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Eszter Katalin Vladar

TitleAsst Professor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-MED
Email

    Collapse Biography 
    Collapse education and training
    Stanford University, Stanford, CApostdoc10/2014Cell biology
    Stanford University, Stanford, CAPhD09/2007Genetics
    UC Davis, Davis, CABS06/2000Genetics
    Collapse awards and honors
    2018 - 2021Boettcher Webb-Waring Biomedical Research Award

    Collapse Overview 
    Collapse overview
    Website: http://cilialab.com/

    Our lungs are constantly bombarded by inhaled pathogens, allergens, toxins and debris. The airway epithelium is the first line of defense against these contaminants. It accomplishes this by acting as a selective physical barrier, by participating in immune surveillance and response, and by the directional movement of cilia that sweep contaminants adhered to the mucus layer out of the lungs. Epithelial dysfunction underlies disease phenotypes and promotes disease progression in chronic inflammatory airway conditions like cystic fibrosis, asthma and COPD – however, current treatments do not directly target or reverse dysfunction. Our work focuses on the multiciliated cells, which each contain hundreds of motile cilia. We use mice and primary mouse and human cell culture to study how multiciliated cells adopt their cell fate, build cilia and orient the cilia for directional clearance. We investigate the pathways that drive these processes during normal development and regeneration and study how they are misregulated in human disease. Our research has the potential to develop novel biomarkers and therapeutics for individuals suffering from chronic airway diseases.

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Kim E, Mathai SK, Stancil IT, Ma X, Hernandez-Gutierrez A, Becerra JN, Marrero-Torres E, Hennessy CE, Hatakka K, Wartchow EP, Estrella A, Huber JP, Cardwell JH, Burnham EL, Zhang Y, Evans CM, Vladar EK, Schwartz DA, Dobrinskikh E, Yang IV. Aberrant Multiciliogenesis in Idiopathic Pulmonary Fibrosis. Am J Respir Cell Mol Biol. 2022 08; 67(2):188-200. PMID: 35608953.
      View in: PubMed
    2. Guo K, Barrett BS, Morrison JH, Mickens KL, Vladar EK, Hasenkrug KJ, Poeschla EM, Santiago ML. Interferon resistance of emerging SARS-CoV-2 variants. Proc Natl Acad Sci U S A. 2022 08 09; 119(32):e2203760119. PMID: 35867811.
      View in: PubMed
    3. Heinzelmann K, Hu Q, Hu Y, Dobrinskikh E, Ansari M, Melo-Narváez MC, Ulke HM, Leavitt C, Mirita C, Trudeau T, Saal ML, Rice P, Gao B, Janssen WJ, Yang IV, Schiller HB, Vladar EK, Lehmann M, Königshoff M. Single-cell RNA sequencing identifies G-protein coupled receptor 87 as a basal cell marker expressed in distal honeycomb cysts in idiopathic pulmonary fibrosis. Eur Respir J. 2022 06; 59(6). PMID: 35604813.
      View in: PubMed
    4. Beswick DM, Humphries SM, Miller JE, Balkissoon CD, Khatiwada A, Vladar EK, Ramakrishnan VR, Lynch DA, Taylor-Cousar JL. Objective and patient-based measures of chronic rhinosinusitis in people with cystic fibrosis treated with highly effective modulator therapy. Int Forum Allergy Rhinol. 2022 11; 12(11):1435-1438. PMID: 35595546.
      View in: PubMed
    5. Nick JA, Dedrick RM, Gray AL, Vladar EK, Smith BE, Freeman KG, Malcolm KC, Epperson LE, Hasan NA, Hendrix J, Callahan K, Walton K, Vestal B, Wheeler E, Rysavy NM, Poch K, Caceres S, Lovell VK, Hisert KB, de Moura VC, Chatterjee D, De P, Weakly N, Martiniano SL, Lynch DA, Daley CL, Strong M, Jia F, Hatfull GF, Davidson RM. Host and pathogen response to bacteriophage engineered against Mycobacterium abscessus lung infection. Cell. 2022 05 26; 185(11):1860-1874.e12. PMID: 35568033.
      View in: PubMed
    6. Bai X, Buckle AM, Vladar EK, Janoff EN, Khare R, Ordway D, Beckham D, Fornis LB, Majluf-Cruz A, Fugit RV, Freed BM, Kim S, Sandhaus RA, Chan ED. Author Correction: Enoxaparin augments alpha-1-antitrypsin inhibition of TMPRSS2, a promising drug combination against COVID-19. Sci Rep. 2022 Apr 19; 12(1):6466. PMID: 35440617.
      View in: PubMed
    7. Bai X, Buckle AM, Vladar EK, Janoff EN, Khare R, Ordway D, Beckham D, Fornis LB, Majluf-Cruz A, Fugit RV, Freed BM, Kim S, Sandhaus RA, Chan ED. Enoxaparin augments alpha-1-antitrypsin inhibition of TMPRSS2, a promising drug combination against COVID-19. Sci Rep. 2022 03 25; 12(1):5207. PMID: 35338216.
      View in: PubMed
    8. Winnica DE, Monzon A, Ye S, Vladar EK, Saal M, Cooney R, Liu C, Sharma S, Holguin F. Airway epithelial Paraoxonase-2 in obese asthma. PLoS One. 2022; 17(3):e0261504. PMID: 35286330.
      View in: PubMed
    9. Beswick DM, Humphries SM, Balkissoon CD, Strand M, E Miller J, Khatiwada A, Vladar EK, Lynch DA, Taylor-Cousar JL. Olfactory dysfunction in people with cystic fibrosis with at least one copy of F508del. Int Forum Allergy Rhinol. 2022 07; 12(7):963-966. PMID: 34908251.
      View in: PubMed
    10. Guntur VP, Manka LA, Moore CM, Wynn E, Vladar EK, Alam R, Pham TH, Fingerlin TE, Martin RJ. Refractory neutrophilic asthma and ciliary genes. J Allergy Clin Immunol. 2022 06; 149(6):1970-1980. PMID: 35034774.
      View in: PubMed
    11. Beswick DM, Humphries SM, Balkissoon CD, Strand M, Vladar EK, Lynch DA, Taylor-Cousar JL. Impact of Cystic Fibrosis Transmembrane Conductance Regulator Therapy on Chronic Rhinosinusitis and Health Status: Deep Learning CT Analysis and Patient-reported Outcomes. Ann Am Thorac Soc. 2022 01; 19(1):12-19. PMID: 34436985.
      View in: PubMed
    12. Beswick DM, Humphries SM, Balkissoon CD, Strand M, Vladar EK, Ramakrishnan VR, Taylor-Cousar JL. Olfactory dysfunction in cystic fibrosis: Impact of CFTR modulator therapy. J Cyst Fibros. 2022 03; 21(2):e141-e147. PMID: 34598881.
      View in: PubMed
    13. Bridges JP, Vladar EK, Huang H, Mason RJ. Respiratory epithelial cell responses to SARS-CoV-2 in COVID-19. Thorax. 2022 02; 77(2):203-209. PMID: 34404754.
      View in: PubMed
    14. Carraro G, Langerman J, Sabri S, Lorenzana Z, Purkayastha A, Zhang G, Konda B, Aros CJ, Calvert BA, Szymaniak A, Wilson E, Mulligan M, Bhatt P, Lu J, Vijayaraj P, Yao C, Shia DW, Lund AJ, Israely E, Rickabaugh TM, Ernst J, Mense M, Randell SH, Vladar EK, Ryan AL, Plath K, Mahoney JE, Stripp BR, Gomperts BN. Transcriptional analysis of cystic fibrosis airways at single-cell resolution reveals altered epithelial cell states and composition. Nat Med. 2021 05; 27(5):806-814. PMID: 33958799.
      View in: PubMed
    15. Beswick DM, Humphries SM, Balkissoon CD, Vladar EK, Ramakrishnan VR, Lynch DA, Taylor-Cousar JL. Machine learning evaluates improvement in sinus computed tomography opacification with CFTR modulator therapy. Int Forum Allergy Rhinol. 2021 05; 11(5):953-954. PMID: 33140564.
      View in: PubMed
    16. Montgomery MT, Sajuthi SP, Cho SH, Everman JL, Rios CL, Goldfarbmuren KC, Jackson ND, Saef B, Cromie M, Eng C, Medina V, Elhawary JR, Oh SS, Rodriguez-Santana J, Vladar EK, Burchard EG, Seibold MA. Genome-Wide Analysis Reveals Mucociliary Remodeling of the Nasal Airway Epithelium Induced by Urban PM2.5. Am J Respir Cell Mol Biol. 2020 08; 63(2):172-184. PMID: 32275839.
      View in: PubMed
    17. Aros CJ, Vijayaraj P, Pantoja CJ, Bisht B, Meneses LK, Sandlin JM, Tse JA, Chen MW, Purkayastha A, Shia DW, Sucre JMS, Rickabaugh TM, Vladar EK, Paul MK, Gomperts BN. Distinct Spatiotemporally Dynamic Wnt-Secreting Niches Regulate Proximal Airway Regeneration and Aging. Cell Stem Cell. 2020 09 03; 27(3):413-429.e4. PMID: 32721381.
      View in: PubMed
    18. Goldfarbmuren KC, Jackson ND, Sajuthi SP, Dyjack N, Li KS, Rios CL, Plender EG, Montgomery MT, Everman JL, Bratcher PE, Vladar EK, Seibold MA. Dissecting the cellular specificity of smoking effects and reconstructing lineages in the human airway epithelium. Nat Commun. 2020 05 19; 11(1):2485. PMID: 32427931.
      View in: PubMed
    19. Vladar EK, Königshoff M. Noncanonical Wnt planar cell polarity signaling in lung development and disease. Biochem Soc Trans. 2020 02 28; 48(1):231-243. PMID: 32096543.
      View in: PubMed
    20. Lang UE, Torres R, Cheung C, Vladar EK, McCalmont TH, Kim J, Judson-Torres RL. Ciliation Index Is a Useful Diagnostic Tool in Challenging Spitzoid Melanocytic Neoplasms. J Invest Dermatol. 2020 07; 140(7):1401-1409.e2. PMID: 31978411.
      View in: PubMed
    21. Stevens EM, Vladar EK, Alanin MC, Christensen ST, von Buchwald C, Milla C. Ciliary Localization of the Intraflagellar Transport Protein IFT88 Is Disrupted in Cystic Fibrosis. Am J Respir Cell Mol Biol. 2020 01; 62(1):120-123. PMID: 31891309.
      View in: PubMed
    22. Smith P, Godde N, Rubio S, Tekeste M, Vladar EK, Axelrod JD, Henderson DJ, Milgrom-Hoffman M, Humbert PO, Hinck L. VANGL2 regulates luminal epithelial organization and cell turnover in the mammary gland. Sci Rep. 2019 05 08; 9(1):7079. PMID: 31068622.
      View in: PubMed
    23. Everman JL, Sajuthi S, Saef B, Rios C, Stoner AM, Numata M, Hu D, Eng C, Oh S, Rodriguez-Santana J, Vladar EK, Voelker DR, Burchard EG, Seibold MA. Functional genomics of CDHR3 confirms its role in HRV-C infection and childhood asthma exacerbations. J Allergy Clin Immunol. 2019 10; 144(4):962-971. PMID: 30930175.
      View in: PubMed
    24. Benam KH, Vladar EK, Janssen WJ, Evans CM. Mucociliary Defense: Emerging Cellular, Molecular, and Animal Models. Ann Am Thorac Soc. 2018 11; 15(Suppl 3):S210-S215. PMID: 30431350.
      View in: PubMed
    25. Vladar EK, Stratton MB, Saal ML, Salazar-De Simone G, Wang X, Wolgemuth D, Stearns T, Axelrod JD. Cyclin-dependent kinase control of motile ciliogenesis. Elife. 2018 08 28; 7. PMID: 30152757.
      View in: PubMed
    26. Kunimoto K, Bayly RD, Vladar EK, Vonderfecht T, Gallagher AR, Axelrod JD. Disruption of Core Planar Cell Polarity Signaling Regulates Renal Tubule Morphogenesis but Is Not Cystogenic. Curr Biol. 2017 Oct 23; 27(20):3120-3131.e4. PMID: 29033332.
      View in: PubMed
    27. Böscke R, Vladar EK, Könnecke M, Hüsing B, Linke R, Pries R, Reiling N, Axelrod JD, Nayak JV, Wollenberg B. Wnt Signaling in Chronic Rhinosinusitis with Nasal Polyps. Am J Respir Cell Mol Biol. 2017 05; 56(5):575-584. PMID: 28059551.
      View in: PubMed
    28. Vladar EK, Nayak JV, Milla CE, Axelrod JD. Airway epithelial homeostasis and planar cell polarity signaling depend on multiciliated cell differentiation. JCI Insight. 2016 Aug 18; 1(13). PMID: 27570836.
      View in: PubMed
    29. Vladar EK, Mitchell BJ. It's a family act: the geminin triplets take center stage in motile ciliogenesis. EMBO J. 2016 05 02; 35(9):904-6. PMID: 27006276.
      View in: PubMed
    30. Gibbs BC, Damerla RR, Vladar EK, Chatterjee B, Wan Y, Liu X, Cui C, Gabriel GC, Zahid M, Yagi H, Szabo-Rogers HL, Suyama KL, Axelrod JD, Lo CW. Prickle1 mutation causes planar cell polarity and directional cell migration defects associated with cardiac outflow tract anomalies and other structural birth defects. Biol Open. 2016 Feb 16; 5(3):323-35. PMID: 26883626.
      View in: PubMed
    31. Lang UE, Cheung C, Vladar EK, Swetter SM, Kim J. Loss of primary cilia correlates with cytologic severity in dysplastic melanocytic nevi. J Cutan Pathol. 2016 Feb; 43(2):113-9. PMID: 26272818.
      View in: PubMed
    32. Vladar EK, Lee YL, Stearns T, Axelrod JD. Observing planar cell polarity in multiciliated mouse airway epithelial cells. Methods Cell Biol. 2015; 127:37-54. PMID: 25837385.
      View in: PubMed
    33. Yuan K, Orcholski ME, Panaroni C, Shuffle EM, Huang NF, Jiang X, Tian W, Vladar EK, Wang L, Nicolls MR, Wu JY, de Jesus Perez VA. Activation of the Wnt/planar cell polarity pathway is required for pericyte recruitment during pulmonary angiogenesis. Am J Pathol. 2015 Jan; 185(1):69-84. PMID: 25447046.
      View in: PubMed
    34. Klos Dehring DA, Vladar EK, Werner ME, Mitchell JW, Hwang P, Mitchell BJ. Deuterosome-mediated centriole biogenesis. Dev Cell. 2013 Oct 14; 27(1):103-12. PMID: 24075808.
      View in: PubMed
    35. Tan FE, Vladar EK, Ma L, Fuentealba LC, Hoh R, Espinoza FH, Axelrod JD, Alvarez-Buylla A, Stearns T, Kintner C, Krasnow MA. Myb promotes centriole amplification and later steps of the multiciliogenesis program. Development. 2013 Oct; 140(20):4277-86. PMID: 24048590.
      View in: PubMed
    36. Vladar EK, Brody SL. Analysis of ciliogenesis in primary culture mouse tracheal epithelial cells. Methods Enzymol. 2013; 525:285-309. PMID: 23522475.
      View in: PubMed
    37. Vladar EK, Bayly RD, Sangoram AM, Scott MP, Axelrod JD. Microtubules enable the planar cell polarity of airway cilia. Curr Biol. 2012 Dec 04; 22(23):2203-12. PMID: 23122850.
      View in: PubMed
    38. Stubbs JL, Vladar EK, Axelrod JD, Kintner C. Multicilin promotes centriole assembly and ciliogenesis during multiciliate cell differentiation. Nat Cell Biol. 2012 Jan 08; 14(2):140-7. PMID: 22231168.
      View in: PubMed
    39. Vladar EK, Antic D, Axelrod JD. Planar cell polarity signaling: the developing cell's compass. Cold Spring Harb Perspect Biol. 2009 Sep; 1(3):a002964. PMID: 20066108.
      View in: PubMed
    40. Bassuk AG, Wallace RH, Buhr A, Buller AR, Afawi Z, Shimojo M, Miyata S, Chen S, Gonzalez-Alegre P, Griesbach HL, Wu S, Nashelsky M, Vladar EK, Antic D, Ferguson PJ, Cirak S, Voit T, Scott MP, Axelrod JD, Gurnett C, Daoud AS, Kivity S, Neufeld MY, Mazarib A, Straussberg R, Walid S, Korczyn AD, Slusarski DC, Berkovic SF, El-Shanti HI. A homozygous mutation in human PRICKLE1 causes an autosomal-recessive progressive myoclonus epilepsy-ataxia syndrome. Am J Hum Genet. 2008 Nov; 83(5):572-81. PMID: 18976727.
      View in: PubMed
    41. Vladar EK, Axelrod JD. Dishevelled links basal body docking and orientation in ciliated epithelial cells. Trends Cell Biol. 2008 Nov; 18(11):517-20. PMID: 18819800.
      View in: PubMed
    42. Vladar EK, Stearns T. Molecular characterization of centriole assembly in ciliated epithelial cells. J Cell Biol. 2007 Jul 02; 178(1):31-42. PMID: 17606865.
      View in: PubMed
    43. Laurencon A, Orme CM, Peters HK, Boulton CL, Vladar EK, Langley SA, Bakis EP, Harris DT, Harris NJ, Wayson SM, Hawley RS, Burtis KC. A large-scale screen for mutagen-sensitive loci in Drosophila. Genetics. 2004 May; 167(1):217-31. PMID: 15166149.
      View in: PubMed
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