Colorado PROFILES, The Colorado Clinical and Translational Sciences Institute (CCTSI)
Keywords
Last Name
Institution

Douglas John Adams

TitleAssociate Professor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-ORTHO General Operations

    Collapse Biography 
    Collapse education and training
    University of IowaPhD04/1996Biomedical Engineering

    Collapse Research 
    Collapse research activities and funding
    R01AR073346     (ACKERT-BICKNELL, CHERYL LYNNE)Sep 1, 2019 - Jul 31, 2025
    NIH
    Identification of Genes Regulating PTH-Mediated Skeletal Strength
    Role: Co-Principal Investigator
    R01AR070813     (KALAJZIC, IVO)Apr 1, 2017 - Feb 28, 2022
    NIH
    Growth Factor Based on Enhancement of Bone Repair
    Role: Co-Investigator
    R01AR070879     (ADAMS, DOUGLAS J)Sep 15, 2016 - Jan 31, 2022
    NIH
    Identification of Genes Regulating Bone Matrix Composition and Quality
    Role: Principal Investigator
    R21AR064941     (ROWE, DAVID W.)Apr 1, 2014 - Mar 31, 2016
    NIH
    Phenotyping Skeletal QTLs in a DO Mouse Population
    Role: Co-Investigator
    R01AR063702     (ROWE, DAVID W.)Aug 1, 2013 - May 31, 2019
    NIH
    Skeletal Phenotyping of KOMP Mice
    Role: Co-Investigator
    S10RR028005     (ADAMS, DOUGLAS J)May 13, 2010 - May 12, 2011
    NIH
    Nanomechanical Test System for Small Length Scale Biomaterials &Tissue Specimens
    Role: Principal Investigator
    R01AR055607     (KALAJZIC, IVO)Dec 1, 2007 - May 31, 2020
    NIH
    Notch Signaling and Bone Fracture Healing
    Role: Co-Investigator
    S10RR022383     (ADAMS, DOUGLAS J)Apr 1, 2006 - Mar 31, 2007
    NIH
    High Resolution In Vivo MicroCT Imaging and Analysis System for Rodents
    Role: Principal Investigator
    P30AR046026     (LORENZO, JOSEPH A)Jun 1, 2001 - Nov 30, 2007
    NIH
    Core Center for Musculoskeletal Research
    Role: Co-Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. David MA, Williams KG, Constantine EP, Matthias J, Ferguson VL, Adams DJ. Demystifying machine learning approaches in digital bone imaging using microCT and HRpQCT. Bone Rep. 2026 Jun; 29:101911. PMID: 42023065.
      View in: PubMed
    2. Kolora LD, Melendez-Suchi C, Butler V, Han L, Almeida M, Shankar K, Adams DJ, Iyer S. IRE1 signaling in osteoprogenitors augments ß-catenin activity and physiologic bone accrual. J Bone Miner Res. 2026 Jan 06. PMID: 41493348.
      View in: PubMed
    3. Jamnick NA, Livingston PD, Gammon CJ, Weinzierl NM, Novinger LJ, Adams DJ, Bonetto A. Vincristine impairs musculoskeletal development in pediatric mice. BMC Cancer. 2025 Nov 18; 25(1):1782. PMID: 41254582.
      View in: PubMed
    4. Hendesi H, Godfrey DA, Ruble AF, Tran AM, Villani DA, Landgrave SH, Hasan NA, Adams DJ, Zuscik MJ. Intermittent fasting alleviates obesity-associated impairments in bone fracture healing: Exploring the role of gut microbiome. Bone Rep. 2025 Dec; 27:101876. PMID: 41466840.
      View in: PubMed
    5. Livingston PD, Labbate Bonaldo AL, Jamnick NA, Weinzierl NM, Gammon CJ, Callaway CS, Lee S, Gao B, Goodspeed A, Carvalho RF, Young CD, Orlicky DJ, Adams DJ, Novinger LJ, Bonetto A. B0092 tumor-bearing mice are a new model for the study of cachexia in head and neck cancer. Am J Physiol Cell Physiol. 2025 Aug 01; 329(2):C646-C658. PMID: 40691041.
      View in: PubMed
    6. Okamoto F, Chitre AS, Missfeldt Sanches T, Chen D, Munro D, Aron AT, Beeson A, Bimschleger HV, Eid M, Garcia Martinez AG, Han W, Holl K, Jackson T, Johnson BB, King CP, Kuhn BN, Lamparelli AC, Netzley AH, Nguyen KH, Peng BF, Tripi JA, Wang T, Ziegler KS, Adams DJ, Baud A, Carrette LLG, Chen H, de Guglielmo G, Dorrestein P, George O, Ishiwari K, Jablonski MM, Jhou TC, Kallupi M, Knight R, Meyer PJ, Solberg Woods LC, Polesskaya O, Palmer AA. Y and mitochondrial chromosomes in the heterogeneous stock rat population. G3 (Bethesda). 2024 11 06; 14(11). PMID: 39250761.
      View in: PubMed
    7. Iyer S, Adams DJ. Bone and the Unfolded Protein Response: In Sickness and in Health. Calcif Tissue Int. 2023 07; 113(1):96-109. PMID: 37243756.
      View in: PubMed
    8. Maynard RD, Villani DA, Schroeder WG, Adams DJ, Zuscik MJ. Surgical Induction of Posttraumatic Osteoarthritis in the Mouse. Methods Mol Biol. 2021; 2230:91-103. PMID: 33197010.
      View in: PubMed
    9. Rowe DW, Hong SH, Zhang C, Shin DG, Adams DJ, Youngstrom DW, Chen L, Wu Z, Zhou Y, Maye P. Skeletal screening IMPC/KOMP using µCT and computer automated cryohistology: Application to the Efna4 KO mouse line. Bone. 2021 03; 144:115688. PMID: 33065355.
      View in: PubMed
    10. Novak S, Roeder E, Sinder BP, Adams DJ, Siebel CW, Grcevic D, Hankenson KD, Matthews BG, Kalajzic I. Modulation of Notch1 signaling regulates bone fracture healing. J Orthop Res. 2020 11; 38(11):2350-2361. PMID: 32141629.
      View in: PubMed
    11. Shin B, Won H, Adams DJ, Lee SK. CD55 Regulates Bone Mass in Mice by Modulating RANKL-Mediated Rac Signaling and Osteoclast Function. J Bone Miner Res. 2020 01; 35(1):130-142. PMID: 31487060.
      View in: PubMed
    12. Hagiwara Y, Dyrna F, Kuntz AF, Adams DJ, Dyment NA. Cells from a GDF5 origin produce zonal tendon-to-bone attachments following anterior cruciate ligament reconstruction. Ann N Y Acad Sci. 2020 01; 1460(1):57-67. PMID: 31596513.
      View in: PubMed
    13. Morris JA, Kemp JP, Youlten SE, Laurent L, Logan JG, Chai RC, Vulpescu NA, Forgetta V, Kleinman A, Mohanty ST, Sergio CM, Quinn J, Nguyen-Yamamoto L, Luco AL, Vijay J, Simon MM, Pramatarova A, Medina-Gomez C, Trajanoska K, Ghirardello EJ, Butterfield NC, Curry KF, Leitch VD, Sparkes PC, Adoum AT, Mannan NS, Komla-Ebri DSK, Pollard AS, Dewhurst HF, Hassall TAD, Beltejar MG, Adams DJ, Vaillancourt SM, Kaptoge S, Baldock P, Cooper C, Reeve J, Ntzani EE, Evangelou E, Ohlsson C, Karasik D, Rivadeneira F, Kiel DP, Tobias JH, Gregson CL, Harvey NC, Grundberg E, Goltzman D, Adams DJ, Lelliott CJ, Hinds DA, Ackert-Bicknell CL, Hsu YH, Maurano MT, Croucher PI, Williams GR, Bassett JHD, Evans DM, Richards JB. Author Correction: An atlas of genetic influences on osteoporosis in humans and mice. Nat Genet. 2019 05; 51(5):920. PMID: 30988516.
      View in: PubMed
    14. Morris JA, Kemp JP, Youlten SE, Laurent L, Logan JG, Chai RC, Vulpescu NA, Forgetta V, Kleinman A, Mohanty ST, Sergio CM, Quinn J, Nguyen-Yamamoto L, Luco AL, Vijay J, Simon MM, Pramatarova A, Medina-Gomez C, Trajanoska K, Ghirardello EJ, Butterfield NC, Curry KF, Leitch VD, Sparkes PC, Adoum AT, Mannan NS, Komla-Ebri DSK, Pollard AS, Dewhurst HF, Hassall TAD, Beltejar MG, Adams DJ, Vaillancourt SM, Kaptoge S, Baldock P, Cooper C, Reeve J, Ntzani EE, Evangelou E, Ohlsson C, Karasik D, Rivadeneira F, Kiel DP, Tobias JH, Gregson CL, Harvey NC, Grundberg E, Goltzman D, Adams DJ, Lelliott CJ, Hinds DA, Ackert-Bicknell CL, Hsu YH, Maurano MT, Croucher PI, Williams GR, Bassett JHD, Evans DM, Richards JB. An atlas of genetic influences on osteoporosis in humans and mice. Nat Genet. 2019 02; 51(2):258-266. PMID: 30598549.
      View in: PubMed
    15. Rowe DW, Adams DJ, Hong SH, Zhang C, Shin DG, Renata Rydzik C, Chen L, Wu Z, Garland G, Godfrey DA, Sundberg JP, Ackert-Bicknell C. Screening Gene Knockout Mice for Variation in Bone Mass: Analysis by µCT and Histomorphometry. Curr Osteoporos Rep. 2018 04; 16(2):77-94. PMID: 29508144.
      View in: PubMed
    16. Adams DJ, Rowe DW, Ackert-Bicknell CL. Genetics of aging bone. Mamm Genome. 2016 08; 27(7-8):367-80. PMID: 27272104.
      View in: PubMed
    17. Gohil SV, Kuo CL, Adams DJ, Maye P, Rowe DW, Nair LS. Evaluation of the donor cell contribution in rhBMP-2 mediated bone formation with chitosan thermogels using fluorescent protein reporter mice. J Biomed Mater Res A. 2016 04; 104(4):928-41. PMID: 26703977.
      View in: PubMed
    18. Adams DJ, Ackert-Bicknell CL. Genetic regulation of bone strength: a review of animal model studies. Bonekey Rep. 2015; 4:714. PMID: 26157577.
      View in: PubMed
    19. Hagiwara Y, Dyment NA, Jiang X, Jiang Ping H, Ackert-Bicknell C, Adams DJ, Rowe DW. Fixation stability dictates the differentiation pathway of periosteal progenitor cells in fracture repair. J Orthop Res. 2015 Jul; 33(7):948-56. PMID: 25639792.
      View in: PubMed
    20. Dole NS, Kapinas K, Kessler CB, Yee SP, Adams DJ, Pereira RC, Delany AM. A single nucleotide polymorphism in osteonectin 3' untranslated region regulates bone volume and is targeted by miR-433. J Bone Miner Res. 2015 Apr; 30(4):723-32. PMID: 25262637.
      View in: PubMed
    21. Matthews BG, Grcevic D, Wang L, Hagiwara Y, Roguljic H, Joshi P, Shin DG, Adams DJ, Kalajzic I. Analysis of aSMA-labeled progenitor cell commitment identifies notch signaling as an important pathway in fracture healing. J Bone Miner Res. 2014; 29(5):1283-94. PMID: 24190076.
      View in: PubMed
    22. Aguila HL, Mun SH, Kalinowski J, Adams DJ, Lorenzo JA, Lee SK. Osteoblast-specific overexpression of human interleukin-7 rescues the bone mass phenotype of interleukin-7-deficient female mice. J Bone Miner Res. 2012 May; 27(5):1030-42. PMID: 22258693.
      View in: PubMed
    23. Sage AP, Lu J, Atti E, Tetradis S, Ascenzi MG, Adams DJ, Demer LL, Tintut Y. Hyperlipidemia induces resistance to PTH bone anabolism in mice via oxidized lipids. J Bone Miner Res. 2011 Jun; 26(6):1197-206. PMID: 21611962.
      View in: PubMed
    24. Verbalis JG, Barsony J, Sugimura Y, Tian Y, Adams DJ, Carter EA, Resnick HE. Hyponatremia-induced osteoporosis. J Bone Miner Res. 2010 Mar; 25(3):554-63. PMID: 19751154.
      View in: PubMed
    25. Barisic-Dujmovic T, Boban I, Adams DJ, Clark SH. Marfan-like skeletal phenotype in the tight skin (Tsk) mouse. Calcif Tissue Int. 2007 Oct; 81(4):305-15. PMID: 17705049.
      View in: PubMed
    26. Lee SK, Kadono Y, Okada F, Jacquin C, Koczon-Jaremko B, Gronowicz G, Adams DJ, Aguila HL, Choi Y, Lorenzo JA. T lymphocyte-deficient mice lose trabecular bone mass with ovariectomy. J Bone Miner Res. 2006 Nov; 21(11):1704-12. PMID: 17002560.
      View in: PubMed
    27. Lee SK, Kalinowski JF, Jacquin C, Adams DJ, Gronowicz G, Lorenzo JA. Interleukin-7 influences osteoclast function in vivo but is not a critical factor in ovariectomy-induced bone loss. J Bone Miner Res. 2006 May; 21(5):695-702. PMID: 16734384.
      View in: PubMed
    28. Chikazu D, Li X, Kawaguchi H, Sakuma Y, Voznesensky OS, Adams DJ, Xu M, Hoshi K, Katavic V, Herschman HR, Raisz LG, Pilbeam CC. Bone morphogenetic protein 2 induces cyclo-oxygenase 2 in osteoblasts via a Cbfa1 binding site: role in effects of bone morphogenetic protein 2 in vitro and in vivo. 2002. J Bone Miner Res. 2005 Oct; 20(10):1888-98. PMID: 16355502.
      View in: PubMed
    29. Chikazu D, Li X, Kawaguchi H, Sakuma Y, Voznesensky OS, Adams DJ, Xu M, Hoshio K, Katavic V, Herschman HR, Raisz LG, Pilbeam CC. Bone morphogenetic protein 2 induces cyclo-oxygenase 2 in osteoblasts via a Cbfal binding site: role in effects of bone morphogenetic protein 2 in vitro and in vivo. J Bone Miner Res. 2002 Aug; 17(8):1430-40. PMID: 12162497.
      View in: PubMed
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