Colorado PROFILES, The Colorado Clinical and Translational Sciences Institute (CCTSI)
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Last Name
Institution

Hollis C. Karoly

TitleAssociate Professor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-PSYCH

    Collapse Research 
    Collapse research activities and funding
    R21AA030837     (GOWIN, JOSHUA LEIGH)Mar 1, 2024 - Feb 28, 2026
    NIH
    Effects of THC on Alcohol Consumption and Neural Correlates of Reward
    Role: Co-Principal Investigator
    K23AA028238     (KAROLY, HOLLIS C)Feb 1, 2021 - Jan 31, 2026
    NIH
    Exploring the Effects of Cannabinoids on Alcohol Consumption and the Microbiota-Gut-Brain Axis
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Prince MA, Paez B, Morse JL, Gray BA, Karoly H, McFarland NM, Emery NN, Crabtree MA, Swaim RC. "Other" Substance Use Among American Indian Reservation-Area High School Youth. J Stud Alcohol Drugs. 2025 May 20. PMID: 40391457.
      View in: PubMed
    2. Grodin EN, Karoly H, Browning BD, Coleman L, Farokhnia M, Kryszak LA, Meredith LR, Squeglia LM. Utilizing blood inflammatory markers in alcohol studies: Considerations and recommendations for study design, sample collection, and data analysis. Neurosci Biobehav Rev. 2025 Jun; 173:106142. PMID: 40216171.
      View in: PubMed
    3. Karoly HC, Prince MA, Emery NN, Smith EE, Piercey CJ, Cuttler C, Conner BT. Correction: Protocol for a mobile laboratory study of co-administration of cannabis concentrates with a standard alcohol dose in humans. PLoS One. 2025; 20(4):e0322401. PMID: 40198644.
      View in: PubMed
    4. Piercey CJ, Schlechter TE, Henry D, Allen-Collins M, Ahern R, Cameron J, Conner BT, Snodgrass JG, Karoly HC. Use of reagent test kits and fentanyl test strips among electronic music festival attendees in Colorado: prevalence, barriers, and behavior in response to drug checking. Harm Reduct J. 2025 Apr 02; 22(1):46. PMID: 40176104.
      View in: PubMed
    5. Gowin JL, Ellingson JM, Karoly HC, Manza P, Ross JM, Sloan ME, Tanabe JL, Volkow ND. Brain Function Outcomes of Recent and Lifetime Cannabis Use. JAMA Netw Open. 2025 Jan 02; 8(1):e2457069. PMID: 39874032.
      View in: PubMed
    6. Piercey CJ, Gray B, Sung A, Henry D, Karoly HC. Protective Behavioral Strategies for Psychedelic Use: A Mini Review of the Evidence. Psychedelic Med (New Rochelle). 2024 Dec; 2(4):234-242. PMID: 40051484.
      View in: PubMed
    7. Karoly HC, Kirk-Provencher KT, Schacht JP, Gowin JL. Alcohol and brain structure across the lifespan: A systematic review of large-scale neuroimaging studies. Addict Biol. 2024 Sep; 29(9):e13439. PMID: 39317645.
      View in: PubMed
    8. Piercey CJ, Hetelekides E, Karoly HC. Simultaneous cannabis and psychedelic use among festival and concert attendees in Colorado: characterizing enhancement and adverse reactions using mixed methods. J Cannabis Res. 2024 Jul 11; 6(1):29. PMID: 38992787.
      View in: PubMed
    9. Stallsmith VT, Piercey CJ, Mataczynski MM, Karoly HC, Emery NN. Probing the Paradox: Investigating the Impact of Affect, Exercise Type, and Cannabis Use on the Alcohol-Exercise Relationship in College Students. Int J Exerc Sci. 2024; 17(3):623-632. PMID: 38863556.
      View in: PubMed
    10. Karoly HC, Prince MA, Conner BT. Alcohol First, Cannabis Last: Identification of an Especially Risky Use Pattern among Individuals Who Co-Use Alcohol and Cannabis. Subst Use Misuse. 2024; 59(3):343-352. PMID: 37853738.
      View in: PubMed
    11. Sznitman SR, Martin-Willett R, Ma W, Karoly HC, Bidwell LC. Daily diary study of associations between alcohol, cannabis, co-use and sleep quality in individuals with intentions to use cannabis to cope with anxiety. Drug Alcohol Rev. 2024 Feb; 43(2):501-511. PMID: 37985016.
      View in: PubMed
    12. Douglass MA, Stanley LR, Karoly HC, Prince MA, Crabtree MA, Swaim RC. Patterns of Simultaneous and non-Simultaneous Use of Cannabis and Alcohol Among American Indian Adolescents. Addict Res Theory. 2024; 32(5):339-345. PMID: 39479370.
      View in: PubMed
    13. Piercey CJ, Mataczynski M, Stallsmith VT, Emery NN, Karoly HC. Examining Associations Between Cannabis Use Disorder and Measures of Weekly and Within-Day Cannabis Frequency, Quantity, and Potency in College Students. Cannabis Cannabinoid Res. 2024 Jun; 9(3):e917-e923. PMID: 37699241.
      View in: PubMed
    14. Ross JM, Karoly HC, Zellers SM, Ellingson JM, Corley RP, Iacono WG, Hewitt JK, McGue M, Vrieze S, Hopfer CJ. Addendum to "Evaluating substance use outcomes of recreational cannabis legalization using a unique co-twin control design". Am J Drug Alcohol Abuse. 2023 Sep 03; 49(5):684. PMID: 38014892.
      View in: PubMed
    15. Martin-Willett R, Skrzynski CJ, Karoly HC, Elmore JS, Bidwell LC. Baseline affective symptomatology moderates acute subjective effects of high potency THC and CBD cannabis concentrates. Exp Clin Psychopharmacol. 2023 Dec; 31(6):1039-1049. PMID: 37289543.
      View in: PubMed
    16. Ross JM, Karoly HC, Zellers SM, Ellingson JM, Corley RP, Iacono WG, Hewitt JK, McGue M, Vrieze S, Hopfer CJ. Evaluating substance use outcomes of recreational cannabis legalization using a unique co-twin control design. Am J Drug Alcohol Abuse. 2023 09 03; 49(5):630-639. PMID: 37262386.
      View in: PubMed
    17. Karoly HC, Drennan ML, Prince MA, Zulic L, Dooley G. Consuming oral cannabidiol prior to a standard alcohol dose has minimal effect on breath alcohol level and subjective effects of alcohol. Psychopharmacology (Berl). 2023 May; 240(5):1119-1129. PMID: 36939855.
      View in: PubMed
    18. Skrzynski CJ, Karoly H, Ellingson JM, Hagerty SL, Bryan AD, Hutchison KE. Comparing the Efficacy of Mindfulness-Based Relapse Prevention Versus Relapse Prevention for Alcohol Use Disorder: A Randomized Control Trial. J Stud Alcohol Drugs. 2023 07; 84(4):560-569. PMID: 36971735.
      View in: PubMed
    19. Karoly HC, Conner BT, Prince MA. Associations between alcohol and cannabis use order, frequency, quantity, and consequences in a college sample of individuals who co-use alcohol and cannabis. Am J Addict. 2023 05; 32(3):283-290. PMID: 36546556.
      View in: PubMed
    20. Karoly HC, Prince MA, Emery NN, Smith EE, Piercey CJ, Conner BT. Protocol for a mobile laboratory study of co-administration of cannabis concentrates with a standard alcohol dose in humans. PLoS One. 2022; 17(11):e0277123. PMID: 36327298.
      View in: PubMed
    21. Drennan ML, Karoly HC, Bryan AD, Hutchison KE, Bidwell LC. Acute objective and subjective intoxication effects of legal-market high potency THC-dominant versus CBD-dominant cannabis concentrates. Sci Rep. 2021 11 05; 11(1):21744. PMID: 34741088.
      View in: PubMed
    22. Bidwell LC, Karoly HC, Torres MO, Master A, Bryan AD, Hutchison KE. A naturalistic study of orally administered vs. inhaled legal market cannabis: cannabinoids exposure, intoxication, and impairment. Psychopharmacology (Berl). 2022 Feb; 239(2):385-397. PMID: 34708254.
      View in: PubMed
    23. Karoly HC, Skrzynski CJ, Moe EN, Bryan AD, Hutchison KE. Exploring relationships between alcohol consumption, inflammation, and brain structure in a heavy drinking sample. Alcohol Clin Exp Res. 2021 11; 45(11):2256-2270. PMID: 34523725.
      View in: PubMed
    24. Karoly HC, Skrzynski CJ, Moe E, Bryan AD, Hutchison KE. Investigating Associations Between Inflammatory Biomarkers, Gray Matter, Neurofilament Light and Cognitive Performance in Healthy Older Adults. Front Aging Neurosci. 2021; 13:719553. PMID: 34539381.
      View in: PubMed
    25. Gibson LP, Karoly HC, Ellingson JM, Klawitter J, Sempio C, Squeri JE, Bryan AD, Bidwell LC, Hutchison KE. Effects of cannabidiol in cannabis flower: Implications for harm reduction. Addict Biol. 2022 01; 27(1):e13092. PMID: 34467598.
      View in: PubMed
    26. Bidwell LC, Martin-Willett R, Karoly HC. Advancing the science on cannabis concentrates and behavioural health. Drug Alcohol Rev. 2021 09; 40(6):900-913. PMID: 33783029.
      View in: PubMed
    27. Karoly HC, Mueller RL, Andrade CC, Hutchison KE. THC and CBD effects on alcohol use among alcohol and cannabis co-users. Psychol Addict Behav. 2021 Sep; 35(6):749-759. PMID: 33764086.
      View in: PubMed
    28. Karoly HC, Ross JM, Prince MA, Zabelski AE, Hutchison KE. Effects of cannabis use on alcohol consumption in a sample of treatment-engaged heavy drinkers in Colorado. Addiction. 2021 09; 116(9):2529-2537. PMID: 33464670.
      View in: PubMed
    29. Karoly HC, Mueller RL, Andrade CC, Hutchison KE. Investigating Relationships Between Alcohol and Cannabis Use in an Online Survey of Cannabis Users: A Focus on Cannabinoid Content and Cannabis for Medical Purposes. Front Psychiatry. 2020; 11:613243. PMID: 33408657.
      View in: PubMed
    30. Martin-Willett R, Ellingson JE, Fries J, Helmuth T, Karoly H, Giordano G, Calhoun VD, Bryan AD. Few Structural Brain Changes Associated With Moderate-Intensity Interval Training and Low-Intensity Continuous Training in a Randomized Trial of Fitness and Older Adults. J Aging Phys Act. 2021 06 01; 29(3):505-515. PMID: 33271506.
      View in: PubMed
    31. Karoly HC, Milburn MA, Brooks-Russell A, Brown M, Streufert J, Bryan AD, Lovrich NP, DeJong W, Cinnamon Bidwell L. Effects of High-Potency Cannabis on Psychomotor Performance in Frequent Cannabis Users. Cannabis Cannabinoid Res. 2022 02; 7(1):107-115. PMID: 33998859.
      View in: PubMed
    32. Bidwell LC, Ellingson JM, Karoly HC, YorkWilliams SL, Hitchcock LN, Tracy BL, Klawitter J, Sempio C, Bryan AD, Hutchison KE. Association of Naturalistic Administration of Cannabis Flower and Concentrates With Intoxication and Impairment. JAMA Psychiatry. 2020 08 01; 77(8):787-796. PMID: 32520316.
      View in: PubMed
    33. Farokhnia M, Berger AL, Karoly HC, Hwa LS, Varodayan FP. The Promise of Neuroimmune Targets for Treating Drug Addiction and Other Psychiatric Disorders: Granulocyte-Colony Stimulating Factor Exemplification. Front Psychiatry. 2020; 11:220. PMID: 32256420.
      View in: PubMed
    34. Karoly HC, Mueller RL, Bidwell LC, Hutchison KE. Cannabinoids and the Microbiota-Gut-Brain Axis: Emerging Effects of Cannabidiol and Potential Applications to Alcohol Use Disorders. Alcohol Clin Exp Res. 2020 02; 44(2):340-353. PMID: 31803950.
      View in: PubMed
    35. Gruber J, Villanueva C, Burr E, Purcell JR, Karoly H. Understanding and Taking Stock of Positive Emotion Disturbance. Soc Personal Psychol Compass. 2020 Jan; 14(1). PMID: 37636238.
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    36. Thayer RE, Hansen NS, Prashad S, Karoly HC, Filbey FM, Bryan AD, Feldstein Ewing SW. Recent tobacco use has widespread associations with adolescent white matter microstructure. Addict Behav. 2020 02; 101:106152. PMID: 31639638.
      View in: PubMed
    37. Karoly HC, Ross JM, Ellingson JM, Feldstein Ewing SW. Exploring Cannabis and Alcohol Co-Use in Adolescents: A Narrative Review of the Evidence. J Dual Diagn. 2020 Jan-Mar; 16(1):58-74. PMID: 31519143.
      View in: PubMed
    38. Liu Y, van den Wildenberg WPM, de Graaf Y, Ames SL, Baldacchino A, B? R, Cadaveira F, Campanella S, Christiansen P, Claus ED, Colzato LS, Filbey FM, Foxe JJ, Garavan H, Hendershot CS, Hester R, Jester JM, Karoly HC, Kr?plin A, Kreusch F, Landr? NI, Littel M, Loeber S, London ED, L?pez-Caneda E, Lubman DI, Luijten M, Marczinski CA, Metrik J, Montgomery C, Papachristou H, Mi Park S, Paz AL, Petit G, Prisciandaro JJ, Quednow BB, Ray LA, Roberts CA, Roberts GMP, de Ruiter MB, Rupp CI, Steele VR, Sun D, Takagi M, Tapert SF, van Holst RJ, Verdejo-Garcia A, Vonmoos M, Wojnar M, Yao Y, Y?cel M, Zack M, Zucker RA, Huizenga HM, Wiers RW. Is (poly-) substance use associated with impaired inhibitory control? A mega-analysis controlling for confounders. Neurosci Biobehav Rev. 2019 10; 105:288-304. PMID: 31319124.
      View in: PubMed
    39. Karoly HC, Schacht JP, Jacobus J, Meredith LR, Taylor CT, Tapert SF, Gray KM, Squeglia LM. Preliminary evidence that computerized approach avoidance training is not associated with changes in fMRI cannabis cue reactivity in non-treatment-seeking adolescent cannabis users. Drug Alcohol Depend. 2019 07 01; 200:145-152. PMID: 31132681.
      View in: PubMed
    40. Karoly HC, Ellingson JM, Hutchison KE. Interactions between TLR4 methylation and alcohol consumption on subjective responses to an alcohol infusion. Alcohol Alcohol. 2018 Nov 01; 53(6):650-658. PMID: 29982285.
      View in: PubMed
    41. Karoly HC, Schacht JP, Meredith LR, Jacobus J, Tapert SF, Gray KM, Squeglia LM. Investigating a novel fMRI cannabis cue reactivity task in youth. Addict Behav. 2019 02; 89:20-28. PMID: 30243035.
      View in: PubMed
    42. Marceau K, Cinnamon Bidwell L, Karoly HC, Evans AS, Todorov AA, Palmer RH, Heath AC, Knopik VS. Within-Family Effects of Smoking during Pregnancy on ADHD: the Importance of Phenotype. J Abnorm Child Psychol. 2018 05; 46(4):685-699. PMID: 28664227.
      View in: PubMed
    43. Gardiner CK, Karoly HC, Thayer RE, Gillman AS, Sabbineni A, Bryan AD. Neural activation during delay discounting is associated with 6-month change in risky sexual behavior in adolescents. Ann Behav Med. 2018 04 19; 52(5):356-366. PMID: 29684133.
      View in: PubMed
    44. Bidwell LC, Karoly HC, Thayer RE, Claus ED, Bryan AD, Weiland BJ, YorkWilliams S, Hutchison KE. DRD2 promoter methylation and measures of alcohol reward: functional activation of reward circuits and clinical severity. Addict Biol. 2019 05; 24(3):539-548. PMID: 29464814.
      View in: PubMed
    45. Karoly HC, Bidwell LC, Mueller RL, Hutchison KE. Investigating the Relationships Between Alcohol Consumption, Cannabis Use, and Circulating Cytokines: A Preliminary Analysis. Alcohol Clin Exp Res. 2018 Mar; 42(3):531-539. PMID: 29286537.
      View in: PubMed
    46. Karoly HC, Thayer RE, Hagerty SL, Hutchison KE. TLR4 Methylation Moderates the Relationship Between Alcohol Use Severity and Gray Matter Loss. J Stud Alcohol Drugs. 2017 09; 78(5):696-705. PMID: 28930057.
      View in: PubMed
    47. Bidwell LC, Marceau K, Brick LA, Karoly HC, Todorov AA, Palmer RH, Heath AC, Knopik VS. Prenatal Exposure Effects on Early Adolescent Substance Use: Preliminary Evidence From a Genetically Informed Bayesian Approach. J Stud Alcohol Drugs. 2017 09; 78(5):789-794. PMID: 28930067.
      View in: PubMed
    48. Thayer RE, YorkWilliams S, Karoly HC, Sabbineni A, Ewing SF, Bryan AD, Hutchison KE. Structural neuroimaging correlates of alcohol and cannabis use in adolescents and adults. Addiction. 2017 Dec; 112(12):2144-2154. PMID: 28646566.
      View in: PubMed
    49. Bidwell LC, Karoly HC, Hutchison KE, Bryan AD. ADHD symptoms impact smoking outcomes and withdrawal in response to Varenicline treatment for smoking cessation. Drug Alcohol Depend. 2017 10 01; 179:18-24. PMID: 28738266.
      View in: PubMed
    50. Gardiner CK, Karoly HC, Bryan AD. Commentary: Differential associations between obesity and behavioral measures of impulsivity. Front Psychol. 2016; 7:949. PMID: 27444563.
      View in: PubMed
    51. Karoly HC, YorkWilliams SL, Hutchison KE. Clinical neuroscience of addiction: similarities and differences between alcohol and other drugs. Alcohol Clin Exp Res. 2015 Nov; 39(11):2073-84. PMID: 26414497.
      View in: PubMed
    52. Karoly HC, Bryan AD, Weiland BJ, Mayer A, Dodd A, Feldstein Ewing SW. Does incentive-elicited nucleus accumbens activation differ by substance of abuse? An examination with adolescents. Dev Cogn Neurosci. 2015 Dec; 16:5-15. PMID: 26070843.
      View in: PubMed
    53. Karoly HC, Callahan T, Schmiege SJ, Ewing SW. Evaluating the Hispanic Paradox in the Context of Adolescent Risky Sexual Behavior: The Role of Parent Monitoring. J Pediatr Psychol. 2016 May; 41(4):429-40. PMID: 25972373.
      View in: PubMed
    54. Littlewood RA, Claus ED, Arenella P, Bogenschutz M, Karoly H, Ewing SW, Bryan AD, Hutchison KE. Dose specific effects of olanzapine in the treatment of alcohol dependence. Psychopharmacology (Berl). 2015 Apr; 232(7):1261-8. PMID: 25304864.
      View in: PubMed
    55. Karoly HC, Weiland BJ, Sabbineni A, Hutchison KE. Preliminary functional MRI results from a combined stop-signal alcohol-cue task. J Stud Alcohol Drugs. 2014 Jul; 75(4):664-73. PMID: 24988265.
      View in: PubMed
    56. Feldstein Ewing SW, Karoly H, Hutchison KE. Commentary on Culverhouse et al. (2014): How genomics can bring us towards health equity. Addiction. 2014 May; 109(5):823-4. PMID: 24720827.
      View in: PubMed
    57. Harlaar N, Bryan AD, Thayer RE, Karoly HC, Oien N, Hutchison KE. Methylation of a CpG site near the ALDH1A2 gene is associated with loss of control over drinking and related phenotypes. Alcohol Clin Exp Res. 2014 Mar; 38(3):713-21. PMID: 24236815.
      View in: PubMed
    58. Karoly HC, Stevens CJ, Thayer RE, Magnan RE, Bryan AD, Hutchison KE. Aerobic exercise moderates the effect of heavy alcohol consumption on white matter damage. Alcohol Clin Exp Res. 2013 Sep; 37(9):1508-15. PMID: 23551199.
      View in: PubMed
    59. Karoly HC, Harlaar N, Hutchison KE. Substance use disorders: a theory-driven approach to the integration of genetics and neuroimaging. Ann N Y Acad Sci. 2013 Apr; 1282:71-91. PMID: 23470155.
      View in: PubMed
    60. Karoly HC, Stevens CJ, Magnan RE, Harlaar N, Hutchison KE, Bryan AD. Genetic Influences on Physiological and Subjective Responses to an Aerobic Exercise Session among Sedentary Adults. J Cancer Epidemiol. 2012; 2012:540563. PMID: 22899923.
      View in: PubMed
    61. Karoly HC, Hutchison KE. Does stress contribute to the incubation of craving? Biol Psychiatry. 2012 Apr 15; 71(8):e39. PMID: 22244359.
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    62. Nudelman A, Karoly H, Braun F, B?hme EH, Erickson RC. Semisynthetic cephalosporins. Synthesis and structure-activity relationships of 7-(1-pyrryl)- and 7-(1-indolyl)acetamidocephalosporin derivatives. J Med Chem. 1978 Sep; 21(9):962-4. PMID: 722761.
      View in: PubMed
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