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Holly M Frost

TitleAffiliate - DHHA
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-PEDS
ORCID ORCID Icon0000-0002-3016-3287 Additional info

    Collapse Research 
    Collapse research activities and funding
    N/A     (FROST, HOLLY)Jul 1, 2023 - Jun 30, 2028
    Patient Centered Outcomes Institute (PCORI)
    DISAPEAR: Interventions to De-Implement Unnecessary Antibiotic Prescribing for Ear Infections
    Role: PI
    1R01HS029153-01     (FROST, HOLLY)Sep 30, 2022 - Sep 30, 2027
    AHRQ
    RELAX: Reducing Length of Antibiotics for Ear Infections
    Role: PI
    N/A     (REWERS, MARIAN)Sep 1, 2022 - Aug 31, 2024
    Juvenile Diabetes Research Foundation
    Autoimmune Antibody Screening for Kids
    Role: CO-I
    N/A     (FROST, HOLLY)Sep 1, 2022 - Mar 31, 2024
    The PEW Charitable Trusts
    Automation of provider audit and feedback reports to reduce unnecessary antibiotic prescribing in outpatient settings.
    Role: PI
    N/A     (PRICE, CONNIE)Jan 1, 2020 - Nov 1, 2022
    Department of Health and Human Services
    Colorado Regional Disaster Health Response System (CORDHRS)
    Role: Subject Matter Expert
    K23HD099925     (FROST, HOLLY)Jul 10, 2019 - Jun 30, 2024
    NIH
    Rapid diagnostic tests for adenovirus conjunctivitis in children: An epidemiologic, clinical, and cost-effectiveness evaluation
    Role: PI
    N/A     (FROST, HOLLY)Jan 1, 2019 - Jul 31, 2023
    The Gerber Foundation
    The NO TEARS study: Using nasopharyngeal organism testing to determine outcomes in children with ear infections.
    Role: PI

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Jenkins TC, Keith A, Stein AB, Hersh AL, Narayan R, Eggleston A, Rinehart DJ, Patel PK, Walter E, Hargraves IG, Frost HM. Interventions to de-implement unnecessary antibiotic prescribing for ear infections (DISAPEAR Trial): protocol for a cluster-randomized trial. BMC Infect Dis. 2024 Jan 24; 24(1):126. PMID: 38267837.
      View in: PubMed
    2. Simione M, Frost HM, Farrar-Muir H, Luo M, Granade?o J, Torres C, Boudreau AA, Moreland J, Wallace J, Young J, Orav J, Sease K, Hambidge SJ, Taveras EM. Evaluating the Implementation of the Connect for Health Pediatric Weight Management Program. JAMA Netw Open. 2024 Jan 02; 7(1):e2352648. PMID: 38270953.
      View in: PubMed
    3. Keith A, Jenkins TC, O'Leary S, Stein AB, Katz SE, Newland J, Rinehart DJ, Gilbert A, Dodd S, Terrill CM, Frost HM. Reducing length of antibiotics for children with ear infections: protocol for a cluster-randomized trial in the USA. J Comp Eff Res. 2023 Nov; 12(11):e230088. PMID: 37855227.
      View in: PubMed
    4. Sebastian T, Durfee J, Wittmer N, Jack J, Keith A, Jenkins TC, Frost HM. Reducing Ophthalmic Antibiotic Use for Non-severe Conjunctivitis in Children. J Pediatric Infect Dis Soc. 2023 Sep 27; 12(9):496-503. PMID: 37696521.
      View in: PubMed
    5. Smith NR, Simione M, Farrar-Muir H, Granadeno J, Moreland JW, Wallace J, Frost HM, Young J, Craddock C, Sease K, Hambidge SJ, Taveras EM, Levy DE. Costs to Implement a Pediatric Weight Management Program Across 3 Distinct Contexts. Med Care. 2023 10 01; 61(10):715-725. PMID: 37943527.
      View in: PubMed
    6. Frost HM, Hersh AL, Hyun DY. Next Steps in Ambulatory Stewardship. Infect Dis Clin North Am. 2023 Dec; 37(4):749-767. PMID: 37640612.
      View in: PubMed
    7. Frost HM, Jenkins TC, Sebastian T, Parker SK, Keith A, Kurtz M, Fletcher DR, Wilson ML, Dominguez SR. Reliability of nasopharyngeal PCR for the detection of otopathogens in children with uncomplicated acute otitis media compared to culture. Diagn Microbiol Infect Dis. 2023 Oct; 107(2):116040. PMID: 37549633.
      View in: PubMed
    8. El Feghaly RE, Nedved A, Katz SE, Frost HM. New insights into the treatment of acute otitis media. Expert Rev Anti Infect Ther. 2023 05; 21(5):523-534. PMID: 37097281.
      View in: PubMed
    9. Sebastian T, Toseef MU, Kurtz M, Frost HM. Nasopharyngeal rapid diagnostic testing to reduce unnecessary antibiotic use and individualize management of acute otitis media. Antimicrob Steward Healthc Epidemiol. 2023; 3(1):e49. PMID: 36970427.
      View in: PubMed
    10. O'Leary SC, Frost HM. Does HPV vaccination initiation at age 9, improve HPV initiation and vaccine series completion rates by age 13? Hum Vaccin Immunother. 2023 12 31; 19(1):2180971. PMID: 36892245.
      View in: PubMed
    11. Frost HM, Wilson ML, Roosevelt GE. Improving Management of Suspected Chlamydia and Gonorrhea in Adolescents with a Rapid Diagnostic Test. Pediatr Qual Saf. 2023 Jan-Feb; 8(1):e634. PMID: 36798111.
      View in: PubMed
    12. Reingold S, Tomcho M, Thomas-Gale T, Haynes C, O'Leary S, Warsh S, Rinehart D, Frost H. Survey of Adolescents' and Emerging Adults' Preferences for Gonorrhea and Chlamydia Testing in Primary Care. Sex Transm Dis. 2023 05 01; 50(5):320-322. PMID: 36649601.
      View in: PubMed
    13. Frost HM, Geno Rasmussen C, Shorrosh H, Pyle L, Bautista K, Frohnert BI, Stahl M, Simmons K, Steck AK, Jia X, Yu L, Rewers M. Prevalence of SARS-CoV-2 Antibodies Among Healthy Children From Colorado From 2020 to 2021: A Brief Report. J Prim Care Community Health. 2023 Jan-Dec; 14:21501319231189147. PMID: 37501515.
      View in: PubMed
    14. Rinehart DJ, Frost HM, Thomas-Gale T, Depue C, Shlay JC. Progress in the Use of Text-Messaging to Support Adolescent Sexual and Reproductive Health. Acad Pediatr. 2023 Jul; 23(5):866-868. PMID: 36572099.
      View in: PubMed
    15. McGrath LJ, Frost HM, Newland JG, O'Neil CA, Sahrmann JM, Ma Y, Butler AM. Utilization of nonguideline concordant antibiotic treatment following acute otitis media in children in the United States. Pharmacoepidemiol Drug Saf. 2023 Feb; 32(2):256-265. PMID: 36269007.
      View in: PubMed
    16. Frost HM, Wittmer N, Keith A, Durfee MJ, Jenkins TC. Sustainability of Interventions to Increase Guideline-Concordant Durations of Antibiotic Therapy for Children with Acute Otitis Media. J Pediatr. 2023 02; 253:292-296.e2. PMID: 36088995.
      View in: PubMed
    17. Frost HM, Bizune D, Gerber JS, Hersh AL, Hicks LA, Tsay SV. Amoxicillin Versus Other Antibiotic Agents for the Treatment of Acute Otitis Media in Children. J Pediatr. 2022 12; 251:98-104.e5. PMID: 35944719.
      View in: PubMed
    18. Frost HM, Hersh AL. More Recent Literature Does Not Support Premise or Conclusions-Reply. JAMA Pediatr. 2022 08 01; 176(8):827-828. PMID: 35696153.
      View in: PubMed
    19. Frost HM, Hersh AL. Rethinking Our Approach to Management of Acute Otitis Media. JAMA Pediatr. 2022 05 01; 176(5):439-440. PMID: 35188531.
      View in: PubMed
    20. Sebastian T, Frost HM. A qualitative evaluation of pediatric conjunctivitis medical decision making and opportunities to improve care. J AAPOS. 2022 06; 26(3):113.e1-113.e6. PMID: 35421542.
      View in: PubMed
    21. Poole NM, Frost H. Targets and Methods to Improve Outpatient Antibiotic Prescribing for Pediatric Patients. Infect Dis Clin North Am. 2022 Mar; 36(1):187-202. PMID: 35168710.
      View in: PubMed
    22. McWhirter L, Lou Y, Reingold S, Warsh S, Thomas-Gale T, Haynes C, Rinehart D, Wendel KA, Frost HM. Rates of Appropriate Treatment and Follow-Up Testing After a Gonorrhea and/or Chlamydia Infection in an Urban Network of Federally Qualified Health Center Systems. Sex Transm Dis. 2022 05 01; 49(5):319-324. PMID: 35001017.
      View in: PubMed
    23. Frost HM, Sebastian T, Keith A, Kurtz M, Dominguez SR, Parker SK, Jenkins TC. COVID-19 and Acute Otitis Media in Children: A Case Series. J Prim Care Community Health. 2022 Jan-Dec; 13:21501319221082351. PMID: 35289210.
      View in: PubMed
    24. Tomcho MM, Lou Y, O'Leary SC, Rinehart DJ, Thomas-Gale T, Penny L, Frost HM. Closing the Equity Gap: An Intervention to Improve Chlamydia and Gonorrhea Testing for Adolescents and Young Adults in Primary Care. J Prim Care Community Health. 2022 Jan-Dec; 13:21501319221131382. PMID: 36300428.
      View in: PubMed
    25. Frost HM, Keith A, Sebastian T, Jenkins TC. Caregiver perspectives and preferences for acute otitis media management. Antimicrob Steward Healthc Epidemiol. 2021; 1(1). PMID: 35340401.
      View in: PubMed
    26. Frost HM, Sebastian T, Durfee J, Jenkins TC. Ophthalmic antibiotic use for acute infectious conjunctivitis in children. J AAPOS. 2021 12; 25(6):350.e1-350.e7. PMID: 34737083.
      View in: PubMed
    27. Tomcho MM, Lou Y, O'Leary SC, Rinehart DJ, Thomas-Gale T, Douglas CM, Wu FJ, Penny L, Federico SG, Frost HM. An Intervention to Improve Chlamydia and Gonorrhea Testing Among Adolescents in Primary Care. Pediatrics. 2021 11; 148(5). PMID: 34675130.
      View in: PubMed
    28. Frost HM, Lou Y, Keith A, Byars A, Jenkins TC. Increasing Guideline-Concordant Durations of Antibiotic Therapy for Acute?Otitis Media. J Pediatr. 2022 01; 240:221-227.e9. PMID: 34274307.
      View in: PubMed
    29. Simione M, Farrar-Muir H, Mini FN, Perkins ME, Luo M, Frost H, Orav EJ, Metlay J, Zai AH, Kistin CJ, Sease K, Hambidge SJ, Taveras EM. Implementation of the Connect for Health pediatric weight management program: study protocol and baseline characteristics. J Comp Eff Res. 2021 08; 10(11):881-892. PMID: 34024120.
      View in: PubMed
    30. Frost HM, Monti JD, Andersen LM, Norlin C, Bizune DJ, Fleming-Dutra KE, Czaja CA. Improving Delayed Antibiotic Prescribing for Acute Otitis Media. Pediatrics. 2021 06; 147(6). PMID: 33980695.
      View in: PubMed
    31. Douglas CM, O'Leary SC, Tomcho MM, Wu FJ, Penny L, Federico SG, Wilson ML, Rinehart DJ, Frost HM. Gonorrhea and Chlamydia Rates Among 12- to 24-Year-Old Patients in an Urban Health System. Sex Transm Dis. 2021 03 01; 48(3):161-166. PMID: 33003186.
      View in: PubMed
    32. Frost HM, Munsiff SS, Lou Y, Jenkins TC. Simplifying outpatient antibiotic stewardship. Infect Control Hosp Epidemiol. 2022 02; 43(2):260-261. PMID: 33517928.
      View in: PubMed
    33. Anderson JL, Frost HM, Meece JK. Spontaneous resolution of blastomycosis symptoms caused by B. dermatitidis. Med Mycol Case Rep. 2020 Dec; 30:43-45. PMID: 33150126.
      View in: PubMed
    34. Simione M, Frost HM, Cournoyer R, Mini FN, Cassidy J, Craddock C, Moreland J, Wallace J, Metlay J, Kistin CJ, Sease K, Hambidge SJ, Taveras EM. Engaging stakeholders in the adaptation of the Connect for Health pediatric weight management program for national implementation. Implement Sci Commun. 2020; 1:55. PMID: 32885211.
      View in: PubMed
    35. Frost HM, Knepper BC, Shihadeh KC, Jenkins TC. A Novel Approach to Evaluate Antibiotic Utilization Across the Spectrum of Inpatient and Ambulatory Care and Implications for Prioritization of Antibiotic Stewardship Efforts. Clin Infect Dis. 2020 04 10; 70(8):1675-1682. PMID: 31162539.
      View in: PubMed
    36. Frost HM, Becker LF, Knepper BC, Shihadeh KC, Jenkins TC. Antibiotic Prescribing Patterns for Acute Otitis Media for Children 2?Years and Older. J Pediatr. 2020 05; 220:109-115.e1. PMID: 32111379.
      View in: PubMed
    37. Koester TM, Timothy P, Meece JK, Osborn RA, Frost HM. Suspected Neuro-invasive Powassan Virus Infection in a Pediatric Patient. Clin Med Res. 2020 08; 18(2-3):95-98. PMID: 32060042.
      View in: PubMed
    38. Frost HM, Andersen LM, Fleming-Dutra KE, Norlin C, Czaja CA. Sustaining outpatient antimicrobial stewardship: Do we need to think further outside the box? Infect Control Hosp Epidemiol. 2020 03; 41(3):382-384. PMID: 31918775.
      View in: PubMed
    39. Anderson JL, Frost HM, King JP, Meece JK. Racial Differences in Clinical Phenotype and Hospitalization of Blastomycosis Patients. Open Forum Infect Dis. 2019 Nov; 6(11):ofz438. PMID: 31696142.
      View in: PubMed
    40. Frost HM, Gerber JS, Hersh AL. Antibiotic Recommendations for Acute Otitis Media and Acute Bacterial Sinusitis. Pediatr Infect Dis J. 2019 02; 38(2):217. PMID: 30640191.
      View in: PubMed
    41. Frost HM, Fritsche TR, Hall MC. Beta-Hemolytic Nongroup A Streptococcal Pharyngitis in Children. J Pediatr. 2019 Mar; 206:268-273.e1. PMID: 30528760.
      View in: PubMed
    42. Frost HM, McLean HQ, Chow BDW. Variability in Antibiotic Prescribing for Upper Respiratory Illnesses by Provider Specialty. J Pediatr. 2018 12; 203:76-85.e8. PMID: 30195553.
      View in: PubMed
    43. Koester TM, Meece JK, Fritsche TR, Frost HM. Infectious Mononucleosis and Lyme Disease as Confounding Diagnoses: A Report of 2 Cases. Clin Med Res. 2018 12; 16(3-4):66-68. PMID: 30166498.
      View in: PubMed
    44. Schotthoefer AM, Hall MC, Vittala S, Bajwa R, Frost HM. Clinical Presentation and Outcomes of Children With Human Granulocytic Anaplasmosis. J Pediatric Infect Dis Soc. 2018 May 15; 7(2):e9-e15. PMID: 28520981.
      View in: PubMed
    45. Thomm AM, Schotthoefer AM, Dupuis AP, Kramer LD, Frost HM, Fritsche TR, Harrington YA, Knox KK, Kehl SC. Development and Validation of a Serologic Test Panel for Detection of Powassan Virus Infection in U.S. Patients Residing in Regions Where Lyme Disease Is Endemic. mSphere. 2018 Jan-Feb; 3(1). PMID: 29359181.
      View in: PubMed
    46. Frost HM, Schotthoefer AM, Thomm AM, Dupuis AP, Kehl SC, Kramer LD, Fritsche TR, Harrington YA, Knox KK. Serologic Evidence of Powassan Virus Infection in Patients with Suspected Lyme Disease1. Emerg Infect Dis. 2017 08; 23(8):1384-1388. PMID: 28726610.
      View in: PubMed
    47. Mareedu N, Schotthoefer AM, Tompkins J, Hall MC, Fritsche TR, Frost HM. Risk Factors for Severe Infection, Hospitalization, and Prolonged Antimicrobial Therapy in Patients with Babesiosis. Am J Trop Med Hyg. 2017 Oct; 97(4):1218-1225. PMID: 28722598.
      View in: PubMed
    48. Frost HM, Anderson J, Ivacic L, Meece J. Blastomycosis in Children: An Analysis of Clinical, Epidemiologic, and Genetic Features. J Pediatric Infect Dis Soc. 2017 Mar 01; 6(1):49-56. PMID: 26703241.
      View in: PubMed
    49. Frost HM, Anderson JL, Ivacic L, Sloss BL, Embil J, Meece JK. Development and validation of a novel single nucleotide polymorphism (SNP) panel for genetic analysis of Blastomyces spp. and association analysis. BMC Infect Dis. 2016 Sep 23; 16(1):509. PMID: 27663837.
      View in: PubMed
    50. Anderson JL, Meece JK, Hall MC, Frost HM. Evidence of delayed dissemination or re-infection with Blastomyces in two immunocompetent hosts. Med Mycol Case Rep. 2016 Sep; 13:9-11. PMID: 27699146.
      View in: PubMed
    51. Schotthoefer AM, Frost HM. Ecology and Epidemiology of Lyme Borreliosis. Clin Lab Med. 2015 Dec; 35(4):723-43. PMID: 26593254.
      View in: PubMed
    52. Frost HM, Novicki TJ. Blastomyces Antigen Detection for Diagnosis and Management of Blastomycosis. J Clin Microbiol. 2015 Nov; 53(11):3660-2. PMID: 26338856.
      View in: PubMed
    53. Frost HM, Robinson CC, Dominguez SR. Epidemiology and clinical presentation of parainfluenza type 4 in children: a 3-year comparative study to parainfluenza types 1-3. J Infect Dis. 2014 Mar 01; 209(5):695-702. PMID: 24133181.
      View in: PubMed
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