Colorado PROFILES, The Colorado Clinical and Translational Sciences Institute (CCTSI)
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David John Kroll

TitleProfessor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOP-Administration
Phone303/315-5228

    Collapse Research 
    Collapse research activities and funding
    F32DK008854     (KROLL, DAVID J)Apr 10, 1993
    NIH/NIDDK
    ASSOCIATION OF DNA TOPOISOMERASE II WITH CREB
    Role: Principal Investigator

    R55GM050381     (KROLL, DAVID J)Sep 12, 1994 - Sep 11, 1996
    NIH/NIGMS
    DNA TOPOISOMERASE II PROTEIN/PROTEIN INTERACTIONS
    Role: Principal Investigator

    R01CA076201     (KROLL, DAVID J)Jan 1, 1998 - Apr 30, 2004
    NIH/NCI
    14 3 3 Implications in Topoisomerase II Pharmacology
    Role: Principal Investigator

    R21CA100721     (KROLL, DAVID J)Apr 1, 2004 - Mar 31, 2007
    NIH/NCI
    Formulation Dependent Help Interactions with Chemothera*
    Role: Principal Investigator

    R01CA104286     (OBERLIES, NICHOLAS HUNTER)Apr 8, 2004 - Feb 28, 2010
    NIH/NCI
    Pure Flavonolignans from S. marianum in Prostate Cancer
    Role: Co-Principal Investigator

    R25GM084007     (DELAUDER, SAUNDRA FLOWERS)Sep 24, 2010 - Aug 31, 2013
    NIH/NIGMS
    NORTH CAROLINA CENTRAL UNIVERSITY EAGLES RISE WITH MENTORING THROUGH THE DOCTORAL
    Role: Co-Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Anestopoulos I, Sfakianos AP, Franco R, Chlichlia K, Panayiotidis MI, Kroll DJ, Pappa A. A Novel Role of Silibinin as a Putative Epigenetic Modulator in Human Prostate Carcinoma. Molecules. 2016 Dec 31; 22(1). PMID: 28042859.
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    2. Sy-Cordero AA, Figueroa M, Raja HA, Meza Aviña ME, Croatt MP, Adcock AF, Kroll DJ, Wani MC, Pearce CJ, Oberlies NH. Spiroscytalin, a new tetramic acid and other metabolites of mixed biogenesis from Scytalidium cuboideum. Tetrahedron. 2015 Nov 25; 71(47):8899-904. PMID: 26525642; PMCID: PMC4624200 [Available on 11/25/16].
    3. El-Elimat T, Figueroa M, Raja HA, Adcock AF, Kroll DJ, Swanson SM, Wani MC, Pearce CJ, Oberlies NH. Waol A, trans-dihydrowaol A, and cis-dihydrowaol A: polyketide-derived ?-lactones from a Volutella species. Tetrahedron Lett. 2013 Aug 07; 54(32):4300-4302. PMID: 23956472.
      View in: PubMed
    4. Figueroa M, Raja H, Falkinham JO, Adcock AF, Kroll DJ, Wani MC, Pearce CJ, Oberlies NH. Peptaibols, tetramic acid derivatives, isocoumarins, and sesquiterpenes from a Bionectria sp. (MSX 47401). J Nat Prod. 2013 Jun 28; 76(6):1007-15. PMID: 23806109; PMCID: PMC3736820.
    5. El-Elimat T, Figueroa M, Raja HA, Graf TN, Adcock AF, Kroll DJ, Day CS, Wani MC, Pearce CJ, Oberlies NH. Benzoquinones and terphenyl compounds as phosphodiesterase-4B inhibitors from a fungus of the order Chaetothyriales (MSX 47445). J Nat Prod. 2013 Mar 22; 76(3):382-7. PMID: 23301853; PMCID: PMC3606633.
    6. Sy-Cordero AA, Graf TN, Runyon SP, Wani MC, Kroll DJ, Agarwal R, Brantley SJ, Paine MF, Polyak SJ, Oberlies NH. Enhanced bioactivity of silybin B methylation products. Bioorg Med Chem. 2013 Feb 01; 21(3):742-7. PMID: 23260576; PMCID: PMC3630461.
    7. Figueroa M, Graf TN, Ayers S, Adcock AF, Kroll DJ, Yang J, Swanson SM, Munoz-Acuna U, Carcache de Blanco EJ, Agrawal R, Wani MC, Darveaux BA, Pearce CJ, Oberlies NH. Cytotoxic epipolythiodioxopiperazine alkaloids from filamentous fungi of the Bionectriaceae. J Antibiot (Tokyo). 2012 Nov; 65(11):559-64. PMID: 22968289; PMCID: PMC3573876.
    8. Kim H, Lantvit D, Hwang CH, Kroll DJ, Swanson SM, Franzblau SG, Orjala J. Indole alkaloids from two cultured cyanobacteria, Westiellopsis sp. and Fischerella muscicola. Bioorg Med Chem. 2012 Sep 01; 20(17):5290-5. PMID: 22863526; PMCID: PMC3429353.
    9. Ayers S, Ehrmann BM, Adcock AF, Kroll DJ, Carcache de Blanco EJ, Shen Q, Swanson SM, Falkinham JO, Wani MC, Mitchell SM, Pearce CJ, Oberlies NH. Peptaibols from two unidentified fungi of the order Hypocreales with cytotoxic, antibiotic, and anthelmintic activities. J Pept Sci. 2012 Aug; 18(8):500-10. PMID: 22744757; PMCID: PMC3494480.
    10. Kim H, Krunic A, Lantvit D, Shen Q, Kroll DJ, Swanson SM, Orjala J. Nitrile-Containing Fischerindoles from the Cultured Cyanobacterium Fischerella sp. Tetrahedron. 2012 Apr 15; 68(15):3205-3209. PMID: 22470225.
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    11. Pearce CJ, Lantvit DD, Shen Q, Jarjoura D, Zhang X, Oberlies NH, Kroll DJ, Wani MC, Orjala J, Soejarto DD, Farnsworth NR, de Blanco EJ, Fuchs JR, Kinghorn AD, Swanson SM. Use of the hollow fiber assay for the discovery of novel anticancer agents from fungi. Methods Mol Biol. 2012; 944:267-77. PMID: 23065624.
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    12. Ayers S, Graf TN, Adcock AF, Kroll DJ, Shen Q, Swanson SM, Matthew S, Carcache de Blanco EJ, Wani MC, Darveaux BA, Pearce CJ, Oberlies NH. Cytotoxic xanthone-anthraquinone heterodimers from an unidentified fungus of the order Hypocreales (MSX 17022). J Antibiot (Tokyo). 2012 Jan; 65(1):3-8. PMID: 22068158; PMCID: PMC3267898.
    13. Ayers S, Ehrmann BM, Adcock AF, Kroll DJ, Wani MC, Pearce CJ, Oberlies NH. Thielavin B methyl ester: a cytotoxic benzoate trimer from an unidentified fungus (MSX 55526) from the Order Sordariales. Tetrahedron Lett. 2011 Nov 02; 52(44):5733-5735. PMID: 22566715.
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    14. Sy-Cordero AA, Graf TN, Adcock AF, Kroll DJ, Shen Q, Swanson SM, Wani MC, Pearce CJ, Oberlies NH. Cyclodepsipeptides, sesquiterpenoids, and other cytotoxic metabolites from the filamentous fungus Trichothecium sp. (MSX 51320). J Nat Prod. 2011 Oct 28; 74(10):2137-42. PMID: 21978324; PMCID: PMC3252997.
    15. Ayers S, Graf TN, Adcock AF, Kroll DJ, Shen Q, Swanson SM, Wani MC, Darveaux BA, Pearce CJ, Oberlies NH. Obionin B: An o-pyranonaphthoquinone decaketide from an unidentified fungus (MSX 63619) from the Order Pleosporales. Tetrahedron Lett. 2011 Oct 05; 52(40):5128-5230. PMID: 22025810.
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    16. Ayers S, Graf TN, Adcock AF, Kroll DJ, Matthew S, Carcache de Blanco EJ, Shen Q, Swanson SM, Wani MC, Pearce CJ, Oberlies NH. Resorcylic acid lactones with cytotoxic and NF-?B inhibitory activities and their structure-activity relationships. J Nat Prod. 2011 May 27; 74(5):1126-31. PMID: 21513293; PMCID: PMC3111092.
    17. Deep G, Gangar SC, Oberlies NH, Kroll DJ, Agarwal R. Isosilybin A induces apoptosis in human prostate cancer cells via targeting Akt, NF-?B, and androgen receptor signaling. Mol Carcinog. 2010 Oct; 49(10):902-12. PMID: 20721970; PMCID: PMC3924888.
    18. Sy-Cordero AA, Graf TN, Wani MC, Kroll DJ, Pearce CJ, Oberlies NH. Dereplication of macrocyclic trichothecenes from extracts of filamentous fungi through UV and NMR profiles. J Antibiot (Tokyo). 2010 Sep; 63(9):539-44. PMID: 20648023; PMCID: PMC2946446.
    19. Ngo N, Brantley SJ, Carrizosa DR, Kashuba AD, Dees EC, Kroll DJ, Oberlies NH, Paine MF. The warfarin-cranberry juice interaction revisited: A systematic in vitro-in vivo evaluation. J Exp Pharmacol. 2010 Jul; 2010(2):83-91. PMID: 20865058.
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    20. Ladas EJ, Kroll DJ, Oberlies NH, Cheng B, Ndao DH, Rheingold SR, Kelly KM. A randomized, controlled, double-blind, pilot study of milk thistle for the treatment of hepatotoxicity in childhood acute lymphoblastic leukemia (ALL). Cancer. 2010 Jan 15; 116(2):506-13. PMID: 20014183; PMCID: PMC3542639.
    21. Alali FQ, Gharaibeh AA, Ghawanmeh A, Tawaha K, Qandil A, Burgess JP, Sy A, Nakanishi Y, Kroll DJ, Oberlies NH. Colchicinoids from Colchicum crocifolium Boiss. (Colchicaceae). Nat Prod Res. 2010; 24(2):152-9. PMID: 20077308.
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    22. Sy-Cordero A, Graf TN, Nakanishi Y, Wani MC, Agarwal R, Kroll DJ, Oberlies NH. Large-scale isolation of flavonolignans from Silybum marianum extract affords new minor constituents and preliminary structure-activity relationships. Planta Med. 2010 Apr; 76(6):644-7. PMID: 19941262; PMCID: PMC2910627.
    23. Brantley SJ, Oberlies NH, Kroll DJ, Paine MF. Two flavonolignans from milk thistle (Silybum marianum) inhibit CYP2C9-mediated warfarin metabolism at clinically achievable concentrations. J Pharmacol Exp Ther. 2010 Mar; 332(3):1081-7. PMID: 19934397; PMCID: PMC2835426.
    24. Li C, Lee D, Graf TN, Phifer SS, Nakanishi Y, Riswan S, Setyowati FM, Saribi AM, Soejarto DD, Farnsworth NR, Falkinham JO, Kroll DJ, Kinghorn AD, Wani MC, Oberlies NH. Bioactive constituents of the stem bark of Mitrephora glabra. J Nat Prod. 2009 Nov; 72(11):1949-53. PMID: 19874044; PMCID: PMC2862477.
    25. Burke PJ, Senter PD, Meyer DW, Miyamoto JB, Anderson M, Toki BE, Manikumar G, Wani MC, Kroll DJ, Jeffrey SC. Design, synthesis, and biological evaluation of antibody-drug conjugates comprised of potent camptothecin analogues. Bioconjug Chem. 2009 Jun; 20(6):1242-50. PMID: 19469529.
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    26. Etheridge AS, Kroll DJ, Mathews JM. Inhibition of paclitaxel metabolism in vitro in human hepatocytes by Ginkgo biloba preparations. J Diet Suppl. 2009; 6(2):104-10. PMID: 22435411.
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    27. Kinghorn AD, Carcache de Blanco EJ, Chai HB, Orjala J, Farnsworth NR, Soejarto DD, Oberlies NH, Wani MC, Kroll DJ, Pearce CJ, Swanson SM, Kramer RA, Rose WC, Fairchild CR, Vite GD, Emanuel S, Jarjoura D, Cope FO. Discovery of anticancer agents of diverse natural origin. Pure Appl Chem. 2009 Jan 01; 81(6):1051-1063. PMID: 20046887.
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    28. Deep G, Raina K, Singh RP, Oberlies NH, Kroll DJ, Agarwal R. Isosilibinin inhibits advanced human prostate cancer growth in athymic nude mice: comparison with silymarin and silibinin. Int J Cancer. 2008 Dec 15; 123(12):2750-8. PMID: 18798272.
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    29. Alali FQ, Tahboub YR, Ibrahim ES, Qandil AM, Tawaha K, Burgess JP, Sy A, Nakanishi Y, Kroll DJ, Oberlies NH. Pyrrolizidine alkaloids from Echium glomeratum (Boraginaceae). Phytochemistry. 2008 Sep; 69(12):2341-6. PMID: 18691727.
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    30. Deep G, Oberlies NH, Kroll DJ, Agarwal R. Identifying the differential effects of silymarin constituents on cell growth and cell cycle regulatory molecules in human prostate cancer cells. Int J Cancer. 2008 Jul 01; 123(1):41-50. PMID: 18435416.
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    31. Deep G, Oberlies NH, Kroll DJ, Agarwal R. Isosilybin B causes androgen receptor degradation in human prostate carcinoma cells via PI3K-Akt-Mdm2-mediated pathway. Oncogene. 2008 Jun 26; 27(28):3986-98. PMID: 18332867.
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    32. Graf TN, Wani MC, Agarwal R, Kroll DJ, Oberlies NH. Gram-scale purification of flavonolignan diastereoisomers from Silybum marianum (Milk Thistle) extract in support of preclinical in vivo studies for prostate cancer chemoprevention. Planta Med. 2007 Nov; 73(14):1495-501. PMID: 17948171.
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    33. Nun TK, Kroll DJ, Oberlies NH, Soejarto DD, Case RJ, Piskaut P, Matainaho T, Hilscher C, Wang L, Dittmer DP, Gao SJ, Damania B. Development of a fluorescence-based assay to screen antiviral drugs against Kaposi's sarcoma associated herpesvirus. Mol Cancer Ther. 2007 Aug; 6(8):2360-70. PMID: 17699731; PMCID: PMC3600170.
    34. Phifer SS, Lee D, Seo EK, Kim NC, Graf TN, Kroll DJ, Navarro HA, Izydore RA, Jiménez F, Garcia R, Rose WC, Fairchild CR, Wild R, Soejarto DD, Farnsworth NR, Kinghorn AD, Oberlies NH, Wall ME, Wani MC. Alvaradoins E-N, antitumor and cytotoxic anthracenone C-glycosides from the leaves of Alvaradoa haitiensis. J Nat Prod. 2007 Jun; 70(6):954-61. PMID: 17552563; PMCID: PMC2442713.
    35. Kroll DJ, Shaw HS, Oberlies NH. Milk thistle nomenclature: why it matters in cancer research and pharmacokinetic studies. Integr Cancer Ther. 2007 Jun; 6(2):110-9. PMID: 17548790.
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    36. Trembath DG, Lal A, Kroll DJ, Oberlies NH, Riggins GJ. A novel small molecule that selectively inhibits glioblastoma cells expressing EGFRvIII. Mol Cancer. 2007 Apr 16; 6:30. PMID: 17437646; PMCID: PMC1855066.
    37. Deep G, Oberlies NH, Kroll DJ, Agarwal R. Isosilybin B and isosilybin A inhibit growth, induce G1 arrest and cause apoptosis in human prostate cancer LNCaP and 22Rv1 cells. Carcinogenesis. 2007 Jul; 28(7):1533-42. PMID: 17389612.
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    38. Morgan MT, Nakanishi Y, Kroll DJ, Griset AP, Carnahan MA, Wathier M, Oberlies NH, Manikumar G, Wani MC, Grinstaff MW. Dendrimer-encapsulated camptothecins: increased solubility, cellular uptake, and cellular retention affords enhanced anticancer activity in vitro. Cancer Res. 2006 Dec 15; 66(24):11913-21. PMID: 17178889.
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    39. Ford ME, Havstad S, Vernon SW, Davis SD, Kroll D, Lamerato L, Swanson GM. Enhancing adherence among older African American men enrolled in a longitudinal cancer screening trial. Gerontologist. 2006 Aug; 46(4):545-50. PMID: 16921009.
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    40. Alali FQ, Tawaha K, El-Elimat T, Qasaymeh R, Li C, Burgess J, Nakanishi Y, Kroll DJ, Wani MC, Oberlies NH. Phytochemical studies and cytotoxicity evaluations of Colchicum tunicatum Feinbr and Colchicum hierosolymitanum Feinbr (Colchicaceae): two native Jordanian meadow saffrons. Nat Prod Res. 2006 May 20; 20(6):558-66. PMID: 16835088.
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    41. Deep G, Singh RP, Agarwal C, Kroll DJ, Agarwal R. Silymarin and silibinin cause G1 and G2-M cell cycle arrest via distinct circuitries in human prostate cancer PC3 cells: a comparison of flavanone silibinin with flavanolignan mixture silymarin. Oncogene. 2006 Feb 16; 25(7):1053-69. PMID: 16205633.
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    42. Basch E, Bent S, Foppa I, Haskmi S, Kroll D, Mele M, Szapary P, Ulbricht C, Vora M, Yong S. Marigold (Calendula officinalis L.): an evidence-based systematic review by the Natural Standard Research Collaboration. J Herb Pharmacother. 2006; 6(3-4):135-59. PMID: 17317655.
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    43. Li C, Lee D, Graf TN, Phifer SS, Nakanishi Y, Burgess JP, Riswan S, Setyowati FM, Saribi AM, Soejarto DD, Farnsworth NR, Falkinham JO, Kroll DJ, Kinghorn AD, Wani MC, Oberlies NH. A hexacyclic ent-trachylobane diterpenoid possessing an oxetane ring from Mitrephora glabra. Org Lett. 2005 Dec 08; 7(25):5709-12. PMID: 16321028; PMCID: PMC2442714.
    44. Lee D, Li C, Graf TN, Vigo JS, Graham JG, Cabieses F, Farnsworth NR, Cordell GA, Kinghorn AD, Kroll DJ, Wani MC, Oberlies NH. Diterpene glycosides from Egletes viscosa. Planta Med. 2005 Aug; 71(8):792-4. PMID: 16142652.
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    45. Davis-Searles PR, Nakanishi Y, Kim NC, Graf TN, Oberlies NH, Wani MC, Wall ME, Agarwal R, Kroll DJ. Milk thistle and prostate cancer: differential effects of pure flavonolignans from Silybum marianum on antiproliferative end points in human prostate carcinoma cells. Cancer Res. 2005 May 15; 65(10):4448-57. PMID: 15899838.
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    46. Alali FQ, El-Elimat T, Li C, Qandil A, Alkofahi A, Tawaha K, Burgess JP, Nakanishi Y, Kroll DJ, Navarro HA, Falkinham JO, Wani MC, Oberlies NH. New colchicinoids from a native Jordanian meadow saffron, colchicum brachyphyllum: isolation of the first naturally occurring dextrorotatory colchicinoid. J Nat Prod. 2005 Feb; 68(2):173-8. PMID: 15730238.
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    47. Shaw HS, Hobbs KB, Kroll DJ, Seewaldt VL. Delayed-type hypersensitivity reaction with iscador M given in combination with cytotoxic chemotherapy. J Clin Oncol. 2004 Nov 01; 22(21):4432-4. PMID: 15514390.
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    48. Kroll DJ. ASHP statement on the use of dietary supplements. Am J Health Syst Pharm. 2004 Aug 15; 61(16):1707-11. PMID: 15540485.
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    49. Gu JQ, Graf TN, Lee D, Chai HB, Mi Q, Kardono LB, Setyowati FM, Ismail R, Riswan S, Farnsworth NR, Cordell GA, Pezzuto JM, Swanson SM, Kroll DJ, Falkinham JO, Wall ME, Wani MC, Kinghorn AD, Oberlies NH. Cytotoxic and antimicrobial constituents of the bark of Diospyros maritima collected in two geographical locations in Indonesia. J Nat Prod. 2004 Jul; 67(7):1156-61. PMID: 15270571.
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    50. Oberlies NH, Kroll DJ. Camptothecin and taxol: historic achievements in natural products research. J Nat Prod. 2004 Feb; 67(2):129-35. PMID: 14987046.
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    51. Kurz EU, Wilson SE, Leader KB, Sampey BP, Allan WP, Yalowich JC, Kroll DJ. The histone deacetylase inhibitor sodium butyrate induces DNA topoisomerase II alpha expression and confers hypersensitivity to etoposide in human leukemic cell lines. Mol Cancer Ther. 2001 Dec; 1(2):121-31. PMID: 12467229.
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    52. Shaw HS, Kroll DJ. The convergence of herb pharmacodynamics and herb-drug interactions on hemostasis. Altern Ther Health Med. 2001 Nov-Dec; 7(6):46-7. PMID: 11712470.
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    53. Kroll DJ, Shaw HS, Wall ME, Oberlies NH. Variability in St. John's wort formulations is an important consideration. Altern Ther Health Med. 2001 Nov-Dec; 7(6):21-2. PMID: 11712467.
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    54. Peebles KA, Baker RK, Kurz EU, Schneider BJ, Kroll DJ. Catalytic inhibition of human DNA topoisomerase IIalpha by hypericin, a naphthodianthrone from St. John's wort (Hypericum perforatum). Biochem Pharmacol. 2001 Oct 15; 62(8):1059-70. PMID: 11597574.
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    55. Baker RK, Kurz EU, Pyatt DW, Irons RD, Kroll DJ. Benzene metabolites antagonize etoposide-stabilized cleavable complexes of DNA topoisomerase IIalpha. Blood. 2001 Aug 01; 98(3):830-3. PMID: 11468185.
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    56. Kurz EU, Leader KB, Kroll DJ, Clark M, Gieseler F. Modulation of human DNA topoisomerase IIalpha function by interaction with 14-3-3epsilon. J Biol Chem. 2000 May 05; 275(18):13948-54. PMID: 10788521.
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    57. Claffey DJ, Meyer JD, Beauvais R, Brandt T, Shefter E, Kroll DJ, Ruth JA, Manning MC. Long chain arginine esters: a new class of cationic detergents for preparation of hydrophobic ion-paired complexes. Biochem Cell Biol. 2000; 78(1):59-65. PMID: 10735564.
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    58. Nebel A, Schneider BJ, Baker RK, Kroll DJ. Potential metabolic interaction between St. John's wort and theophylline. Ann Pharmacother. 1999 Apr; 33(4):502. PMID: 10332544.
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    59. Tjalkens RB, Luckey SW, Kroll DJ, Petersen DR. Alpha, beta-unsaturated aldehydes mediate inducible expression of glutathione S-transferase in hepatoma cells through activation of the antioxidant response element (ARE). Adv Exp Med Biol. 1999; 463:123-31. PMID: 10352677.
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    60. Winslow LC, Kroll DJ. Herbs as medicines. Arch Intern Med. 1998 Nov 09; 158(20):2192-9. PMID: 9818799.
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    61. Tjalkens RB, Luckey SW, Kroll DJ, Petersen DR. Alpha,beta-unsaturated aldehydes increase glutathione S-transferase mRNA and protein: correlation with activation of the antioxidant response element. Arch Biochem Biophys. 1998 Nov 01; 359(1):42-50. PMID: 9799558.
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    62. Meyer JD, Falk RF, Kelly RM, Shively JE, Withrow SJ, Dernell WS, Kroll DJ, Randolph TW, Manning MC. Preparation and in vitro characterization of gentamycin-impregnated biodegradable beads suitable for treatment of osteomyelitis. J Pharm Sci. 1998 Sep; 87(9):1149-54. PMID: 9724569.
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    63. Anchordoquy TJ, Girouard LG, Carpenter JF, Kroll DJ. Stability of lipid/DNA complexes during agitation and freeze-thawing. J Pharm Sci. 1998 Sep; 87(9):1046-51. PMID: 9724553.
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    64. Anchordoquy TJ, Carpenter JF, Kroll DJ. Maintenance of transfection rates and physical characterization of lipid/DNA complexes after freeze-drying and rehydration. Arch Biochem Biophys. 1997 Dec 01; 348(1):199-206. PMID: 9390192.
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    65. Kroll DJ. Homologous and heterologous protein-protein interactions of human DNA topoisomerase IIalpha. Arch Biochem Biophys. 1997 Sep 15; 345(2):175-84. PMID: 9308887.
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    66. Hartley DP, Kroll DJ, Petersen DR. Prooxidant-initiated lipid peroxidation in isolated rat hepatocytes: detection of 4-hydroxynonenal- and malondialdehyde-protein adducts. Chem Res Toxicol. 1997 Aug; 10(8):895-905. PMID: 9282839.
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    67. Brandt TL, Kroll DJ. NF-M trans-activates the human DNA topoisomerase II alpha promoter independently of c-Myb in HL-60 cells. Leuk Res. 1997 Aug; 21(8):711-20. PMID: 9379678.
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    68. Brandt TL, Fraser DJ, Leal S, Halandras PM, Kroll AR, Kroll DJ. c-Myb trans-activates the human DNA topoisomerase IIalpha gene promoter. J Biol Chem. 1997 Mar 07; 272(10):6278-84. PMID: 9045645.
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    69. Fraser DJ, Brandt TL, Kroll DJ. Topoisomerase II alpha promoter trans-activation early in monocytic differentiation of HL-60 human leukemia cells. Mol Pharmacol. 1995 Apr; 47(4):696-706. PMID: 7723730.
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    70. Anderson RJ, Sponsel HT, Kroll DJ, Jackson S, Breckon R, Hoeffler JP. Escape from the antiproliferative effect of transforming growth factor-beta 1 in LLC-PK1 renal epithelial cells. Kidney Int. 1994 Mar; 45(3):642-9. PMID: 8196265.
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    71. Kroll DJ, Abdel-Malek Abdel-Hafiz H, Marcell T, Simpson S, Chen CY, Gutierrez-Hartmann A, Lustbader JW, Hoeffler JP. A multifunctional prokaryotic protein expression system: overproduction, affinity purification, and selective detection. DNA Cell Biol. 1993 Jun; 12(5):441-53. PMID: 7686011.
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    72. Abdel-Hafiz HA, Chen CY, Marcell T, Kroll DJ, Hoeffler JP. Structural determinants outside of the leucine zipper influence the interactions of CREB and ATF-2: interaction of CREB with ATF-2 blocks E1a-ATF-2 complex formation. Oncogene. 1993 May; 8(5):1161-74. PMID: 8479741.
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    73. Kroll DJ, Sullivan DM, Gutierrez-Hartmann A, Hoeffler JP. Modification of DNA topoisomerase II activity via direct interactions with the cyclic adenosine-3',5'-monophosphate response element-binding protein and related transcription factors. Mol Endocrinol. 1993 Mar; 7(3):305-18. PMID: 8387155.
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    74. Abdel-Hafiz HA, Heasley LE, Kyriakis JM, Avruch J, Kroll DJ, Johnson GL, Hoeffler JP. Activating transcription factor-2 DNA-binding activity is stimulated by phosphorylation catalyzed by p42 and p54 microtubule-associated protein kinases. Mol Endocrinol. 1992 Dec; 6(12):2079-89. PMID: 1337144.
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    75. Kroll DJ, Rowe TC. Phosphorylation of DNA topoisomerase II in a human tumor cell line. J Biol Chem. 1991 Apr 25; 266(12):7957-61. PMID: 1850428.
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    76. Kroll DJ, Borgert CJ, Wiedmann TW, Rowe TC. Drug sensitivity of heat-resistant mouse B16 melanoma variants. Radiat Res. 1990 Oct; 124(1):15-21. PMID: 2236492.
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    77. Kroll DJ, Graichen ME, Leonard TB. Strain difference in rat renal microsomal epoxide hydrolase elevation after mercuric chloride treatment. Carcinogenesis. 1988 Feb; 9(2):193-8. PMID: 3338102.
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    78. Rowe TC, Couto E, Kroll DJ. Camptothecin inhibits hsp 70 heat-shock transcription and induces DNA strand breaks in hsp 70 genes in Drosophila. NCI Monogr. 1987; (4):49-53. PMID: 2819731.
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