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Maria Cecilia Caino

TitleAsst Professor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM - Pharmacology

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    F32CA177018     (CAINO, MARIA CECILIA)Sep 23, 2013 - Sep 22, 2016
    Mitochondrial Hsp90s Regulation of Tumor Bioenergetics and Metastasis
    Role: Principal Investigator

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    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Seo JH, Agarwal E, Bryant KG, Caino MC, Kim ET, Kossenkov AV, Tang HY, Languino LR, Gabrilovich DI, Cohen AR, Speicher DW, Altieri DC. Syntaphilin Ubiquitination Regulates Mitochondrial Dynamics and Tumor Cell Movements. Cancer Res. 2018 Aug 01; 78(15):4215-4228. PMID: 29898993.
      View in: PubMed
    2. Williams M, Caino MC. Mitochondrial Dynamics in Type 2 Diabetes and Cancer. Front Endocrinol (Lausanne). 2018; 9:211. PMID: 29755415.
      View in: PubMed
    3. Caino MC, Seo JH, Wang Y, Rivadeneira DB, Gabrilovich DI, Kim ET, Weeraratna AT, Languino LR, Altieri DC. Syntaphilin controls a mitochondrial rheostat for proliferation-motility decisions in cancer. J Clin Invest. 2017 Oct 02; 127(10):3755-3769. PMID: 28891816.
      View in: PubMed
    4. Caino MC, Seo JH, Aguinaldo A, Wait E, Bryant KG, Kossenkov AV, Hayden JE, Vaira V, Morotti A, Ferrero S, Bosari S, Gabrilovich DI, Languino LR, Cohen AR, Altieri DC. A neuronal network of mitochondrial dynamics regulates metastasis. Nat Commun. 2016 12 19; 7:13730. PMID: 27991488.
      View in: PubMed
    5. Chae YC, Vaira V, Caino MC, Tang HY, Seo JH, Kossenkov AV, Ottobrini L, Martelli C, Lucignani G, Bertolini I, Locatelli M, Bryant KG, Ghosh JC, Lisanti S, Ku B, Bosari S, Languino LR, Speicher DW, Altieri DC. Mitochondrial Akt Regulation of Hypoxic Tumor Reprogramming. Cancer Cell. 2016 08 08; 30(2):257-272. PMID: 27505672.
      View in: PubMed
    6. Seo JH, Rivadeneira DB, Caino MC, Chae YC, Speicher DW, Tang HY, Vaira V, Bosari S, Palleschi A, Rampini P, Kossenkov AV, Languino LR, Altieri DC. The Mitochondrial Unfoldase-Peptidase Complex ClpXP Controls Bioenergetics Stress and Metastasis. PLoS Biol. 2016 07; 14(7):e1002507. PMID: 27389535.
      View in: PubMed
    7. Caino MC, Altieri DC. Molecular Pathways: Mitochondrial Reprogramming in Tumor Progression and Therapy. Clin Cancer Res. 2016 Feb 01; 22(3):540-5. PMID: 26660517; PMCID: PMC4738153 [Available on 02/01/17].
    8. Caino MC, Altieri DC. Disabling mitochondrial reprogramming in cancer. Pharmacol Res. 2015 Dec; 102:42-5. PMID: 26365877; PMCID: PMC4684442 [Available on 12/01/16].
    9. Rivadeneira DB, Caino MC, Seo JH, Angelin A, Wallace DC, Languino LR, Altieri DC. Survivin promotes oxidative phosphorylation, subcellular mitochondrial repositioning, and tumor cell invasion. Sci Signal. 2015 Aug 11; 8(389):ra80. PMID: 26268608; PMCID: PMC4539531.
    10. Caino MC, Ghosh JC, Chae YC, Vaira V, Rivadeneira DB, Faversani A, Rampini P, Kossenkov AV, Aird KM, Zhang R, Webster MR, Weeraratna AT, Bosari S, Languino LR, Altieri DC. PI3K therapy reprograms mitochondrial trafficking to fuel tumor cell invasion. Proc Natl Acad Sci U S A. 2015 Jul 14; 112(28):8638-43. PMID: 26124089; PMCID: PMC4507184.
    11. Ghosh JC, Siegelin MD, Vaira V, Faversani A, Tavecchio M, Chae YC, Lisanti S, Rampini P, Giroda M, Caino MC, Seo JH, Kossenkov AV, Michalek RD, Schultz DC, Bosari S, Languino LR, Altieri DC. Adaptive mitochondrial reprogramming and resistance to PI3K therapy. J Natl Cancer Inst. 2015 Mar; 107(3). PMID: 25650317; PMCID: PMC4565533.
    12. Caino MC, Altieri DC. Cancer cells exploit adaptive mitochondrial dynamics to increase tumor cell invasion. Cell Cycle. 2015; 14(20):3242-7. PMID: 26317663; PMCID: PMC4825634.
    13. Garg R, Caino MC, Kazanietz MG. Regulation of Transcriptional Networks by PKC Isozymes: Identification of c-Rel as a Key Transcription Factor for PKC-Regulated Genes. PLoS One. 2013; 8(6):e67319. PMID: 23826267.
      View in: PubMed
    14. Caino MC, Chae YC, Vaira V, Ferrero S, Nosotti M, Martin NM, Weeraratna A, O'Connell M, Jernigan D, Fatatis A, Languino LR, Bosari S, Altieri DC. Metabolic stress regulates cytoskeletal dynamics and metastasis of cancer cells. J Clin Invest. 2013 Jul; 123(7):2907-20. PMID: 23921130; PMCID: PMC3998961.
    15. Chae YC, Caino MC, Lisanti S, Ghosh JC, Dohi T, Danial NN, Villanueva J, Ferrero S, Vaira V, Santambrogio L, Bosari S, Languino LR, Herlyn M, Altieri DC. Control of tumor bioenergetics and survival stress signaling by mitochondrial HSP90s. Cancer Cell. 2012 Sep 11; 22(3):331-44. PMID: 22975376; PMCID: PMC3615709.
    16. Caino MC, Lopez-Haber C, Kissil JL, Kazanietz MG. Non-small cell lung carcinoma cell motility, rac activation and metastatic dissemination are mediated by protein kinase C epsilon. PLoS One. 2012; 7(2):e31714. PMID: 22384062; PMCID: PMC3288050.
    17. Caino MC, Lopez-Haber C, Kim J, Mochly-Rosen D, Kazanietz MG. Proteins kinase C? is required for non-small cell lung carcinoma growth and regulates the expression of apoptotic genes. Oncogene. 2012 May 17; 31(20):2593-600. PMID: 21996750; PMCID: PMC3432976.
    18. Caino MC, von Burstin VA, Lopez-Haber C, Kazanietz MG. Differential regulation of gene expression by protein kinase C isozymes as determined by genome-wide expression analysis. J Biol Chem. 2011 Apr 01; 286(13):11254-64. PMID: 21252239; PMCID: PMC3064181.
    19. Filone CM, Hanna SL, Caino MC, Bambina S, Doms RW, Cherry S. Rift valley fever virus infection of human cells and insect hosts is promoted by protein kinase C epsilon. PLoS One. 2010 Nov 24; 5(11):e15483. PMID: 21124804; PMCID: PMC2991366.
    20. Meshki J, Caino MC, von Burstin VA, Griner E, Kazanietz MG. Regulation of prostate cancer cell survival by protein kinase Cepsilon involves bad phosphorylation and modulation of the TNFalpha/JNK pathway. J Biol Chem. 2010 Aug 20; 285(34):26033-40. PMID: 20566643; PMCID: PMC2924002.
    21. Griner EM, Caino MC, Sosa MS, Colón-González F, Chalmers MJ, Mischak H, Kazanietz MG. A novel cross-talk in diacylglycerol signaling: the Rac-GAP beta2-chimaerin is negatively regulated by protein kinase Cdelta-mediated phosphorylation. J Biol Chem. 2010 May 28; 285(22):16931-41. PMID: 20335173; PMCID: PMC2878072.
    22. Caino MC, Meshki J, Kazanietz MG. Hallmarks for senescence in carcinogenesis: novel signaling players. Apoptosis. 2009 Apr; 14(4):392-408. PMID: 19169823.
      View in: PubMed
    23. Xiao L, Caino MC, von Burstin VA, Oliva JL, Kazanietz MG. Phorbol ester-induced apoptosis and senescence in cancer cell models. Methods Enzymol. 2008; 446:123-39. PMID: 18603119.
      View in: PubMed
    24. Oliva JL, Caino MC, Senderowicz AM, Kazanietz MG. S-Phase-specific activation of PKC alpha induces senescence in non-small cell lung cancer cells. J Biol Chem. 2008 Feb 29; 283(9):5466-76. PMID: 18162471.
      View in: PubMed
    25. Caino MC, Oliva JL, Jiang H, Penning TM, Kazanietz MG. Benzo[a]pyrene-7,8-dihydrodiol promotes checkpoint activation and G2/M arrest in human bronchoalveolar carcinoma H358 cells. Mol Pharmacol. 2007 Mar; 71(3):744-50. PMID: 17114299.
      View in: PubMed
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