Hydrochlorothiazide
"Hydrochlorothiazide" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A thiazide diuretic often considered the prototypical member of this class. It reduces the reabsorption of electrolytes from the renal tubules. This results in increased excretion of water and electrolytes, including sodium, potassium, chloride, and magnesium. It is used in the treatment of several disorders including edema, hypertension, diabetes insipidus, and hypoparathyroidism.
Descriptor ID |
D006852
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MeSH Number(s) |
D02.886.590.700.135.261.476 D02.886.655.500.261.476 D03.633.100.174.261.476
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Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Hydrochlorothiazide".
Below are MeSH descriptors whose meaning is more specific than "Hydrochlorothiazide".
This graph shows the total number of publications written about "Hydrochlorothiazide" by people in this website by year, and whether "Hydrochlorothiazide" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
Year | Major Topic | Minor Topic | Total |
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2006 | 1 | 0 | 1 | 2007 | 2 | 0 | 2 | 2012 | 1 | 0 | 1 | 2014 | 2 | 1 | 3 |
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Below are the most recent publications written about "Hydrochlorothiazide" by people in Profiles.
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Cushman WC, Goff DC. More HOPE for Prevention with Statins. N Engl J Med. 2016 May 26; 374(21):2085-7.
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Saseen JJ, Ghushchyan V, Nair KV. Comparing clinical effectiveness and drug toxicity with hydrochlorothiazide and chlorthalidone using two potency ratios in a managed care population. J Clin Hypertens (Greenwich). 2015 Feb; 17(2):134-40.
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Wilson L, Nair KV, Saseen JJ. Comparison of new-onset gout in adults prescribed chlorthalidone vs. hydrochlorothiazide for hypertension. J Clin Hypertens (Greenwich). 2014 Dec; 16(12):864-8.
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Rozance PJ. Update on neonatal hypoglycemia. Curr Opin Endocrinol Diabetes Obes. 2014 Feb; 21(1):45-50.
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Friedman GD, Asgari MM, Warton EM, Chan J, Habel LA. Antihypertensive drugs and lip cancer in non-Hispanic whites. Arch Intern Med. 2012 Sep 10; 172(16):1246-51.
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Leviel F, H?bner CA, Houillier P, Morla L, El Moghrabi S, Brideau G, Hassan H, Hatim H, Parker MD, Kurth I, Kougioumtzes A, Sinning A, Pech V, Riemondy KA, Miller RL, Hummler E, Shull GE, Aronson PS, Doucet A, Wall SM, Chambrey R, Eladari D. The Na+-dependent chloride-bicarbonate exchanger SLC4A8 mediates an electroneutral Na+ reabsorption process in the renal cortical collecting ducts of mice. J Clin Invest. 2010 May; 120(5):1627-35.
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Reungjui S, Hu H, Mu W, Roncal CA, Croker BP, Patel JM, Nakagawa T, Srinivas T, Byer K, Simoni J, Wesson D, Sitprija V, Johnson RJ. Thiazide-induced subtle renal injury not observed in states of equivalent hypokalemia. Kidney Int. 2007 Dec; 72(12):1483-92.
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Reungjui S, Roncal CA, Mu W, Srinivas TR, Sirivongs D, Johnson RJ, Nakagawa T. Thiazide diuretics exacerbate fructose-induced metabolic syndrome. J Am Soc Nephrol. 2007 Oct; 18(10):2724-31.
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Ruscin JM, Page RL, Scott J. Hydrochlorothiazide-induced angioedema in a patient allergic to sulfonamide antibiotics: evidence from a case report and a review of the literature. Am J Geriatr Pharmacother. 2006 Dec; 4(4):325-9.
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Mazzali M, Kanellis J, Han L, Feng L, Xia YY, Chen Q, Kang DH, Gordon KL, Watanabe S, Nakagawa T, Lan HY, Johnson RJ. Hyperuricemia induces a primary renal arteriolopathy in rats by a blood pressure-independent mechanism. Am J Physiol Renal Physiol. 2002 Jun; 282(6):F991-7.
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