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Eszter Katalin Vladar

TitleAsst Professor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus

    Collapse Biography 
    Collapse education and training
    Stanford University, Stanford, CApostdoc10/2014Cell biology
    Stanford University, Stanford, CAPhD09/2007Genetics
    UC Davis, Davis, CABS06/2000Genetics
    Collapse awards and honors
    2018 - 2021Boettcher Webb-Waring Biomedical Research Award

    Collapse Overview 
    Collapse overview

    Our lungs are constantly bombarded by inhaled pathogens, allergens, toxins and debris. The airway epithelium is the first line of defense against these contaminants. It accomplishes this by acting as a selective physical barrier, by participating in immune surveillance and response, and by the directional movement of cilia that sweep contaminants adhered to the mucus layer out of the lungs. Epithelial dysfunction underlies disease phenotypes and promotes disease progression in chronic inflammatory airway conditions like cystic fibrosis, asthma and COPD – however, current treatments do not directly target or reverse dysfunction. Our work focuses on the multiciliated cells, which each contain hundreds of motile cilia. We use mice and primary mouse and human cell culture to study how multiciliated cells adopt their cell fate, build cilia and orient the cilia for directional clearance. We investigate the pathways that drive these processes during normal development and regeneration and study how they are misregulated in human disease. Our research has the potential to develop novel biomarkers and therapeutics for individuals suffering from chronic airway diseases.

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Everman JL, Sajuthi S, Saef B, Rios C, Stoner AM, Numata M, Hu D, Eng C, Oh S, Rodriguez-Santana J, Vladar EK, Voelker DR, Burchard EG, Seibold MA. Functional genomics of CDHR3 confirms its role in HRV-C infection and childhood asthma exacerbations. J Allergy Clin Immunol. 2019 Mar 28. PMID: 30930175.
      View in: PubMed
    2. Benam KH, Vladar EK, Janssen WJ, Evans CM. Mucociliary Defense: Emerging Cellular, Molecular, and Animal Models. Ann Am Thorac Soc. 2018 Nov; 15(Supplement_3):S210-S215. PMID: 30431350.
      View in: PubMed
    3. Vladar EK, Stratton MB, Saal ML, Salazar-De Simone G, Wang X, Wolgemuth D, Stearns T, Axelrod JD. Cyclin-dependent kinase control of motile ciliogenesis. Elife. 2018 08 28; 7. PMID: 30152757.
      View in: PubMed
    4. Kunimoto K, Bayly RD, Vladar EK, Vonderfecht T, Gallagher AR, Axelrod JD. Disruption of Core Planar Cell Polarity Signaling Regulates Renal Tubule Morphogenesis but Is Not Cystogenic. Curr Biol. 2017 Oct 23; 27(20):3120-3131.e4. PMID: 29033332.
      View in: PubMed
    5. Böscke R, Vladar EK, Könnecke M, Hüsing B, Linke R, Pries R, Reiling N, Axelrod JD, Nayak JV, Wollenberg B. Wnt Signaling in Chronic Rhinosinusitis with Nasal Polyps. Am J Respir Cell Mol Biol. 2017 05; 56(5):575-584. PMID: 28059551.
      View in: PubMed
    6. Vladar EK, Nayak JV, Milla CE, Axelrod JD. Airway epithelial homeostasis and planar cell polarity signaling depend on multiciliated cell differentiation. JCI Insight. 2016 Aug 18; 1(13). PMID: 27570836.
      View in: PubMed
    7. Vladar EK, Mitchell BJ. It's a family act: the geminin triplets take center stage in motile ciliogenesis. EMBO J. 2016 05 02; 35(9):904-6. PMID: 27006276.
      View in: PubMed
    8. Gibbs BC, Damerla RR, Vladar EK, Chatterjee B, Wan Y, Liu X, Cui C, Gabriel GC, Zahid M, Yagi H, Szabo-Rogers HL, Suyama KL, Axelrod JD, Lo CW. Prickle1 mutation causes planar cell polarity and directional cell migration defects associated with cardiac outflow tract anomalies and other structural birth defects. Biol Open. 2016 Feb 16; 5(3):323-35. PMID: 26883626; PMCID: PMC4810743.
    9. Lang UE, Cheung C, Vladar EK, Swetter SM, Kim J. Loss of primary cilia correlates with cytologic severity in dysplastic melanocytic nevi. J Cutan Pathol. 2016 Feb; 43(2):113-9. PMID: 26272818.
      View in: PubMed
    10. Vladar EK, Lee YL, Stearns T, Axelrod JD. Observing planar cell polarity in multiciliated mouse airway epithelial cells. Methods Cell Biol. 2015; 127:37-54. PMID: 25837385.
      View in: PubMed
    11. Yuan K, Orcholski ME, Panaroni C, Shuffle EM, Huang NF, Jiang X, Tian W, Vladar EK, Wang L, Nicolls MR, Wu JY, de Jesus Perez VA. Activation of the Wnt/planar cell polarity pathway is required for pericyte recruitment during pulmonary angiogenesis. Am J Pathol. 2015 Jan; 185(1):69-84. PMID: 25447046; PMCID: PMC4278244.
    12. Klos Dehring DA, Vladar EK, Werner ME, Mitchell JW, Hwang P, Mitchell BJ. Deuterosome-mediated centriole biogenesis. Dev Cell. 2013 Oct 14; 27(1):103-12. PMID: 24075808; PMCID: PMC3816757.
    13. Tan FE, Vladar EK, Ma L, Fuentealba LC, Hoh R, Espinoza FH, Axelrod JD, Alvarez-Buylla A, Stearns T, Kintner C, Krasnow MA. Myb promotes centriole amplification and later steps of the multiciliogenesis program. Development. 2013 Oct; 140(20):4277-86. PMID: 24048590.
      View in: PubMed
    14. Vladar EK, Brody SL. Analysis of ciliogenesis in primary culture mouse tracheal epithelial cells. Methods Enzymol. 2013; 525:285-309. PMID: 23522475.
      View in: PubMed
    15. Vladar EK, Bayly RD, Sangoram AM, Scott MP, Axelrod JD. Microtubules enable the planar cell polarity of airway cilia. Curr Biol. 2012 Dec 04; 22(23):2203-12. PMID: 23122850; PMCID: PMC3518597.
    16. Stubbs JL, Vladar EK, Axelrod JD, Kintner C. Multicilin promotes centriole assembly and ciliogenesis during multiciliate cell differentiation. Nat Cell Biol. 2012 Jan 08; 14(2):140-7. PMID: 22231168; PMCID: PMC3329891.
    17. Vladar EK, Antic D, Axelrod JD. Planar cell polarity signaling: the developing cell's compass. Cold Spring Harb Perspect Biol. 2009 Sep; 1(3):a002964. PMID: 20066108; PMCID: PMC2773631.
    18. Bassuk AG, Wallace RH, Buhr A, Buller AR, Afawi Z, Shimojo M, Miyata S, Chen S, Gonzalez-Alegre P, Griesbach HL, Wu S, Nashelsky M, Vladar EK, Antic D, Ferguson PJ, Cirak S, Voit T, Scott MP, Axelrod JD, Gurnett C, Daoud AS, Kivity S, Neufeld MY, Mazarib A, Straussberg R, Walid S, Korczyn AD, Slusarski DC, Berkovic SF, El-Shanti HI. A homozygous mutation in human PRICKLE1 causes an autosomal-recessive progressive myoclonus epilepsy-ataxia syndrome. Am J Hum Genet. 2008 Nov; 83(5):572-81. PMID: 18976727; PMCID: PMC2668041.
    19. Vladar EK, Axelrod JD. Dishevelled links basal body docking and orientation in ciliated epithelial cells. Trends Cell Biol. 2008 Nov; 18(11):517-20. PMID: 18819800; PMCID: PMC3989925.
    20. Vladar EK, Stearns T. Molecular characterization of centriole assembly in ciliated epithelial cells. J Cell Biol. 2007 Jul 02; 178(1):31-42. PMID: 17606865; PMCID: PMC2064416.
    21. Laurencon A, Orme CM, Peters HK, Boulton CL, Vladar EK, Langley SA, Bakis EP, Harris DT, Harris NJ, Wayson SM, Hawley RS, Burtis KC. A large-scale screen for mutagen-sensitive loci in Drosophila. Genetics. 2004 May; 167(1):217-31. PMID: 15166149; PMCID: PMC1470880.
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