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Jane E . Reusch

TitleProfessor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-MED
Phone303/399-8020

    Collapse Research 
    Collapse research activities and funding
    K08DK002351     (REUSCH, JANE E)Jun 15, 1995 - May 31, 2001
    NIH/NIDDK
    INSULIN REGULATION OF NUCLEAR PROTEIN PHOSPHATASE 2A
    Role: Principal Investigator
    R01DK064741     (REUSCH, JANE E)Apr 15, 2004 - Mar 31, 2010
    NIH/NIDDK
    Transcriptional Regulation of PDGF Receptor Alpha
    Role: Principal Investigator
    I01BX002046     (REUSCH, JANE E)Oct 1, 2013 - Mar 31, 2022
    VA
    Pharmacological Restoration of Diabetic Vascular Dysfunction
    Role: Principal Investigator
    I01CX001532     (REUSCH, JANE E)Jul 1, 2017 - Jun 30, 2021
    VA
    Cardiovascular Mechanisms of Exercise Intolerance in Diabetes and the Role of Sex
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Scalzo RL, Knaub LA, Hull SE, Keller AC, Hunter K, Walker LA, Reusch JEB. Glucagon-like peptide-1 receptor antagonism impairs basal exercise capacity and vascular adaptation to aerobic exercise training in rats. Physiol Rep. 2018 Jul; 6(13):e13754. PMID: 29984491.
      View in: PubMed
    2. McClatchey PM, Mignemi NA, Xu Z, Williams IM, Reusch JEB, McGuinness OP, Wasserman DH. Automated quantification of microvascular perfusion. Microcirculation. 2018 Jun 16; e12482. PMID: 29908041.
      View in: PubMed
    3. Raghavan S, Liu WG, Saxon DR, Grunwald GK, Maddox TM, Reusch JEB, Berkowitz SA, Caplan L. Oral diabetes medication monotherapy and short-term mortality in individuals with type 2 diabetes and coronary artery disease. BMJ Open Diabetes Res Care. 2018; 6(1):e000516. PMID: 29942524.
      View in: PubMed
    4. Wahl MP, Scalzo RL, Regensteiner JG, Reusch JEB. Mechanisms of Aerobic Exercise Impairment in Diabetes: A Narrative Review. Front Endocrinol (Lausanne). 2018; 9:181. PMID: 29720965.
      View in: PubMed
    5. Cree-Green M, Scalzo RL, Harrall K, Newcomer BR, Schauer IE, Huebschmann AG, McMillin S, Brown MS, Orlicky D, Knaub L, Nadeau KJ, McClatchey PM, Bauer TA, Regensteiner JG, Reusch JEB. Supplemental Oxygen Improves In Vivo Mitochondrial Oxidative Phosphorylation Flux in Sedentary Obese Adults With Type 2 Diabetes. Diabetes. 2018 07; 67(7):1369-1379. PMID: 29643061.
      View in: PubMed
    6. Scalzo RL, Bauer TA, Harrall K, Moreau K, Ozemek C, Herlache L, McMillin S, Huebschmann AG, Dorosz J, Reusch JEB, Regensteiner JG. Acute vitamin C improves cardiac function, not exercise capacity, in adults with type 2 diabetes. Diabetol Metab Syndr. 2018; 10:7. PMID: 29456629.
      View in: PubMed
    7. Reusch JEB, Kumar TR, Regensteiner JG, Zeitler PS. Identifying the Critical Gaps in Research on Sex Differences in Metabolism Across the Life Span. Endocrinology. 2018 01 01; 159(1):9-19. PMID: 29300998.
      View in: PubMed
    8. Bjornstad P, Cree-Green M, Baumgartner A, Coe G, Reyes YG, Schäfer M, Pyle L, Regensteiner JG, Reusch JE, Nadeau KJ. Achieving ADA/ISPAD clinical guideline goals is associated with higher insulin sensitivity and cardiopulmonary fitness in adolescents with type 1 diabetes: Results from RESistance to InSulin in Type 1 ANd Type 2 diabetes (RESISTANT) and Effects of MEtformin on CardiovasculaR Function in AdoLescents with Type 1 Diabetes (EMERALD) Studies. Pediatr Diabetes. 2018 05; 19(3):436-442. PMID: 29082640.
      View in: PubMed
    9. McClatchey PM, Frisbee JC, Reusch JEB. A conceptual framework for predicting and addressing the consequences of disease-related microvascular dysfunction. Microcirculation. 2017 Aug; 24(6). PMID: 28135021.
      View in: PubMed
    10. Home PD, Ahrén B, Reusch JEB, Rendell M, Weissman PN, Cirkel DT, Miller D, Ambery P, Carr MC, Nauck MA. Three-year data from 5 HARMONY phase 3 clinical trials of albiglutide in type 2 diabetes mellitus: Long-term efficacy with or without rescue therapy. Diabetes Res Clin Pract. 2017 Sep; 131:49-60. PMID: 28683300.
      View in: PubMed
    11. Mason McClatchey P, Bauer TA, Regensteiner JG, Schauer IE, Huebschmann AG, Reusch JEB. Dissociation of local and global skeletal muscle oxygen transport metrics in type 2 diabetes. J Diabetes Complications. 2017 Aug; 31(8):1311-1317. PMID: 28571935.
      View in: PubMed
    12. Lu L, Ye S, Scalzo RL, Reusch JEB, Greyson CR, Schwartz GG. Metformin prevents ischaemic ventricular fibrillation in metabolically normal pigs. Diabetologia. 2017 08; 60(8):1550-1558. PMID: 28497164.
      View in: PubMed
    13. Reusch JE, Manson JE. Management of Type 2 Diabetes in 2017: Getting to Goal. JAMA. 2017 03 14; 317(10):1015-1016. PMID: 28249081.
      View in: PubMed
    14. Bjornstad P, Cree-Green M, Baumgartner A, Coe G, Reyes YG, Schafer M, Pyle L, Regensteiner JG, Reusch JEB, Nadeau KJ. Leptin is associated with cardiopulmonary fitness independent of body-mass index and insulin sensitivity in adolescents with type 1 diabetes: a brief report from the EMERALD study. J Diabetes Complications. 2017 May; 31(5):850-853. PMID: 28336216.
      View in: PubMed
    15. Mason McClatchey P, Wu F, Olfert IM, Ellis CG, Goldman D, Reusch JE, Frisbee JC. Impaired Tissue Oxygenation in Metabolic Syndrome Requires Increased Microvascular Perfusion Heterogeneity. J Cardiovasc Transl Res. 2017 Feb; 10(1):69-81. PMID: 28168652.
      View in: PubMed
    16. Chosich J, Bradford AP, Allshouse AA, Reusch JE, Santoro N, Schauer IE. Acute recapitulation of the hyperinsulinemia and hyperlipidemia characteristic of metabolic syndrome suppresses gonadotropins. Obesity (Silver Spring). 2017 03; 25(3):553-560. PMID: 28158916.
      View in: PubMed
    17. Cree-Green M, Gupta A, Coe GV, Baumgartner AD, Pyle L, Reusch JE, Brown MS, Newcomer BR, Nadeau KJ. Insulin resistance in type 2 diabetes youth relates to serum free fatty acids and muscle mitochondrial dysfunction. J Diabetes Complications. 2017 Jan; 31(1):141-148. PMID: 27839922.
      View in: PubMed
    18. Scalzo RL, Moreau KL, Ozemek C, Herlache L, McMillin S, Gilligan S, Huebschmann AG, Bauer TA, Dorosz J, Reusch JE, Regensteiner JG. Exenatide improves diastolic function and attenuates arterial stiffness but does not alter exercise capacity in individuals with type 2 diabetes. J Diabetes Complications. 2017 Feb; 31(2):449-455. PMID: 27884660.
      View in: PubMed
    19. Keller AC, Badani H, McClatchey PM, Baird NL, Bowlin JL, Bouchard R, Perng GC, Reusch JE, Kaufer BB, Gilden D, Shahzad A, Kennedy PG, Cohrs RJ. Varicella zoster virus infection of human fetal lung cells alters mitochondrial morphology. J Neurovirol. 2016 10; 22(5):674-682. PMID: 27245593.
      View in: PubMed
    20. McClatchey PM, Schafer M, Hunter KS, Reusch JE. The endothelial glycocalyx promotes homogenous blood flow distribution within the microvasculature. Am J Physiol Heart Circ Physiol. 2016 Jul 01; 311(1):H168-76. PMID: 27199117.
      View in: PubMed
    21. Bjornstad P, Truong U, Pyle L, Dorosz JL, Cree-Green M, Baumgartner A, Coe G, Regensteiner JG, Reusch JE, Nadeau KJ. Youth with type 1 diabetes have worse strain and less pronounced sex differences in early echocardiographic markers of diabetic cardiomyopathy compared to their normoglycemic peers: A RESistance to InSulin in Type 1 ANd Type 2 diabetes (RESISTANT) Study. J Diabetes Complications. 2016 Aug; 30(6):1103-10. PMID: 27133451.
      View in: PubMed
    22. Bjornstad P, Truong U, Dorosz JL, Cree-Green M, Baumgartner A, Coe G, Pyle L, Regensteiner JG, Reusch JE, Nadeau KJ. Cardiopulmonary Dysfunction and Adiponectin in Adolescents With Type 2 Diabetes. J Am Heart Assoc. 2016 Mar 18; 5(3):e002804. PMID: 26994128; PMCID: PMC4943257.
      View in: PubMed, PubMed Central
    23. McClatchey PM, Keller AC, Bouchard R, Knaub LA, Reusch JE. Raw and processed microscope images of fixed cells at baseline and following various experimental perturbations. Data Brief. 2016 Mar; 6:998-1006. PMID: 26949731.
      View in: PubMed
    24. Keller AC, Knaub LA, McClatchey PM, Connon CA, Bouchard R, Miller MW, Geary KE, Walker LA, Klemm DJ, Reusch JE. Differential Mitochondrial Adaptation in Primary Vascular Smooth Muscle Cells from a Diabetic Rat Model. Oxid Med Cell Longev. 2016; 2016:8524267. PMID: 27034743; PMCID: PMC4737048.
      View in: PubMed, PubMed Central
    25. Klionsky DJ, Abdelmohsen K, Abe A, Abedin MJ, Abeliovich H, Acevedo Arozena A, Adachi H, Adams CM, Adams PD, Adeli K, Adhihetty PJ, Adler SG, Agam G, Agarwal R, Aghi MK, Agnello M, Agostinis P, Aguilar PV, Aguirre-Ghiso J, Airoldi EM, Ait-Si-Ali S, Akematsu T, Akporiaye ET, Al-Rubeai M, Albaiceta GM, Albanese C, Albani D, Albert ML, Aldudo J, Algül H, Alirezaei M, Alloza I, Almasan A, Almonte-Beceril M, Alnemri ES, Alonso C, Altan-Bonnet N, Altieri DC, Alvarez S, Alvarez-Erviti L, Alves S, Amadoro G, Amano A, Amantini C, Ambrosio S, Amelio I, Amer AO, Amessou M, Amon A, An Z, Anania FA, Andersen SU, Andley UP, Andreadi CK, Andrieu-Abadie N, Anel A, Ann DK, Anoopkumar-Dukie S, Antonioli M, Aoki H, Apostolova N, Aquila S, Aquilano K, Araki K, Arama E, Aranda A, Araya J, Arcaro A, Arias E, Arimoto H, Ariosa AR, Armstrong JL, Arnould T, Arsov I, Asanuma K, Askanas V, Asselin E, Atarashi R, Atherton SS, Atkin JD, Attardi LD, Auberger P, Auburger G, Aurelian L, Autelli R, Avagliano L, Avantaggiati ML, Avrahami L, Awale S, Azad N, Bachetti T, Backer JM, Bae DH, Bae JS, Bae ON, Bae SH, Baehrecke EH, Baek SH, Baghdiguian S, Bagniewska-Zadworna A, Bai H, Bai J, Bai XY, Bailly Y, Balaji KN, Balduini W, Ballabio A, Balzan R, Banerjee R, Bánhegyi G, Bao H, Barbeau B, Barrachina MD, Barreiro E, Bartel B, Bartolomé A, Bassham DC, Bassi MT, Bast RC, Basu A, Batista MT, Batoko H, Battino M, Bauckman K, Baumgarner BL, Bayer KU, Beale R, Beaulieu JF, Beck GR, Becker C, Beckham JD, Bédard PA, Bednarski PJ, Begley TJ, Behl C, Behrends C, Behrens GM, Behrns KE, Bejarano E, Belaid A, Belleudi F, Bénard G, Berchem G, Bergamaschi D, Bergami M, Berkhout B, Berliocchi L, Bernard A, Bernard M, Bernassola F, Bertolotti A, Bess AS, Besteiro S, Bettuzzi S, Bhalla S, Bhattacharyya S, Bhutia SK, Biagosch C, Bianchi MW, Biard-Piechaczyk M, Billes V, Bincoletto C, Bingol B, Bird SW, Bitoun M, Bjedov I, Blackstone C, Blanc L, Blanco GA, Blomhoff HK, Boada-Romero E, Böckler S, Boes M, Boesze-Battaglia K, Boise LH, Bolino A, Boman A, Bonaldo P, Bordi M, Bosch J, Botana LM, Botti J, Bou G, Bouché M, Bouchecareilh M, Boucher MJ, Boulton ME, Bouret SG, Boya P, Boyer-Guittaut M, Bozhkov PV, Brady N, Braga VM, Brancolini C, Braus GH, Bravo-San Pedro JM, Brennan LA, Bresnick EH, Brest P, Bridges D, Bringer MA, Brini M, Brito GC, Brodin B, Brookes PS, Brown EJ, Brown K, Broxmeyer HE, Bruhat A, Brum PC, Brumell JH, Brunetti-Pierri N, Bryson-Richardson RJ, Buch S, Buchan AM, Budak H, Bulavin DV, Bultman SJ, Bultynck G, Bumbasirevic V, Burelle Y, Burke RE, Burmeister M, Bütikofer P, Caberlotto L, Cadwell K, Cahova M, Cai D, Cai J, Cai Q, Calatayud S, Camougrand N, Campanella M, Campbell GR, Campbell M, Campello S, Candau R, Caniggia I, Cantoni L, Cao L, Caplan AB, Caraglia M, Cardinali C, Cardoso SM, Carew JS, Carleton LA, Carlin CR, Carloni S, Carlsson SR, Carmona-Gutierrez D, Carneiro LA, Carnevali O, Carra S, Carrier A, Carroll B, Casas C, Casas J, Cassinelli G, Castets P, Castro-Obregon S, Cavallini G, Ceccherini I, Cecconi F, Cederbaum AI, Ceña V, Cenci S, Cerella C, Cervia D, Cetrullo S, Chaachouay H, Chae HJ, Chagin AS, Chai CY, Chakrabarti G, Chamilos G, Chan EY, Chan MT, Chandra D, Chandra P, Chang CP, Chang RC, Chang TY, Chatham JC, Chatterjee S, Chauhan S, Che Y, Cheetham ME, Cheluvappa R, Chen CJ, Chen G, Chen GC, Chen G, Chen H, Chen JW, Chen JK, Chen M, Chen M, Chen P, Chen Q, Chen Q, Chen SD, Chen S, Chen SS, Chen W, Chen WJ, Chen WQ, Chen W, Chen X, Chen YH, Chen YG, Chen Y, Chen Y, Chen Y, Chen YJ, Chen YQ, Chen Y, Chen Z, Chen Z, Cheng A, Cheng CH, Cheng H, Cheong H, Cherry S, Chesney J, Cheung CH, Chevet E, Chi HC, Chi SG, Chiacchiera F, Chiang HL, Chiarelli R, Chiariello M, Chieppa M, Chin LS, Chiong M, Chiu GN, Cho DH, Cho SG, Cho WC, Cho YY, Cho YS, Choi AM, Choi EJ, Choi EK, Choi J, Choi ME, Choi SI, Chou TF, Chouaib S, Choubey D, Choubey V, Chow KC, Chowdhury K, Chu CT, Chuang TH, Chun T, Chung H, Chung T, Chung YL, Chwae YJ, Cianfanelli V, et al. Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy. 2016; 12(1):1-222. PMID: 26799652.
      View in: PubMed
    26. McClatchey PM, Keller AC, Bouchard R, Knaub LA, Reusch JE. Fully automated software for quantitative measurements of mitochondrial morphology. Mitochondrion. 2016 Jan; 26:58-71. PMID: 26688338.
      View in: PubMed
    27. Regensteiner JG, Golden S, Huebschmann AG, Barrett-Connor E, Chang AY, Chyun D, Fox CS, Kim C, Mehta N, Reckelhoff JF, Reusch JE, Rexrode KM, Sumner AE, Welty FK, Wenger NK, Anton B. Sex Differences in the Cardiovascular Consequences of Diabetes Mellitus: A Scientific Statement From the American Heart Association. Circulation. 2015 Dec 22; 132(25):2424-47. PMID: 26644329.
      View in: PubMed
    28. Huebschmann AG, Kohrt WM, Herlache L, Wolfe P, Daugherty S, Reusch JE, Bauer TA, Regensteiner JG. Type 2 diabetes exaggerates exercise effort and impairs exercise performance in older women. BMJ Open Diabetes Res Care. 2015; 3(1):e000124. PMID: 26464803; PMCID: PMC4597414.
      View in: PubMed, PubMed Central
    29. Cree-Green M, Newcomer BR, Coe G, Newnes L, Baumgartner A, Brown MS, Pyle L, Reusch JE, Nadeau KJ. Peripheral insulin resistance in obese girls with hyperandrogenism is related to oxidative phosphorylation and elevated serum free fatty acids. Am J Physiol Endocrinol Metab. 2015 May 01; 308(9):E726-33. PMID: 25714677; PMCID: PMC4420897.
      View in: PubMed, PubMed Central
    30. Keller AC, Knaub LA, Miller MW, Birdsey N, Klemm DJ, Reusch JE. Saxagliptin restores vascular mitochondrial exercise response in the Goto-Kakizaki rat. J Cardiovasc Pharmacol. 2015 Feb; 65(2):137-47. PMID: 25264749; PMCID: PMC4320657.
      View in: PubMed, PubMed Central
    31. Regensteiner JG, Bauer TA, Huebschmann AG, Herlache L, Weinberger HD, Wolfel EE, Reusch JE. Sex differences in the effects of type 2 diabetes on exercise performance. Med Sci Sports Exerc. 2015 Jan; 47(1):58-65. PMID: 24811327; PMCID: PMC4296732.
      View in: PubMed, PubMed Central
    32. Irwin DC, Garat CV, Crossno JT, MacLean PS, Sullivan TM, Erickson PF, Jackman MR, Harral JW, Reusch JE, Klemm DJ. Obesity-related pulmonary arterial hypertension in rats correlates with increased circulating inflammatory cytokines and lipids and with oxidant damage in the arterial wall but not with hypoxia. Pulm Circ. 2014 Dec; 4(4):638-53. PMID: 25610600; PMCID: PMC4278624.
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    33. Bjornstad P, Cree-Green M, Baumgartner A, Maahs DM, Cherney DZ, Pyle L, Regensteiner JG, Reusch JE, Nadeau KJ. Renal function is associated with peak exercise capacity in adolescents with type 1 diabetes. Diabetes Care. 2015 Jan; 38(1):126-31. PMID: 25414156; PMCID: PMC4274775.
      View in: PubMed, PubMed Central
    34. Reusch J, Stewart MW, Perkins CM, Cirkel DT, Ye J, Perry CR, Reinhardt RR, Bode BW. Efficacy and safety of once-weekly glucagon-like peptide 1 receptor agonist albiglutide (HARMONY 1 trial): 52-week primary endpoint results from a randomized, double-blind, placebo-controlled trial in patients with type 2 diabetes mellitus not controlled on pioglitazone, with or without metformin. Diabetes Obes Metab. 2014 Dec; 16(12):1257-64. PMID: 25155146.
      View in: PubMed
    35. Cree-Green M, Newcomer BR, Brown M, Hull A, West AD, Singel D, Reusch JE, McFann K, Regensteiner JG, Nadeau KJ. Method for controlled mitochondrial perturbation during phosphorus MRS in children. Med Sci Sports Exerc. 2014 Oct; 46(10):2030-6. PMID: 24576856; PMCID: PMC4145039.
      View in: PubMed, PubMed Central
    36. Cree-Green M, Newcomer BR, Brown MS, Baumgartner AD, Bergman B, Drew B, Regensteiner JG, Pyle L, Reusch JE, Nadeau KJ. Delayed skeletal muscle mitochondrial ADP recovery in youth with type 1 diabetes relates to muscle insulin resistance. Diabetes. 2015 Feb; 64(2):383-92. PMID: 25157095; PMCID: PMC4303961.
      View in: PubMed, PubMed Central
    37. König AB, Junginger S, Reusch J, Louwen F, Badenhoop K. Gestational diabetes outcome in a single center study: higher BMI in children after six months. Horm Metab Res. 2014 Oct; 46(11):804-9. PMID: 24867135.
      View in: PubMed
    38. Geary K, Knaub LA, Schauer IE, Keller AC, Watson PA, Miller MW, Garat CV, Nadeau KJ, Cree-Green M, Pugazhenthi S, Regensteiner JG, Klemm DJ, Reusch JE. Targeting mitochondria to restore failed adaptation to exercise in diabetes. Biochem Soc Trans. 2014 Apr; 42(2):231-8. PMID: 24646223; PMCID: PMC4103429.
      View in: PubMed, PubMed Central
    39. Garat CV, Crossno JT, Sullivan TM, Reusch JE, Klemm DJ. Inhibition of phosphatidylinositol 3-kinase/Akt signaling attenuates hypoxia-induced pulmonary artery remodeling and suppresses CREB depletion in arterial smooth muscle cells. J Cardiovasc Pharmacol. 2013 Dec; 62(6):539-48. PMID: 24084215; PMCID: PMC4143163.
      View in: PubMed, PubMed Central
    40. Strobel F, Reusch J, Penna-Martinez M, Ramos-Lopez E, Klahold E, Klepzig C, Wehrle J, Kahles H, Badenhoop K. Effect of a randomised controlled vitamin D trial on insulin resistance and glucose metabolism in patients with type 2 diabetes mellitus. Horm Metab Res. 2014 Jan; 46(1):54-8. PMID: 24198221.
      View in: PubMed
    41. Kelsey MM, Forster JE, Van Pelt RE, Reusch JE, Nadeau KJ. Adipose tissue insulin resistance in adolescents with and without type 2 diabetes. Pediatr Obes. 2014 Oct; 9(5):373-80. PMID: 23861170; PMCID: PMC4285336.
      View in: PubMed, PubMed Central
    42. Miller MW, Knaub LA, Olivera-Fragoso LF, Keller AC, Balasubramaniam V, Watson PA, Reusch JE. Nitric oxide regulates vascular adaptive mitochondrial dynamics. Am J Physiol Heart Circ Physiol. 2013 Jun 15; 304(12):H1624-33. PMID: 23585138; PMCID: PMC3680775.
      View in: PubMed, PubMed Central
    43. Low Wang CC, Lu L, Leitner JW, Sarraf M, Gianani R, Draznin B, Greyson CR, Reusch JE, Schwartz GG. Arterial insulin resistance in Yucatan micropigs with diet-induced obesity and metabolic syndrome. J Diabetes Complications. 2013 Jul-Aug; 27(4):307-15. PMID: 23558108; PMCID: PMC3696427.
      View in: PubMed, PubMed Central
    44. Reusch JE, Bridenstine M, Regensteiner JG. Type 2 diabetes mellitus and exercise impairment. Rev Endocr Metab Disord. 2013 Mar; 14(1):77-86. PMID: 23299658; PMCID: PMC3593997.
      View in: PubMed, PubMed Central
    45. Huang JV, Lu L, Ye S, Bergman BC, Sparagna GC, Sarraf M, Reusch JE, Greyson CR, Schwartz GG. Impaired contractile recovery after low-flow myocardial ischemia in a porcine model of metabolic syndrome. Am J Physiol Heart Circ Physiol. 2013 Mar 15; 304(6):H861-73. PMID: 23335793; PMCID: PMC3602770.
      View in: PubMed, PubMed Central
    46. Knaub LA, McCune S, Chicco AJ, Miller M, Moore RL, Birdsey N, Lloyd MI, Villarreal J, Keller AC, Watson PA, Reusch JE. Impaired response to exercise intervention in the vasculature in metabolic syndrome. Diab Vasc Dis Res. 2013 May; 10(3):222-38. PMID: 23162060; PMCID: PMC4139293.
      View in: PubMed, PubMed Central
    47. Wang CC, Reusch JE. Diabetes and cardiovascular disease: changing the focus from glycemic control to improving long-term survival. Am J Cardiol. 2012 Nov 06; 110(9 Suppl):58B-68B. PMID: 23062569; PMCID: PMC3480668.
      View in: PubMed, PubMed Central
    48. Reusch JE. Beyond phosphorylation: nuclear export in vascular remodeling. Arterioscler Thromb Vasc Biol. 2011 Sep; 31(9):1955-6. PMID: 21849704; PMCID: PMC3162556.
      View in: PubMed, PubMed Central
    49. Klemm DJ, Majka SM, Crossno JT, Psilas JC, Reusch JE, Garat CV. Reduction of reactive oxygen species prevents hypoxia-induced CREB depletion in pulmonary artery smooth muscle cells. J Cardiovasc Pharmacol. 2011 Aug; 58(2):181-91. PMID: 21562428; PMCID: PMC3155008.
      View in: PubMed, PubMed Central
    50. Nadeau KJ, Reusch JE. Cardiovascular function/dysfunction in adolescents with type 1 diabetes. Curr Diab Rep. 2011 Jun; 11(3):185-92. PMID: 21336845.
      View in: PubMed
    51. Reusch JE, Wang CC. Cardiovascular disease in diabetes: where does glucose fit in? J Clin Endocrinol Metab. 2011 Aug; 96(8):2367-76. PMID: 21593112; PMCID: PMC3146789.
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    52. Garat CV, Crossno JT, Sullivan TM, Reusch JE, Klemm DJ. Thiazolidinediones prevent PDGF-BB-induced CREB depletion in pulmonary artery smooth muscle cells by preventing upregulation of casein kinase 2 alpha' catalytic subunit. J Cardiovasc Pharmacol. 2010 May; 55(5):469-80. PMID: 20147842; PMCID: PMC2874608.
      View in: PubMed, PubMed Central
    53. Schauer IE, Knaub LA, Lloyd M, Watson PA, Gliwa C, Lewis KE, Chait A, Klemm DJ, Gunter JM, Bouchard R, McDonald TO, O'Brien KD, Reusch JE. CREB downregulation in vascular disease: a common response to cardiovascular risk. Arterioscler Thromb Vasc Biol. 2010 Apr; 30(4):733-41. PMID: 20150559; PMCID: PMC2841720.
      View in: PubMed, PubMed Central
    54. Nadeau KJ, Regensteiner JG, Bauer TA, Brown MS, Dorosz JL, Hull A, Zeitler P, Draznin B, Reusch JE. Insulin resistance in adolescents with type 1 diabetes and its relationship to cardiovascular function. J Clin Endocrinol Metab. 2010 Feb; 95(2):513-21. PMID: 19915016; PMCID: PMC2840859.
      View in: PubMed, PubMed Central
    55. Pratley RE, Reusch JE, Fleck PR, Wilson CA, Mekki Q. Efficacy and safety of the dipeptidyl peptidase-4 inhibitor alogliptin added to pioglitazone in patients with type 2 diabetes: a randomized, double-blind, placebo-controlled study. Curr Med Res Opin. 2009 Oct; 25(10):2361-71. PMID: 19650752.
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    56. Huebschmann AG, Reis EN, Emsermann C, Dickinson LM, Reusch JE, Bauer TA, Regensteiner JG. Women with type 2 diabetes perceive harder effort during exercise than nondiabetic women. Appl Physiol Nutr Metab. 2009 Oct; 34(5):851-7. PMID: 19935846.
      View in: PubMed
    57. Rosenstock J, Reusch J, Bush M, Yang F, Stewart M. Potential of albiglutide, a long-acting GLP-1 receptor agonist, in type 2 diabetes: a randomized controlled trial exploring weekly, biweekly, and monthly dosing. Diabetes Care. 2009 Oct; 32(10):1880-6. PMID: 19592625; PMCID: PMC2752910.
      View in: PubMed, PubMed Central
    58. Nadeau KJ, Zeitler PS, Bauer TA, Brown MS, Dorosz JL, Draznin B, Reusch JE, Regensteiner JG. Insulin resistance in adolescents with type 2 diabetes is associated with impaired exercise capacity. J Clin Endocrinol Metab. 2009 Oct; 94(10):3687-95. PMID: 19584191; PMCID: PMC2758737.
      View in: PubMed, PubMed Central
    59. Regensteiner JG, Bauer TA, Reusch JE, Quaife RA, Chen MY, Smith SC, Miller TM, Groves BM, Wolfel EE. Cardiac dysfunction during exercise in uncomplicated type 2 diabetes. Med Sci Sports Exerc. 2009 May; 41(5):977-84. PMID: 19346991; PMCID: PMC2903427.
      View in: PubMed, PubMed Central
    60. Venkatachalam K, Venkatesan B, Valente AJ, Melby PC, Nandish S, Reusch JE, Clark RA, Chandrasekar B. WISP1, a pro-mitogenic, pro-survival factor, mediates tumor necrosis factor-alpha (TNF-alpha)-stimulated cardiac fibroblast proliferation but inhibits TNF-alpha-induced cardiomyocyte death. J Biol Chem. 2009 May 22; 284(21):14414-27. PMID: 19339243; PMCID: PMC2682890.
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    61. Boehncke S, Poettgen K, Maser-Gluth C, Reusch J, Boehncke WH, Badenhoop K. [Endurance capabilities of triathlon competitors with type 1 diabetes mellitus]. Dtsch Med Wochenschr. 2009 Apr; 134(14):677-82. PMID: 19319767.
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    62. Schauer IE, Reusch JE. Nonesterified fatty acid exposure activates protective and mitogenic pathways in vascular smooth muscle cells by alternate signaling pathways. Metabolism. 2009 Mar; 58(3):319-27. PMID: 19217446; PMCID: PMC2901169.
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    63. Nadeau KJ, Ehlers LB, Aguirre LE, Reusch JE, Draznin B. Discordance between intramuscular triglyceride and insulin sensitivity in skeletal muscle of Zucker diabetic rats after treatment with fenofibrate and rosiglitazone. Diabetes Obes Metab. 2007 Sep; 9(5):714-23. PMID: 17697064.
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    64. Bauer TA, Reusch JE, Levi M, Regensteiner JG. Skeletal muscle deoxygenation after the onset of moderate exercise suggests slowed microvascular blood flow kinetics in type 2 diabetes. Diabetes Care. 2007 Nov; 30(11):2880-5. PMID: 17675540.
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    65. Reusch JE, Draznin BB. Atherosclerosis in diabetes and insulin resistance. Diabetes Obes Metab. 2007 Jul; 9(4):455-63. PMID: 17587387.
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    66. Sarkar SA, Gunter J, Bouchard R, Reusch JE, Wiseman A, Gill RG, Hutton JC, Pugazhenthi S. Dominant negative mutant forms of the cAMP response element binding protein induce apoptosis and decrease the anti-apoptotic action of growth factors in human islets. Diabetologia. 2007 Aug; 50(8):1649-59. PMID: 17593347.
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    67. Watson PA, Reusch JE, McCune SA, Leinwand LA, Luckey SW, Konhilas JP, Brown DA, Chicco AJ, Sparagna GC, Long CS, Moore RL. Restoration of CREB function is linked to completion and stabilization of adaptive cardiac hypertrophy in response to exercise. Am J Physiol Heart Circ Physiol. 2007 Jul; 293(1):H246-59. PMID: 17337597.
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    68. Crossno JT, Garat CV, Reusch JE, Morris KG, Dempsey EC, McMurtry IF, Stenmark KR, Klemm DJ. Rosiglitazone attenuates hypoxia-induced pulmonary arterial remodeling. Am J Physiol Lung Cell Mol Physiol. 2007 Apr; 292(4):L885-97. PMID: 17189321.
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    69. Singh U, Devaraj S, Dasu MR, Ciobanu D, Reusch J, Jialal I. C-reactive protein decreases interleukin-10 secretion in activated human monocyte-derived macrophages via inhibition of cyclic AMP production. Arterioscler Thromb Vasc Biol. 2006 Nov; 26(11):2469-75. PMID: 16917108.
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    70. Garat CV, Fankell D, Erickson PF, Reusch JE, Bauer NN, McMurtry IF, Klemm DJ. Platelet-derived growth factor BB induces nuclear export and proteasomal degradation of CREB via phosphatidylinositol 3-kinase/Akt signaling in pulmonary artery smooth muscle cells. Mol Cell Biol. 2006 Jul; 26(13):4934-48. PMID: 16782881; PMCID: PMC1489168.
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    71. Huebschmann AG, Regensteiner JG, Vlassara H, Reusch JE. Diabetes and advanced glycoxidation end products. Diabetes Care. 2006 Jun; 29(6):1420-32. PMID: 16732039.
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    72. Nadeau KJ, Ehlers LB, Aguirre LE, Moore RL, Jew KN, Ortmeyer HK, Hansen BC, Reusch JE, Draznin B. Exercise training and calorie restriction increase SREBP-1 expression and intramuscular triglyceride in skeletal muscle. Am J Physiol Endocrinol Metab. 2006 Jul; 291(1):E90-8. PMID: 16449296.
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    73. Regensteiner JG, Bauer TA, Reusch JE. Rosiglitazone improves exercise capacity in individuals with type 2 diabetes. Diabetes Care. 2005 Dec; 28(12):2877-83. PMID: 16306548.
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    74. Arany I, Megyesi JK, Reusch JE, Safirstein RL. CREB mediates ERK-induced survival of mouse renal tubular cells after oxidant stress. Kidney Int. 2005 Oct; 68(4):1573-82. PMID: 16164634.
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    75. Bergenstal RM, Nag SS, Reusch JE, Sajjan SG, Alexander CM. Macrovascular risk factors in patients with diabetes: physician treatment strategies and extent of control. Endocr Pract. 2005 May-Jun; 11(3):172-9. PMID: 16239203.
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    76. Drexler AJ, Nesto RW, Abrahamson MJ, Bakris G, Bell D, Brunzell J, Dandona P, Davidson J, Fonseca V, Fowler M, Frye R, Giles T, Haffner S, Hollenberg N, Hsueh W, Law R, Plutzky J, Ratner R, Reusch J, Selwyn A, Sowers J, Wyne K, Young LH. Evaluating the cardiovascular effects of the thiazolidinediones and their place in the management of type 2 diabetes in relation to the metabolic syndrome. Metab Syndr Relat Disord. 2005; 3(2):147-73. PMID: 18370723.
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    77. Reusch JE, Watson PA. Loss of CREB regulation of vascular smooth muscle cell quiescence in diabetes. Rev Endocr Metab Disord. 2004 Aug; 5(3):209-19. PMID: 15211092.
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    78. McCall DT, Sauaia A, Hamman RF, Reusch JE, Barton P. Are low-income elderly patients at risk for poor diabetes care? Diabetes Care. 2004 May; 27(5):1060-5. PMID: 15111521.
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    79. Reusch JE. Time management in academic medicine. J Investig Med. 2004 May; 52(4):259-61. PMID: 15521549.
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    80. Watt WC, Sakano H, Lee ZY, Reusch JE, Trinh K, Storm DR. Odorant stimulation enhances survival of olfactory sensory neurons via MAPK and CREB. Neuron. 2004 Mar 25; 41(6):955-67. PMID: 15046727.
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    81. Haskins K, Kench J, Powers K, Bradley B, Pugazhenthi S, Reusch J, McDuffie M. Role for oxidative stress in the regeneration of islet beta cells? J Investig Med. 2004 Jan; 52(1):45-9. PMID: 14989369.
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    82. Reusch JE, Regensteiner JG, Watson PA. Novel actions of thiazolidinediones on vascular function and exercise capacity. Am J Med. 2003 Dec 08; 115 Suppl 8A:69S-74S. PMID: 14678869.
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    83. Haskins K, Bradley B, Powers K, Fadok V, Flores S, Ling X, Pugazhenthi S, Reusch J, Kench J. Oxidative stress in type 1 diabetes. Ann N Y Acad Sci. 2003 Nov; 1005:43-54. PMID: 14679039.
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    84. Reusch JE. Diabetes, microvascular complications, and cardiovascular complications: what is it about glucose? J Clin Invest. 2003 Oct; 112(7):986-8. PMID: 14523035; PMCID: PMC198532.
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    85. Reusch JE, Klemm DJ. Cyclic AMP response element-binding protein in the vessel wall: good or bad? Circulation. 2003 Sep 09; 108(10):1164-6. PMID: 12963681.
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    86. Brandenburg SL, Lindenfeld J, Reusch JE, Regensteiner JG. Cardiovascular risk in women with type 2 diabetes. Med Clin North Am. 2003 Sep; 87(5):955-69. PMID: 14621326.
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    87. Vaishnav D, Jambal P, Reusch JE, Pugazhenthi S. SP600125, an inhibitor of c-jun N-terminal kinase, activates CREB by a p38 MAPK-mediated pathway. Biochem Biophys Res Commun. 2003 Aug 08; 307(4):855-60. PMID: 12878189.
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    88. Jambal P, Masterson S, Nesterova A, Bouchard R, Bergman B, Hutton JC, Boxer LM, Reusch JE, Pugazhenthi S. Cytokine-mediated down-regulation of the transcription factor cAMP-response element-binding protein in pancreatic beta-cells. J Biol Chem. 2003 Jun 20; 278(25):23055-65. PMID: 12679364.
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    89. Pugazhenthi S, Nesterova A, Jambal P, Audesirk G, Kern M, Cabell L, Eves E, Rosner MR, Boxer LM, Reusch JE. Oxidative stress-mediated down-regulation of bcl-2 promoter in hippocampal neurons. J Neurochem. 2003 Mar; 84(5):982-96. PMID: 12603823.
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    90. Reusch JE, Gadsby R. Thiazolidinedione therapy: the benefits of aggressive and early use in type 2 diabetes. Diabetes Technol Ther. 2003; 5(4):685-93. PMID: 14511423.
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    91. Regensteiner JG, Popylisen S, Bauer TA, Lindenfeld J, Gill E, Smith S, Oliver-Pickett CK, Reusch JE, Weil JV. Oral L-arginine and vitamins E and C improve endothelial function in women with type 2 diabetes. Vasc Med. 2003; 8(3):169-75. PMID: 14989557.
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    92. Reusch JE. Current concepts in insulin resistance, type 2 diabetes mellitus, and the metabolic syndrome. Am J Cardiol. 2002 Sep 05; 90(5A):19G-26G. PMID: 12231075.
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    93. Watson PA, Vinson C, Nesterova A, Reusch JE. Content and activity of cAMP response element-binding protein regulate platelet-derived growth factor receptor-alpha content in vascular smooth muscles. Endocrinology. 2002 Aug; 143(8):2922-9. PMID: 12130557.
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    94. Eckel RH, Wassef M, Chait A, Sobel B, Barrett E, King G, Lopes-Virella M, Reusch J, Ruderman N, Steiner G, Vlassara H. Prevention Conference VI: Diabetes and Cardiovascular Disease: Writing Group II: pathogenesis of atherosclerosis in diabetes. Circulation. 2002 May 07; 105(18):e138-43. PMID: 11994264.
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    95. Brandenburg SL, Reusch JE, Felder KK, Nelson-Wong E, Lindenfeld J, Manco-Johnson M, Regensteiner JG. Impaired fibrinolysis in premenopausal women and age-matched men with Type 2 diabetes mellitus: a pilot study. J Investig Med. 2002 Mar; 50(2):110-5. PMID: 11930948.
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    96. Reusch JE, Klemm DJ. Inhibition of cAMP-response element-binding protein activity decreases protein kinase B/Akt expression in 3T3-L1 adipocytes and induces apoptosis. J Biol Chem. 2002 Jan 11; 277(2):1426-32. PMID: 11694510.
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    97. Klemm DJ, Watson PA, Frid MG, Dempsey EC, Schaack J, Colton LA, Nesterova A, Stenmark KR, Reusch JE. cAMP response element-binding protein content is a molecular determinant of smooth muscle cell proliferation and migration. J Biol Chem. 2001 Dec 07; 276(49):46132-41. PMID: 11560924.
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    98. Watson PA, Nesterova A, Burant CF, Klemm DJ, Reusch JE. Diabetes-related changes in cAMP response element-binding protein content enhance smooth muscle cell proliferation and migration. J Biol Chem. 2001 Dec 07; 276(49):46142-50. PMID: 11560925.
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    99. Klemm DJ, Leitner JW, Watson P, Nesterova A, Reusch JE, Goalstone ML, Draznin B. Insulin-induced adipocyte differentiation. Activation of CREB rescues adipogenesis from the arrest caused by inhibition of prenylation. J Biol Chem. 2001 Jul 27; 276(30):28430-5. PMID: 11375992.
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    100. Pugazhenthi S, Nesterova A, Sable C, Heidenreich KA, Boxer LM, Heasley LE, Reusch JE. Akt/protein kinase B up-regulates Bcl-2 expression through cAMP-response element-binding protein. J Biol Chem. 2000 Apr 14; 275(15):10761-6. PMID: 10753867.
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    101. Reusch JE, Colton LA, Klemm DJ. CREB activation induces adipogenesis in 3T3-L1 cells. Mol Cell Biol. 2000 Feb; 20(3):1008-20. PMID: 10629058; PMCID: PMC85218.
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    102. Brandenburg SL, Reusch JE, Bauer TA, Jeffers BW, Hiatt WR, Regensteiner JG. Effects of exercise training on oxygen uptake kinetic responses in women with type 2 diabetes. Diabetes Care. 1999 Oct; 22(10):1640-6. PMID: 10526728.
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    103. Pugazhenthi S, Miller E, Sable C, Young P, Heidenreich KA, Boxer LM, Reusch JE. Insulin-like growth factor-I induces bcl-2 promoter through the transcription factor cAMP-response element-binding protein. J Biol Chem. 1999 Sep 24; 274(39):27529-35. PMID: 10488088.
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    104. Reusch JE, Klemm DJ. Nutrition and fat cell differentiation. Endocrinology. 1999 Jul; 140(7):2935-7. PMID: 10385383.
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    105. Pugazhenthi S, Boras T, O'Connor D, Meintzer MK, Heidenreich KA, Reusch JE. Insulin-like growth factor I-mediated activation of the transcription factor cAMP response element-binding protein in PC12 cells. Involvement of p38 mitogen-activated protein kinase-mediated pathway. J Biol Chem. 1999 Jan 29; 274(5):2829-37. PMID: 9915817.
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    106. Regensteiner JG, Bauer TA, Reusch JE, Brandenburg SL, Sippel JM, Vogelsong AM, Smith S, Wolfel EE, Eckel RH, Hiatt WR. Abnormal oxygen uptake kinetic responses in women with type II diabetes mellitus. J Appl Physiol (1985). 1998 Jul; 85(1):310-7. PMID: 9655791.
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    107. Reusch JE. Focus on insulin resistance in type 2 diabetes: therapeutic implications. Diabetes Educ. 1998 Mar-Apr; 24(2):188-93. PMID: 9555358.
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    108. Klemm DJ, Roesler WJ, Boras T, Colton LA, Felder K, Reusch JE. Insulin stimulates cAMP-response element binding protein activity in HepG2 and 3T3-L1 cell lines. J Biol Chem. 1998 Jan 09; 273(2):917-23. PMID: 9422750.
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    109. Carel K, DePaolo D, Reusch JE, Leitner JW, Draznin B. Reduced phosphorylation of mitogen-activated protein kinase kinase in response to insulin in cells with truncated C-terminal domain of insulin receptor. Endocrinology. 1996 Jun; 137(6):2362-6. PMID: 8641187.
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    110. DePaolo D, Reusch JE, Carel K, Bhuripanyo P, Leitner JW, Draznin B. Functional interactions of phosphatidylinositol 3-kinase with GTPase-activating protein in 3T3-L1 adipocytes. Mol Cell Biol. 1996 Apr; 16(4):1450-7. PMID: 8657118; PMCID: PMC231129.
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    111. Reusch JE. New directions in treating insulin resistance. Hosp Pract (1995). 1995 Sep 15; 30(9):9-10. PMID: 7559840.
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    112. Reusch JE, Hsieh P, Bhuripanyo P, Carel K, Leitner JW, Olefsky JM, Draznin B. Insulin inhibits nuclear phosphatase activity: requirement for the C-terminal domain of the insulin receptor. Endocrinology. 1995 Jun; 136(6):2464-9. PMID: 7750468.
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    113. Reusch JE, Bhuripanyo P, Carel K, Leitner JW, Hsieh P, DePaolo D, Draznin B. Differential requirement for p21ras activation in the metabolic signaling by insulin. J Biol Chem. 1995 Feb 03; 270(5):2036-40. PMID: 7836430.
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    114. Reusch JE, Hsieh P, Klemm D, Hoeffler J, Draznin B. Insulin inhibits dephosphorylation of adenosine 3',5'-monophosphate response element-binding protein/activating transcription factor-1: effect on nuclear phosphoserine phosphatase-2a. Endocrinology. 1994 Dec; 135(6):2418-22. PMID: 7988426.
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    115. Begum N, Leitner W, Reusch JE, Sussman KE, Draznin B. GLUT-4 phosphorylation and its intrinsic activity. Mechanism of Ca(2+)-induced inhibition of insulin-stimulated glucose transport. J Biol Chem. 1993 Feb 15; 268(5):3352-6. PMID: 8381427.
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    116. Reusch JE, Sussman KE, Draznin B. Inverse relationship between GLUT-4 phosphorylation and its intrinsic activity. J Biol Chem. 1993 Feb 15; 268(5):3348-51. PMID: 8429011.
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    117. Reusch JE, Kleinschmidt-DeMasters BK, Lillehei KO, Rappe D, Gutierrez-Hartmann A. Preoperative diagnosis of lymphocytic hypophysitis (adenohypophysitis) unresponsive to short course dexamethasone: case report. Neurosurgery. 1992 Feb; 30(2):268-72. PMID: 1545900.
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    118. Reusch JE, Begum N, Sussman KE, Draznin B. Regulation of GLUT-4 phosphorylation by intracellular calcium in adipocytes. Endocrinology. 1991 Dec; 129(6):3269-73. PMID: 1659526.
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    119. Roemeling RV, Olshefski R, Langevin T, Berestka J, Reusch JJ, Reusch JE, Lakatua D, Wick MR, Hrushesky WJ. Cisplatin chronotherapy and disulfiram rescue reduce toxicity without interfering with anticancer activity: animal findings and preliminary clinical experiences. Chronobiol Int. 1986; 3(1):55-64. PMID: 3677194.
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