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Suet Nee Chen

TitleAssistant Professor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-MED

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Gigli M, Stolfo D, Barbati G, Graw S, Chen SN, Merlo M, Medo K, Gregorio C, Dal Ferro M, Paldino A, Perotto M, Peter van Tintelen J, Te Riele ASJM, Baas AF, Wilde AM, Amin AS, Houweling AC, Elliott P, Cannie D, Michels M, Schoonvelde SAC, Prasad S, Tayal PU, Yazdani M, Morris-Rosendahl D, Garcia-Pavia P, Cabrera-Romero E, Bauce B, Pilichou K, Fatkin D, Johnson R, Judge DP, Foil KL, Heymans S, Verdonschot JAJ, Stroeks SLVM, Lakdawala NK, Anisha P, O'Neill M, Shoemaker MB, Roden DM, Calkins H, James CA, Murray B, Parikh VN, Ashley EA, Reuter C, Imazio M, Canepa M, Ameri P, Song J, Sinagra G, Taylor MRG, Mestroni L. Arrhythmic Risk Stratification of Carriers of Filamin C Truncating Variants. JAMA Cardiol. 2025 Apr 01; 10(4):359-369. PMID: 39937464.
      View in: PubMed
    2. Gao S, Chen SN, Mestroni L. Unraveling "Hot Phases" of Arrhythmogenic Cardiomyopathy. JACC Basic Transl Sci. 2025 Mar; 10(3):381-382. PMID: 40139878.
      View in: PubMed
    3. Canciello G, Lombardi R, Borrelli F, Ordine L, Chen SN, Santoro C, Frisso G, di Napoli S, Polizzi R, Cristiano S, Esposito G, Losi MA. Echocardiographic Strain Abnormalities Precede Left Ventricular Hypertrophy Development in Hypertrophic Cardiomyopathy Mutation Carriers. Int J Mol Sci. 2024 Jul 25; 25(15). PMID: 39125703.
      View in: PubMed
    4. Lazzarino M, Zanetti M, Chen SN, Gao S, Pe?a B, Lam CK, Wu JC, Taylor MRG, Mestroni L, Sbaizero O. Defective Biomechanics and Pharmacological Rescue of Human Cardiomyocytes with Filamin C Truncations. Int J Mol Sci. 2024 Mar 03; 25(5). PMID: 38474188.
      View in: PubMed
    5. Gao S, He L, Lam CK, Taylor MRG, Mestroni L, Lombardi R, Chen SN. Filamin C Deficiency Impairs Sarcomere Stability and Activates Focal Adhesion Kinase through PDGFRA Signaling in Induced Pluripotent Stem Cell-Derived Cardiomyocytes. Cells. 2024 02 02; 13(3). PMID: 38334670.
      View in: PubMed
    6. O'Neill MJ, Chen SN, Rumping L, Johnson R, van Slegtenhorst M, Glazer AM, Yang T, Solus JF, Laudeman J, Mitchell DW, Vanags LR, Kroncke BM, Anderson K, Gao S, Verdonschot JAJ, Brunner H, Hellebrekers D, Taylor MRG, Roden DM, Wessels MW, Lekanne Dit Deprez RH, Fatkin D, Mestroni L, Shoemaker MB. Multicenter clinical and functional evidence reclassifies a recurrent noncanonical filamin C splice-altering variant. Heart Rhythm. 2023 08; 20(8):1158-1166. PMID: 37164047.
      View in: PubMed
    7. Lombardi R, Chen SN. A polygenic risk score after corrective surgery for transposition of the great arteries: Can genetics add value to clinical predictors of outcome? Int J Cardiol. 2023 02 15; 373:55-56. PMID: 36442671.
      View in: PubMed
    8. Braidotti N, Chen SN, Long CS, Cojoc D, Sbaizero O. Piezo1 Channel as a Potential Target for Hindering Cardiac Fibrotic Remodeling. Int J Mol Sci. 2022 Jul 22; 23(15). PMID: 35897650.
      View in: PubMed
    9. Chen SN, Lam CK, Wan YW, Gao S, Malak OA, Zhao SR, Lombardi R, Ambardekar AV, Bristow MR, Cleveland J, Gigli M, Sinagra G, Graw S, Taylor MRG, Wu JC, Mestroni L. Activation of PDGFRA signaling contributes to filamin C-related arrhythmogenic cardiomyopathy. Sci Adv. 2022 Feb 25; 8(8):eabk0052. PMID: 35196083.
      View in: PubMed
    10. Gao S, Mumme-Monheit A, Chen SN, Spector EB, Slavov D, Baralle FE, Bristow MR, Mestroni L, Taylor MRG. An LMNA synonymous variant associated with severe dilated cardiomyopathy: Case report. Am J Med Genet A. 2022 02; 188(2):600-605. PMID: 34652067.
      View in: PubMed
    11. Rouhi L, Cheedipudi SM, Chen SN, Fan S, Lombardi R, Chen X, Coarfa C, Robertson MJ, Gurha P, Marian AJ. Haploinsufficiency of Tmem43 in cardiac myocytes activates the DNA damage response pathway leading to a late-onset senescence-associated pro-fibrotic cardiomyopathy. Cardiovasc Res. 2021 09 28; 117(11):2377-2394. PMID: 33070193.
      View in: PubMed
    12. Lachaize V, Pe?a B, Ciubotaru C, Cojoc D, Chen SN, Taylor MRG, Mestroni L, Sbaizero O. Compromised Biomechanical Properties, Cell-Cell Adhesion and Nanotubes Communication in Cardiac Fibroblasts Carrying the Lamin A/C D192G Mutation. Int J Mol Sci. 2021 Aug 25; 22(17). PMID: 34502098.
      View in: PubMed
    13. Zanetti M, Chen SN, Conti M, Taylor MRG, Sbaizero O, Mestroni L, Lazzarino M. Microfabricated cantilevers for parallelized cell-cell adhesion measurements. Eur Biophys J. 2022 Mar; 51(2):147-156. PMID: 34304293.
      View in: PubMed
    14. Chen SN, Mestroni L, Taylor MRG. Genetics of dilated cardiomyopathy. Curr Opin Cardiol. 2021 05 01; 36(3):288-294. PMID: 33769382.
      View in: PubMed
    15. Lombardi R, Chen SN. Editorial of Special Issue "Genetics and Molecular Pathogenesis of Non-Ischemic Cardiomyopathies". Int J Mol Sci. 2020 Dec 10; 21(24). PMID: 33321793.
      View in: PubMed
    16. Gao S, Puthenvedu D, Lombardi R, Chen SN. Established and Emerging Mechanisms in the Pathogenesis of Arrhythmogenic Cardiomyopathy: A Multifaceted Disease. Int J Mol Sci. 2020 Aug 31; 21(17). PMID: 32878278.
      View in: PubMed
    17. Coste Pradas J, Auguste G, Matkovich SJ, Lombardi R, Chen SN, Garnett T, Chamberlain K, Riyad JM, Weber T, Singh SK, Robertson MJ, Coarfa C, Marian AJ, Gurha P. Identification of Genes and Pathways Regulated by Lamin A in Heart. J Am Heart Assoc. 2020 08 18; 9(16):e015690. PMID: 32805188.
      View in: PubMed
    18. Gao S, Chen SN, Di Nardo C, Lombardi R. Arrhythmogenic Cardiomyopathy and Skeletal Muscle Dystrophies: Shared Histopathological Features and Pathogenic Mechanisms. Front Physiol. 2020; 11:834. PMID: 32848821.
      View in: PubMed
    19. Borin D, Pe?a B, Chen SN, Long CS, Taylor MRG, Mestroni L, Sbaizero O. Altered microtubule structure, hemichannel localization and beating activity in cardiomyocytes expressing pathologic nuclear lamin A/C. Heliyon. 2020 Jan; 6(1):e03175. PMID: 32021920.
      View in: PubMed
    20. Chen SN, Sbaizero O, Taylor MRG, Mestroni L. Lamin A/C Cardiomyopathy: Implications for Treatment. Curr Cardiol Rep. 2019 11 26; 21(12):160. PMID: 31773301.
      View in: PubMed
    21. Chen SN, Lombardi R, Karmouch J, Tsai JY, Czernuszewicz G, Taylor MRG, Mestroni L, Coarfa C, Gurha P, Marian AJ. DNA Damage Response/TP53 Pathway Is Activated and Contributes to the Pathogenesis of Dilated Cardiomyopathy Associated With LMNA (Lamin A/C) Mutations. Circ Res. 2019 03 15; 124(6):856-873. PMID: 30696354.
      View in: PubMed
    22. Laurini E, Martinelli V, Lanzicher T, Puzzi L, Borin D, Chen SN, Long CS, Lee P, Mestroni L, Taylor MRG, Sbaizero O, Pricl S. Biomechanical defects and rescue of cardiomyocytes expressing pathologic nuclear lamins. Cardiovasc Res. 2018 05 01; 114(6):846-857. PMID: 29432544.
      View in: PubMed
    23. Chen SN. Passion and Determination Are the Genesis of Research. Circ Res. 2018 03 02; 122(5):655-656. PMID: 29496795.
      View in: PubMed
    24. Chen SN, Taylor MRG, Mestroni L. Modeling Cardiomyopathy and Arrhythmias in Induced Pluripotent Stem Cell-Derived Cardiomyocytes. Circ Genom Precis Med. 2018 03; 11(3):e002088. PMID: 29545481.
      View in: PubMed
    25. Chen SN, Taylor MRG, Mestroni L. Unraveling Missing Genes and Missing Inheritance in Arrhythmogenic Cardiomyopathy. Circ Arrhythm Electrophysiol. 2017 10; 10(10). PMID: 29038109.
      View in: PubMed
    26. Lombardi R, Chen SN, Ruggiero A, Gurha P, Czernuszewicz GZ, Willerson JT, Marian AJ. Cardiac Fibro-Adipocyte Progenitors Express Desmosome Proteins and Preferentially Differentiate to Adipocytes Upon Deletion of the Desmoplakin Gene. Circ Res. 2016 06 24; 119(1):41-54. PMID: 27121621.
      View in: PubMed
    27. Chen SN, Gurha P, Lombardi R, Ruggiero A, Willerson JT, Marian AJ. The hippo pathway is activated and is a causal mechanism for adipogenesis in arrhythmogenic cardiomyopathy. Circ Res. 2014 Jan 31; 114(3):454-68. PMID: 24276085.
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    28. Ruggiero A, Chen SN, Lombardi R, Rodriguez G, Marian AJ. Pathogenesis of hypertrophic cardiomyopathy caused by myozenin 2 mutations is independent of calcineurin activity. Cardiovasc Res. 2013 Jan 01; 97(1):44-54. PMID: 22987565.
      View in: PubMed
    29. Chen SN, Czernuszewicz G, Tan Y, Lombardi R, Jin J, Willerson JT, Marian AJ. Human molecular genetic and functional studies identify TRIM63, encoding Muscle RING Finger Protein 1, as a novel gene for human hypertrophic cardiomyopathy. Circ Res. 2012 Sep 14; 111(7):907-19. PMID: 22821932.
      View in: PubMed
    30. Chen SN, Cilingiroglu M, Todd J, Lombardi R, Willerson JT, Gotto AM, Ballantyne CM, Marian AJ. Candidate genetic analysis of plasma high-density lipoprotein-cholesterol and severity of coronary atherosclerosis. BMC Med Genet. 2009 Oct 30; 10:111. PMID: 19878569.
      View in: PubMed
    31. Lombardi R, Rodriguez G, Chen SN, Ripplinger CM, Li W, Chen J, Willerson JT, Betocchi S, Wickline SA, Efimov IR, Marian AJ. Resolution of established cardiac hypertrophy and fibrosis and prevention of systolic dysfunction in a transgenic rabbit model of human cardiomyopathy through thiol-sensitive mechanisms. Circulation. 2009 Mar 17; 119(10):1398-407. PMID: 19255346.
      View in: PubMed
    32. Chen SN, Ballantyne CM, Gotto AM, Marian AJ. The 9p21 susceptibility locus for coronary artery disease and the severity of coronary atherosclerosis. BMC Cardiovasc Disord. 2009 Jan 27; 9:3. PMID: 19173706.
      View in: PubMed
    33. Daw EW, Chen SN, Czernuszewicz G, Lombardi R, Lu Y, Ma J, Roberts R, Shete S, Marian AJ. Genome-wide mapping of modifier chromosomal loci for human hypertrophic cardiomyopathy. Hum Mol Genet. 2007 Oct 15; 16(20):2463-71. PMID: 17652099.
      View in: PubMed
    34. Osio A, Tan L, Chen SN, Lombardi R, Nagueh SF, Shete S, Roberts R, Willerson JT, Marian AJ. Myozenin 2 is a novel gene for human hypertrophic cardiomyopathy. Circ Res. 2007 Mar 30; 100(6):766-8. PMID: 17347475.
      View in: PubMed
    35. Marian AJ, Senthil V, Chen SN, Lombardi R. Antifibrotic effects of antioxidant N-acetylcysteine in a mouse model of human hypertrophic cardiomyopathy mutation. J Am Coll Cardiol. 2006 Feb 21; 47(4):827-34. PMID: 16487852.
      View in: PubMed
    36. Senthil V, Chen SN, Tsybouleva N, Halder T, Nagueh SF, Willerson JT, Roberts R, Marian AJ. Prevention of cardiac hypertrophy by atorvastatin in a transgenic rabbit model of human hypertrophic cardiomyopathy. Circ Res. 2005 Aug 05; 97(3):285-92. PMID: 16020756.
      View in: PubMed
    37. Chen SN, Ballantyne CM, Gotto AM, Tan Y, Willerson JT, Marian AJ. A common PCSK9 haplotype, encompassing the E670G coding single nucleotide polymorphism, is a novel genetic marker for plasma low-density lipoprotein cholesterol levels and severity of coronary atherosclerosis. J Am Coll Cardiol. 2005 May 17; 45(10):1611-9. PMID: 15893176.
      View in: PubMed
    38. Nagueh SF, Chen S, Patel R, Tsybouleva N, Lutucuta S, Kopelen HA, Zoghbi WA, Qui?ones MA, Roberts R, Marian AJ. Evolution of expression of cardiac phenotypes over a 4-year period in the beta-myosin heavy chain-Q403 transgenic rabbit model of human hypertrophic cardiomyopathy. J Mol Cell Cardiol. 2004 May; 36(5):663-73. PMID: 15135661.
      View in: PubMed
    39. Tsybouleva N, Zhang L, Chen S, Patel R, Lutucuta S, Nemoto S, DeFreitas G, Entman M, Carabello BA, Roberts R, Marian AJ. Aldosterone, through novel signaling proteins, is a fundamental molecular bridge between the genetic defect and the cardiac phenotype of hypertrophic cardiomyopathy. Circulation. 2004 Mar 16; 109(10):1284-91. PMID: 14993121.
      View in: PubMed
    40. Chen S, Tsybouleva N, Ballantyne CM, Gotto AM, Marian AJ. Effects of PPARalpha, gamma and delta haplotypes on plasma levels of lipids, severity and progression of coronary atherosclerosis and response to statin therapy in the lipoprotein coronary atherosclerosis study. Pharmacogenetics. 2004 Jan; 14(1):61-71. PMID: 15128052.
      View in: PubMed
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