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Breck A. Duerkop

TitleAsst Professor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-IMM MICRO GENERAL OPER
Phone303/724-8670

    Collapse Research 
    Collapse research activities and funding
    F32DK089718     (DUERKOP, BRECK A)Jul 1, 2010 - Jun 30, 2013
    NIH
    Interactions of a commensal bacterium with the intestinal mucosal surface
    Role: Principal Investigator

    K01DK102436     (DUERKOP, BRECK A)Sep 15, 2014 - Aug 31, 2019
    NIH
    The contribution of bacteriophages to host-microbe interactions in the intestine
    Role: Principal Investigator

    R01AI141479     (DUERKOP, BRECK A)Sep 14, 2018 - Aug 31, 2023
    NIH
    Mechanistic basis of bacteriophages for the decolonization of vancomycin resistant enterococci in the intestine.
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Kirsch JM, Brzozowski RS, Faith D, Round JL, Secor PR, Duerkop BA. Bacteriophage-Bacteria Interactions in the Gut: From Invertebrates to Mammals. Annu Rev Virol. 2021 Jul 13. PMID: 34255542.
      View in: PubMed
    2. Palacios Araya D, Palmer KL, Duerkop BA. CRISPR-based antimicrobials to obstruct antibiotic-resistant and pathogenic bacteria. PLoS Pathog. 2021 Jul; 17(7):e1009672. PMID: 34237097.
      View in: PubMed
    3. Mangalea MR, Paez-Espino D, Kieft K, Chatterjee A, Chriswell ME, Seifert JA, Feser ML, Demoruelle MK, Sakatos A, Anantharaman K, Deane KD, Kuhn KA, Holers VM, Duerkop BA. Individuals at risk for rheumatoid arthritis harbor differential intestinal bacteriophage communities with distinct metabolic potential. Cell Host Microbe. 2021 05 12; 29(5):726-739.e5. PMID: 33957082.
      View in: PubMed
    4. Canfield GS, Chatterjee A, Espinosa J, Mangalea MR, Sheriff EK, Keidan M, McBride SW, McCollister BD, Hang HC, Duerkop BA. Lytic bacteriophages facilitate antibiotic sensitization of Enterococcus faecium. Antimicrob Agents Chemother. 2021 Mar 01. PMID: 33649110.
      View in: PubMed
    5. Spencer BL, Chatterjee A, Duerkop BA, Baker CJ, Doran KS. Complete Genome Sequence of Neonatal Clinical Group B Streptococcal Isolate CJB111. Microbiol Resour Announc. 2021 Jan 14; 10(2). PMID: 33446593.
      View in: PubMed
    6. Chatterjee A, Willett JLE, Dunny GM, Duerkop BA. Phage infection and sub-lethal antibiotic exposure mediate Enterococcus faecalis type VII secretion system dependent inhibition of bystander bacteria. PLoS Genet. 2021 01; 17(1):e1009204. PMID: 33411815.
      View in: PubMed
    7. Kleiner M, Bushnell B, Sanderson KE, Hooper LV, Duerkop BA. Transductomics: sequencing-based detection and analysis of transduced DNA in pure cultures and microbial communities. Microbiome. 2020 11 15; 8(1):158. PMID: 33190645.
      View in: PubMed
    8. Alhajjar N, Chatterjee A, Spencer BL, Burcham LR, Willett JLE, Dunny GM, Duerkop BA, Doran KS. Genome-Wide Mutagenesis Identifies Factors Involved in Enterococcus faecalis Vaginal Adherence and Persistence. Infect Immun. 2020 09 18; 88(10). PMID: 32778611.
      View in: PubMed
    9. Morrisette T, Lev KL, Kebriaei R, Abdul-Mutakabbir JC, Stamper KC, Morales S, Lehman SM, Canfield GS, Duerkop BA, Arias CA, Rybak MJ. Bacteriophage-Antibiotic Combinations for Enterococcus faecium with Varying Bacteriophage and Daptomycin Susceptibilities. Antimicrob Agents Chemother. 2020 08 20; 64(9). PMID: 32571816.
      View in: PubMed
    10. Canfield GS, Duerkop BA. Molecular mechanisms of enterococcal-bacteriophage interactions and implications for human health. Curr Opin Microbiol. 2020 08; 56:38-44. PMID: 32652484.
      View in: PubMed
    11. Mangalea MR, Duerkop BA. Fitness Trade-Offs Resulting from Bacteriophage Resistance Potentiate Synergistic Antibacterial Strategies. Infect Immun. 2020 06 22; 88(7). PMID: 32094257.
      View in: PubMed
    12. Chatterjee A, Willett JLE, Nguyen UT, Monogue B, Palmer KL, Dunny GM, Duerkop BA. Parallel Genomics Uncover Novel Enterococcal-Bacteriophage Interactions. mBio. 2020 03 03; 11(2). PMID: 32127456.
      View in: PubMed
    13. Johnson CN, Duerkop BA. Dyeing to connect. Nat Microbiol. 2019 12; 4(12):2033-2034. PMID: 31754272.
      View in: PubMed
    14. Rodrigues M, McBride SW, Hullahalli K, Palmer KL, Duerkop BA. Conjugative Delivery of CRISPR-Cas9 for the Selective Depletion of Antibiotic-Resistant Enterococci. Antimicrob Agents Chemother. 2019 11; 63(11). PMID: 31527030.
      View in: PubMed
    15. Price VJ, McBride SW, Hullahalli K, Chatterjee A, Duerkop BA, Palmer KL. Enterococcus faecalis CRISPR-Cas Is a Robust Barrier to Conjugative Antibiotic Resistance Dissemination in the Murine Intestine. mSphere. 2019 07 24; 4(4). PMID: 31341074.
      View in: PubMed
    16. Chatterjee A, Johnson CN, Luong P, Hullahalli K, McBride SW, Schubert AM, Palmer KL, Carlson PE, Duerkop BA. Bacteriophage Resistance Alters Antibiotic-Mediated Intestinal Expansion of Enterococci. Infect Immun. 2019 06; 87(6). PMID: 30936157.
      View in: PubMed
    17. Chatterjee A, Duerkop BA. Sugar and Fatty Acids Ack-celerate Prophage Induction. . 2019 02 13; 25(2):175-176. PMID: 30763529.
      View in: PubMed
    18. Duerkop BA. Bacteriophages shift the focus of the mammalian microbiota. PLoS Pathog. 2018 10; 14(10):e1007310. PMID: 30359456.
      View in: PubMed
    19. Duerkop BA, Kleiner M, Paez-Espino D, Zhu W, Bushnell B, Hassell B, Winter SE, Kyrpides NC, Hooper LV. Murine colitis reveals a disease-associated bacteriophage community. Nat Microbiol. 2018 09; 3(9):1023-1031. PMID: 30038310.
      View in: PubMed
    20. Chatterjee A, Duerkop BA. Beyond Bacteria: Bacteriophage-Eukaryotic Host Interactions Reveal Emerging Paradigms of Health and Disease. Front Microbiol. 2018; 9:1394. PMID: 29997604.
      View in: PubMed
    21. Zhu W, Winter MG, Byndloss MX, Spiga L, Duerkop BA, Hughes ER, Büttner L, de Lima Romão E, Behrendt CL, Lopez CA, Sifuentes-Dominguez L, Huff-Hardy K, Wilson RP, Gillis CC, Tükel Ç, Koh AY, Burstein E, Hooper LV, Bäumler AJ, Winter SE. Precision editing of the gut microbiota ameliorates colitis. Nature. 2018 01 11; 553(7687):208-211. PMID: 29323293.
      View in: PubMed
    22. Hughes ER, Winter MG, Duerkop BA, Spiga L, Furtado de Carvalho T, Zhu W, Gillis CC, Büttner L, Smoot MP, Behrendt CL, Cherry S, Santos RL, Hooper LV, Winter SE. Microbial Respiration and Formate Oxidation as Metabolic Signatures of Inflammation-Associated Dysbiosis. . 2017 Feb 08; 21(2):208-219. PMID: 28182951.
      View in: PubMed
    23. Duerkop BA, Huo W, Bhardwaj P, Palmer KL, Hooper LV. Molecular Basis for Lytic Bacteriophage Resistance in Enterococci. mBio. 2016 08 30; 7(4). PMID: 27578757.
      View in: PubMed
    24. Kleiner M, Hooper LV, Duerkop BA. Evaluation of methods to purify virus-like particles for metagenomic sequencing of intestinal viromes. BMC Genomics. 2015 Jan 22; 16:7. PMID: 25608871.
      View in: PubMed
    25. Duerkop BA, Hooper LV. Resident viruses and their interactions with the immune system. Nat Immunol. 2013 Jul; 14(7):654-9. PMID: 23778792.
      View in: PubMed
    26. Duerkop BA, Clements CV, Rollins D, Rodrigues JL, Hooper LV. A composite bacteriophage alters colonization by an intestinal commensal bacterium. Proc Natl Acad Sci U S A. 2012 Oct 23; 109(43):17621-6. PMID: 23045666.
      View in: PubMed
    27. McClean AE, Duerkop BA, Greenberg EP, Kluepfel DA. AHL signals induce rubrifacine production in a bruI mutant of Brenneria rubrifaciens. Phytopathology. 2012 Feb; 102(2):195-203. PMID: 22236075.
      View in: PubMed
    28. Seyedsayamdost MR, Chandler JR, Blodgett JA, Lima PS, Duerkop BA, Oinuma K, Greenberg EP, Clardy J. Quorum-sensing-regulated bactobolin production by Burkholderia thailandensis E264. Org Lett. 2010 Feb 19; 12(4):716-9. PMID: 20095633.
      View in: PubMed
    29. Duerkop BA, Vaishnava S, Hooper LV. Immune responses to the microbiota at the intestinal mucosal surface. Immunity. 2009 Sep 18; 31(3):368-76. PMID: 19766080.
      View in: PubMed
    30. Chandler JR, Duerkop BA, Hinz A, West TE, Herman JP, Churchill ME, Skerrett SJ, Greenberg EP. Mutational analysis of Burkholderia thailandensis quorum sensing and self-aggregation. J Bacteriol. 2009 Oct; 191(19):5901-9. PMID: 19648250.
      View in: PubMed
    31. Duerkop BA, Varga J, Chandler JR, Peterson SB, Herman JP, Churchill ME, Parsek MR, Nierman WC, Greenberg EP. Quorum-sensing control of antibiotic synthesis in Burkholderia thailandensis. J Bacteriol. 2009 Jun; 191(12):3909-18. PMID: 19376863.
      View in: PubMed
    32. Duerkop BA, Herman JP, Ulrich RL, Churchill ME, Greenberg EP. The Burkholderia mallei BmaR3-BmaI3 quorum-sensing system produces and responds to N-3-hydroxy-octanoyl homoserine lactone. J Bacteriol. 2008 Jul; 190(14):5137-41. PMID: 18487338.
      View in: PubMed
    33. Duerkop BA, Ulrich RL, Greenberg EP. Octanoyl-homoserine lactone is the cognate signal for Burkholderia mallei BmaR1-BmaI1 quorum sensing. J Bacteriol. 2007 Jul; 189(14):5034-40. PMID: 17496085.
      View in: PubMed
    34. Chang HK, Thalhofer C, Duerkop BA, Mehling JS, Verma S, Gollob KJ, Almeida R, Wilson ME. Oxidant generation by single infected monocytes after short-term fluorescence labeling of a protozoan parasite. Infect Immun. 2007 Feb; 75(2):1017-24. PMID: 17118986.
      View in: PubMed
    35. Müh U, Hare BJ, Duerkop BA, Schuster M, Hanzelka BL, Heim R, Olson ER, Greenberg EP. A structurally unrelated mimic of a Pseudomonas aeruginosa acyl-homoserine lactone quorum-sensing signal. Proc Natl Acad Sci U S A. 2006 Nov 07; 103(45):16948-52. PMID: 17075036.
      View in: PubMed
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