet. 2014 Jul; 44(4):356-67. PMID: 24687270; PMCID: PMC4098655.
    14. Dalwani MS, Tregellas JR, Andrews-Hanna JR, Mikulich-Gilbertson SK, Raymond KM, Banich MT, Crowley TJ, Sakai JT. Default mode network activity in male adolescents with conduct and substance use disorder. Drug Alcohol Depend. 2014 Jan 01; 134:242-250. PMID: 24210423; PMCID: PMC3895766.
    15. Thurstone C, Salomonsen-Sautel S, Mikulich-Gilbertson SK, Hartman CA, Sakai JT, Hoffenberg AS, McQueen MB, Min SJ, Crowley TJ, Corley RP, Hewitt JK, Hopfer CJ. Prevalence and predictors of injection drug use and risky sexual behaviors among adolescents in substance treatment. Am J Addict. 2013 Nov-Dec; 22(6):558-65. PMID: 24131163; PMCID: PMC3931469.
    16. Hopfer C, Salomonsen-Sautel S, Mikulich-Gilbertson S, Min SJ, McQueen M, Crowley T, Young S, Corley R, Sakai J, Thurstone C, Hoffenberg A, Hartman C, Hewitt J. Conduct disorder and initiation of substance use: a prospective longitudinal study. J Am Acad Child Adolesc Psychiatry. 2013 May; 52(5):511-518.e4. PMID: 23622852; PMCID: PMC3813459.
    17. Tanabe J, York P, Krmpotich T, Miller D, Dalwani M, Sakai JT, Mikulich-Gilbertson SK, Thompson L, Claus E, Banich M, Rojas DC. Insula and orbitofrontal cortical morphology in substance dependence is modulated by sex. AJNR Am J Neuroradiol. 2013 Jun-Jul; 34(6):1150-6. PMID: 23153869; PMCID: PMC3809125.
    18. Salomonsen-Sautel S, Sakai JT, Thurstone C, Corley R, Hopfer C. Medical marijuana use among adolescents in substance abuse treatment. J Am Acad Child Adolesc Psychiatry. 2012 Jul; 51(7):694-702. PMID: 22721592; PMCID: PMC3381870.
    19. Sakai JT, Dalwani MS, Gelhorn HL, Mikulich-Gilbertson SK, Crowley TJ. A behavioral test of accepting benefits that cost others: associations with conduct problems and callous-unemotionality. PLoS One. 2012; 7(4):e36158. PMID: 22558367; PMCID: PMC3338604.
    20. Sakai JT, Crowley TJ, Stallings MC, McQueen M, Hewitt JK, Hopfer C, Hoft NR, Ehringer MA. Test of association between 10 single nucleotide polymorphisms in the oxytocin receptor gene and conduct disorder. Psychiatr Genet. 2012 Apr; 22(2):99-102. PMID: 21934640; PMCID: PMC3337143.
    21. Dalwani M, Sakai JT, Mikulich-Gilbertson SK, Tanabe J, Raymond K, McWilliams SK, Thompson LL, Banich MT, Crowley TJ. Reduced cortical gray matter volume in male adolescents with substance and conduct problems. Drug Alcohol Depend. 2011 Nov 01; 118(2-3):295-305. PMID: 21592680; PMCID: PMC3170449.
    22. Sakai JT, Boardman JD, Gelhorn HL, Smolen A, Corley RP, Huizinga D, Menard S, Hewitt JK, Stallings MC. Using trajectory analyses to refine phenotype for genetic association: conduct problems and the serotonin transporter (5HTTLPR). Psychiatr Genet. 2010 Oct; 20(5):199-206. PMID: 20421847; PMCID: PMC2934879.
    23. Sakai JT, Wang C, Price RK. Substance use and dependence among Native Hawaiians, Other Pacific Islanders, and Asian ethnic groups in the United States: contrasting multiple-race and single-race prevalence rates from a national survey. J Ethn Subst Abuse. 2010; 9(3):173-85. PMID: 20737344; PMCID: PMC2929933.
    24. Sakai JT, Stallings MC, Crowley TJ, Gelhorn HL, McQueen MB, Ehringer MA. Test of association between GABRA2 (SNP rs279871) and adolescent conduct/alcohol use disorders utilizing a sample of clinic referred youth with serious substance and conduct problems, controls and available first degree relatives. Drug Alcohol Depend. 2010 Jan 15; 106(2-3):199-203. PMID: 19783384; PMCID: PMC2841007.
    25. Gelhorn H, Hartman C, Sakai J, Mikulich-Gilbertson S, Stallings M, Young S, Rhee S, Corley R, Hewitt J, Hopfer C, Crowley T. An item response theory analysis of DSM-IV conduct disorder. J Am Acad Child Adolesc Psychiatry. 2009 Jan; 48(1):42-50. PMID: 19034046; PMCID: PMC2773289.
    26. Gelhorn H, Hartman C, Sakai J, Stallings M, Young S, Rhee SH, Corley R, Hewitt J, Hopfer C, Crowley T. Toward DSM-V: an item response theory analysis of the diagnostic process for DSM-IV alcohol abuse and dependence in adolescents. J Am Acad Child Adolesc Psychiatry. 2008 Nov; 47(11):1329-39. PMID: 18827724; PMCID: PMC2800944.
    27. Schulz-Heik RJ, Maentz SK, Rhee SH, Gelhorn HL, Young SE, Timberlake DS, Smolen A, Stetler GL, Sakai JT, Crowley TJ. Case-control and within-family tests for an association between conduct disorder and DAT1. Psychiatr Genet. 2008 Feb; 18(1):17-24. PMID: 18197081.
      View in: PubMed
    28. Hartman CA, Gelhorn H, Crowley TJ, Sakai JT, Stallings M, Young SE, Rhee SH, Corley R, Hewitt JK, Hopfer CJ. Item response theory analysis of DSM-IV cannabis abuse and dependence criteria in adolescents. J Am Acad Child Adolesc Psychiatry. 2008 Feb; 47(2):165-73. PMID: 18176333; PMCID: PMC2443687.
    29. Plomondon ME, Ho PM, Wang L, Greiner GT, Shore JH, Sakai JT, Fihn SD, Rumsfeld JS. Severe mental illness and mortality of hospitalized ACS patients in the VHA. BMC Health Serv Res. 2007 Sep 18; 7:146. PMID: 17877804; PMCID: PMC2082028.
    30. Sakai JT, Risk NK, Tanaka CA, Price RK. Conduct disorder among Asians and Native Hawaiian/Pacific Islanders in the USA. Psychol Med. 2008 Jul; 38(7):1013-25. PMID: 17803831.
      View in: PubMed
    31. Mikulich-Gilbertson SK, Salomonsen-Sautel S, Sakai JT, Booth RE. Gender similarities and differences in antisocial behavioral syndromes among injection drug users. Am J Addict. 2007 Sep-Oct; 16(5):372-82. PMID: 17882608.
      View in: PubMed
    32. Gelhorn HL, Sakai JT, Price RK, Crowley TJ. DSM-IV conduct disorder criteria as predictors of antisocial personality disorder. Compr Psychiatry. 2007 Nov-Dec; 48(6):529-38. PMID: 17954138; PMCID: PMC2764329.
    33. Sakai JT, Lessem JM, Haberstick BC, Hopfer CJ, Smolen A, Ehringer MA, Timberlake D, Hewitt JK. Case-control and within-family tests for association between 5HTTLPR and conduct problems in a longitudinal adolescent sample. Psychiatr Genet. 2007 Aug; 17(4):207-14. PMID: 17621163.
      View in: PubMed
    34. Haberstick BC, Timberlake D, Smolen A, Sakai JT, Hopfer CJ, Corley RP, Young SE, Stallings MC, Huizinga D, Menard S, Hartman C, Grotpeter J, Hewitt JK. Between- and within-family association test of the dopamine receptor D2 TaqIA polymorphism and alcohol abuse and dependence in a general population sample of adults. J Stud Alcohol Drugs. 2007 May; 68(3):362-70. PMID: 17446975; PMCID: PMC2507866.
    35. Timberlake DS, Haberstick BC, Hopfer CJ, Bricker J, Sakai JT, Lessem JM, Hewitt JK. Progression from marijuana use to daily smoking and nicotine dependence in a national sample of U.S. adolescents. Drug Alcohol Depend. 2007 May 11; 88(2-3):272-81. PMID: 17174040.
      View in: PubMed
    36. Sakai JT, Young SE, Stallings MC, Timberlake D, Smolen A, Stetler GL, Crowley TJ. Case-control and within-family tests for an association between conduct disorder and 5HTTLPR. Am J Med Genet B Neuropsychiatr Genet. 2006 Dec 05; 141B(8):825-32. PMID: 16972235.
      View in: PubMed
    37. Sakai JT, Hopfer CJ, Hartman C, Haberstick BC, Smolen A, Corley RP, Stallings MC, Young SE, Timberlake D, Hewitt JK, Crowley TJ. Test of association between TaqIA A1 allele and alcohol use disorder phenotypes in a sample of adolescent patients with serious substance and behavioral problems. Drug Alcohol Depend. 2007 May 11; 88(2-3):130-7. PMID: 17069991.
      View in: PubMed
    38. Weissberg M, Sakai JT, Miyoshi TJ, Fryer GE. Medical student attitudes to risk taking and self-perceived influence on medical practice. Med Educ. 2006 Aug; 40(8):722-9. PMID: 16869916.
      View in: PubMed
    39. Sakai JT, Mikulich-Gilbertson SK, Long RJ, Crowley TJ. Validity of transdermal alcohol monitoring: fixed and self-regulated dosing. Alcohol Clin Exp Res. 2006 Jan; 30(1):26-33. PMID: 16433729.
      View in: PubMed
    40. Sakai JT, Mikulich-Gilbertson SK, Crowley TJ. Adolescent inhalant use among male patients in treatment for substance and behavior problems: two-year outcome. Am J Drug Alcohol Abuse. 2006; 32(1):29-40. PMID: 16450641.
      View in: PubMed
    41. Sakai JT, Ho PM, Shore JH, Risk NK, Price RK. Asians in the United States: substance dependence and use of substance-dependence treatment. J Subst Abuse Treat. 2005 Sep; 29(2):75-84. PMID: 16135336.
      View in: PubMed
    42. Sakai JT, Hall SK, Mikulich-Gilbertson SK, Crowley TJ. Inhalant use, abuse, and dependence among adolescent patients: commonly comorbid problems. J Am Acad Child Adolesc Psychiatry. 2004 Sep; 43(9):1080-8. PMID: 15322411.
      View in: PubMed
    43. Sakai JT, Stallings MC, Mikulich-Gilbertson SK, Corley RP, Young SE, Hopfer CJ, Crowley TJ. Mate similarity for substance dependence and antisocial personality disorder symptoms among parents of patients and controls. Drug Alcohol Depend. 2004 Aug 16; 75(2):165-75. PMID: 15276222.
      View in: PubMed
    44. Faraone SV, Biederman J, Weiffenbach B, Keith T, Chu MP, Weaver A, Spencer TJ, Wilens TE, Frazier J, Cleves M, Sakai J. Dopamine D4 gene 7-repeat allele and attention deficit hyperactivity disorder. Am J Psychiatry. 1999 May; 156(5):768-70. PMID: 10327912.
      View in: PubMed
    45. Sakai J, Kim M, Shore J, Hepfer M. The risk of purified protein derivative positivity in homeless men with psychotic symptoms. South Med J. 1998 Apr; 91(4):345-8. PMID: 9563425.
      View in: PubMed
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