Colorado PROFILES, The Colorado Clinical and Translational Sciences Institute (CCTSI)
Keywords
Last Name
Institution

Contact Us
If you have any questions or feedback please contact us.

Uwe Christians

TitleProfessor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-Anesthesiology
Phone303/724-5665

    Collapse Research 
    Collapse research activities and funding
    R01HL071805     (CHRISTIANS, UWE)Apr 8, 2003 - Mar 31, 2008
    NIH/NHLBI
    The Role of Statin Lactones in Statin Toxicity
    Role: Principal Investigator

    R01DK065094     (CHRISTIANS, UWE)Jul 15, 2003 - Apr 30, 2009
    NIH/NIDDK
    Effects of Immunosuppressants on Cell Metabolism
    Role: Principal Investigator

    R01HD070511     (CHRISTIANS, UWE)Jul 20, 2011 - Apr 30, 2016
    NIH/NICHD
    In Vivo Assessment of Calcineurin Inhibitor Toxicity in Children
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Klawitter J, Pennington A, Klawitter J, Thurman JM, Christians U. Mitochondrial cyclophilin D ablation is associated with the activation of Akt/p70S6K pathway in the mouse kidney. Sci Rep. 2017 Sep 05; 7(1):10540. PMID: 28874678.
      View in: PubMed
    2. Schroeder T, Piantadosi CA, Natoli MJ, Autmizguine J, Cohen-Wolkowieczs M, Hamilton KL, Bell C, Klawitter J, Christians U, Irwin DC, Noveck RJ. Safety and ergogenic properties of combined aminophylline and ambrisentan in hypoxia. Clin Pharmacol Ther. 2017 Aug 31. PMID: 28857147.
      View in: PubMed
    3. Kem WR, Olincy A, Johnson L, Harris J, Wagner BD, Buchanan RW, Christians U, Freedman R. Pharmacokinetic Limitations on Effects of an Alpha7 Nicotinic Receptor Agonist in Schizophrenia: Randomized Trial with an Extended Release Formulation. Neuropsychopharmacology. 2017 Aug 21. PMID: 28825423.
      View in: PubMed
    4. Atigh MK, Turner E, Christians U, Yazdani SK. The use of an occlusion perfusion catheter to deliver paclitaxel to the arterial wall. Cardiovasc Ther. 2017 Aug; 35(4). PMID: 28445625.
      View in: PubMed
    5. Klepacki J, Davari B, Boulet M, Lizarraga R, Christians U. A High-throughput HPLC-MS/MS Assay for the Detection, Quantification, and Simultaneous Structural Confirmation of 136 Drugs and Metabolites in Human Urine. Ther Drug Monit. 2017 Jun 22. PMID: 28650900.
      View in: PubMed
    6. Klawitter J, Sempio C, Mörlein S, De Bloois E, Klepacki J, Henthorn T, Leehey MA, Hoffenberg EJ, Knupp K, Wang GS, Hopfer C, Kinney G, Bowler R, Foreman N, Galinkin J, Christians U, Klawitter J. An Atmospheric Pressure Ionization MS/MS Assay using Online Extraction for the Analysis of 11 Cannabinoids and Metabolites in Human Plasma and Urine. Ther Drug Monit. 2017 Jun 19. PMID: 28640062.
      View in: PubMed
    7. Grenz A, Bauerle JD, Dalton JH, Ridyard D, Badulak A, Tak E, McNamee EN, Clambey E, Moldovan R, Reyes G, Klawitter J, Ambler K, Magee K, Christians U, Brodsky KS, Ravid K, Choi DS, Wen J, Lukashev D, Blackburn MR, Osswald H, Coe IR, Nürnberg B, Haase VH, Xia Y, Sitkovsky M, Eltzschig HK. Equilibrative nucleoside transporter 1 (ENT1) regulates postischemic blood flow during acute kidney injury in mice. J Clin Invest. 2017 Jun 01; 127(6):2438. PMID: 28569735.
      View in: PubMed
    8. Heischmann S, Christians U. Validation of the cell line LS180 as a model for study of the gastrointestinal toxicity of mycophenolic acid. Xenobiotica. 2017 May 30; 1-9. PMID: 28489504.
      View in: PubMed
    9. Strand TE, Khiabani HZ, Boico A, Radiloff D, Zhao Y, Hamilton KL, Christians U, Klawitter J, Noveck RJ, Piantadosi CA, Bell C, Irwin D, Schroeder T. The novel combination of theophylline and bambuterol as a potential treatment of hypoxemia in humans. Can J Physiol Pharmacol. 2017 May 03; 1-10. PMID: 28467859.
      View in: PubMed
    10. Diwan TS, Lichvar AB, Leino AD, Vinks AA, Christians U, Shields AR, Cardi MA, Fukuda T, Mizuno T, Kaiser T, Woodle ES, Alloway RR. Pharmacokinetic and pharmacogenetic analysis of immunosuppressive agents after laparoscopic sleeve gastrectomy. Clin Transplant. 2017 Jun; 31(6). PMID: 28342282.
      View in: PubMed
    11. Klawitter J, Seres T, Pennington A, Beatty JT, Klawitter J, Christians U. Ablation of Cyclophilin D Results in an Activation of FAK, Akt, and ERK Pathways in the Mouse Heart. J Cell Biochem. 2017 Sep; 118(9):2933-2940. PMID: 28230282.
      View in: PubMed
    12. Pedroso AP, Souza AP, Dornellas AP, Oyama LM, Nascimento CM, Santos GM, Rosa JC, Bertolla RP, Klawitter J, Christians U, Tashima AK, Ribeiro EB. Intrauterine Growth Restriction Programs the Hypothalamus of Adult Male Rats: Integrated Analysis of Proteomic and Metabolomic Data. J Proteome Res. 2017 Apr 07; 16(4):1515-1525. PMID: 28314371.
      View in: PubMed
    13. Heischmann S, Dzieciatkowska M, Hansen K, Leibfritz D, Christians U. The Immunosuppressant Mycophenolic Acid Alters Nucleotide and Lipid Metabolism in an Intestinal Cell Model. Sci Rep. 2017 Mar 22; 7:45088. PMID: 28327659.
      View in: PubMed
    14. Mishra N, Wang P, Goldsmith D, Zhao X, Xue Y, Christians U, Minassian BA. Everolimus does not prevent Lafora body formation in murine Lafora disease. Neurol Genet. 2017 Feb; 3(1):e127. PMID: 28097224.
      View in: PubMed
    15. Mizuno T, Fukuda T, Christians U, Perentesis JP, Fouladi M, Vinks AA. Population pharmacokinetics of temsirolimus and sirolimus in children with recurrent solid tumours: a report from the Children's Oncology Group. Br J Clin Pharmacol. 2017 May; 83(5):1097-1107. PMID: 28000286.
      View in: PubMed
    16. Checkley W, Deza MP, Klawitter J, Romero KM, Klawitter J, Pollard SL, Wise RA, Christians U, Hansel NN. Identifying biomarkers for asthma diagnosis using targeted metabolomics approaches. Respir Med. 2016 Dec; 121:59-66. PMID: 27888993.
      View in: PubMed
    17. Emoto C, Fukuda T, Mizuno T, Schniedewind B, Christians U, Adams DM, Vinks AA. Characterizing the Developmental Trajectory of Sirolimus Clearance in Neonates and Infants. CPT Pharmacometrics Syst Pharmacol. 2016 Aug; 5(8):411-7. PMID: 27501453; PMCID: PMC4999604.
    18. Klepacki J, Klawitter J, Klawitter J, Karimpour-Fard A, Thurman J, Ingle G, Patel D, Christians U. Amino acids in a targeted versus a non-targeted metabolomics LC-MS/MS assay. Are the results consistent? Clin Biochem. 2016 Sep; 49(13-14):955-61. PMID: 27288551.
      View in: PubMed
    19. O'Connor S, Zhang YL, Christians U, Morrison JE, Friesen RH. Remifentanil and propofol undergo separation and layering when mixed in the same syringe for total intravenous anesthesia. Paediatr Anaesth. 2016 Jul; 26(7):703-9. PMID: 27146802.
      View in: PubMed
    20. Christians U, Klawitter J, Klawitter J. Biomarkers in Transplantation--Proteomics and Metabolomics. Ther Drug Monit. 2016 Apr; 38 Suppl 1:S70-4. PMID: 26418702; PMCID: PMC4769975 [Available on 04/01/17].
    21. Shipkova M, López OM, Picard N, Noceti O, Sommerer C, Christians U, Wieland E. Analytical Aspects of the Implementation of Biomarkers in Clinical Transplantation. Ther Drug Monit. 2016 Apr; 38 Suppl 1:S80-92. PMID: 26418704.
      View in: PubMed
    22. Brunet M, Shipkova M, van Gelder T, Wieland E, Sommerer C, Budde K, Haufroid V, Christians U, López-Hoyos M, Barten MJ, Bergan S, Picard N, Millán López O, Marquet P, Hesselink DA, Noceti O, Pawinski T, Wallemacq P, Oellerich M. Barcelona Consensus on Biomarker-Based Immunosuppressive Drugs Management in Solid Organ Transplantation. Ther Drug Monit. 2016 Apr; 38 Suppl 1:S1-20. PMID: 26977997.
      View in: PubMed
    23. Seger C, Shipkova M, Christians U, Billaud EM, Wang P, Holt DW, Brunet M, Kunicki PK, Pawinski T, Langman LJ, Marquet P, Oellerich M, Wieland E, Wallemacq P. Assuring the Proper Analytical Performance of Measurement Procedures for Immunosuppressive Drug Concentrations in Clinical Practice: Recommendations of the International Association of Therapeutic Drug Monitoring and Clinical Toxicology Immunosuppressive Drug Scientific Committee. Ther Drug Monit. 2016 Apr; 38(2):170-89. PMID: 26982493.
      View in: PubMed
    24. Repine JE, Wilson P, Elkins N, Klawitter J, Christians U, Peters B, Smith DM. Inhalation of two putative Gulf War toxins by mice. J Environ Sci Health B. 2016; 51(6):366-73. PMID: 26950528.
      View in: PubMed
    25. Fæste CK, Moen A, Schniedewind B, Haug Anonsen J, Klawitter J, Christians U. Development of liquid chromatography-tandem mass spectrometry methods for the quantitation of Anisakis simplex proteins in fish. J Chromatogr A. 2016 Feb 05; 1432:58-72. PMID: 26787163.
      View in: PubMed
    26. Christians U, Vinks AA, Langman LJ, Clarke W, Wallemacq P, van Gelder T, Renjen V, Marquet P, Meyer EJ. Impact of Laboratory Practices on Interlaboratory Variability in Therapeutic Drug Monitoring of Immunosuppressive Drugs. Ther Drug Monit. 2015 Dec; 37(6):718-24. PMID: 26291980.
      View in: PubMed
    27. Shokati T, Bodenberger N, Gadpaille H, Schniedewind B, Vinks AA, Jiang W, Alloway RR, Christians U. Quantification of the Immunosuppressant Tacrolimus on Dried Blood Spots Using LC-MS/MS. J Vis Exp. 2015 Nov 08; (105):e52424. PMID: 26575262.
      View in: PubMed
    28. Hadamitzky M, Bösche K, Wirth T, Buck B, Beetz O, Christians U, Schniedewind B, Lückemann L, Güntürkün O, Engler H, Schedlowski M. Memory-updating abrogates extinction of learned immunosuppression. Brain Behav Immun. 2016 Feb; 52:40-8. PMID: 26386321.
      View in: PubMed
    29. Klawitter J, McFann K, Pennington AT, Wang W, Klawitter J, Christians U, Schrier RW, Gitomer B, Cadnapaphornchai MA. Pravastatin Therapy and Biomarker Changes in Children and Young Adults with Autosomal Dominant Polycystic Kidney Disease. Clin J Am Soc Nephrol. 2015 Sep 04; 10(9):1534-41. PMID: 26224879; PMCID: PMC4559520.
    30. Emoto C, Fukuda T, Mizuno T, Cox S, Schniedewind B, Christians U, Widemann BC, Fisher MJ, Weiss B, Perentesis J, Vinks AA. Age-dependent changes in sirolimus metabolite formation in patients with neurofibromatosis type 1. Ther Drug Monit. 2015 Jun; 37(3):395-9. PMID: 25162215.
      View in: PubMed
    31. Schniedewind B, Niederlechner S, Galinkin JL, Johnson-Davis KL, Christians U, Meyer EJ. Long-term cross-validation of everolimus therapeutic drug monitoring assays: the Zortracker study. Ther Drug Monit. 2015 Jun; 37(3):296-303. PMID: 25970506; PMCID: PMC4820066.
    32. Klawitter J, Nashan B, Christians U. Everolimus and sirolimus in transplantation-related but different. Expert Opin Drug Saf. 2015 Jul; 14(7):1055-70. PMID: 25912929.
      View in: PubMed
    33. Klepacki J, Klawitter J, Klawitter J, Thurman JM, Christians U. A high-performance liquid chromatography-tandem mass spectrometry-based targeted metabolomics kidney dysfunction marker panel in human urine. Clin Chim Acta. 2015 Jun 15; 446:43-53. PMID: 25871999.
      View in: PubMed
    34. Bösche K, Weissenborn K, Christians U, Witzke O, Engler H, Schedlowski M, Hadamitzky M. Neurobehavioral consequences of small molecule-drug immunosuppression. Neuropharmacology. 2015 Sep; 96(Pt A):83-93. PMID: 25529273.
      View in: PubMed
    35. Klawitter J, Reed-Gitomer BY, McFann K, Pennington A, Klawitter J, Abebe KZ, Klepacki J, Cadnapaphornchai MA, Brosnahan G, Chonchol M, Christians U, Schrier RW. Endothelial dysfunction and oxidative stress in polycystic kidney disease. Am J Physiol Renal Physiol. 2014 Dec 01; 307(11):F1198-206. PMID: 25234311; PMCID: PMC4254971.
    36. Fernandez-Bustamante A, Klawitter J, Repine JE, Agazio A, Janocha AJ, Shah C, Moss M, Douglas IS, Tran ZV, Erzurum SC, Christians U, Seres T. Early effect of tidal volume on lung injury biomarkers in surgical patients with healthy lungs. Anesthesiology. 2014 Sep; 121(3):469-81. PMID: 24809976; PMCID: PMC4165799.
    37. Fæste CK, Jonscher KR, Dooper MM, Egge-Jacobsen W, Moen A, Daschner A, Egaas E, Christians U. Characterisation of potential novel allergens in the fish parasite Anisakis simplex. EuPA Open Proteom. 2014 Sep; 4:140-155. PMID: 27110489.
      View in: PubMed
    38. Klawitter J, Bek S, Zakaria M, Zeng C, Hornberger A, Gilbert R, Shokati T, Klawitter J, Christians U, Boernsen KO. Fatty acid desaturation index in human plasma: comparison of different analytical methodologies for the evaluation of diet effects. Anal Bioanal Chem. 2014 Oct; 406(25):6399-408. PMID: 25116600.
      View in: PubMed
    39. Shihab F, Christians U, Smith L, Wellen JR, Kaplan B. Focus on mTOR inhibitors and tacrolimus in renal transplantation: pharmacokinetics, exposure-response relationships, and clinical outcomes. Transpl Immunol. 2014 Jun; 31(1):22-32. PMID: 24861504.
      View in: PubMed
    40. Klawitter J, Klawitter J, Schmitz V, Shokati T, Epshtein E, Thurman JM, Christians U. Mycophenolate mofetil enhances the negative effects of sirolimus and tacrolimus on rat kidney cell metabolism. PLoS One. 2014; 9(1):e86202. PMID: 24497939; PMCID: PMC3907404.
    41. Klawitter J, Klawitter J, McFann K, Pennington AT, Abebe KZ, Brosnahan G, Cadnapaphornchai MA, Chonchol M, Gitomer B, Christians U, Schrier RW. Bioactive lipid mediators in polycystic kidney disease. J Lipid Res. 2014 Jun; 55(6):1139-49. PMID: 24343898; PMCID: PMC4031945.
    42. Tak E, Ridyard D, Kim JH, Zimmerman M, Werner T, Wang XX, Shabeka U, Seo SW, Christians U, Klawitter J, Moldovan R, Garcia G, Levi M, Haase V, Ravid K, Eltzschig HK, Grenz A. CD73-dependent generation of adenosine and endothelial Adora2b signaling attenuate diabetic nephropathy. J Am Soc Nephrol. 2014 Mar; 25(3):547-63. PMID: 24262796; PMCID: PMC3935577.
    43. Renner B, Klawitter J, Goldberg R, McCullough JW, Ferreira VP, Cooper JE, Christians U, Thurman JM. Cyclosporine induces endothelial cell release of complement-activating microparticles. J Am Soc Nephrol. 2013 Nov; 24(11):1849-62. PMID: 24092930; PMCID: PMC3810078.
    44. Fernandez-Bustamante A, Klawitter J, Wilson P, Elkins ND, Agazio A, Shibata T, Uchida K, Christians U, Repine JE. Early increase in alveolar macrophage prostaglandin 15d-PGJ2 precedes neutrophil recruitment into lungs of cytokine-insufflated rats. Inflammation. 2013 Oct; 36(5):1030-40. PMID: 23616184.
      View in: PubMed
    45. Frassetto L, Floren L, Barin B, Browne M, Wolfe A, Roland M, Stock P, Carlson L, Christians U, Benet L. Changes in clearance, volume and bioavailability of immunosuppressants when given with HAART in HIV-1 infected liver and kidney transplant recipients. Biopharm Drug Dispos. 2013 Nov; 34(8):442-51. PMID: 24030928; PMCID: PMC4018225.
    46. Ogasawara K, Chitnis SD, Gohh RY, Christians U, Akhlaghi F. Multidrug resistance-associated protein 2 (MRP2/ABCC2) haplotypes significantly affect the pharmacokinetics of tacrolimus in kidney transplant recipients. Clin Pharmacokinet. 2013 Sep; 52(9):751-62. PMID: 23633119; PMCID: PMC3755037.
    47. Pian P, Labovitz E, Hoffman K, Clavijo CF, Rzasa Lynn R, Galinkin JL, Vinks AA, Malik P, Christians U. Quantification of the 5-lipoxygenase inhibitor zileuton in human plasma using high performance liquid chromatography-tandem mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci. 2013 Oct 15; 937:79-83. PMID: 24029553.
      View in: PubMed
    48. Klawitter J, Zafar I, Klawitter J, Pennington AT, Klepacki J, Gitomer BY, Schrier RW, Christians U, Edelstein CL. Effects of lovastatin treatment on the metabolic distributions in the Han:SPRD rat model of polycystic kidney disease. BMC Nephrol. 2013 Jul 31; 14:165. PMID: 23902712; PMCID: PMC3751441.
    49. Emoto C, Fukuda T, Cox S, Christians U, Vinks AA. Development of a Physiologically-Based Pharmacokinetic Model for Sirolimus: Predicting Bioavailability Based on Intestinal CYP3A Content. CPT Pharmacometrics Syst Pharmacol. 2013 Jul 24; 2:e59. PMID: 23884207; PMCID: PMC3731827.
    50. Lemos PA, Farooq V, Takimura CK, Gutierrez PS, Virmani R, Kolodgie F, Christians U, Kharlamov A, Doshi M, Sojitra P, van Beusekom HM, Serruys PW. Emerging technologies: polymer-free phospholipid encapsulated sirolimus nanocarriers for the controlled release of drug from a stent-plus-balloon or a stand-alone balloon catheter. EuroIntervention. 2013 May 20; 9(1):148-56. PMID: 23685303.
      View in: PubMed
    51. Taylor RR, Hoffman KL, Schniedewind B, Clavijo C, Galinkin JL, Christians U. Comparison of the quantification of acetaminophen in plasma, cerebrospinal fluid and dried blood spots using high-performance liquid chromatography-tandem mass spectrometry. J Pharm Biomed Anal. 2013 Sep; 83:1-9. PMID: 23670126; PMCID: PMC3991461.
    52. Razzaghi H, Tempczyk-Russell A, Haubold K, Santorico SA, Shokati T, Christians U, Churchill ME. Genetic and structure-function studies of missense mutations in human endothelial lipase. PLoS One. 2013; 8(3):e55716. PMID: 23536757; PMCID: PMC3607615.
    53. Klepacki J, Brunner N, Schmitz V, Klawitter J, Christians U, Klawitter J. Development and validation of an LC-MS/MS assay for the quantification of the trans-methylation pathway intermediates S-adenosylmethionine and S-adenosylhomocysteine in human plasma. Clin Chim Acta. 2013 Jun 05; 421:91-7. PMID: 23499573; PMCID: PMC4033670.
    54. Chitnis SD, Ogasawara K, Schniedewind B, Gohh RY, Christians U, Akhlaghi F. Concentration of tacrolimus and major metabolites in kidney transplant recipients as a function of diabetes mellitus and cytochrome P450 3A gene polymorphism. Xenobiotica. 2013 Jul; 43(7):641-9. PMID: 23278282; PMCID: PMC4116556.
    55. Bohra R, Klepacki J, Klawitter J, Klawitter J, Thurman JM, Christians U. Proteomics and metabolomics in renal transplantation-quo vadis? Transpl Int. 2013 Mar; 26(3):225-41. PMID: 23350848; PMCID: PMC4006577.
    56. Niederlechner S, Klawitter J, Baird C, Kallweit AR, Christians U, Wischmeyer PE. Fibronectin-integrin signaling is required for L-glutamine's protection against gut injury. PLoS One. 2012; 7(11):e50185. PMID: 23185570; PMCID: PMC3502344.
    57. Christians U, Klepacki J, Shokati T, Klawitter J, Klawitter J. Mass Spectrometry-Based Multiplexing for the Analysis of Biomarkers in Drug Development and Clinical Diagnostics- How Much is too Much? Microchem J. 2012 Nov 01; 105:32-38. PMID: 23645936.
      View in: PubMed
    58. Bohra R, Schöning W, Klawitter J, Brunner N, Schmitz V, Shokati T, Lawrence R, Arbelaez MF, Schniedewind B, Christians U, Klawitter J. Everolimus and sirolimus in combination with cyclosporine have different effects on renal metabolism in the rat. PLoS One. 2012; 7(10):e48063. PMID: 23118926; PMCID: PMC3485290.
    59. Macy ME, Duncan T, Whitlock J, Hunger SP, Boklan J, Narendren A, Herzog C, Arceci RJ, Bagatell R, Trippett T, Christians U, Rolla K, Ivy SP, Gore L. A multi-center phase Ib study of oxaliplatin (NSC#266046) in combination with fluorouracil and leucovorin in pediatric patients with advanced solid tumors. Pediatr Blood Cancer. 2013 Feb; 60(2):230-6. PMID: 23024067; PMCID: PMC3522763.
    60. Klawitter J, Klawitter J, Agardi E, Corby K, Leibfritz D, Lowes BD, Christians U, Seres T. Association of DJ-1/PTEN/AKT- and ASK1/p38-mediated cell signalling with ischaemic cardiomyopathy. Cardiovasc Res. 2013 Jan 01; 97(1):66-76. PMID: 23015639.
      View in: PubMed
    61. Leitman DC, Christians U. MF101: a multi-component botanical selective estrogen receptor beta modulator for the treatment of menopausal vasomotor symptoms. Expert Opin Investig Drugs. 2012 Jul; 21(7):1031-42. PMID: 22616988.
      View in: PubMed
    62. Grenz A, Bauerle JD, Dalton JH, Ridyard D, Badulak A, Tak E, McNamee EN, Clambey E, Moldovan R, Reyes G, Klawitter J, Ambler K, Magee K, Christians U, Brodsky KS, Ravid K, Choi DS, Wen J, Lukashev D, Blackburn MR, Osswald H, Coe IR, Nürnberg B, Haase VH, Xia Y, Sitkovsky M, Eltzschig HK. Equilibrative nucleoside transporter 1 (ENT1) regulates postischemic blood flow during acute kidney injury in mice. J Clin Invest. 2012 02; 122(2):693-710. PMID: 22269324; PMCID: PMC3266792.
    63. Pacheco-López G, Doenlen R, Krügel U, Arnold M, Wirth T, Riether C, Engler A, Niemi MB, Christians U, Engler H, Schedlowski M. Neurobehavioural activation during peripheral immunosuppression. Int J Neuropsychopharmacol. 2013 Feb; 16(1):137-49. PMID: 22217400.
      View in: PubMed
    64. Aquilante CL, Kiser JJ, Anderson PL, Christians U, Kosmiski LA, Daily EB, Hoffman KL, Hopley CW, Predhomme JA, Schniedewind B, Sidhom MS. Influence of SLCO1B1 polymorphisms on the drug-drug interaction between darunavir/ritonavir and pravastatin. J Clin Pharmacol. 2012 Nov; 52(11):1725-38. PMID: 22174437.
      View in: PubMed
    65. Clavijo CF, Thomas JJ, Cromie M, Schniedewind B, Hoffman KL, Christians U, Galinkin JL. A low blood volume LC-MS/MS assay for the quantification of fentanyl and its major metabolites norfentanyl and despropionyl fentanyl in children. J Sep Sci. 2011 Dec; 34(24):3568-77. PMID: 21916010.
      View in: PubMed
    66. Klepacki J, Klawitter J, Bendrick-Peart J, Schniedewind B, Heischmann S, Shokati T, Christians U, Klawitter J. A high-throughput U-HPLC-MS/MS assay for the quantification of mycophenolic acid and its major metabolites mycophenolic acid glucuronide and mycophenolic acid acyl-glucuronide in human plasma and urine. J Chromatogr B Analyt Technol Biomed Life Sci. 2012 Feb 01; 883-884:113-9. PMID: 21839692; PMCID: PMC3232328.
    67. Christians U, Klawitter J, Hornberger A, Klawitter J. How unbiased is non-targeted metabolomics and is targeted pathway screening the solution? Curr Pharm Biotechnol. 2011 Jul; 12(7):1053-66. PMID: 21466457.
      View in: PubMed
    68. Strom T, Shokati T, Klawitter J, Klawitter J, Hoffman K, Schiebel HM, Christians U. Structural identification of SAR-943 metabolites generated by human liver microsomes in vitro using mass spectrometry in combination with analysis of fragmentation patterns. J Mass Spectrom. 2011 Jul; 46(7):615-24. PMID: 21671437.
      View in: PubMed
    69. Klawitter J, Klawitter J, Gurshtein J, Corby K, Fong S, Tagliaferri M, Quattrochi L, Cohen I, Shtivelman E, Christians U. Bezielle (BZL101)-induced oxidative stress damage followed by redistribution of metabolic fluxes in breast cancer cells: a combined proteomic and metabolomic study. Int J Cancer. 2011 Dec 15; 129(12):2945-57. PMID: 21509784.
      View in: PubMed
    70. Clavijo CF, Hoffman KL, Thomas JJ, Carvalho B, Chu LF, Drover DR, Hammer GB, Christians U, Galinkin JL. A sensitive assay for the quantification of morphine and its active metabolites in human plasma and dried blood spots using high-performance liquid chromatography-tandem mass spectrometry. Anal Bioanal Chem. 2011 May; 400(3):715-28. PMID: 21400080.
      View in: PubMed
    71. Klawitter J, Haschke M, Shokati T, Klawitter J, Christians U. Quantification of 15-F2t-isoprostane in human plasma and urine: results from enzyme-linked immunoassay and liquid chromatography/tandem mass spectrometry cannot be compared. Rapid Commun Mass Spectrom. 2011 Feb 28; 25(4):463-8. PMID: 21259353.
      View in: PubMed
    72. Fæste CK, Rønning HT, Christians U, Granum PE. Liquid chromatography and mass spectrometry in food allergen detection. J Food Prot. 2011 Feb; 74(2):316-45. PMID: 21333155.
      View in: PubMed
    73. Christians U, Klawitter J, Klawitter J, Brunner N, Schmitz V. Biomarkers of immunosuppressant organ toxicity after transplantation: status, concepts and misconceptions. Expert Opin Drug Metab Toxicol. 2011 Feb; 7(2):175-200. PMID: 21241200; PMCID: PMC3079351.
    74. Cohen MN, Christians U, Henthorn T, Vu Tran Z, Moll V, Zuk J, Galinkin J. Pharmacokinetics of single-dose intravenous ketorolac in infants aged 2-11 months. Anesth Analg. 2011 Mar; 112(3):655-60. PMID: 21233498.
      View in: PubMed
    75. Banerjee S, Gianino SM, Gao F, Christians U, Gutmann DH. Interpreting mammalian target of rapamycin and cell growth inhibition in a genetically engineered mouse model of Nf1-deficient astrocytes. Mol Cancer Ther. 2011 Feb; 10(2):279-91. PMID: 21216928; PMCID: PMC3857701.
    76. Thethi T, Rajapurkar M, Walker P, McDuffie R, Goff DC, Probstfield J, Yau CL, Shah S, Christians U, Buse J, Fonseca V. Urinary catalytic iron in patients with type 2 diabetes without microalbuminuria--a substudy of the ACCORD Trial. Clin Chem. 2011 Feb; 57(2):341-4. PMID: 21159897.
      View in: PubMed
    77. Gottschalk S, Cummins CL, Leibfritz D, Christians U, Benet LZ, Serkova NJ. Age and sex differences in the effects of the immunosuppressants cyclosporine, sirolimus and everolimus on rat brain metabolism. Neurotoxicology. 2011 Jan; 32(1):50-7. PMID: 21075140.
      View in: PubMed
    78. Ostojic MC, Perisic Z, Sagic D, Jung R, Zhang YL, Bendrick-Peart J, Betts R, Christians U. The pharmacokinetics of Biolimus A9 after elution from the BioMatrix II stent in patients with coronary artery disease: the Stealth PK Study. Eur J Clin Pharmacol. 2011 Apr; 67(4):389-398. PMID: 20963405.
      View in: PubMed
    79. Angst MS, Phillips NG, Drover DR, Tingle M, Galinkin JL, Christians U, Swan GE, Lazzeroni LC, Clark JD. Opioid pharmacogenomics using a twin study paradigm: methods and procedures for determining familial aggregation and heritability. Twin Res Hum Genet. 2010 Oct; 13(5):412-25. PMID: 20874462.
      View in: PubMed
    80. Klawitter J, Haschke M, Kahle C, Dingmann C, Klawitter J, Leibfritz D, Christians U. Toxicodynamic effects of ciclosporin are reflected by metabolite profiles in the urine of healthy individuals after a single dose. Br J Clin Pharmacol. 2010 Aug; 70(2):241-51. PMID: 20653677; PMCID: PMC2911554.
    81. Stevens KE, Cornejo B, Adams CE, Zheng L, Yonchek J, Hoffman KL, Christians U, Kem WR. Continuous administration of a selective alpha7 nicotinic partial agonist, DMXBA, improves sensory inhibition without causing tachyphylaxis or receptor upregulation in DBA/2 mice. Brain Res. 2010 Sep 17; 1352:140-6. PMID: 20599427; PMCID: PMC3932956.
    82. Tada N, Virmani R, Grant G, Bartlett L, Black A, Clavijo C, Christians U, Betts R, Savage D, Su SH, Shulze J, Kar S. Polymer-free biolimus a9-coated stent demonstrates more sustained intimal inhibition, improved healing, and reduced inflammation compared with a polymer-coated sirolimus-eluting cypher stent in a porcine model. Circ Cardiovasc Interv. 2010 Apr; 3(2):174-83. PMID: 20407114.
      View in: PubMed
    83. Steudel W, Dingmann C, Zhang YL, Bendrick-Peart J, Clavijo C, Shulze J, Betts R, Christians U. Randomized, double-blind, placebo-controlled, single intravenous dose-escalation study to evaluate the safety, tolerability, and pharmacokinetics of the novel coronary smooth muscle cell proliferation inhibitor Biolimus A9 in healthy individuals. J Clin Pharmacol. 2011 Jan; 51(1):29-39. PMID: 20305057.
      View in: PubMed
    84. Klawitter J, Gottschalk S, Hainz C, Leibfritz D, Christians U, Serkova NJ. Immunosuppressant neurotoxicity in rat brain models: oxidative stress and cellular metabolism. Chem Res Toxicol. 2010 Mar 15; 23(3):608-19. PMID: 20148532; PMCID: PMC2841482.
    85. Klawitter J, Shokati T, Moll V, Christians U, Klawitter J. Effects of lovastatin on breast cancer cells: a proteo-metabonomic study. Breast Cancer Res. 2010; 12(2):R16. PMID: 20205716; PMCID: PMC2879560.
    86. Christians U, Klawitter J, Clavijo CF. Bioequivalence testing of immunosuppressants: concepts and misconceptions. Kidney Int Suppl. 2010 Mar; (115):S1-7. PMID: 20150904.
      View in: PubMed
    87. Faeste CK, Christians U, Egaas E, Jonscher KR. Characterization of potential allergens in fenugreek (Trigonella foenum-graecum) using patient sera and MS-based proteomic analysis. J Proteomics. 2010 May 07; 73(7):1321-33. PMID: 20219717; PMCID: PMC2894366.
    88. Klawitter J, Klawitter J, Kushner E, Jonscher K, Bendrick-Peart J, Leibfritz D, Christians U, Schmitz V. Association of immunosuppressant-induced protein changes in the rat kidney with changes in urine metabolite patterns: a proteo-metabonomic study. J Proteome Res. 2010 Feb 05; 9(2):865-75. PMID: 19994912; PMCID: PMC3955702.
    89. Klawitter J, Zhang YL, Klawitter J, Anderson N, Serkova NJ, Christians U. Development and validation of a sensitive assay for the quantification of imatinib using LC/LC-MS/MS in human whole blood and cell culture. Biomed Chromatogr. 2009 Dec; 23(12):1251-8. PMID: 19517424; PMCID: PMC3044679.
    90. Marusyk A, Casás-Selves M, Henry CJ, Zaberezhnyy V, Klawitter J, Christians U, DeGregori J. Irradiation alters selection for oncogenic mutations in hematopoietic progenitors. Cancer Res. 2009 Sep 15; 69(18):7262-9. PMID: 19738065; PMCID: PMC2745506.
    91. Clavijo C, Strom T, Moll V, Betts R, Zhang YL, Christians U, Bendrick-Peart J. Development and validation of a semi-automated assay for the highly sensitive quantification of Biolimus A9 in human whole blood using high-performance liquid chromatography-tandem mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci. 2009 Nov 01; 877(29):3506-14. PMID: 19762292; PMCID: PMC2765116.
    92. Klawitter J, Kominsky DJ, Brown JL, Klawitter J, Christians U, Leibfritz D, Melo JV, Eckhardt SG, Serkova NJ. Metabolic characteristics of imatinib resistance in chronic myeloid leukaemia cells. Br J Pharmacol. 2009 Sep; 158(2):588-600. PMID: 19663881; PMCID: PMC2757699.
    93. Prior JE, Shokati T, Christians U, Gill RT. Identification and characterization of a bacterial cytochrome P450 for the metabolism of diclofenac. Appl Microbiol Biotechnol. 2010 Jan; 85(3):625-33. PMID: 19636551.
      View in: PubMed
    94. Thethi TK, Rao A, Kawji H, Mallik T, Yau CL, Christians U, Fonseca V. Consequences of delayed pump infusion line change in patients with type 1 diabetes mellitus treated with continuous subcutaneous insulin infusion. J Diabetes Complications. 2010 Mar-Apr; 24(2):73-8. PMID: 19395280; PMCID: PMC2854665.
    95. Tissot van Patot MC, Serkova NJ, Haschke M, Kominsky DJ, Roach RC, Christians U, Henthorn TK, Honigman B. Enhanced leukocyte HIF-1alpha and HIF-1 DNA binding in humans after rapid ascent to 4300 m. Free Radic Biol Med. 2009 Jun 01; 46(11):1551-7. PMID: 19303436.
      View in: PubMed
    96. Schmitz V, Klawitter J, Bendrick-Peart J, Schoening W, Puhl G, Haschke M, Klawitter J, Consoer J, Rivard CJ, Chan L, Tran ZV, Leibfritz D, Christians U. Metabolic profiles in urine reflect nephrotoxicity of sirolimus and cyclosporine following rat kidney transplantation. Nephron Exp Nephrol. 2009; 111(4):e80-91. PMID: 19293597.
      View in: PubMed
    97. Klawitter J, Anderson N, Klawitter J, Christians U, Leibfritz D, Eckhardt SG, Serkova NJ. Time-dependent effects of imatinib in human leukaemia cells: a kinetic NMR-profiling study. Br J Cancer. 2009 Mar 24; 100(6):923-31. PMID: 19259085; PMCID: PMC2661771.
    98. Klawitter J, Bendrick-Peart J, Rudolph B, Beckey V, Klawitter J, Haschke M, Rivard C, Chan L, Leibfritz D, Christians U, Schmitz V. Urine metabolites reflect time-dependent effects of cyclosporine and sirolimus on rat kidney function. Chem Res Toxicol. 2009 Jan; 22(1):118-28. PMID: 19099400; PMCID: PMC2646011.
    99. Elkiweri IA, Zhang YL, Christians U, Ng KY, Tissot van Patot MC, Henthorn TK. Competitive substrates for P-glycoprotein and organic anion protein transporters differentially reduce blood organ transport of fentanyl and loperamide: pharmacokinetics and pharmacodynamics in Sprague-Dawley rats. Anesth Analg. 2009 Jan; 108(1):149-59. PMID: 19095843; PMCID: PMC2637614.
    100. Ostojic M, Sagic D, Jung R, Zhang YL, Nedeljkovic M, Mangovski L, Stojkovic S, Debeljacki D, Colic M, Beleslin B, Milosavljevic B, Orlic D, Topic D, Karanovic N, Paunovic D, Christians U. The pharmacokinetics of Biolimus A9 after elution from the Nobori stent in patients with coronary artery disease: the NOBORI PK study. Catheter Cardiovasc Interv. 2008 Dec 01; 72(7):901-8. PMID: 19016466; PMCID: PMC2597665.
    101. Clavijo C, Bendrick-Peart J, Zhang YL, Johnson G, Gasparic A, Christians U. An automated, highly sensitive LC-MS/MS assay for the quantification of the opiate antagonist naltrexone and its major metabolite 6beta-naltrexol in dog and human plasma. J Chromatogr B Analyt Technol Biomed Life Sci. 2008 Oct 15; 874(1-2):33-41. PMID: 18805072.
      View in: PubMed
    102. Kupfer R, Swanson L, Chow S, Staub RE, Zhang YL, Cohen I, Christians U. Oxidative in vitro metabolism of liquiritigenin, a bioactive compound isolated from the Chinese herbal selective estrogen beta-receptor agonist MF101. Drug Metab Dispos. 2008 Nov; 36(11):2261-9. PMID: 18669586.
      View in: PubMed
    103. Filler G, Bendrick-Peart J, Strom T, Zhang YL, Johnson G, Christians U. Characterization of sirolimus metabolites in pediatric solid organ transplant recipients. Pediatr Transplant. 2009 Feb; 13(1):44-53. PMID: 18482220.
      View in: PubMed
    104. Klawitter J, Rivard CJ, Brown LM, Capasso JM, Almeida NE, Maunsbach AB, Pihakaski-Maunsbach K, Berl T, Leibfritz D, Christians U, Chan L. A metabonomic and proteomic analysis of changes in IMCD3 cells chronically adapted to hypertonicity. Nephron Physiol. 2008; 109(1):p1-10. PMID: 18460876.
      View in: PubMed
    105. Filler G, Bendrick-Peart J, Christians U. Pharmacokinetics of mycophenolate mofetil and sirolimus in children. Ther Drug Monit. 2008 Apr; 30(2):138-42. PMID: 18367972.
      View in: PubMed
    106. Christians U, Schmitz V, Schöning W, Bendrick-Peart J, Klawitter J, Haschke M, Klawitter J. Toxicodynamic therapeutic drug monitoring of immunosuppressants: promises, reality, and challenges. Ther Drug Monit. 2008 Apr; 30(2):151-8. PMID: 18367974.
      View in: PubMed
    107. Strom T, Haschke M, Boyd J, Roberts M, Arabshahi L, Marbach P, Christians U. Crossreactivity of isolated everolimus metabolites with the Innofluor Certican immunoassay for therapeutic drug monitoring of everolimus. Ther Drug Monit. 2007 Dec; 29(6):743-9. PMID: 18043471.
      View in: PubMed
    108. Strom T, Haschke M, Zhang YL, Bendrick-Peart J, Boyd J, Roberts M, Arabshahi L, Marbach P, Christians U. Identification of everolimus metabolite patterns in trough blood samples of kidney transplant patients. Ther Drug Monit. 2007 Oct; 29(5):592-9. PMID: 17898649.
      View in: PubMed
    109. Laudi S, Steudel W, Jonscher K, Schöning W, Schniedewind B, Kaisers U, Christians U, Trump S. Comparison of lung proteome profiles in two rodent models of pulmonary arterial hypertension. Proteomics. 2007 Jul; 7(14):2469-78. PMID: 17623304.
      View in: PubMed
    110. Laudi S, Trump S, Schmitz V, West J, McMurtry IF, Mutlak H, Christians U, Weimann J, Kaisers U, Steudel W. Serotonin transporter protein in pulmonary hypertensive rats treated with atorvastatin. Am J Physiol Lung Cell Mol Physiol. 2007 Sep; 293(3):L630-8. PMID: 17575010.
      View in: PubMed
    111. Boernsen KO, Egge-Jacobsen W, Inverardi B, Strom T, Streit F, Schiebel HM, Benet LZ, Christians U. Assessment and validation of the MS/MS fragmentation patterns of the macrolide immunosuppressant everolimus. J Mass Spectrom. 2007 Jun; 42(6):793-802. PMID: 17511017.
      View in: PubMed
    112. Perry TW, Christians U, Trotter JF, Bendrick-Peart J. Pharmacokinetics of enteric-coated mycophenolate sodium in stable liver transplant recipients. Clin Transplant. 2007 May-Jun; 21(3):413-6. PMID: 17488394.
      View in: PubMed
    113. Klawitter J, Schmitz V, Klawitter J, Leibfritz D, Christians U. Development and validation of an assay for the quantification of 11 nucleotides using LC/LC-electrospray ionization-MS. Anal Biochem. 2007 Jun 15; 365(2):230-9. PMID: 17475198.
      View in: PubMed
    114. Laudi S, Weimann J, Haschke M, Trump S, Schmitz V, Christians U, Kaisers U, Steudel W. Worsening of long-term myocardial function after successful pharmacological pretreatment with cyclosporine. J Physiol Pharmacol. 2007 Mar; 58(1):19-32. PMID: 17440223.
      View in: PubMed
    115. Haschke M, Zhang YL, Kahle C, Klawitter J, Korecka M, Shaw LM, Christians U. HPLC-atmospheric pressure chemical ionization MS/MS for quantification of 15-F2t-isoprostane in human urine and plasma. Clin Chem. 2007 Mar; 53(3):489-97. PMID: 17259231.
      View in: PubMed
    116. Filler G, de Barros VR, Jagger JE, Christians U. Cyclosporin twice or three times daily dosing in pediatric transplant patients - it is not the same! Pediatr Transplant. 2006 Dec; 10(8):953-6. PMID: 17096765.
      View in: PubMed
    117. Ng KY, Zhou H, Zhang YL, Hybertson B, Randolph T, Christians U. Quantification of isoniazid and acetylisoniazid in rat plasma and alveolar macrophages by liquid chromatography-tandem mass spectrometry with on-line extraction. J Chromatogr B Analyt Technol Biomed Life Sci. 2007 Mar 01; 847(2):188-98. PMID: 17070115.
      View in: PubMed
    118. Nagata H, Nishitai R, Shirota C, Zhang JL, Koch CA, Cai J, Awwad M, Schuurman HJ, Christians U, Abe M, Baranowska-Kortylewicz J, Platt JL, Fox IJ. Prolonged survival of porcine hepatocytes in cynomolgus monkeys. Gastroenterology. 2007 Jan; 132(1):321-9. PMID: 17241882.
      View in: PubMed
    119. Filler G, Gow RM, Nadarajah R, Jacob P, Johnson G, Zhang YL, Christians U. Pharmacokinetics of pyridostigmine in a child with postural tachycardia syndrome. Pediatrics. 2006 Nov; 118(5):e1563-8. PMID: 17015495.
      View in: PubMed
    120. Schmelzer E, Acikgoez A, Frühauf NR, Crome O, Klempnauer J, Christians U, Bader A. Biotransformation of cyclosporin in primary rat, porcine and human liver cell co-cultures. Xenobiotica. 2006 Aug; 36(8):693-708. PMID: 16891250.
      View in: PubMed
    121. Schmitz V, Klawitter J, Bendrick-Peart J, Haschke M, Beckey VE, Laudi S, Neumann U, Schoening W, Neuhaus P, Christians U, Puhl G. Impact of organ preservation using HTK for graft flush and subsequent storage in UW in rat kidney transplantation. Eur Surg Res. 2006; 38(4):388-98. PMID: 16847398.
      View in: PubMed
    122. Filler G, Lathia A, LeBlanc C, Christians U. Unexpectedly high exposure to enteric-coated mycophenolate sodium upon once-daily dosing. Pediatr Nephrol. 2006 Aug; 21(8):1206-8. PMID: 16721583.
      View in: PubMed
    123. Hering BJ, Wijkstrom M, Graham ML, Hårdstedt M, Aasheim TC, Jie T, Ansite JD, Nakano M, Cheng J, Li W, Moran K, Christians U, Finnegan C, Mills CD, Sutherland DE, Bansal-Pakala P, Murtaugh MP, Kirchhof N, Schuurman HJ. Prolonged diabetes reversal after intraportal xenotransplantation of wild-type porcine islets in immunosuppressed nonhuman primates. Nat Med. 2006 Mar; 12(3):301-3. PMID: 16491083.
      View in: PubMed
    124. Christians U, Strom T, Zhang YL, Steudel W, Schmitz V, Trump S, Haschke M. Active drug transport of immunosuppressants: new insights for pharmacokinetics and pharmacodynamics. Ther Drug Monit. 2006 Feb; 28(1):39-44. PMID: 16418692.
      View in: PubMed
    125. Van Patot MC, Hill AE, Dingmann C, Gaul L, Fralick K, Christians U, Honigman B, Salman MD. Risk of impaired coagulation in warfarin patients ascending to altitude (>2400 m). High Alt Med Biol. 2006; 7(1):39-46. PMID: 16544965.
      View in: PubMed
    126. Zhang YL, Bendrick-Peart J, Strom T, Haschke M, Christians U. Development and validation of a high-throughput assay for quantification of the proliferation inhibitor ABT-578 using LC/LC-MS/MS in blood and tissue samples. Ther Drug Monit. 2005 Dec; 27(6):770-8. PMID: 16306853.
      View in: PubMed
    127. Christians U, Schmitz V, Haschke M. Functional interactions between P-glycoprotein and CYP3A in drug metabolism. Expert Opin Drug Metab Toxicol. 2005 Dec; 1(4):641-54. PMID: 16863430.
      View in: PubMed
    128. Serkova NJ, Christians U. Biomarkers for toxicodynamic monitoring of immunosuppressants: NMR-based quantitative metabonomics of the blood. Ther Drug Monit. 2005 Dec; 27(6):733-7. PMID: 16404806.
      View in: PubMed
    129. Zhou H, Zhang Y, Biggs DL, Manning MC, Randolph TW, Christians U, Hybertson BM, Ng KY. Microparticle-based lung delivery of INH decreases INH metabolism and targets alveolar macrophages. J Control Release. 2005 Oct 03; 107(2):288-99. PMID: 16009444.
      View in: PubMed
    130. Filler G, Womiloju T, Feber J, Lepage N, Christians U. Adding sirolimus to tacrolimus-based immunosuppression in pediatric renal transplant recipients reduces tacrolimus exposure. Am J Transplant. 2005 Aug; 5(8):2005-10. PMID: 15996252.
      View in: PubMed
    131. Frassetto L, Baluom M, Jacobsen W, Christians U, Roland ME, Stock PG, Carlson L, Benet LZ. Cyclosporine pharmacokinetics and dosing modifications in human immunodeficiency virus-infected liver and kidney transplant recipients. Transplantation. 2005 Jul 15; 80(1):13-7. PMID: 16003227.
      View in: PubMed
    132. Trotter JF, Osborne JC, Heller M, Christians U. Effect of hepatitis C infection on tacrolimus doses and blood levels in liver transplantation recipients. Aliment Pharmacol Ther. 2005 Jul 01; 22(1):37-44. PMID: 15963078.
      View in: PubMed
    133. Wijkstrom M, Kirchhof N, Graham M, Ingulli E, Colvin RB, Christians U, Hering BJ, Schuurman HJ. Cyclosporine toxicity in immunosuppressed streptozotocin-diabetic nonhuman primates. Toxicology. 2005 Feb 01; 207(1):117-27. PMID: 15590127.
      View in: PubMed
    134. Tissot van Patot MC, Leadbetter G, Keyes LE, Bendrick-Peart J, Beckey VE, Christians U, Hackett P. Greater free plasma VEGF and lower soluble VEGF receptor-1 in acute mountain sickness. J Appl Physiol (1985). 2005 May; 98(5):1626-9. PMID: 15649874.
      View in: PubMed
    135. Lam TT, Hausen B, Hook L, Lau M, Higgins J, Christians U, Jacobsen W, Baluom M, Duthaler R, Katopodis A, Chavez G, Cozzi E, Harrison R, Schuurman HJ, Borie D, Morris RE. The effect of soluble complement receptor type 1 on acute humoral xenograft rejection in hDAF-transgenic pig-to-primate life-supporting kidney xenografts. Xenotransplantation. 2005 Jan; 12(1):20-9. PMID: 15598270.
      View in: PubMed
    136. Egge-Jacobsen W, Unger M, Niemann CU, Baluom M, Hirai S, Benet LZ, Christians U. Automated, fast, and sensitive quantification of drugs in human plasma by LC/LC-MS: quantification of 6 protease inhibitors and 3 nonnucleoside transcriptase inhibitors. Ther Drug Monit. 2004 Oct; 26(5):546-62. PMID: 15385839.
      View in: PubMed
    137. Christians U, Gottschalk S, Miljus J, Hainz C, Benet LZ, Leibfritz D, Serkova N. Alterations in glucose metabolism by cyclosporine in rat brain slices link to oxidative stress: interactions with mTOR inhibitors. Br J Pharmacol. 2004 Oct; 143(3):388-96. PMID: 15339861; PMCID: PMC1575349.
    138. Christians U. Transport proteins and intestinal metabolism: P-glycoprotein and cytochrome P4503A. Ther Drug Monit. 2004 Apr; 26(2):104-6. PMID: 15228147.
      View in: PubMed
    139. Serkova NJ, Christians U, Benet LZ. Biochemical mechanisms of cyclosporine neurotoxicity. Mol Interv. 2004 Apr; 4(2):97-107. PMID: 15087483.
      View in: PubMed
    140. Bîrsan T, Dambrin C, Marsh KC, Jacobsen W, Djuric SW, Mollison KW, Christians U, Carter GW, Morris RE. Preliminary in vivo pharmacokinetic and pharmacodynamic evaluation of a novel calcineurin-independent inhibitor of NFAT. Transpl Int. 2004 Mar; 17(3):145-50. PMID: 14735234.
      View in: PubMed
    141. Serkova N, Christians U. Transplantation: toxicokinetics and mechanisms of toxicity of cyclosporine and macrolides. Curr Opin Investig Drugs. 2003 Nov; 4(11):1287-96. PMID: 14758767.
      View in: PubMed
    142. Wischmeyer PE, Jayakar D, Williams U, Singleton KD, Riehm J, Bacha EA, Jeevanandam V, Christians U, Serkova N. Single dose of glutamine enhances myocardial tissue metabolism, glutathione content, and improves myocardial function after ischemia-reperfusion injury. JPEN J Parenter Enteral Nutr. 2003 Nov-Dec; 27(6):396-403. PMID: 14621120.
      View in: PubMed
    143. Cummins CL, Jacobsen W, Christians U, Benet LZ. CYP3A4-transfected Caco-2 cells as a tool for understanding biochemical absorption barriers: studies with sirolimus and midazolam. J Pharmacol Exp Ther. 2004 Jan; 308(1):143-55. PMID: 14569063.
      View in: PubMed
    144. Wiseman AC, Kam I, Christians U, Jani A, Bak T, Wachs M, Chan L. Fixed-dose sirolimus with reduced dose calcineurin inhibitor: the University of Colorado experience. Transplant Proc. 2003 May; 35(3 Suppl):122S-124S. PMID: 12742482.
      View in: PubMed
    145. Dambrin C, Klupp J, Bîrsan T, Luna J, Suzuki T, Lam T, Stähr P, Hausen B, Christians U, Fitzgerald P, Berry G, Morris R. Sirolimus (rapamycin) monotherapy prevents graft vascular disease in nonhuman primate recipients of orthotopic aortic allografts. Circulation. 2003 May 13; 107(18):2369-74. PMID: 12719285.
      View in: PubMed
    146. Frassetto L, Thai T, Aggarwal AM, Bucher P, Jacobsen W, Christians U, Benet LZ, Floren LC. Pharmacokinetic interactions between cyclosporine and protease inhibitors in HIV+ subjects. Drug Metab Pharmacokinet. 2003; 18(2):114-20. PMID: 15618725.
      View in: PubMed
    147. Niemann CU, Stabernack C, Serkova N, Jacobsen W, Christians U, Eger EI. Cyclosporine can increase isoflurane MAC. Anesth Analg. 2002 Oct; 95(4):930-4, table of contents. PMID: 12351270.
      View in: PubMed
    148. Kirchner G, Mueller L, Winkler M, Loss M, Roechte F, Deters M, Christians U, Kaever V, Klempnauer J, Sewing K, Manns M. Long-term pharmacokinetics of the metabolites of everolimus and cyclosporine in renal transplant recipients. Transplant Proc. 2002 Sep; 34(6):2233-4. PMID: 12270379.
      View in: PubMed
    149. Niemann CU, Saeed M, Akbari H, Jacobsen W, Benet LZ, Christians U, Serkova N. Close association between the reduction in myocardial energy metabolism and infarct size: dose-response assessment of cyclosporine. J Pharmacol Exp Ther. 2002 Sep; 302(3):1123-8. PMID: 12183671.
      View in: PubMed
    150. Cho CW, Liu Y, Cobb WN, Henthorn TK, Lillehei K, Christians U, Ng KY. Ultrasound-induced mild hyperthermia as a novel approach to increase drug uptake in brain microvessel endothelial cells. Pharm Res. 2002 Aug; 19(8):1123-9. PMID: 12240937.
      View in: PubMed
    151. Serkova N, Donohoe P, Gottschalk S, Hainz C, Niemann CU, Bickler PE, Litt L, Benet LZ, Leibfritz D, Christians U. Comparison of the effects of cyclosporin a on the metabolism of perfused rat brain slices during normoxia and hypoxia. J Cereb Blood Flow Metab. 2002 Mar; 22(3):342-52. PMID: 11891440.
      View in: PubMed
    152. Christians U, Jacobsen W, Benet LZ, Lampen A. Mechanisms of clinically relevant drug interactions associated with tacrolimus. Clin Pharmacokinet. 2002; 41(11):813-51. PMID: 12190331.
      View in: PubMed
    153. Liu Y, Lillehei K, Cobb WN, Christians U, Ng KY. Overcoming MDR by ultrasound-induced hyperthermia and P-glycoprotein modulation. Biochem Biophys Res Commun. 2001 Nov 23; 289(1):62-8. PMID: 11708777.
      View in: PubMed
    154. Tsunoda SM, Harris RZ, Christians U, Velez RL, Freeman RB, Benet LZ, Warshaw A. Red wine decreases cyclosporine bioavailability. Clin Pharmacol Ther. 2001 Nov; 70(5):462-7. PMID: 11719733.
      View in: PubMed
    155. Hausen B, Klupp J, Christians U, Higgins JP, Baumgartner RE, Hook LE, Friedrich S, Celnicker A, Morris RE. Coadministration of either cyclosporine or steroids with humanized monoclonal antibodies against CD80 and CD86 successfully prolong allograft survival after life supporting renal transplantation in cynomolgus monkeys. Transplantation. 2001 Sep 27; 72(6):1128-37. PMID: 11579312.
      View in: PubMed
    156. Serkova N, Jacobsen W, Niemann CU, Litt L, Benet LZ, Leibfritz D, Christians U. Sirolimus, but not the structurally related RAD (everolimus), enhances the negative effects of cyclosporine on mitochondrial metabolism in the rat brain. Br J Pharmacol. 2001 Jul; 133(6):875-85. PMID: 11454661; PMCID: PMC1572850.
    157. Kuhn B, Jacobsen W, Christians U, Benet LZ, Kollman PA. Metabolism of sirolimus and its derivative everolimus by cytochrome P450 3A4: insights from docking, molecular dynamics, and quantum chemical calculations. J Med Chem. 2001 Jun 07; 44(12):2027-34. PMID: 11384247.
      View in: PubMed
    158. van Gelder T, Klupp J, Sawamoto T, Christians U, Morris RE. ATP-binding cassette transporters and calcineurin inhibitors: potential clinical implications. Transplant Proc. 2001 May; 33(3):2420-1. PMID: 11377580.
      View in: PubMed
    159. van Gelder T, Klupp J, Barten MJ, Christians U, Morris RE. Comparison of the effects of tacrolimus and cyclosporine on the pharmacokinetics of mycophenolic acid. Ther Drug Monit. 2001 Apr; 23(2):119-28. PMID: 11294511.
      View in: PubMed
    160. Jacobsen W, Serkova N, Hausen B, Morris RE, Benet LZ, Christians U. Comparison of the in vitro metabolism of the macrolide immunosuppressants sirolimus and RAD. Transplant Proc. 2001 Feb-Mar; 33(1-2):514-5. PMID: 11266932.
      View in: PubMed
    161. Kirchner GI, Jacobsen W, Deters M, Christians U, Nashan B, Winkler M, Vidal C, Kaever V, Sewing K, Manns MP. Fast quantification method for sirolimus and its major metabolites. Transplant Proc. 2001 Feb-Mar; 33(1-2):1091-2. PMID: 11267205.
      View in: PubMed
    162. Dambrin C, Birsan T, Klupp J, Christians U, Morris R. In vivo effect of sirolimus on T cells, B cells and monocytes in non-human primates. J Heart Lung Transplant. 2001 Feb; 20(2):234. PMID: 11250450.
      View in: PubMed
    163. Van Gelder T, Klupp J, Barten MJ, Christians U, Morris RE. Co-administration of tacrolimus and mycophenolate mofetil does not increase mycophenolic acid (MPA) exposure, but co-administration of cyclosporine inhibits the enterohepatic recirculation of MPA, thereby decreasing its exposure. J Heart Lung Transplant. 2001 Feb; 20(2):160-161. PMID: 11250239.
      View in: PubMed
    164. Sawamoto T, Van Gelder T, Christians U, Okamura N, Jacobsen W, Benet L. Membrane transport of mycophenolate mofetil and its active metabolite, mycophenolic acid in MDCK and MDR1-MDCK cell monolayers. J Heart Lung Transplant. 2001 Feb; 20(2):234-235. PMID: 11250452.
      View in: PubMed
    165. Mancinelli LM, Frassetto L, Floren LC, Dressler D, Carrier S, Bekersky I, Benet LZ, Christians U. The pharmacokinetics and metabolic disposition of tacrolimus: a comparison across ethnic groups. Clin Pharmacol Ther. 2001 Jan; 69(1):24-31. PMID: 11180035.
      View in: PubMed
    166. Jacobsen W, Kuhn B, Soldner A, Kirchner G, Sewing KF, Kollman PA, Benet LZ, Christians U. Lactonization is the critical first step in the disposition of the 3-hydroxy-3-methylglutaryl-CoA reductase inhibitor atorvastatin. Drug Metab Dispos. 2000 Nov; 28(11):1369-78. PMID: 11038166.
      View in: PubMed
    167. Braun F, Christians U, Laabs S, Elias K, Shipkova M, Schütz E, Ringe B. An ex vivo model to study the intestinal biotransformation of immunosuppressives. Transplant Proc. 2000 Nov; 32(7):2536. PMID: 11120282.
      View in: PubMed
    168. Jacobsen W, Christians U, Benet LZ. In vitro evaluation of the disposition of A novel cysteine protease inhibitor. Drug Metab Dispos. 2000 Nov; 28(11):1343-51. PMID: 11038163.
      View in: PubMed
    169. Braun F, Christians U, Laabs S, Elias K, Shipkova M, Schütz E, Ringe B. An ex vivo model to study the intestinal biotransformation of immunosuppressive drugs. Transplant Proc. 2000 Nov; 32(7):1999. PMID: 11120037.
      View in: PubMed
    170. Christians U, Jacobsen W, Serkova N, Benet LZ, Vidal C, Sewing KF, Manns MP, Kirchner GI. Automated, fast and sensitive quantification of drugs in blood by liquid chromatography-mass spectrometry with on-line extraction: immunosuppressants. J Chromatogr B Biomed Sci Appl. 2000 Oct 01; 748(1):41-53. PMID: 11092585.
      View in: PubMed
    171. Ikonen TS, Gummert JF, Hayase M, Honda Y, Hausen B, Christians U, Berry GJ, Yock PG, Morris RE. Sirolimus (rapamycin) halts and reverses progression of allograft vascular disease in non-human primates. Transplantation. 2000 Sep 27; 70(6):969-75. PMID: 11014651.
      View in: PubMed
    172. Serkova N, Hausen B, Berry GJ, Jacobsen W, Benet LZ, Morris RE, Christians U. Tissue distribution and clinical monitoring of the novel macrolide immunosuppressant SDZ-RAD and its metabolites in monkey lung transplant recipients: interaction with cyclosporine. J Pharmacol Exp Ther. 2000 Jul; 294(1):323-32. PMID: 10871329.
      View in: PubMed
    173. Christians U, First MR, Benet LZ. Recommendations for bioequivalence testing of cyclosporine generics revisited. Ther Drug Monit. 2000 Jun; 22(3):330-45. PMID: 10850403.
      View in: PubMed
    174. Hausen B, Boeke K, Berry GJ, Christians U, Schüler W, Morris RE. Successful treatment of acute, ongoing rat lung allograft rejection with the novel immunosuppressant SDZ-RAD. Ann Thorac Surg. 2000 Mar; 69(3):904-9. PMID: 10750781.
      View in: PubMed
    175. Soldner A, Benet LZ, Mutschler E, Christians U. Active transport of the angiotensin-II antagonist losartan and its main metabolite EXP 3174 across MDCK-MDR1 and caco-2 cell monolayers. Br J Pharmacol. 2000 Mar; 129(6):1235-43. PMID: 10725273; PMCID: PMC1571937.
    176. Hausen B, Gummert J, Berry GJ, Christians U, Serkova N, Ikonen T, Hook L, Legay F, Schuler W, Schreier MH, Morris RE. Prevention of acute allograft rejection in nonhuman primate lung transplant recipients: induction with chimeric anti-interleukin-2 receptor monoclonal antibody improves the tolerability and potentiates the immunosuppressive activity of a regimen using low doses of both microemulsion cyclosporine and 40-O-(2-hydroxyethyl)-rapamycin. Transplantation. 2000 Feb 27; 69(4):488-96. PMID: 10708100.
      View in: PubMed
    177. Serkova N, Litt L, Leibfritz D, Hausen B, Morris RE, James TL, Benet LZ, Christians U. The novel immunosuppressant SDZ-RAD protects rat brain slices from cyclosporine-induced reduction of high-energy phosphates. Br J Pharmacol. 2000 Feb; 129(3):485-92. PMID: 10711346; PMCID: PMC1571863.
    178. Hausen B, Ikonen T, Briffa N, Berry GJ, Christians U, Robbins RC, Hook L, Serkova N, Benet LZ, Schuler W, Morris RE. Combined immunosuppression with cyclosporine (neoral) and SDZ RAD in non-human primate lung transplantation: systematic pharmacokinetic-based trials to improve efficacy and tolerability. Transplantation. 2000 Jan 15; 69(1):76-86. PMID: 10653384.
      View in: PubMed
    179. Ikonen TS, Gummert JF, Serkova N, Hayase M, Honda Y, Kobayase Y, Hausen B, Yock PG, Christians U, Morris RE. Efficacies of sirolimus (rapamycin) and cyclosporine in allograft vascular disease in non-human primates: trough levels of sirolimus correlate with inhibition of progression of arterial intimal thickening. Transpl Int. 2000; 13 Suppl 1:S314-20. PMID: 11112022.
      View in: PubMed
    180. Jacobsen W, Kirchner G, Hallensleben K, Mancinelli L, Deters M, Hackbarth I, Baner K, Benet LZ, Sewing KF, Christians U. Small intestinal metabolism of the 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitor lovastatin and comparison with pravastatin. J Pharmacol Exp Ther. 1999 Oct; 291(1):131-9. PMID: 10490896.
      View in: PubMed
    181. Canafax DM, Irish WD, Moran HB, Squiers E, Levy R, Pouletty P, First MR, Christians U. An individual bioequivalence approach to compare the intrasubject variability of two ciclosporin formulations, SangCya and Neoral. Pharmacology. 1999 Aug; 59(2):78-88. PMID: 10450062.
      View in: PubMed
    182. Hausen B, Berry GJ, Dagum P, Ikonen T, Christians U, Briffa N, Hook L, Morris RE. The histology of subcutaneously implanted donor bronchial rings correlates with rejection scores of lung allografts in a primate lung transplant model. J Heart Lung Transplant. 1999 Jul; 18(7):714-24. PMID: 10452349.
      View in: PubMed
    183. Christians U. Generic immunosuppressants: the European perspective. Transplant Proc. 1999 May; 31(3A Suppl):19S-22S. PMID: 10330954.
      View in: PubMed
    184. Serkova N, Litt L, James TL, Sadée W, Leibfritz D, Benet LZ, Christians U. Evaluation of individual and combined neurotoxicity of the immunosuppressants cyclosporine and sirolimus by in vitro multinuclear NMR spectroscopy. J Pharmacol Exp Ther. 1999 May; 289(2):800-6. PMID: 10215655.
      View in: PubMed
    185. Hausen B, Boeke K, Berry GJ, Segarra I, Benet LZ, Christians U, Morris RE. Coadministration of neoral and the novel rapamycin analog, SDZ RAD, to rat lung allograft recipients: potentiation of immunosuppressive efficacy and improvement of tolerability of staggered versus simultaneous treatment. Transplantation. 1999 Apr 15; 67(7):956-62. PMID: 10221478.
      View in: PubMed
    186. Soldner A, Christians U, Susanto M, Wacher VJ, Silverman JA, Benet LZ. Grapefruit juice activates P-glycoprotein-mediated drug transport. Pharm Res. 1999 Apr; 16(4):478-85. PMID: 10227700.
      View in: PubMed
    187. Hausen B, Boeke K, Berry GJ, Gummert JF, Christians U, Morris RE. Potentiation of immunosuppressive efficacy by combining the novel leflunomide analog, HMR 279, with microemulsion cyclosporine in a rat lung transplant model. Transplantation. 1999 Feb 15; 67(3):354-9. PMID: 10030278.
      View in: PubMed
    188. Hausen B, Boeke K, Berry GJ, Segarra IT, Christians U, Morris RE. Suppression of acute rejection in allogeneic rat lung transplantation: a study of the efficacy and pharmacokinetics of rapamycin derivative (SDZ RAD) used alone and in combination with a microemulsion formulation of cyclosporine. J Heart Lung Transplant. 1999 Feb; 18(2):150-9. PMID: 10194039.
      View in: PubMed
    189. Jacobsen W, Kirchner G, Hallensleben K, Mancinelli L, Deters M, Hackbarth I, Benet LZ, Sewing KF, Christians U. Comparison of cytochrome P-450-dependent metabolism and drug interactions of the 3-hydroxy-3-methylglutaryl-CoA reductase inhibitors lovastatin and pravastatin in the liver. Drug Metab Dispos. 1999 Feb; 27(2):173-9. PMID: 9929499.
      View in: PubMed
    190. Gummert JF, Christians U, Barten M, Silva H, Morris RE. High-performance liquid chromatographic assay with a simple extraction procedure for sensitive quantification of mycophenolic acid in rat and human plasma. J Chromatogr B Biomed Sci Appl. 1999 Jan 22; 721(2):321-6. PMID: 10052706.
      View in: PubMed
    191. Kirchner GI, Vidal C, Jacobsen W, Franzke A, Hallensleben K, Christians U, Sewing KF. Simultaneous on-line extraction and analysis of sirolimus (rapamycin) and ciclosporin in blood by liquid chromatography-electrospray mass spectrometry. J Chromatogr B Biomed Sci Appl. 1999 Jan 22; 721(2):285-94. PMID: 10052701.
      View in: PubMed
    192. Segarra I, Brazelton TR, Guterman N, Hausen B, Jacobsen W, Morris RE, Benet LZ, Christians U. Development of a high-performance liquid chromatographic-electrospray mass spectrometric assay for the specific and sensitive quantification of the novel immunosuppressive macrolide 40-O-(2-hydroxyethyl)rapamycin. J Chromatogr B Biomed Sci Appl. 1998 Dec 11; 720(1-2):179-87. PMID: 9892080.
      View in: PubMed
    193. Christians U, Jacobsen W, Floren LC. Metabolism and drug interactions of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors in transplant patients: are the statins mechanistically similar? Pharmacol Ther. 1998 Oct; 80(1):1-34. PMID: 9804052.
      View in: PubMed
    194. Lampen A, Zhang Y, Hackbarth I, Benet LZ, Sewing KF, Christians U. Metabolism and transport of the macrolide immunosuppressant sirolimus in the small intestine. J Pharmacol Exp Ther. 1998 Jun; 285(3):1104-12. PMID: 9618413.
      View in: PubMed
    195. Serkova N, Christians U, Flögel U, Pfeuffer J, Leibfritz D. Assessment of the mechanism of astrocyte swelling induced by the macrolide immunosuppressant sirolimus using multinuclear nuclear magnetic resonance spectroscopy. Chem Res Toxicol. 1997 Dec; 10(12):1359-63. PMID: 9437526.
      View in: PubMed
    196. Braun F, Schütz E, Christians U, Lorf T, Schiffmann JH, Armstrong VW, Schröter W, Sewing KF, Oellerich M, Ringe B. Pitfalls in monitoring tacrolimus (FK 506). Ther Drug Monit. 1997 Dec; 19(6):628-31. PMID: 9421102.
      View in: PubMed
    197. Sperschneider H, Wagner C, Korn A, Christians U. [Effect of diltiazem on concentration of cyclosporin metabolites in Sandimmune and Neoral treated kidney transplant patients]. Med Klin (Munich). 1997 Oct 15; 92(10):589-96. PMID: 9446006.
      View in: PubMed
    198. Olbricht C, Wanner C, Eisenhauer T, Kliem V, Doll R, Boddaert M, O'Grady P, Krekler M, Mangold B, Christians U. Accumulation of lovastatin, but not pravastatin, in the blood of cyclosporine-treated kidney graft patients after multiple doses. Clin Pharmacol Ther. 1997 Sep; 62(3):311-21. PMID: 9333107.
      View in: PubMed
    199. Winkler M, Christians U, Baumann J, Gonschior AK, Wonigeit K, Pichlmayr R. Evaluation of the Pro-Trac tacrolimus monoclonal whole-blood enzyme-linked immunosorbent assay for monitoring of tacrolimus levels in patients after kidney, heart, and liver transplantation. Ther Drug Monit. 1996 Dec; 18(6):640-6. PMID: 8946659.
      View in: PubMed
    200. Braun F, Lorf T, Schütz E, Christians U, Grupp C, Sattler B, Canelo R, Sewing KF, Armstrong VW, Oellerich M, Ringe B. Clinical relevance of monitoring tacrolimus: comparison of microparticle enzyme immunoassay, enzyme-linked immunosorbent assay, and liquid chromatography mass spectrometry in renal transplant recipients converted from cyclosporine to tacrolimus. Transplant Proc. 1996 Dec; 28(6):3175-6. PMID: 8962231.
      View in: PubMed
    201. Kliem V, Wanner C, Eisenhauer T, Olbricht CJ, Doll R, Boddaert M, O'Grady P, Krekler M, Mangold B, Christians U. Comparison of pravastatin and lovastatin in renal transplant patients receiving cyclosporine. Transplant Proc. 1996 Dec; 28(6):3126-8. PMID: 8962211.
      View in: PubMed
    202. Serkova N, Brand A, Christians U, Leibfritz D. Evaluation of the effects of immunosuppressants on neuronal and glial cells in vitro by multinuclear magnetic resonance spectroscopy. Biochim Biophys Acta. 1996 Nov 08; 1314(1-2):93-104. PMID: 8972722.
      View in: PubMed
    203. Streit F, Christians U, Schiebel HM, Meyer A, Sewing KF. Structural identification of three metabolites and a degradation product of the macrolide immunosuppressant sirolimus (rapamycin) by electrospray-MS/MS after incubation with human liver microsomes. Drug Metab Dispos. 1996 Nov; 24(11):1272-8. PMID: 8937863.
      View in: PubMed
    204. Winkler M, Haller G, Oldhafer K, Bechstein WO, Kattner A, Maibücher A, Färber L, Ringe B, Christians U, Neuhaus P, Pichlmayr R. A new oral formulation of cyclosporine for early oral immunosuppressive therapy in liver transplant recipients. Transplantation. 1996 Oct 27; 62(8):1063-8. PMID: 8900302.
      View in: PubMed
    205. Meyer K, Fobker M, Christians U, Erren M, Sewing KF, Assmann G, Benninghoven A. Characterization of glucuronidated phase II metabolites of the immunosuppressant cyclosporine in urine of transplant patients using time-of-flight secondary-ion mass spectrometry. Drug Metab Dispos. 1996 Oct; 24(10):1151-4. PMID: 8894518.
      View in: PubMed
    206. Streit F, Christians U, Schiebel HM, Napoli KL, Ernst L, Linck A, Kahan BD, Sewing KF. Sensitive and specific quantification of sirolimus (rapamycin) and its metabolites in blood of kidney graft recipients by HPLC/electrospray-mass spectrometry. Clin Chem. 1996 Sep; 42(9):1417-25. PMID: 8787698.
      View in: PubMed
    207. Gonschior AK, Christians U, Winkler M, Linck A, Baumann J, Sewing KF. Tacrolimus (FK506) metabolite patterns in blood from liver and kidney transplant patients. Clin Chem. 1996 Sep; 42(9):1426-32. PMID: 8787699.
      View in: PubMed
    208. Pethig K, Geiger M, Korn A, Grote M, Christians U, Wahlers T. Follow-up after conversion to Neoral in stable heart transplant recipients. Transplant Proc. 1996 Aug; 28(4):2282-4. PMID: 8769226.
      View in: PubMed
    209. Christians U, Bleck JS, Lampen A, Bader A, Thiesemann C, Kliem V, Repp H, Westhoff-Bleck M, Manns M, Sewing KF. Are cytochrome P450 3A enzymes in the small intestine responsible for different cyclosporine metabolite patterns in stable male and female renal allograft recipients after co-administration of diltiazem? Transplant Proc. 1996 Aug; 28(4):2159-61. PMID: 8769186.
      View in: PubMed
    210. Pethig K, Ruhparwar A, Korn A, Christians U, Wahlers T. Conversion from Sandimmune to Neoral in stable heart transplant recipients. Transplant Proc. 1996 Aug; 28(4):2287-9. PMID: 8769228.
      View in: PubMed
    211. Althaus C, Dagres E, Reinhard T, Christians U, Sundmacher R. Cyclosporin-A and its metabolites in the anterior chamber after topical and systemic application as determined with high-performance liquid chromatography-electrospray mass spectrometry. Ger J Ophthalmol. 1996 Jul; 5(4):189-94. PMID: 8854101.
      View in: PubMed
    212. Bleck JS, Thiesemann C, Kliem V, Christians U, Hecker H, Repp H, Frei U, Westhoff-Bleck M, Manns M, Sewing KF. Diltiazem increases blood concentrations of cyclized cyclosporine metabolites resulting in different cyclosporine metabolite patterns in stable male and female renal allograft recipients. Br J Clin Pharmacol. 1996 Jun; 41(6):551-6. PMID: 8799521; PMCID: PMC2042616.
    213. Lampen A, Christians U, Gonschior AK, Bader A, Hackbarth I, von Engelhardt W, Sewing KF. Metabolism of the macrolide immunosuppressant, tacrolimus, by the pig gut mucosa in the Ussing chamber. Br J Pharmacol. 1996 Apr; 117(8):1730-4. PMID: 8732283; PMCID: PMC1909570.
    214. Christians U, Schmidt G, Bader A, Lampen A, Schottmann R, Linck A, Sewing KF. Identification of drugs inhibiting the in vitro metabolism of tacrolimus by human liver microsomes. Br J Clin Pharmacol. 1996 Mar; 41(3):187-90. PMID: 8866917.
      View in: PubMed
    215. Lampen A, Christians U, Bader A, Hackbarth I, Sewing KF. Drug interactions and interindividual variability of ciclosporin metabolism in the small intestine. Pharmacology. 1996 Mar; 52(3):159-68. PMID: 8849485.
      View in: PubMed
    216. Bader A, Knop E, Böker KH, Crome O, Frühauf N, Gonschior AK, Christians U, Esselmann H, Pichlmayr R, Sewing KF. Tacrolimus (FK 506) biotransformation in primary rat hepatocytes depends on extracellular matrix geometry. Naunyn Schmiedebergs Arch Pharmacol. 1996 Mar; 353(4):461-73. PMID: 8935714.
      View in: PubMed
    217. Jusko WJ, Thomson AW, Fung J, McMaster P, Wong SH, Zylber-Katz E, Christians U, Winkler M, Fitzsimmons WE, Lieberman R, et al. Consensus document: therapeutic monitoring of tacrolimus (FK-506). Ther Drug Monit. 1995 Dec; 17(6):606-14. PMID: 8588229.
      View in: PubMed
    218. Christians U, Sewing KF. Alternative cyclosporine metabolic pathways and toxicity. Clin Biochem. 1995 Dec; 28(6):547-59. PMID: 8595701.
      View in: PubMed
    219. Lampen A, Christians U, Guengerich FP, Watkins PB, Kolars JC, Bader A, Gonschior AK, Dralle H, Hackbarth I, Sewing KF. Metabolism of the immunosuppressant tacrolimus in the small intestine: cytochrome P450, drug interactions, and interindividual variability. Drug Metab Dispos. 1995 Dec; 23(12):1315-24. PMID: 8689938.
      View in: PubMed
    220. Christians U, Kohlhaw K, Sürig T, Bader A, Schottmann R, Linck A, Ringe B, Sewing KF. Parallel blood concentrations of second-generation cyclosporine metabolites and bilirubin in liver graft recipients. Ther Drug Monit. 1995 Oct; 17(5):487-98. PMID: 8585112.
      View in: PubMed
    221. Gonschior AK, Christians U, Winkler M, Schiebel HM, Linck A, Sewing KF. Simplified high-performance liquid chromatography-mass spectrometry assay for measurement of tacrolimus and its metabolites and cross-validation with microparticle enzyme immunoassay. Ther Drug Monit. 1995 Oct; 17(5):504-10. PMID: 8585114.
      View in: PubMed
    222. Bader A, Knop E, Frühauf N, Crome O, Böker K, Christians U, Oldhafer K, Ringe B, Pichlmayr R, Sewing KF. Reconstruction of liver tissue in vitro: geometry of characteristic flat bed, hollow fiber, and spouted bed bioreactors with reference to the in vivo liver. Artif Organs. 1995 Sep; 19(9):941-50. PMID: 8687303.
      View in: PubMed
    223. Winkler M, Wonigeit K, Undre N, Ringe B, Oldhafer K, Christians U, Pichlmayr R. Comparison of plasma vs whole blood as matrix for FK 506 drug level monitoring. Transplant Proc. 1995 Feb; 27(1):822-5. PMID: 7533433.
      View in: PubMed
    224. Bader A, Reimer P, Knop E, Böker K, Christians U, Weissleder R, Sewing KF. An organotypical in vitro model of the liver parenchyma for uptake studies of diagnostic MR receptor agents. Magn Reson Imaging. 1995; 13(7):991-1002. PMID: 8583878.
      View in: PubMed
    225. Gonschior AK, Christians U, Braun F, Winkler M, Linck A, Baumann J, Sewing KF. Measurement of blood concentrations of FK506 (tacrolimus) and its metabolites in seven liver graft patients after the first dose by h.p.l.c.-MS and microparticle enzyme immunoassay (MEIA). Br J Clin Pharmacol. 1994 Dec; 38(6):567-71. PMID: 7534100; PMCID: PMC1364920.
    226. Christians U, Kohlhaw K, Esselmann H, Sürig T, Luy M, Kaltefleiter M, Beyrau R, Linck A, Ringe B, Oellerich M, et al. The yin and yang of lidocaine and cyclosporine metabolism in liver graft recipients. Transplant Proc. 1994 Oct; 26(5):2827-8. PMID: 7940891.
      View in: PubMed
    227. Kohlhaw K, Christians U, Sürig T, Lamesch P, Hauss J, Sewing KF, Pichlmayr R. Cyclosporine and bilirubin metabolites compete for the hepatic excretory system. Transplant Proc. 1994 Oct; 26(5):2798-9. PMID: 7940880.
      View in: PubMed
    228. Bader A, Zech K, Crome O, Christians U, Ringe B, Pichlmayr R, Sewing KF. Use of organotypical cultures of primary hepatocytes to analyse drug biotransformation in man and animals. Xenobiotica. 1994 Jul; 24(7):623-33. PMID: 7975727.
      View in: PubMed
    229. Winkler M, Christians U, Stoll K, Baumann J, Pichlmayr R. Comparison of different assays for the quantitation of FK 506 levels in blood or plasma. Ther Drug Monit. 1994 Jun; 16(3):281-6. PMID: 7521978.
      View in: PubMed
    230. Christians U, Spiekermann K, Bader A, Schottmann R, Linck A, Wonigeit K, Sewing KF, Link H. Cyclosporine metabolite pattern in blood from patients with acute GVHD after BMT. Bone Marrow Transplant. 1993 Jul; 12(1):27-33. PMID: 8374534.
      View in: PubMed
    231. Hoof T, Demmer A, Christians U, Tümmler B. Reversal of multidrug resistance in Chinese hamster ovary cells by the immunosuppressive agent rapamycin. Eur J Pharmacol. 1993 Jun 15; 246(1):53-8. PMID: 7689059.
      View in: PubMed
    232. Christians U, Sewing KF. Cyclosporin metabolism in transplant patients. Pharmacol Ther. 1993 Feb-Mar; 57(2-3):291-345. PMID: 8361996.
      View in: PubMed
    233. Christians U, Braun F, Schmidt M, Kosian N, Schiebel HM, Ernst L, Winkler M, Kruse C, Linck A, Sewing KF. Specific and sensitive measurement of FK506 and its metabolites in blood and urine of liver-graft recipients. Clin Chem. 1992 Oct; 38(10):2025-32. PMID: 1382896.
      View in: PubMed
    234. Sattler M, Guengerich FP, Yun CH, Christians U, Sewing KF. Cytochrome P-450 3A enzymes are responsible for biotransformation of FK506 and rapamycin in man and rat. Drug Metab Dispos. 1992 Sep-Oct; 20(5):753-61. PMID: 1385058.
      View in: PubMed
    235. Radeke HH, Christians U, Sewing KF, Resch K. The synergistic immunosuppressive potential of cyclosporin metabolite combinations. Int J Immunopharmacol. 1992 May; 14(4):595-604. PMID: 1521927.
      View in: PubMed
    236. Christians U, Sattler M, Schiebel HM, Kruse C, Radeke HH, Linck A, Sewing KF. Isolation of two immunosuppressive metabolites after in vitro metabolism of rapamycin. Drug Metab Dispos. 1992 Mar-Apr; 20(2):186-91. PMID: 1352208.
      View in: PubMed
    237. Christians U, Braun F, Kosian N, Schmidt M, Schiebel HM, Ernst L, Kruse C, Winkler M, Holze I, Linck A, et al. High performance liquid chromatography/mass spectrometry of FK 506 and its metabolites in blood, bile, and urine of liver grafted patients. Transplant Proc. 1991 Dec; 23(6):2741-4. PMID: 1721262.
      View in: PubMed
    238. Christians U, Braun F, Sattler M, Almeidal VM, Linck A, Sewing KF. Interactions of FK 506 and cyclosporine metabolism. Transplant Proc. 1991 Dec; 23(6):2794-6. PMID: 1721280.
      View in: PubMed
    239. Christians U, Strohmeyer S, Kownatzki R, Schiebel HM, Bleck J, Kohlhaw K, Schottmann R, Sewing KF. Investigations on the metabolic pathways of cyclosporine: II. Elucidation of the metabolic pathways in vitro by human liver microsomes. Xenobiotica. 1991 Sep; 21(9):1199-210. PMID: 1788988.
      View in: PubMed
    240. Christians U, Strohmeyer S, Kownatzki R, Schiebel HM, Bleck J, Greipel J, Kohlhaw K, Schottmann R, Sewing KF. Investigations on the metabolic pathways of cyclosporine: I. Excretion of cyclosporine and its metabolites in human bile--isolation of 12 new cyclosporine metabolites. Xenobiotica. 1991 Sep; 21(9):1185-98. PMID: 1788987.
      View in: PubMed
    241. Christians U, Radeke HH, Kownatzki R, Schiebel HM, Schottmann R, Sewing KF. Isolation of an immunosuppressive metabolite of FK506 generated by human microsome preparations. Clin Biochem. 1991 Jun; 24(3):271-5. PMID: 1714802.
      View in: PubMed
    242. Radeke HH, Christians U, Bleck JS, Sewing KF, Resch K. Additive and synergistic effects of cyclosporine metabolites on glomerular mesangial cells. Kidney Int. 1991 Jun; 39(6):1255-66. PMID: 1895678.
      View in: PubMed
    243. Schlitt HJ, Christians U, Bleck J, Kohlhaw K, Ringe B, Bunzendahl H, Sewing KF, Wonigeit K, Pichlmayr R. Contribution of cyclosporin metabolites to immunosuppression in liver-transplanted patients with severe graft dysfunction. Transpl Int. 1991 Apr; 4(1):38-44. PMID: 1829359.
      View in: PubMed
    244. Sewing KF, Christians U. FK 506. Lancet. 1991 Feb 23; 337(8739):499. PMID: 1704090.
      View in: PubMed
    245. Christians U, Kruse C, Kownatzki R, Schiebel HM, Schwinzer R, Sattler M, Schottmann R, Linck A, Almeida VM, Braun F, et al. Measurement of FK 506 by HPLC and isolation and characterization of its metabolites. Transplant Proc. 1991 Feb; 23(1 Pt 2):940-1. PMID: 1703358.
      View in: PubMed
    246. Christians U, Kohlhaw K, Budniak J, Bleck JS, Schottmann R, Schlitt HJ, Almeida VM, Deters M, Wonigeit K, Pichlmayr R, et al. Ciclosporin metabolite pattern in blood and urine of liver graft recipients. II. Influence of cholestasis and rejection. Eur J Clin Pharmacol. 1991; 41(4):291-6. PMID: 1804641.
      View in: PubMed
    247. Bleck JS, Schlitt HJ, Christians U, Schottmann R, Thiesemann C, Strohmeyer S, Kohlhaw K, Wonigeit K, Pichlmayr R, Sewing KF. Ciclosporin metabolite pattern in blood and urine of kidney graft patients in relation to liver function. Eur J Clin Pharmacol. 1991; 40(6):565-9. PMID: 1679393.
      View in: PubMed
    248. Christians U, Kohlhaw K, Budniak J, Bleck JS, Schottmann R, Schlitt HJ, Almeida VM, Deters M, Wonigeit K, Pichlmayr R, et al. Ciclosporin metabolite pattern in blood and urine of liver graft recipients. I. Association of ciclosporin metabolites with nephrotoxicity. Eur J Clin Pharmacol. 1991; 41(4):285-90. PMID: 1804640.
      View in: PubMed
    249. Sewing KF, Christians U, Kohlhaw K, Radeke H, Strohmeyer S, Kownatzki R, Budniak J, Schottmann R, Bleck JS, Almeida VM, et al. Biologic activity of cyclosporine metabolites. Transplant Proc. 1990 Jun; 22(3):1129-34. PMID: 2349673.
      View in: PubMed
    250. Bleck JS, Nashan B, Christians U, Schottmann R, Wonigeit K, Sewing KF. Single dose pharmacokinetics of ciclosporin and its main metabolites after oral ciclosporin as oily solution or capsule. Arzneimittelforschung. 1990 Jan; 40(1):62-4. PMID: 2340002.
      View in: PubMed
    251. Bleck JS, Schlitt HJ, Christians U, Thiesemann C, Strohmeyer S, Schottmann R, Kohlhaw K, Wonigeit K, Sewing KF. Urinary excretion of ciclosporin and 17 of its metabolites in renal allograft recipients. Pharmacology. 1989; 39(3):160-4. PMID: 2587622.
      View in: PubMed
    252. Christians U, Schlitt HJ, Bleck JS, Schiebel HM, Kownatzki R, Maurer G, Strohmeyer SS, Schottmann R, Wonigeit K, Pichlmayr R, et al. Measurement of cyclosporine and 18 metabolites in blood, bile, and urine by high-performance liquid chromatography. Transplant Proc. 1988 Apr; 20(2 Suppl 2):609-13. PMID: 3284110.
      View in: PubMed
    253. Nashan B, Bleck J, Wonigeit K, Vogt P, Christians U, Sewing KF, Beveridge T, Pichlmayr R. Effect of the application form of cyclosporine on blood levels: comparison of oral solution and capsules. Transplant Proc. 1988 Apr; 20(2 Suppl 2):637-9. PMID: 3284113.
      View in: PubMed
    254. Sewing KF, Christians U, Bleck JS, Strohmeyer S, Beil W, Kohlhaw K, Wonigeit K. [Drug monitoring of cyclosporin by using high-performance liquid chromatography]. Dtsch Med Wochenschr. 1988 Feb 26; 113(8):311-4. PMID: 3277835.
      View in: PubMed
    255. Sewing KF, Christians U, Bleck JS, Schottmann R, Strohmeyer SS. Measurement and disposition of ciclosporin and its metabolites. Bibl Cardiol. 1988; (43):63-72. PMID: 3067724.
      View in: PubMed
    256. Christians U, Zimmer KO, Wonigeit K, Maurer G, Sewing KF. Liquid-chromatographic measurement of cyclosporin A and its metabolites in blood, bile, and urine. Clin Chem. 1988 Jan; 34(1):34-9. PMID: 3276417.
      View in: PubMed
    257. Schlitt HJ, Christians U, Wonigeit K, Sewing KF, Pichlmayr R. Immunosuppressive activity of cyclosporine metabolites in vitro. Transplant Proc. 1987 Oct; 19(5):4248-51. PMID: 2960052.
      View in: PubMed
    258. Christians U, Zimmer KO, Wonigeit K, Sewing KF. Measurement of cyclosporin A and of four metabolites in whole blood by high-performance liquid chromatography. J Chromatogr. 1987 Jan 23; 413:121-9. PMID: 3558661.
      View in: PubMed
    259. Christians U. [A paraplegic skipper of his own sailing yacht]. Rehabilitation (Stuttg). 1985 May; 24(2):96-9. PMID: 4012026.
      View in: PubMed
    Christians's Networks
    Click the "See All" links for more information and interactive visualizations!
    Concepts Expand Description
    _
    Co-Authors Expand Description
    _
    Similar People Expand Description
    _
    Same Department Expand Description
    Physical Neighbors Expand Description
    _

    Copyright © 2017 The Regents of the University of Colorado, a body corporate. All rights reserved. (Harvard PROFILES RNS software version: 2.10.0)