 Memantine
"Memantine" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
AMANTADINE derivative that has some dopaminergic effects. It has been proposed as an antiparkinson agent.
| Descriptor ID |
D008559
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| MeSH Number(s) |
D02.455.426.100.050.035.500
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| Concept/Terms |
Memantine- Memantine
- Memantin
- 1,3-Dimethyl-5-aminoadamantane
- 1-Amino-3,5-dimethyladamantane
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Below are MeSH descriptors whose meaning is more general than "Memantine".
Below are MeSH descriptors whose meaning is more specific than "Memantine".
This graph shows the total number of publications written about "Memantine" by people in this website by year, and whether "Memantine" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 1 | 0 | 1 | | 2003 | 0 | 1 | 1 | | 2006 | 1 | 0 | 1 | | 2007 | 1 | 0 | 1 | | 2010 | 1 | 0 | 1 | | 2011 | 1 | 0 | 1 | | 2012 | 1 | 1 | 2 | | 2014 | 0 | 1 | 1 | | 2015 | 0 | 1 | 1 | | 2017 | 0 | 1 | 1 | | 2020 | 2 | 0 | 2 | | 2022 | 1 | 0 | 1 |
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Below are the most recent publications written about "Memantine" by people in Profiles.
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Costa ACS, Brandão AC, Boada R, Barrionuevo VL, Taylor HG, Roth E, Stasko MR, Johnson MW, Assir FF, Roberto MP, Salmona P, Abreu-Silveira G, Bederman I, Prendergast E, Hüls A, Abrishamcar S, Mustacchi Z, Scheidemantel T, Roizen NJ, Ruedrich S. Safety, efficacy, and tolerability of memantine for cognitive and adaptive outcome measures in adolescents and young adults with Down syndrome: a randomised, double-blind, placebo-controlled phase 2 trial. Lancet Neurol. 2022 01; 21(1):31-41.
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Swerdlow NR, Bhakta SG, Talledo J, Kotz J, Roberts BZ, Clifford RE, Thomas ML, Joshi YB, Molina JL, Light GA. Memantine effects on auditory discrimination and training in schizophrenia patients. Neuropsychopharmacology. 2020 12; 45(13):2180-2188.
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Molina JL, Voytek B, Thomas ML, Joshi YB, Bhakta SG, Talledo JA, Swerdlow NR, Light GA. Memantine Effects on Electroencephalographic Measures of Putative Excitatory/Inhibitory Balance in Schizophrenia. Biol Psychiatry Cogn Neurosci Neuroimaging. 2020 06; 5(6):562-568.
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Block A, Ahmed MM, Rueda N, Hernandez MC, Martinez-Cué C, Gardiner KJ. The GABAAa5-selective Modulator, RO4938581, Rescues Protein Anomalies in the Ts65Dn Mouse Model of Down Syndrome. Neuroscience. 2018 02 21; 372:192-212.
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Day NL, Carle MS, Floyd CL. Post-injury administration of a combination of memantine and 17ß-estradiol is protective in a rat model of traumatic brain injury. Neurochem Int. 2017 Dec; 111:57-68.
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Higuera C, Gardiner KJ, Cios KJ. Self-Organizing Feature Maps Identify Proteins Critical to Learning in a Mouse Model of Down Syndrome. PLoS One. 2015; 10(6):e0129126.
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Ahmed MM, Dhanasekaran AR, Block A, Tong S, Costa AC, Stasko M, Gardiner KJ. Protein dynamics associated with failed and rescued learning in the Ts65Dn mouse model of Down syndrome. PLoS One. 2015; 10(3):e0119491.
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Seritan AL, Nguyen DV, Mu Y, Tassone F, Bourgeois JA, Schneider A, Cogswell JB, Cook KR, Leehey MA, Grigsby J, Olichney JM, Adams PE, Legg W, Zhang L, Hagerman PJ, Hagerman RJ. Memantine for fragile X-associated tremor/ataxia syndrome: a randomized, double-blind, placebo-controlled trial. J Clin Psychiatry. 2014 Mar; 75(3):264-71.
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Ahmed MM, Dhanasekaran AR, Block A, Tong S, Costa AC, Gardiner KJ. Protein profiles associated with context fear conditioning and their modulation by memantine. Mol Cell Proteomics. 2014 Apr; 13(4):919-37.
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Boada R, Hutaff-Lee C, Schrader A, Weitzenkamp D, Benke TA, Goldson EJ, Costa AC. Antagonism of NMDA receptors as a potential treatment for Down syndrome: a pilot randomized controlled trial. Transl Psychiatry. 2012 Jul 17; 2:e141.
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