 Lewy Bodies
"Lewy Bodies" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Intracytoplasmic, eosinophilic, round to elongated inclusions found in vacuoles of injured or fragmented neurons. The presence of Lewy bodies is the histological marker of the degenerative changes in LEWY BODY DISEASE and PARKINSON DISEASE but they may be seen in other neurological conditions. They are typically found in the substantia nigra and locus coeruleus but they are also seen in the basal forebrain, hypothalamic nuclei, and neocortex.
| Descriptor ID |
D016631
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| MeSH Number(s) |
A08.675.460 A11.284.420.460 A11.671.460
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Lewy Bodies".
Below are MeSH descriptors whose meaning is more specific than "Lewy Bodies".
This graph shows the total number of publications written about "Lewy Bodies" by people in this website by year, and whether "Lewy Bodies" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 1 | 0 | 1 | | 2008 | 1 | 0 | 1 | | 2020 | 0 | 1 | 1 | | 2022 | 0 | 1 | 1 |
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Below are the most recent publications written about "Lewy Bodies" by people in Profiles.
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Monogue B, Chen Y, Sparks H, Behbehani R, Chai A, Rajic AJ, Massey A, Kleinschmidt-Demasters BK, Vermeren M, Kunath T, Beckham JD. Alpha-synuclein supports type 1 interferon signalling in neurons and brain tissue. Brain. 2022 10 21; 145(10):3622-3636.
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Pelak VS. The clinical approach to the identification of higher-order visual dysfunction in neurodegenerative disease. Curr Neurol Neurosci Rep. 2022 04; 22(4):229-242.
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Coerver KA, Subramanian PS. Visual hallucinations in psychiatric, neurologic, and ophthalmologic disease. Curr Opin Ophthalmol. 2020 Nov; 31(6):475-482.
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Zhou W, Milder JB, Freed CR. Transgenic mice overexpressing tyrosine-to-cysteine mutant human alpha-synuclein: a progressive neurodegenerative model of diffuse Lewy body disease. J Biol Chem. 2008 Apr 11; 283(15):9863-70.
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Filley CM. Neuropsychiatric features of Lewy body disease. Brain Cogn. 1995 Aug; 28(3):229-39.
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