Receptor, EphB4
"Receptor, EphB4" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An eph family receptor found in a variety of adult and embryonic tissues. Unlike the majority of proteins in this class there is little or no expression of EphB4 receptor in the BRAIN. It has been found at high levels in developing mammary glands and in invasive mammary tumors.
Descriptor ID |
D036224
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MeSH Number(s) |
D08.811.913.696.620.682.725.400.850.750 D12.776.543.750.630.500.781
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Concept/Terms |
Receptor, EphB4- Receptor, EphB4
- EPHB4 Protein
- Hepatoma Transmembrane Kinase
- Kinase, Hepatoma Transmembrane
- Transmembrane Kinase, Hepatoma
- EphB4 Receptor
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Below are MeSH descriptors whose meaning is more general than "Receptor, EphB4".
Below are MeSH descriptors whose meaning is more specific than "Receptor, EphB4".
This graph shows the total number of publications written about "Receptor, EphB4" by people in this website by year, and whether "Receptor, EphB4" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
Year | Major Topic | Minor Topic | Total |
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1999 | 0 | 1 | 1 | 2014 | 1 | 0 | 1 | 2016 | 1 | 0 | 1 | 2018 | 1 | 0 | 1 | 2019 | 2 | 0 | 2 | 2020 | 1 | 0 | 1 | 2022 | 1 | 0 | 1 |
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Below are the most recent publications written about "Receptor, EphB4" by people in Profiles.
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Bhatia S, Nguyen D, Darragh LB, Van Court B, Sharma J, Knitz MW, Piper M, Bukkapatnam S, Gadwa J, Bickett TE, Bhuvane S, Corbo S, Wu B, Lee Y, Fujita M, Joshi M, Heasley LE, Ferris RL, Rodriguez O, Albanese C, Kapoor M, Pasquale EB, Karam SD. EphB4 and ephrinB2 act in opposition in the head and neck tumor microenvironment. Nat Commun. 2022 06 20; 13(1):3535.
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Bhatia S, Bukkapatnam S, Van Court B, Phan A, Oweida A, Gadwa J, Mueller AC, Piper M, Darragh L, Nguyen D, Gilani A, Knitz M, Bickett T, Green A, Venkataraman S, Vibhakar R, Cittelly D, Karam SD. The effects of ephrinB2 signaling on proliferation and invasion in glioblastoma multiforme. Mol Carcinog. 2020 09; 59(9):1064-1075.
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Lennon S, Oweida A, Milner D, Phan AV, Bhatia S, Van Court B, Darragh L, Mueller AC, Raben D, Mart?nez-Torrecuadrada JL, Pitts TM, Somerset H, Jordan KR, Hansen KC, Williams J, Messersmith WA, Schulick RD, Owens P, Goodman KA, Karam SD. Pancreatic Tumor Microenvironment Modulation by EphB4-ephrinB2 Inhibition and Radiation Combination. Clin Cancer Res. 2019 06 01; 25(11):3352-3365.
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Bhatia S, Oweida A, Lennon S, Darragh LB, Milner D, Phan AV, Mueller AC, Van Court B, Raben D, Serkova NJ, Wang XJ, Jimeno A, Clambey ET, Pasquale EB, Karam SD. Inhibition of EphB4-Ephrin-B2 Signaling Reprograms the Tumor Immune Microenvironment in Head and Neck Cancers. Cancer Res. 2019 05 15; 79(10):2722-2735.
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Bhatia S, Sharma J, Bukkapatnam S, Oweida A, Lennon S, Phan A, Milner D, Uyanga N, Jimeno A, Raben D, Somerset H, Heasley L, Karam SD. Inhibition of EphB4-Ephrin-B2 Signaling Enhances Response to Cetuximab-Radiation Therapy in Head and Neck Cancers. Clin Cancer Res. 2018 09 15; 24(18):4539-4550.
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Bhatia S, Hirsch K, Sharma J, Oweida A, Griego A, Keysar S, Jimeno A, Raben D, Krasnoperov V, Gill PS, Pasquale EB, Wang XJ, Karam SD. Enhancing radiosensitization in EphB4 receptor-expressing Head and Neck Squamous Cell Carcinomas. Sci Rep. 2016 12 12; 6:38792.
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Model LS, Hall MR, Wong DJ, Muto A, Kondo Y, Ziegler KR, Feigel A, Quint C, Niklason L, Dardik A. Arterial shear stress reduces eph-b4 expression in adult human veins. Yale J Biol Med. 2014 Sep; 87(3):359-71.
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Li D, Liu S, Liu R, Zhou Y, Park R, Naga K, Krasnoperov V, Gill PS, Li Z, Shan H, Conti PS. EphB4-targeted imaging with antibody h131, h131-F(ab')2 and h131-Fab. Mol Pharm. 2013 Dec 02; 10(12):4527-33.
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Liu S, Li D, Park R, Liu R, Xia Z, Guo J, Krasnoperov V, Gill PS, Li Z, Shan H, Conti PS. PET imaging of colorectal and breast cancer by targeting EphB4 receptor with 64Cu-labeled hAb47 and hAb131 antibodies. J Nucl Med. 2013 Jul; 54(7):1094-100.
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Li D, Liu S, Liu R, Park R, Hughes L, Krasnoperov V, Gill PS, Li Z, Shan H, Conti PS. Targeting the EphB4 receptor for cancer diagnosis and therapy monitoring. Mol Pharm. 2013 Jan 07; 10(1):329-36.
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