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Jesse A Davidson

TitleAssociate Professor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-PEDS

    Collapse Biography 
    Collapse education and training
    Yale University, New Haven, CTBS05/1995Molecular Biophysics and Biochemistry
    Duke University School of Medicine, Durham, NCMD05/2000Medicine
    University of North Carolina, Chapel Hill School of Public Health, Chapel Hill, NCMPH08/2000Epidemiology
    Mount Sinai Hospital, New York, NYInternship06/2001Medicine
    Children's Hospital Colorado, Aurora, COResidency06/2007Pediatrics
    Children's Hospital Colorado, Aurora, COFellowship06/2013Pediatric Cardiology
    Children's Hospital Colorado, Aurora, COFellowship06/2013Pediatric Critical Care
    Children's Hospital Colorado, Aurora, COFellowship06/2013Advanced Pediatric Echocardiography
    University of Colorado, Aurora, COMSc12/2018Clinical Sciences

    Collapse Overview 

    Collapse Research 
    Collapse research activities and funding
    K24HL167910     (DAVIDSON, JESSE)Sep 1, 2024 - Aug 31, 2029
    NIH
    Systems biology of acute and chronic multi-organ failure in children with congenital heart disease
    Role: Principal Investigator
    R01HL156936     (DAVIDSON, JESSE)May 1, 2021 - Apr 30, 2026
    NIH
    Metabolic profiling and comprehensive metabolic pathway mapping: a systems biology approach to cardiovascular failure and organ injury following infant congenital heart disease surgery
    Role: Principal Investigator
    AHA18IPA34170070     (Jesse Davidson)Jul 1, 2018 - Jun 30, 2020
    American Heart Association
    Pulmonary Vascular Growth in Infants with Single Ventricle Heart Disease: Deep Phenotyping and Biomarker Development.
    Role Description: This study will utilize both hypothesis-driven and unbiased approaches to the evaluation of pulmonary vascular development and post-operative complications/hypoxemia in single ventricle patients undergoing stage 2 palliation. Endothelin-1 levels will be the primary targeted biomarker, while unbiased approaches will include metabolomic and proteomic evaluation and pathway analysis.
    Role: Principal Investigator
         (Jonathan Kheir)Jan 1, 2018 - Dec 31, 2020
    Gerber Foundation
    Hungry for more: applying the growth chart concept to the care we provide following congenital heart surgery.
    Role Description: Multicenter study utilizing automated data extraction to create care curves for post-operative management of children with congenital heart disease.
    Role: Site Principal Investigator
    AHA17IRG33410724     (Jesse Davidson)Jan 1, 2017 - Dec 31, 2018
    American Heart Association
    Alkaline phosphatase for the prevention of acute lung injury in a piglet model of cardiopulmonary bypass with deep hypothermic circulatory arrest.
    Role Description: Initial evaluation of the effects of systemically or enterally administered alkaline phosphatase to reduce injury to the lungs in a piglet model of cardiopulmonary bypass with deep hypothermic circulatory arrest.
    Role: Principal Investigator
    DOD PR152240     (Jesse Davidson)Aug 15, 2016 - Feb 14, 2018
    Department of Defense
    Alkaline phosphatase for the prevention of intestinal and renal injury in a piglet model of cardiopulmonary bypass with deep hypothermic circulatory arrest.
    Role Description: Initial evaluation of the effects of systemically or enterally administered alkaline phosphatase to reduce injury to the intestines and kidneys in a rodent model of cardiopulmonary bypass.
    Role: Principal Investigator
    K23HL123634     (DAVIDSON, JESSE)Jul 21, 2014 - Jun 30, 2019
    NIH
    Alkaline Phosphatase in Infant Cardiopulmonary Bypass: Kinetics and Relationship
    Role: Principal Investigator
    13CRP17300016     (Jesse Davidson)Jul 1, 2013 - Aug 30, 2014
    American Heart Association
    Alkaline Phosphatase in Infant Cardiopulmonary Bypass: Kinetics and Relationship to Inflammation, Organ Injury, and Outcome.
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Ali EA, Syed A, Khailova L, Iguidbashian JP, Suarez-Pierre A, Klawitter J, Stone M, Mancuso CA, Frank BS, Davidson JA. Novel Biomarkers of Necrotizing Enterocolitis in Neonates Undergoing Congenital Heart Disease Surgery: A Pilot Cohort Study. J Am Heart Assoc. 2023 08; 12(15):e030712. PMID: 37489765.
      View in: PubMed
    2. Wolfe KR, Caprarola SD, Clark C, Davidson J, Everitt MD, Faul L, Hageman C, Kelly SL, Maloney E, Patteson H, Scott S, Talbot A, Tong S, DiMaria KL. Implementation of the Cardiac Inpatient Neurodevelopmental Care Optimization (CINCO) programme: an interdisciplinary, generalisable approach to inpatient neurodevelopmental care. Cardiol Young. 2023 Apr 12; 1-8. PMID: 37042605.
      View in: PubMed
    3. Frank BS, Khailova L, Dekermanjian J, Mitchell MB, Morgan GJ, Twite M, Christians U, DiMaria MV, Klawitter J, Davidson JA. Interstage Single Ventricle Heart Disease Infants Show Dysregulation in Multiple Metabolic Pathways: Targeted Metabolomics Analysis. JACC Adv. 2023 Jan; 2(1). PMID: 36875009.
      View in: PubMed
    4. Salomon JD, Qiu H, Feng D, Owens J, Khailova L, Osorio Lujan S, Iguidbashian J, Chhonker YS, Murry DJ, Riethoven JJ, Lindsey ML, Singh AB, Davidson JA. Piglet cardiopulmonary bypass induces intestinal dysbiosis and barrier dysfunction associated with systemic inflammation. Dis Model Mech. 2023 05 01; 16(5). PMID: 36426663.
      View in: PubMed
    5. Iguidbashian KG, Robison J, Khailova L, Jaggers J, Ing R, Lawson S, Osorio Lujan SM, Klawitter J, Davidson JA. Correction: Changes in infant porcine pulmonary tissue oxylipins induced by cardiopulmonary bypass. Pediatr Res. 2022 Nov; 92(5):1488. PMID: 35854094.
      View in: PubMed
    6. Iguidbashian KG, Robison J, Khailova L, Jaggers J, Ing R, Lawson S, Osorio Lujan SM, Klawitter J, Davidson JA. Changes in infant porcine pulmonary tissue oxylipins induced by cardiopulmonary bypass. Pediatr Res. 2022 11; 92(5):1274-1281. PMID: 35681098.
      View in: PubMed
    7. Davidson JA, Robison J, Khailova L, Frank BS, Jaggers J, Ing RJ, Lawson S, Iguidbashian J, Ali E, Treece A, Soranno DE, Osorio-Lujan S, Klawitter J. Metabolomic profiling demonstrates evidence for kidney and urine metabolic dysregulation in a piglet model of cardiac surgery-induced acute kidney injury. Am J Physiol Renal Physiol. 2022 07 01; 323(1):F20-F32. PMID: 35532069.
      View in: PubMed
    8. Frank BS, Khailova L, Silveira L, Mitchell MB, Morgan GJ, DiMaria MV, Davidson JA. Increased Circulating Endothelin 1 Is Associated With Postoperative Hypoxemia in Infants With Single-Ventricle Heart Disease Undergoing Superior Cavopulmonary Anastomosis. J Am Heart Assoc. 2022 03 15; 11(6):e024007. PMID: 35243904.
      View in: PubMed
    9. Cooney SJ, Klawitter J, Khailova L, Robison J, Jaggers J, Ing RJ, Lawson S, Frank BS, Lujan SO, Davidson JA. Regional lung metabolic profile in a piglet model of cardiopulmonary bypass with circulatory arrest. Metabolomics. 2021 09 22; 17(10):89. PMID: 34553313.
      View in: PubMed
    10. Persson JN, Holstein J, Silveira L, Irons A, Rajab TK, Jaggers J, Twite MD, Scahill C, Kohn M, Gold C, Davidson JA. Validation of Point-of-Care Ultrasound to Measure Perioperative Edema in Infants With Congenital Heart Disease. Front Pediatr. 2021; 9:727571. PMID: 34497787.
      View in: PubMed
    11. Sperotto F, Davidson JA, Smith-Parrish MN, Elhoff JJ, Sinha A, Blinder JJ, Ehrmann DE, Marino BS, Kheir JN. Development of Care Curves Following the Stage 1 Palliation: A Comparison of Intensive Care Among 5 Centers. J Am Heart Assoc. 2021 06; 10(11):e019396. PMID: 34013742.
      View in: PubMed
    12. Davidson JA, Frank BS, Urban TT, Twite M, Jaggers J, Khailova L, Klawitter J. Serum metabolic profile of postoperative acute kidney injury following infant cardiac surgery with cardiopulmonary bypass. Pediatr Nephrol. 2021 10; 36(10):3259-3269. PMID: 33954809.
      View in: PubMed
    13. Watson JD, Davidson JA. The Microbiome is a Welcome Addition to the Growing "Omes" of Cardiopulmonary Bypass in Congenital Heart Disease Surgery. JACC Basic Transl Sci. 2021 Apr; 6(4):328-330. PMID: 33999038.
      View in: PubMed
    14. Frank BS, Khailova L, Silveira L, Mitchell MB, Morgan GJ, Hsieh EWY, DiMaria MV, Twite M, Klawitter J, Davidson JA. Proteomic profiling identifies key differences between inter-stage infants with single ventricle heart disease and healthy controls. Transl Res. 2021 03; 229:24-37. PMID: 33045409.
      View in: PubMed
    15. Pagano E, Frank B, Jaggers J, Twite M, Urban TT, Klawitter J, Davidson J. Alterations in Metabolites Associated with Hypoxemia in Neonates and Infants with Congenital Heart Disease. Congenit Heart Dis. 2020 Sep 07; 15(4):251-265. PMID: 34413893.
      View in: PubMed
    16. Sabapathy D, Klawitter J, Silveira L, Khailova L, Mitchell MB, Morgan GJ, DiMaria MV, Twite M, Frank BS, Davidson JA. Activation of kynurenine pathway of tryptophan metabolism after infant cardiac surgery with cardiopulmonary bypass: a prospective cohort study. Metabolomics. 2020 09 05; 16(9):93. PMID: 32889608.
      View in: PubMed
    17. Czaja AS, Anderson HD, Ghosh D, Davidson J, Campbell JD, Valuck RJ. Increased Odds of Ventricular Arrhythmias Associated with Selective Serotonin Reuptake Inhibitor Use among the Pediatric and Young Adult Population: A Case-Control Study. J Pediatr. 2020 11; 226:173-178.e8. PMID: 32645405.
      View in: PubMed
    18. Watson JD, Urban TT, Tong SS, Zenge J, Khailova L, Wischmeyer PE, Davidson JA. Immediate Post-operative Enterocyte Injury, as Determined by Increased Circulating Intestinal Fatty Acid Binding Protein, Is Associated With Subsequent Development of Necrotizing Enterocolitis After Infant Cardiothoracic Surgery. Front Pediatr. 2020; 8:267. PMID: 32537446.
      View in: PubMed
    19. Czaja AS, Collins K, Valuck RJ, Anderson HD, Ghosh D, Davidson JA. Validity of administrative claims-based algorithms for ventricular arrhythmia and cardiac arrest in the pediatric population. Pharmacoepidemiol Drug Saf. 2020 11; 29(11):1499-1503. PMID: 32283564.
      View in: PubMed
    20. Frank BS, Sch?fer M, Douwes JM, Ivy DD, Abman SH, Davidson JA, Burzlaff S, Mitchell MB, Morgan GJ, Browne LP, Barker AJ, Truong U, von Alvensleben JC. Novel measures of left ventricular electromechanical discoordination predict clinical outcomes in children with pulmonary arterial hypertension. Am J Physiol Heart Circ Physiol. 2020 02 01; 318(2):H401-H412. PMID: 31858817.
      View in: PubMed
    21. Davidson JA, Khailova L, Treece A, Robison J, Soranno DE, Jaggers J, Ing RJ, Lawson S, Lujan SO. Alkaline Phosphatase Treatment of Acute Kidney Injury in an Infant Piglet Model of Cardiopulmonary Bypass with Deep Hypothermic Circulatory Arrest. Sci Rep. 2019 10 02; 9(1):14175. PMID: 31578351.
      View in: PubMed
    22. Davidson JA, Urban TT, Tong S, Maddux A, Hill G, Frank BS, Watson JD, Jaggers J, Sim?es EAF, Wischmeyer P. Alkaline Phosphatase Activity and Endotoxemia After Infant Cardiothoracic Surgery. Shock. 2019 03; 51(3):328-336. PMID: 29664834.
      View in: PubMed
    23. Frank BS, Urban TT, Lewis K, Tong S, Cassidy C, Mitchell MB, Nichols CS, Davidson JA. Circulating biomarkers of left ventricular hypertrophy in pediatric coarctation of the aorta. Congenit Heart Dis. 2019 May; 14(3):446-453. PMID: 30650250.
      View in: PubMed
    24. Aschner Y, Davidson JA. Early Plasma Matrix Metalloproteinase Profiles Offer New Insight into the Biology and Prognosis of Pediatric Acute Respiratory Distress Syndrome. Am J Respir Crit Care Med. 2019 01 15; 199(2):134-136. PMID: 30160977.
      View in: PubMed
    25. Davidson JA, Pfeifer Z, Frank B, Tong S, Urban TT, Wischmeyer PA, Mourani P, Landeck B, Christians U, Klawitter J. Metabolomic Fingerprinting of Infants Undergoing Cardiopulmonary Bypass: Changes in Metabolic Pathways and Association With Mortality and Cardiac Intensive Care Unit Length of Stay. J Am Heart Assoc. 2018 12 18; 7(24):e010711. PMID: 30561257.
      View in: PubMed
    26. Persson JN, Baird CH, Tong S, Urban TT, Klawitter J, Wischmeyer PE, Davidson JA. Infant cardiopulmonary bypass: CD73 kinetics, association with clinical outcomes, and influence on serum adenosine production capacity. Pediatr Res. 2018 04; 83(4):858-865. PMID: 29278640.
      View in: PubMed
    27. Frank BS, Urban TT, Tong S, Cassidy C, Mitchell MB, Nichols CS, Davidson JA. Endothelin-1 activation in pediatric patients undergoing surgical coarctation of the aorta repair. World J Cardiol. 2017 Dec 26; 9(12):822-829. PMID: 29317988.
      View in: PubMed
    28. Davidson JA, Urban TT, Baird C, Tong S, Woodruff A, Twite M, Jaggers J, Sim?es EAF, Wischmeyer P. Alkaline Phosphatase in Infant Cardiopulmonary Bypass: Kinetics and Relationship to Organ Injury and Major Cardiovascular Events. J Pediatr. 2017 11; 190:49-55.e2. PMID: 29144270.
      View in: PubMed
    29. McIntosh AM, Davidson JA, Scott HF. The authors reply. Pediatr Crit Care Med. 2017 10; 18(10):1003-1005. PMID: 28976472.
      View in: PubMed
    30. McIntosh AM, Tong S, Deakyne SJ, Davidson JA, Scott HF. Validation of the Vasoactive-Inotropic Score in Pediatric Sepsis. Pediatr Crit Care Med. 2017 Aug; 18(8):750-757. PMID: 28486385.
      View in: PubMed
    31. Davidson JA, Urban T, Tong S, Twite M, Woodruff A, Wischmeyer PE, Klawitter J. Alkaline Phosphatase, Soluble Extracellular Adenine Nucleotides, and Adenosine Production after Infant Cardiopulmonary Bypass. PLoS One. 2016; 11(7):e0158981. PMID: 27384524.
      View in: PubMed
    32. Frank B, Davidson J, Tong S, Martin B, Heizer H, Anderson MS, Glode MP, Dominguez SR, Jone PN. Myocardial Strain and Strain Rate in Kawasaki Disease: Range, Recovery, and Relationship to Systemic Inflammation/Coronary Artery Dilation. J Clin Exp Cardiolog. 2016 Apr; 7(4). PMID: 27182455.
      View in: PubMed
    33. Jone PN, Tapia D, Davidson J, Fagan TE, Browne L, Ing RJ, Kay J. Successful Treatment of Myocardial Infarction in an Infant With Kawasaki Disease. Semin Cardiothorac Vasc Anesth. 2015 Sep; 19(3):255-9. PMID: 25700695.
      View in: PubMed
    34. Davidson J, Tong S, Hauck A, Lawson DS, da Cruz E, Kaufman J. Kinetics of procalcitonin and C-reactive protein and the relationship to postoperative infection in young infants undergoing cardiovascular surgery. Pediatr Res. 2013 Oct; 74(4):413-9. PMID: 23863853.
      View in: PubMed
    35. Llamado R, Czaja A, Stence N, Davidson J. Continuous octreotide infusion for sulfonylurea-induced hypoglycemia in a toddler. J Emerg Med. 2013 Dec; 45(6):e209-13. PMID: 23827165.
      View in: PubMed
    36. Davidson J, Tong S, Hauck A, Lawson DS, Jaggers J, Kaufman J, da Cruz E. Alkaline phosphatase activity after cardiothoracic surgery in infants and correlation with post-operative support and inflammation: a prospective cohort study. Crit Care. 2012 Aug 20; 16(4):R160. PMID: 22906145.
      View in: PubMed
    37. Davidson J, Tong S, Hancock H, Hauck A, da Cruz E, Kaufman J. Prospective validation of the vasoactive-inotropic score and correlation to short-term outcomes in neonates and infants after cardiothoracic surgery. Intensive Care Med. 2012 Jul; 38(7):1184-90. PMID: 22527067.
      View in: PubMed
    38. Bosshart H, Humphrey J, Deignan E, Davidson J, Drazba J, Yuan L, Oorschot V, Peters PJ, Bonifacino JS. The cytoplasmic domain mediates localization of furin to the trans-Golgi network en route to the endosomal/lysosomal system. J Cell Biol. 1994 Sep; 126(5):1157-72. PMID: 7914893.
      View in: PubMed
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