Colorado PROFILES, The Colorado Clinical and Translational Sciences Institute (CCTSI)
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Last Name
Institution

John P Welsh

TitleAffiliate
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-NEUR General Operations

    Collapse Research 
    Collapse research activities and funding
    R61MH135114     (WELSH, JOHN P)Jul 8, 2024 - Apr 30, 2026
    NIH
    Integrated movement tracking for pediatric OPM-MEG studies of intellectual disability
    Role: Principal Investigator
    R01MH100887     (WELSH, JOHN P)Feb 13, 2014 - Dec 31, 2019
    NIH
    Eyeblink conditioning in school-aged children with ASD
    Role: Principal Investigator
    R21NS079110     (WELSH, JOHN P)Feb 15, 2012 - Jan 31, 2014
    NIH
    NMDA receptor modulation of electrical synapses in the primate brain
    Role: Principal Investigator
    R21NS079154     (WELSH, JOHN P)Feb 15, 2012 - Jan 31, 2014
    NIH
    Optical Augmentation of Implicit Timing
    Role: Principal Investigator
    S10RR016858     (WELSH, JOHN P)May 1, 2002 - Apr 30, 2003
    NIH
    Confocal Microscope
    Role: Principal Investigator
    R21RR014345     (WELSH, JOHN P)May 1, 2000 - Feb 28, 2005
    NIH
    SILICON BIOCAPSULES-- DELIVERY OF NEUROSECRETORY CELLS
    Role: Principal Investigator
    R01NS031224     (WELSH, JOHN P)Mar 1, 1993 - Jun 30, 2021
    NIH
    Central Rhythmogenesis and Behavior
    Role: Principal Investigator
    R56NS031224     (WELSH, JOHN P)Mar 1, 1993 - Jun 30, 2009
    NIH
    Central Rhythmogenesis and Behavior
    Role: Principal Investigator
    F32NS008844     (WELSH, JOHN P)Mar 14, 1990
    NIH
    MULTIPLE PURKINJE CELL RECORDING DURING BEHAVIOR
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Hartmann M, Rauscher M, Robinson J, Welsh J, Roush D. Integration of QSAR models with high throughput screening to accelerate the development of polishing chromatography unit operations. J Chromatogr A. 2025 Apr 26; 1747:465818. PMID: 40023049.
      View in: PubMed
    2. Welsh JP, Altern SH, Lyall JY, Burgess S, Rauscher MA, Lenhoff AM, Cramer SM, Williams C. Coupling high-throughput and modeling approaches to streamline early-stage process development for biologics. Biotechnol Prog. 2025 May-Jun; 41(3):e3523. PMID: 39846604.
      View in: PubMed
    3. Wittkopp F, Welsh J, Todd R, Staby A, Roush D, Lyall J, Karkov S, Hunt S, Griesbach J, Bertran MO, Babi D. Current state of implementation of in silico tools in the biopharmaceutical industry-Proceedings of the 5th modeling workshop. Biotechnol Bioeng. 2024 Sep; 121(9):2952-2973. PMID: 38853778.
      View in: PubMed
    4. Altern SH, Lyall JY, Welsh JP, Burgess S, Kumar V, Williams C, Lenhoff AM, Cramer SM. High-throughput in silico workflow for optimization and characterization of multimodal chromatographic processes. Biotechnol Prog. 2024 Nov-Dec; 40(6):e3483. PMID: 38856182.
      View in: PubMed
    5. Liu P, Hartmann M, Shankaran A, Li H, Welsh J. Combining descriptive and predictive modeling to systematically design depth filtration-based harvest processes for biologics. Biotechnol Bioeng. 2024 Sep; 121(9):2924-2935. PMID: 38837221.
      View in: PubMed
    6. Li Z, Chen J, Martinez-Fonts K, Rauscher M, Rivera S, Welsh J, Kandula S. Cationic polymer precipitation for enhanced impurity removal in downstream processing. Biotechnol Bioeng. 2023 07; 120(7):1902-1913. PMID: 37148495.
      View in: PubMed
    7. Altern SH, Welsh JP, Lyall JY, Kocot AJ, Burgess S, Kumar V, Williams C, Lenhoff AM, Cramer SM. Isotherm model discrimination for multimodal chromatography using mechanistic models derived from high-throughput batch isotherm data. J Chromatogr A. 2023 Mar 29; 1693:463878. PMID: 36827799.
      View in: PubMed
    8. Welsh JP, Munson J, St John T, Meehan CN, Tran Abraham E, Reitz FB, Begay KK, Dager SR, Estes AM. Relationship of Impairments in Associative Learning With Intellectual Disability and Cerebellar Hypoplasia in Autistic Children. Neurology. 2023 02 07; 100(6):e639-e650. PMID: 36443015.
      View in: PubMed
    9. McKechnie WS, Thom V, Kupracz L, Pollard J, Kandula S, Welsh J. A high-throughput approach to developing and optimizing mixed-mode membrane chromatography for protein purification. Biotechnol Prog. 2023 03; 39(2):e3308. PMID: 36300814.
      View in: PubMed
    10. Lautz JD, Tsegay KB, Zhu Z, Gniffke EP, Welsh JP, Smith SEP. Synaptic protein interaction networks encode experience by assuming stimulus-specific and brain-region-specific states. Cell Rep. 2021 11 30; 37(9):110076. PMID: 34852231.
      View in: PubMed
    11. Heavner WE, Lautz JD, Speed HE, Gniffke EP, Immendorf KB, Welsh JP, Baertsch NA, Smith SEP. Remodeling of the Homer-Shank interactome mediates homeostatic plasticity. Sci Signal. 2021 05 04; 14(681). PMID: 33947797.
      View in: PubMed
    12. Roush D, Asthagiri D, Babi DK, Benner S, Bilodeau C, Carta G, Ernst P, Fedesco M, Fitzgibbon S, Flamm M, Griesbach J, Grosskopf T, Hansen EB, Hahn T, Hunt S, Insaidoo F, Lenhoff A, Lin J, Marke H, Marques B, Papadakis E, Schlegel F, Staby A, Stenvang M, Sun L, Tessier PM, Todd R, von Lieres E, Welsh J, Willson R, Wang G, Wucherpfennig T, Zavalov O. Toward in silico CMC: An industrial collaborative approach to model-based process development. Biotechnol Bioeng. 2020 12; 117(12):3986-4000. PMID: 32725887.
      View in: PubMed
    13. Bikdeli B, Caraballo C, Welsh J, Ross JS, Kaul S, Stone GW, Krumholz HM. Non-inferiority trials using a surrogate marker as the primary endpoint: An increasing phenotype in cardiovascular trials. Clin Trials. 2020 12; 17(6):723-728. PMID: 32838556.
      View in: PubMed
    14. Coffman J, Marques B, Orozco R, Aswath M, Mohammad H, Zimmermann E, Khouri J, Griesbach J, Izadi S, Williams A, Sankar K, Walters B, Lin J, Hepbildikler S, Schiel J, Welsh J, Ferreira G, Delmar J, Mody N, Afdahl C, Cui T, Khalaf R, Hanke A, Pampel L, Parimal S, Hong X, Patil U, Pollard J, Insaidoo F, Robinson J, Chandra D, Blanco M, Panchal J, Soundararajan S, Roush D, Tugcu N, Cramer S, Haynes C, Willson RC. Highland games: A benchmarking exercise in predicting biophysical and drug properties of monoclonal antibodies from amino acid sequences. Biotechnol Bioeng. 2020 07; 117(7):2100-2115. PMID: 32255523.
      View in: PubMed
    15. Bailly M, Mieczkowski C, Juan V, Metwally E, Tomazela D, Baker J, Uchida M, Kofman E, Raoufi F, Motlagh S, Yu Y, Park J, Raghava S, Welsh J, Rauscher M, Raghunathan G, Hsieh M, Chen YL, Nguyen HT, Nguyen N, Cipriano D, Fayadat-Dilman L. Predicting Antibody Developability Profiles Through Early Stage Discovery Screening. MAbs. 2020 Jan-Dec; 12(1):1743053. PMID: 32249670.
      View in: PubMed
    16. Moore-Kelly C, Welsh J, Rodger A, Dafforn TR, Thomas ORT. Automated High-Throughput Capillary Circular Dichroism and Intrinsic Fluorescence Spectroscopy for Rapid Determination of Protein Structure. Anal Chem. 2019 11 05; 91(21):13794-13802. PMID: 31584804.
      View in: PubMed
    17. Benner SW, Welsh JP, Rauscher MA, Pollard JM. Prediction of lab and manufacturing scale chromatography performance using mini-columns and mechanistic modeling. J Chromatogr A. 2019 May 24; 1593:54-62. PMID: 30739757.
      View in: PubMed
    18. Lu Y, Zhang H, Wang Y, Zhou T, Welsh J, Liu J, Guan W, Li J, Li X, Zheng X, Spertus JA, Masoudi FA, Krumholz HM, Jiang L. Percutaneous Coronary Intervention in Patients Without Acute Myocardial Infarction in China: Results From the China PEACE Prospective Study of Percutaneous Coronary Intervention. JAMA Netw Open. 2018 12 07; 1(8):e185446. PMID: 30646292.
      View in: PubMed
    19. Konstantinidis S, Welsh JP, Titchener-Hooker NJ, Roush DJ, Velayudhan A. Data-driven multi-objective optimization via grid compatible simplex technique and desirability approach for challenging high throughput chromatography applications. Biotechnol Prog. 2018 11; 34(6):1393-1406. PMID: 30294895.
      View in: PubMed
    20. Welsh J, Lu Y, Dhruva SS, Bikdeli B, Desai NR, Benchetrit L, Zimmerman CO, Mu L, Ross JS, Krumholz HM. Age of Data at the Time of Publication of Contemporary Clinical Trials. JAMA Netw Open. 2018 08 03; 1(4):e181065. PMID: 30646100.
      View in: PubMed
    21. Welsh JP, Estes AM. Exploring the social brain. Elife. 2018 03 01; 7. PMID: 29493508.
      View in: PubMed
    22. Carvalho SB, Moleirinho MG, Wheatley D, Welsh J, Gantier R, Alves PM, Peixoto C, Carrondo MJT. Universal label-free in-process quantification of influenza virus-like particles. Biotechnol J. 2017 Aug; 12(8). PMID: 28514082.
      View in: PubMed
    23. Welsh JP, Oristaglio JT. Autism and Classical Eyeblink Conditioning: Performance Changes of the Conditioned Response Related to Autism Spectrum Disorder Diagnosis. Front Psychiatry. 2016; 7:137. PMID: 27563293.
      View in: PubMed
    24. Turecek J, Han VZ, Cuzon Carlson VC, Grant KA, Welsh JP. Electrical Coupling and Synchronized Subthreshold Oscillations in the Inferior Olive of the Rhesus Macaque. J Neurosci. 2016 06 15; 36(24):6497-502. PMID: 27307237.
      View in: PubMed
    25. Konstantinidis S, Welsh JP, Roush DJ, Velayudhan A. Application of simplex-based experimental optimization to challenging bioprocess development problems: Case studies in downstream processing. Biotechnol Prog. 2016 03; 32(2):404-19. PMID: 26821762.
      View in: PubMed
    26. Petroff MG, Bao H, Welsh JP, van Beuningen-de Vaan M, Pollard JM, Roush DJ, Kandula S, Machielsen P, Tugcu N, Linden TO. High throughput chromatography strategies for potential use in the formal process characterization of a monoclonal antibody. Biotechnol Bioeng. 2016 06; 113(6):1273-83. PMID: 26639315.
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    27. Edgar JC, Khan SY, Blaskey L, Chow VY, Rey M, Gaetz W, Cannon KM, Monroe JF, Cornew L, Qasmieh S, Liu S, Welsh JP, Levy SE, Roberts TP. Neuromagnetic oscillations predict evoked-response latency delays and core language deficits in autism spectrum disorders. J Autism Dev Disord. 2015 Feb; 45(2):395-405. PMID: 23963591.
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    28. Zhu Z, Zeng XH, Turecek J, Han VZ, Welsh JP. RNA interference of GluN1 inhibits neuronal rhythmogenesis in the adult inferior olive. J Mol Neurosci. 2015 Feb; 55(2):416-29. PMID: 24930901.
      View in: PubMed
    29. Welsh JP, Petroff MG, Rowicki P, Bao H, Linden T, Roush DJ, Pollard JM. A practical strategy for using miniature chromatography columns in a standardized high-throughput workflow for purification development of monoclonal antibodies. Biotechnol Prog. 2014 May-Jun; 30(3):626-35. PMID: 24616450.
      View in: PubMed
    30. Turecek J, Yuen GS, Han VZ, Zeng XH, Bayer KU, Welsh JP. NMDA receptor activation strengthens weak electrical coupling in mammalian brain. Neuron. 2014 Mar 19; 81(6):1375-1388. PMID: 24656255.
      View in: PubMed
    31. Lu Y, Welsh JP, Swartz JR. Production and stabilization of the trimeric influenza hemagglutinin stem domain for potentially broadly protective influenza vaccines. Proc Natl Acad Sci U S A. 2014 Jan 07; 111(1):125-30. PMID: 24344259.
      View in: PubMed
    32. Mohr C, Kolotushkina O, Kaplan JS, Welsh J, Daunais JB, Grant KA, Rossi DJ. Primate cerebellar granule cells exhibit a tonic GABAAR conductance that is not affected by alcohol: a possible cellular substrate of the low level of response phenotype. Front Neural Circuits. 2013; 7:189. PMID: 24324408.
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    33. Lu Y, Welsh JP, Chan W, Swartz JR. Escherichia coli-based cell free production of flagellin and ordered flagellin display on virus-like particles. Biotechnol Bioeng. 2013 Aug; 110(8):2073-85. PMID: 23519642.
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    34. Fatemi SH, Aldinger KA, Ashwood P, Bauman ML, Blaha CD, Blatt GJ, Chauhan A, Chauhan V, Dager SR, Dickson PE, Estes AM, Goldowitz D, Heck DH, Kemper TL, King BH, Martin LA, Millen KJ, Mittleman G, Mosconi MW, Persico AM, Sweeney JA, Webb SJ, Welsh JP. Consensus paper: pathological role of the cerebellum in autism. Cerebellum. 2012 Sep; 11(3):777-807. PMID: 22370873.
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    35. Welsh JP, Lu Y, He XS, Greenberg HB, Swartz JR. Cell-free production of trimeric influenza hemagglutinin head domain proteins as vaccine antigens. Biotechnol Bioeng. 2012 Dec; 109(12):2962-9. PMID: 22729608.
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    36. House NS, Welsh JP, English JC. Sarcoidosis-induced alopecia. Dermatol Online J. 2012 Aug 15; 18(8):4. PMID: 22948054.
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    37. Yang WC, Welsh JP, Lee J, Cooke JP, Swartz JR. Solubility partner IF2 Domain I enables high yield synthesis of transducible transcription factors in Escherichia coli. Protein Expr Purif. 2011 Nov; 80(1):145-51. PMID: 21757009.
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    38. Welsh JP, Han VZ, Rossi DJ, Mohr C, Odagiri M, Daunais JB, Grant KA. Bidirectional plasticity in the primate inferior olive induced by chronic ethanol intoxication and sustained abstinence. Proc Natl Acad Sci U S A. 2011 Jun 21; 108(25):10314-9. PMID: 21642533.
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    39. Welsh JP, Bonomo J, Swartz JR. Localization of BiP to translating ribosomes increases soluble accumulation of secreted eukaryotic proteins in an Escherichia coli cell-free system. Biotechnol Bioeng. 2011 Aug; 108(8):1739-48. PMID: 21351069.
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    40. Vianney-Rodrigues P, Iancu OD, Welsh JP. Gamma oscillations in the auditory cortex of awake rats. Eur J Neurosci. 2011 Jan; 33(1):119-29. PMID: 21059115.
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    41. Bonomo J, Welsh JP, Manthiram K, Swartz JR. Comparing the functional properties of the Hsp70 chaperones, DnaK and BiP. Biophys Chem. 2010 Jun; 149(1-2):58-66. PMID: 20435400.
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    42. Welsh JP, Patel KG, Manthiram K, Swartz JR. Multiply mutated Gaussia luciferases provide prolonged and intense bioluminescence. Biochem Biophys Res Commun. 2009 Nov 27; 389(4):563-8. PMID: 19825431.
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    43. Welsh JP, Allen HB. Purple-red papules on foot. J Fam Pract. 2008 Jun; 57(6):389-91. PMID: 18544322.
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    44. Welsh JP, Ko C, Hsu WT. Lymphomatoid drug reaction secondary to methylphenidate hydrochloride. Cutis. 2008 Jan; 81(1):61-4. PMID: 18306850.
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    45. Templet JT, Welsh JP, Cusack CA. Childhood dermatitis herpetiformis: a case report and review of the literature. Cutis. 2007 Dec; 80(6):473-6. PMID: 18246879.
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    46. Welsh JP, Skvarka CB, Ko C, Cusack CA. Mystery of the silk road. Am J Med. 2007 Apr; 120(4):322-4. PMID: 17398224.
      View in: PubMed
    47. Welsh JP, Cusack CA, Ko C. Urticarial vasculitis secondary to paroxetine. J Drugs Dermatol. 2006 Nov-Dec; 5(10):1012-4. PMID: 17373154.
      View in: PubMed
    48. Welsh JP, Skvarka CB, Allen HB. A novel visual clue for the diagnosis of hypertrophic lichen planus. Arch Dermatol. 2006 Jul; 142(7):954. PMID: 16847230.
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    49. Placantonakis DG, Bukovsky AA, Aicher SA, Kiem HP, Welsh JP. Continuous electrical oscillations emerge from a coupled network: a study of the inferior olive using lentiviral knockdown of connexin36. J Neurosci. 2006 May 10; 26(19):5008-16. PMID: 16687492.
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    50. Welsh JP, Yamaguchi H, Zeng XH, Kojo M, Nakada Y, Takagi A, Sugimori M, Llinás RR. Normal motor learning during pharmacological prevention of Purkinje cell long-term depression. Proc Natl Acad Sci U S A. 2005 Nov 22; 102(47):17166-71. PMID: 16278298.
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    51. Welsh JP, Ahn ES, Placantonakis DG. Is autism due to brain desynchronization? Int J Dev Neurosci. 2005 Apr-May; 23(2-3):253-63. PMID: 15749250.
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    52. Placantonakis DG, Bukovsky AA, Zeng XH, Kiem HP, Welsh JP. Fundamental role of inferior olive connexin 36 in muscle coherence during tremor. Proc Natl Acad Sci U S A. 2004 May 04; 101(18):7164-9. PMID: 15103021.
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    53. Johnson JL, Welsh JP. Independently movable multielectrode array to record multiple fast-spiking neurons in the cerebral cortex during cognition. Methods. 2003 May; 30(1):64-78. PMID: 12695104.
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    54. Welsh JP. Functional significance of climbing-fiber synchrony: a population coding and behavioral analysis. Ann N Y Acad Sci. 2002 Dec; 978:188-204. PMID: 12582053.
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    55. Placantonakis D, Cicirata F, Welsh JP. A dominant negative mutation of neuronal connexin 36 that blocks intercellular permeability. Brain Res Mol Brain Res. 2002 Jan 31; 98(1-2):15-28. PMID: 11834292.
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    56. Welsh JP, Placantonakis DG, Warsetsky SI, Marquez RG, Bernstein L, Aicher SA. The serotonin hypothesis of myoclonus from the perspective of neuronal rhythmicity. Adv Neurol. 2002; 89:307-29. PMID: 11968457.
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    57. Welsh JP, Yuen G, Placantonakis DG, Vu TQ, Haiss F, O'Hearn E, Molliver ME, Aicher SA. Why do Purkinje cells die so easily after global brain ischemia? Aldolase C, EAAT4, and the cerebellar contribution to posthypoxic myoclonus. Adv Neurol. 2002; 89:331-59. PMID: 11968459.
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    58. Llinás R, Lang EJ, Welsh JP, Makarenko VI. A New Approach to the Analysis of Multidimensional Neuronal Activity: Markov Random Fields. Neural Netw. 1997 Jul; 10(5):785-789. PMID: 12662870.
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