 Eflornithine
"Eflornithine" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An inhibitor of ORNITHINE DECARBOXYLASE, the rate limiting enzyme of the polyamine biosynthetic pathway.
| Descriptor ID |
D000518
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| MeSH Number(s) |
D12.125.068.665.340 D12.125.095.765.340
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| Concept/Terms |
Eflornithine- Eflornithine
- alpha-Difluoromethyl Ornithine
- Ornithine, alpha-Difluoromethyl
- alpha Difluoromethyl Ornithine
- alpha-Difluoromethylornithine
- alpha Difluoromethylornithine
Eflornithine Hydrochloride- Eflornithine Hydrochloride
- Hydrochloride, Eflornithine
- Eflornithine Monohydrochloride, Monohydrate
- Monohydrochloride, Monohydrate Eflornithine
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Below are MeSH descriptors whose meaning is more general than "Eflornithine".
Below are MeSH descriptors whose meaning is more specific than "Eflornithine".
This graph shows the total number of publications written about "Eflornithine" by people in this website by year, and whether "Eflornithine" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1999 | 0 | 1 | 1 | | 2001 | 0 | 1 | 1 | | 2011 | 0 | 1 | 1 | | 2013 | 0 | 1 | 1 | | 2016 | 0 | 1 | 1 |
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Below are the most recent publications written about "Eflornithine" by people in Profiles.
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Setty BA, Jin Y, Houghton PJ, Yeager ND, Gross TG, Nelin LD. Hypoxic Proliferation of Osteosarcoma Cells Depends on Arginase II. Cell Physiol Biochem. 2016; 39(2):802-13.
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Jasuja R, Costello JC, Singh R, Gupta V, Spina CS, Toraldo G, Jang H, Li H, Serra C, Guo W, Chauhan P, Narula NS, Guarneri T, Ergun A, Travison TG, Collins JJ, Bhasin S. Combined administration of testosterone plus an ornithine decarboxylase inhibitor as a selective prostate-sparing anabolic therapy. Aging Cell. 2014 Apr; 13(2):303-10.
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Prado R, Francis SO, Mason MN, Wing G, Gamble RG, Dellavalle R. Nonmelanoma skin cancer chemoprevention. Dermatol Surg. 2011 Nov; 37(11):1566-78.
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Meyskens FL, McLaren CE, Pelot D, Fujikawa-Brooks S, Carpenter PM, Hawk E, Kelloff G, Lawson MJ, Kidao J, McCracken J, Albers CG, Ahnen DJ, Turgeon DK, Goldschmid S, Lance P, Hagedorn CH, Gillen DL, Gerner EW. Difluoromethylornithine plus sulindac for the prevention of sporadic colorectal adenomas: a randomized placebo-controlled, double-blind trial. Cancer Prev Res (Phila). 2008 Jun; 1(1):32-8.
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Fadok VA, Daleke DL, Henson PM, Bratton DL. Loss of phospholipid asymmetry and surface exposure of phosphatidylserine is required for phagocytosis of apoptotic cells by macrophages and fibroblasts. J Biol Chem. 2001 Jan 12; 276(2):1071-7.
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Bratton DL, Fadok VA, Richter DA, Kailey JM, Frasch SC, Nakamura T, Henson PM. Polyamine regulation of plasma membrane phospholipid flip-flop during apoptosis. J Biol Chem. 1999 Oct 01; 274(40):28113-20.
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Schedin PJ, Strange R, Singh M, Kaeck MR, Fontaine SC, Thompson HJ. Treatment with chemopreventive agents, difluoromethylornithine and retinyl acetate, results in altered mammary extracellular matrix. Carcinogenesis. 1995 Aug; 16(8):1787-94.
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Backous DD, Henley CM, Dunn JK, Jenkins HA. alpha-Difluoromethylornithine delays behavioral recovery and induces decompensation after unilateral labyrinthectomy. Otolaryngol Head Neck Surg. 1994 Oct; 111(4):377-84.
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Markwell MA, Berger SP, Paul SM. The polyamine synthesis inhibitor alpha-difluoromethylornithine blocks NMDA-induced neurotoxicity. Eur J Pharmacol. 1990 Jul 17; 182(3):607-9.
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Atkinson JE, Olson JW, Altiere RJ, Gillespie MN. Evidence that hypoxic pulmonary vascular remodeling in rats is polyamine dependent. J Appl Physiol (1985). 1987 Apr; 62(4):1562-8.
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