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Ramon Lorca

TitleAsst Professor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-OB/GYN RS GENERAL OPS
Phone303/724-1126
ORCID ORCID Icon0000-0002-7330-6284 Additional info

    Collapse Overview 

    Collapse Research 
    Collapse research activities and funding
    R21HD102628     (LORCA, RAMON)Apr 1, 2021 - Mar 31, 2023
    NIH
    Optogenetic control of vascular function during pregnancy
    Role Description: This project is aimed to validate and further characterize a murine model of intrauterine growth restriction using optogenetics.
    Role: Principal Investigator
    20IPA35320027     (Ramon Lorca)Jan 1, 2021 - Dec 31, 2022
    American Heart Association
    Optogenetic control of vascular function during pregnancy
    Role Description: This project is aimed to the initial development of a novel murine model of intrauterine growth restriction using optogenetics.
    Role: Principal Investigator
    R03HD101659     (LORCA, RAMON)Dec 1, 2020 - Nov 30, 2022
    NIH
    Myometrial artery potassium channel activity in intrauterine growth restriction pregnancy
    Role Description: This project will determine the role of K+ channels and intracellular Ca2+ in the regulation of myometrial artery vasoreactivity, both important contributors to uteroplacental perfusion, and, in turn, fetal growth.
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Jones AK, Rozance PJ, Brown LD, Lorca RA, Julian CG, Moore LG, Limesand SW, Wesolowski SR. Uteroplacental nutrient flux and evidence for metabolic reprogramming during sustained hypoxemia. Physiol Rep. 2021 09; 9(18):e15033. PMID: 34558219.
      View in: PubMed
    2. Lorca RA, Houck JA, Laurent LC, Matarazzo CJ, Baker K, Horii M, Nelson KK, Bales ES, Euser AG, Parast MM, Moore LG, Julian CG. High altitude regulates the expression of AMPK pathways in human placenta. Placenta. 2021 01 15; 104:267-276. PMID: 33472134.
      View in: PubMed
    3. Bok R, Guerra DD, Lorca RA, Wennersten SA, Harris PS, Rauniyar AK, Stabler SP, MacLean KN, Roede JR, Brown LD, Hurt KJ. Cystathionine ?-lyase promotes estrogen-stimulated uterine artery blood flow via glutathione homeostasis. Redox Biol. 2021 04; 40:101827. PMID: 33485059.
      View in: PubMed
    4. Lane SL, Houck JA, Doyle AS, Bales ES, Lorca RA, Julian CG, Moore LG. AMP-activated protein kinase activator AICAR attenuates hypoxia-induced murine fetal growth restriction in part by improving uterine artery blood flow. J Physiol. 2020 09; 598(18):4093-4105. PMID: 32592403.
      View in: PubMed
    5. Lorca RA, Matarazzo CJ, Bales ES, Houck JA, Orlicky DJ, Euser AG, Julian CG, Moore LG. AMPK activation in pregnant human myometrial arteries from high-altitude and intrauterine growth-restricted pregnancies. Am J Physiol Heart Circ Physiol. 2020 07 01; 319(1):H203-H212. PMID: 32502374.
      View in: PubMed
    6. Lane SL, Doyle AS, Bales ES, Lorca RA, Julian CG, Moore LG. Increased uterine artery blood flow in hypoxic murine pregnancy is not sufficient to prevent fetal growth restriction?. Biol Reprod. 2020 03 13; 102(3):660-670. PMID: 31711123.
      View in: PubMed
    7. Guerra DD, Bok R, Lorca RA, Hurt KJ. Protein kinase A facilitates relaxation of mouse ileum via phosphorylation of neuronal nitric oxide synthase. Br J Pharmacol. 2020 06; 177(12):2765-2778. PMID: 31975425.
      View in: PubMed
    8. Lane SL, Doyle AS, Bales ES, Houck JA, Lorca RA, Moore LG, Julian CG. Peroxisome proliferator-activated receptor gamma blunts endothelin-1-mediated contraction of the uterine artery in a murine model of high-altitude pregnancy. FASEB J. 2020 03; 34(3):4283-4292. PMID: 31970838.
      View in: PubMed
    9. Vaughan OR, Thompson F, Lorca RA, Julian CG, Powell TL, Moore LG, Jansson T. Effect of high altitude on human placental amino acid transport. J Appl Physiol (1985). 2020 01 01; 128(1):127-133. PMID: 31804891.
      View in: PubMed
    10. Guerra DD, Bok R, Vyas V, Orlicky DJ, Lorca RA, Hurt KJ. Akt phosphorylation of neuronal nitric oxide synthase regulates gastrointestinal motility in mouse ileum. Proc Natl Acad Sci U S A. 2019 08 27; 116(35):17541-17546. PMID: 31405982.
      View in: PubMed
    11. Lorca RA, Lane SL, Bales ES, Nsier H, Yi H, Donnelly MA, Euser AG, Julian CG, Moore LG. High Altitude Reduces NO-Dependent Myometrial Artery Vasodilator Response During Pregnancy. Hypertension. 2019 06; 73(6):1319-1326. PMID: 31006328.
      View in: PubMed
    12. Lane SL, Dodson RB, Doyle AS, Park H, Rathi H, Matarrazo CJ, Moore LG, Lorca RA, Wolfson GH, Julian CG. Pharmacological activation of peroxisome proliferator-activated receptor ? (PPAR-?) protects against hypoxia-associated fetal growth restriction. FASEB J. 2019 08; 33(8):8999-9007. PMID: 31039323.
      View in: PubMed
    13. Lorca RA, Wakle-Prabagaran M, Freeman WE, Pillai MK, England SK. The large-conductance voltage- and Ca2+ -activated K+ channel and its ?1-subunit modulate mouse uterine artery function during pregnancy. J Physiol. 2018 03 15; 596(6):1019-1033. PMID: 29319186.
      View in: PubMed
    14. Li Y, Lorca RA, Su EJ. Molecular and cellular underpinnings of normal and abnormal human placental blood flows. J Mol Endocrinol. 2018 01; 60(1):R9-R22. PMID: 29097590.
      View in: PubMed
    15. Lorca RA, Ma X, England SK. The unique N-terminal sequence of the BKCa channel a-subunit determines its modulation by ?-subunits. PLoS One. 2017; 12(7):e0182068. PMID: 28750098.
      View in: PubMed
    16. Wakle-Prabagaran M, Lorca RA, Ma X, Stamnes SJ, Amazu C, Hsiao JJ, Karch CM, Hyrc KL, Wright ME, England SK. BKCa channel regulates calcium oscillations induced by alpha-2-macroglobulin in human myometrial smooth muscle cells. Proc Natl Acad Sci U S A. 2016 Apr 19; 113(16):E2335-44. PMID: 27044074.
      View in: PubMed
    17. Yao J, Shcherbakova DM, Li C, Krumholz A, Lorca RA, Reinl E, England SK, Verkhusha VV, Wang LV. Reversibly switchable fluorescence microscopy with enhanced resolution and image contrast. J Biomed Opt. 2014 Aug; 19(8):086018. PMID: 25144452.
      View in: PubMed
    18. Lorca RA, Prabagaran M, England SK. Functional insights into modulation of BKCa channel activity to alter myometrial contractility. Front Physiol. 2014; 5:289. PMID: 25132821.
      View in: PubMed
    19. Li Y, Lorca RA, Ma X, Rhodes A, England SK. BK channels regulate myometrial contraction by modulating nuclear translocation of NF-?B. Endocrinology. 2014 Aug; 155(8):3112-22. PMID: 24914944.
      View in: PubMed
    20. Lorca RA, Stamnes SJ, Pillai MK, Hsiao JJ, Wright ME, England SK. N-terminal isoforms of the large-conductance Ca??-activated K? channel are differentially modulated by the auxiliary ?1-subunit. J Biol Chem. 2014 Apr 04; 289(14):10095-103. PMID: 24569989.
      View in: PubMed
    21. Decker AR, McNeill MS, Lambert AM, Overton JD, Chen YC, Lorca RA, Johnson NA, Brockerhoff SE, Mohapatra DP, MacArthur H, Panula P, Masino MA, Runnels LW, Cornell RA. Abnormal differentiation of dopaminergic neurons in zebrafish trpm7 mutant larvae impairs development of the motor pattern. Dev Biol. 2014 Feb 15; 386(2):428-39. PMID: 24291744.
      View in: PubMed
    22. Ketsawatsomkron P, Lorca RA, Keen HL, Weatherford ET, Liu X, Pelham CJ, Grobe JL, Faraci FM, England SK, Sigmund CD. PPAR? regulates resistance vessel tone through a mechanism involving RGS5-mediated control of protein kinase C and BKCa channel activity. Circ Res. 2012 Nov 09; 111(11):1446-58. PMID: 22962432.
      View in: PubMed
    23. Loo L, Shepherd AJ, Mickle AD, Lorca RA, Shutov LP, Usachev YM, Mohapatra DP. The C-type natriuretic peptide induces thermal hyperalgesia through a noncanonical G??-dependent modulation of TRPV1 channel. J Neurosci. 2012 Aug 29; 32(35):11942-55. PMID: 22933780.
      View in: PubMed
    24. Lorca RA, Varela-Nallar L, Inestrosa NC, Huidobro-Toro JP. The Cellular Prion Protein Prevents Copper-Induced Inhibition of P2X(4) Receptors. Int J Alzheimers Dis. 2011; 2011:706576. PMID: 22114745.
      View in: PubMed
    25. Lorca RA, Rozas C, Loyola S, Moreira-Ramos S, Zeise ML, Kirkwood A, Huidobro-Toro JP, Morales B. Zinc enhances long-term potentiation through P2X receptor modulation in the hippocampal CA1 region. Eur J Neurosci. 2011 Apr; 33(7):1175-1185. PMID: 21324005.
      View in: PubMed
    26. Yang J, Huang J, Maity B, Gao Z, Lorca RA, Gudmundsson H, Li J, Stewart A, Swaminathan PD, Ibeawuchi SR, Shepherd A, Chen CK, Kutschke W, Mohler PJ, Mohapatra DP, Anderson ME, Fisher RA. RGS6, a modulator of parasympathetic activation in heart. Circ Res. 2010 Nov 26; 107(11):1345-9. PMID: 20864673.
      View in: PubMed
    27. Kalashnikova E, Lorca RA, Kaur I, Barisone GA, Li B, Ishimaru T, Trimmer JS, Mohapatra DP, D?az E. SynDIG1: an activity-regulated, AMPA- receptor-interacting transmembrane protein that regulates excitatory synapse development. Neuron. 2010 Jan 14; 65(1):80-93. PMID: 20152115.
      View in: PubMed
    28. Arias-Cavieres A, Rozas C, Reyes-Parada M, Barrera N, Pancetti F, Loyola S, Lorca RA, Zeise ML, Morales B. MDMA ("ecstasy") impairs learning in the Morris Water Maze and reduces hippocampal LTP in young rats. Neurosci Lett. 2010 Jan 29; 469(3):375-9. PMID: 20026184.
      View in: PubMed
    29. Huidobro-Toro JP, Lorca RA, Coddou C. Trace metals in the brain: allosteric modulators of ligand-gated receptor channels, the case of ATP-gated P2X receptors. Eur Biophys J. 2008 Mar; 37(3):301-14. PMID: 17972073.
      View in: PubMed
    30. Lorca RA, Coddou C, Gazit?a MC, Bull P, Arredondo C, Huidobro-Toro JP. Extracellular histidine residues identify common structural determinants in the copper/zinc P2X2 receptor modulation. J Neurochem. 2005 Oct; 95(2):499-512. PMID: 16190872.
      View in: PubMed
    31. Coddou C, Lorca RA, Acu?a-Castillo C, Grauso M, Rassendren F, Huidobro-Toro JP. Heavy metals modulate the activity of the purinergic P2X4 receptor. Toxicol Appl Pharmacol. 2005 Jan 15; 202(2):121-31. PMID: 15629187.
      View in: PubMed
    32. Chac?n MA, Barr?a MI, Lorca R, Huidobro-Toro JP, Inestrosa NC. A human prion protein peptide (PrP(59-91)) protects against copper neurotoxicity. Mol Psychiatry. 2003 Oct; 8(10):853-62, 835. PMID: 14515136.
      View in: PubMed
    33. Lorca RA, Chac?n M, Barr?a MI, Inestrosa NC, Huidobro-Toro JP. The human prion octarepeat fragment prevents and reverses the inhibitory action of copper in the P2X4 receptor without modifying the zinc action. J Neurochem. 2003 May; 85(3):709-16. PMID: 12694397.
      View in: PubMed
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