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Michael Aaron Rosenberg

TitleAssociate Professor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-MED

    Collapse Overview 
    Collapse overview
    I have specific projects using big data to guide clinical decision support tools, as well use of monitors and sensor data for individualized medicine (website: analyzemydata.org). Also happy to help mentor fellows on projects of their interest with quantitative analysis and study design. I will be serving as a cardiology mentor for the 2018-2019 academic year.

    Collapse Research 
    Collapse research activities and funding
    R01HL146824     (ROSENBERG, MICHAEL A)Feb 1, 2020 - Jan 31, 2025
    NIH
    Development of End-To-End Clinical Decision Support Tools To Prevent Cardiotoxic Drug Response
    Role: Principal Investigator

    K23HL127296     (ROSENBERG, MICHAEL A)Aug 1, 2015 - Mar 31, 2021
    NIH
    Genetics of Cardiotoxic Drug Response
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Rosenberg MA. Deep Learning and Biased Prediction: More Questions Than Answers? Circ Heart Fail. 2024 01; 17(1):e011368. PMID: 38126237.
      View in: PubMed
    2. Lowe RN, Wright G, Olivas L, Teel C, Suresh K, Macke LB, Sieja A, Rosenberg MA, Trinkley KE. Evaluating the prescribing and monitoring of medications associated with QTc-prolongation in the ambulatory care setting. J Eval Clin Pract. 2024 Apr; 30(3):385-392. PMID: 38073034.
      View in: PubMed
    3. Stumph JD, Cornwell WK, Rosenberg MA, Khodaee M. Profound First-Degree Atrioventricular Block in a High-Level Basketball Athlete. Sports Health. 2023 Nov 09; 19417381231210297. PMID: 37946461.
      View in: PubMed
    4. Rosenberg MA, Adewumi J, Aleong RG. A Discussion of the Contemporary Prediction Models for Atrial Fibrillation. Med Res Arch. 2023 Oct; 11(10). PMID: 38050581.
      View in: PubMed
    5. Barrett CD, Nickel A, Rosenberg MA, Ream K, Tzou WS, Aleong R, Tumolo A, Garg L, Zipse M, West JJ, Varosy P, Sandhu A. PRIME score for prediction of permanent pacemaker implantation after transcatheter aortic valve replacement. Catheter Cardiovasc Interv. 2023 12; 102(7):1357-1363. PMID: 37735946.
      View in: PubMed
    6. Ashur C, Zirille F, Aleong RG, Varosy PD, West JJ, Sandhu A, Tumolo AZ, Rosenberg MA, Sabzwari SRA, Barrett C, Cerbin L, Saqi B, Varela D, Zipse MM, Tzou WS, Garg L. Right versus left-sided implantation of left bundle branch area pacemaker insertion. J Interv Card Electrophysiol. 2024 Mar; 67(2):257-258. PMID: 37731143.
      View in: PubMed
    7. Kim R, Suresh K, Rosenberg MA, Tan MS, Malone DC, Allen LA, Kao DP, Anderson HD, Tiwari P, Trinkley KE. A machine learning evaluation of patient characteristics associated with prescribing of guideline-directed medical therapy for heart failure. Front Cardiovasc Med. 2023; 10:1169574. PMID: 37416920.
      View in: PubMed
    8. Trinkley KE, Dafoe A, Malone DC, Allen LA, Huebschmann A, Khazanie P, Lunowa C, Matlock DC, Suresh K, Rosenberg MA, Swat SA, Sosa A, Morris MA. Clinician challenges to evidence-based prescribing for heart failure and reduced ejection fraction: A qualitative evaluation. J Eval Clin Pract. 2023 12; 29(8):1363-1371. PMID: 37335624.
      View in: PubMed
    9. Barrett CD, Suzuki Y, Hussein S, Garg L, Tumolo A, Sandhu A, West JJ, Zipse M, Aleong R, Varosy P, Tzou WS, Banaei-Kashani F, Rosenberg MA. Evaluation of Quantitative Decision-Making for Rhythm Management of Atrial Fibrillation Using Tabular Q-Learning. J Am Heart Assoc. 2023 05 02; 12(9):e028483. PMID: 37119087.
      View in: PubMed
    10. Simon ST, Trinkley KE, Malone DC, Rosenberg MA. Interpretable Machine Learning Prediction of Drug-Induced QT Prolongation: Electronic Health Record Analysis. J Med Internet Res. 2022 12 01; 24(12):e42163. PMID: 36454608.
      View in: PubMed
    11. Simon S, Mandair D, Albakri A, Fohner A, Simon N, Lange L, Biggs M, Mukamal K, Psaty B, Rosenberg M. The Impact of Time Horizon on Classification Accuracy: Application of Machine Learning to Prediction of Incident Coronary Heart Disease. JMIR Cardio. 2022 Nov 02; 6(2):e38040. PMID: 36322114.
      View in: PubMed
    12. Stacy J, Kim R, Barrett C, Sekar B, Simon S, Banaei-Kashani F, Rosenberg MA. Qualitative Evaluation of an Artificial Intelligence-Based Clinical Decision Support System to Guide Rhythm Management of Atrial Fibrillation: Survey Study. JMIR Form Res. 2022 Aug 11; 6(8):e36443. PMID: 35969422.
      View in: PubMed
    13. Sabzwari SRA, Rosenberg MA, Mann J, Cerbin L, Barrett C, Garg L, Aleong RG, Sandhu A, West J, Tumolo AZ, Varosy PD, Sauer WH, Zipse MM, Tzou WS. Limitations of Unipolar Signals in Guiding Successful Outflow Tract Premature Ventricular Contraction Ablation. JACC Clin Electrophysiol. 2022 07; 8(7):843-853. PMID: 35643806.
      View in: PubMed
    14. Mande A, Moore SL, Banaei-Kashani F, Echalier B, Bull S, Rosenberg MA. Assessment of a Mobile Health iPhone App for Semiautomated Self-management of Chronic Recurrent Medical Conditions Using an N-of-1 Trial Framework: Feasibility Pilot Study. JMIR Form Res. 2022 Apr 12; 6(4):e34827. PMID: 35412460.
      View in: PubMed
    15. Huck DM, Rosenberg MA, Stauffer BL. Nebivolol and incident cardiovascular events in hypertensive patients compared with nonvasodilatory beta blockers. J Hypertens. 2022 05 01; 40(5):1019-1029. PMID: 35202021.
      View in: PubMed
    16. Kim RS, Simon S, Powers B, Sandhu A, Sanchez J, Borne RT, Tumolo A, Zipse M, West JJ, Aleong R, Tzou W, Rosenberg MA. Machine Learning Methodologies for Prediction of Rhythm-Control Strategy in Patients Diagnosed With Atrial Fibrillation: Observational, Retrospective, Case-Control Study. JMIR Med Inform. 2021 Dec 06; 9(12):e29225. PMID: 34874889.
      View in: PubMed
    17. Varela DL, Rosenberg MA, Borne RT, Sandhu A, Zipse MM, Tzou WS, Sauer WH, Scheinman MM, Nguyen DT. Increased incidence of cavotricuspid isthmus atrial flutter following slow pathway ablation. J Interv Card Electrophysiol. 2022 Apr; 63(3):581-589. PMID: 34532821.
      View in: PubMed
    18. Rosenberg MA. Trusting Magic: Interpretability of Predictions From Machine Learning Algorithms. Circulation. 2021 03 30; 143(13):1299-1301. PMID: 33779269.
      View in: PubMed
    19. Trinkley KE, Pell JM, Martinez DD, Maude NR, Hale G, Rosenberg MA. Assessing Prescriber Behavior with a Clinical Decision Support Tool to Prevent Drug-Induced Long QT Syndrome. Appl Clin Inform. 2021 01; 12(1):190-197. PMID: 33694143.
      View in: PubMed
    20. Simon ST, Mandair D, Tiwari P, Rosenberg MA. Prediction of Drug-Induced Long QT Syndrome Using Machine Learning Applied to Harmonized Electronic Health Record Data. J Cardiovasc Pharmacol Ther. 2021 07; 26(4):335-340. PMID: 33682475.
      View in: PubMed
    21. Albakri A, Orkaby A, Rosenberg MA. Feasibility of Frailty Assessment Integrated with Cardiac Implantable Electronic Device Clinic Follow-up: A Pilot Investigation. Gerontol Geriatr Med. 2021 Jan-Dec; 7:2333721420987342. PMID: 33457464.
      View in: PubMed
    22. Mandair D, Tiwari P, Simon S, Colborn KL, Rosenberg MA. Prediction of incident myocardial infarction using machine learning applied to harmonized electronic health record data. BMC Med Inform Decis Mak. 2020 10 02; 20(1):252. PMID: 33008368.
      View in: PubMed
    23. Mantini N, Borne RT, Varosy PD, Rosenberg MA, Marzec LN, Sauer WH, Nguyen DT. Use of cell phone adapters is associated with reduction in disparities in remote monitoring of cardiac implantable electronic devices. J Interv Card Electrophysiol. 2021 Apr; 60(3):469-475. PMID: 32399863.
      View in: PubMed
    24. Tiwari P, Colborn KL, Smith DE, Xing F, Ghosh D, Rosenberg MA. Assessment of a Machine Learning Model Applied to Harmonized Electronic Health Record Data for the Prediction of Incident Atrial Fibrillation. JAMA Netw Open. 2020 01 03; 3(1):e1919396. PMID: 31951272.
      View in: PubMed
    25. Levy AE, Biswas M, Weber R, Tarakji K, Chung M, Noseworthy PA, Newton-Cheh C, Rosenberg MA. Applications of machine learning in decision analysis for dose management for dofetilide. PLoS One. 2019; 14(12):e0227324. PMID: 31891645.
      View in: PubMed
    26. Biswas M, Levy A, Weber R, Tarakji K, Chung M, Noseworthy PA, Newton-Cheh C, Rosenberg MA. Multicenter Analysis of Dosing Protocols for Sotalol Initiation. J Cardiovasc Pharmacol Ther. 2020 05; 25(3):212-218. PMID: 31707834.
      View in: PubMed
    27. Chen MY, Orkaby AR, Rosenberg MA, Driver JA. Frailty, Implantable Cardioverter Defibrillators, and Mortality: a Systematic Review. J Gen Intern Med. 2019 10; 34(10):2224-2231. PMID: 31264082.
      View in: PubMed
    28. Ream K, Sandhu A, Valle J, Weber R, Kaizer A, Wiktor DM, Borne RT, Tumolo AZ, Kunkel M, Zipse MM, Schuller J, Tompkins C, Rosenberg M, Nguyen DT, Cleveland JC, Fullerton D, Carroll JD, Messenger J, Sauer WH, Aleong RG, Tzou WS. Ambulatory Rhythm Monitoring to?Detect?Late High-Grade Atrioventricular Block Following Transcatheter Aortic?Valve?Replacement. J Am Coll Cardiol. 2019 05 28; 73(20):2538-2547. PMID: 31118148.
      View in: PubMed
    29. Marzec L, Raghavan S, Banaei-Kashani F, Creasy S, Melanson EL, Lange L, Ghosh D, Rosenberg MA. Device-measured physical activity data for classification of patients with ventricular arrhythmia events: A pilot investigation. PLoS One. 2018; 13(10):e0206153. PMID: 30372463.
      View in: PubMed
    30. Roselli C, Chaffin MD, Weng LC, Aeschbacher S, Ahlberg G, Albert CM, Almgren P, Alonso A, Anderson CD, Aragam KG, Arking DE, Barnard J, Bartz TM, Benjamin EJ, Bihlmeyer NA, Bis JC, Bloom HL, Boerwinkle E, Bottinger EB, Brody JA, Calkins H, Campbell A, Cappola TP, Carlquist J, Chasman DI, Chen LY, Chen YI, Choi EK, Choi SH, Christophersen IE, Chung MK, Cole JW, Conen D, Cook J, Crijns HJ, Cutler MJ, Damrauer SM, Daniels BR, Darbar D, Delgado G, Denny JC, Dichgans M, D?rr M, Dudink EA, Dudley SC, Esa N, Esko T, Eskola M, Fatkin D, Felix SB, Ford I, Franco OH, Geelhoed B, Grewal RP, Gudnason V, Guo X, Gupta N, Gustafsson S, Gutmann R, Hamsten A, Harris TB, Hayward C, Heckbert SR, Hernesniemi J, Hocking LJ, Hofman A, Horimoto ARVR, Huang J, Huang PL, Huffman J, Ingelsson E, Ipek EG, Ito K, Jimenez-Conde J, Johnson R, Jukema JW, K??b S, K?h?nen M, Kamatani Y, Kane JP, Kastrati A, Kathiresan S, Katschnig-Winter P, Kavousi M, Kessler T, Kietselaer BL, Kirchhof P, Kleber ME, Knight S, Krieger JE, Kubo M, Launer LJ, Laurikka J, Lehtim?ki T, Leineweber K, Lemaitre RN, Li M, Lim HE, Lin HJ, Lin H, Lind L, Lindgren CM, Lokki ML, London B, Loos RJF, Low SK, Lu Y, Lyytik?inen LP, Macfarlane PW, Magnusson PK, Mahajan A, Malik R, Mansur AJ, Marcus GM, Margolin L, Margulies KB, M?rz W, McManus DD, Melander O, Mohanty S, Montgomery JA, Morley MP, Morris AP, M?ller-Nurasyid M, Natale A, Nazarian S, Neumann B, Newton-Cheh C, Niemeijer MN, Nikus K, Nilsson P, Noordam R, Oellers H, Olesen MS, Orho-Melander M, Padmanabhan S, Pak HN, Par? G, Pedersen NL, Pera J, Pereira A, Porteous D, Psaty BM, Pulit SL, Pullinger CR, Rader DJ, Refsgaard L, Ribas?s M, Ridker PM, Rienstra M, Risch L, Roden DM, Rosand J, Rosenberg MA, Rost N, Rotter JI, Saba S, Sandhu RK, Schnabel RB, Schramm K, Schunkert H, Schurman C, Scott SA, Sepp?l? I, Shaffer C, Shah S, Shalaby AA, Shim J, Shoemaker MB, Siland JE, Sinisalo J, Sinner MF, Slowik A, Smith AV, Smith BH, Smith JG, Smith JD, Smith NL, Soliman EZ, Sotoodehnia N, Stricker BH, Sun A, Sun H, Svendsen JH, Tanaka T, Tanriverdi K, Taylor KD, Teder-Laving M, Teumer A, Th?riault S, Trompet S, Tucker NR, Tveit A, Uitterlinden AG, Van Der Harst P, Van Gelder IC, Van Wagoner DR, Verweij N, Vlachopoulou E, V?lker U, Wang B, Weeke PE, Weijs B, Weiss R, Weiss S, Wells QS, Wiggins KL, Wong JA, Woo D, Worrall BB, Yang PS, Yao J, Yoneda ZT, Zeller T, Zeng L, Lubitz SA, Lunetta KL, Ellinor PT. Multi-ethnic genome-wide association study for atrial fibrillation. Nat Genet. 2018 06 11; 50(9):1225-1233. PMID: 29892015.
      View in: PubMed
    31. Rosenberg MA, Shores MM, Matsumoto AM, Bu?kov? P, Lange LA, Kronmal RA, Heckbert SR, Mukamal KJ. Serum androgens and risk of atrial fibrillation in older men: The Cardiovascular Health Study. Clin Cardiol. 2018 Jun; 41(6):830-836. PMID: 29671886.
      View in: PubMed
    32. Rosenberg MA, Lubitz SA, Lin H, Kosova G, Castro VM, Huang P, Ellinor PT, Perlis RH, Newton-Cheh C. Validation of Polygenic Scores for QT Interval in Clinical Populations. Circ Cardiovasc Genet. 2017 Oct; 10(5). PMID: 28986454.
      View in: PubMed
    33. Roetker NS, Armasu SM, Pankow JS, Lutsey PL, Tang W, Rosenberg MA, Palmer TM, MacLehose RF, Heckbert SR, Cushman M, de Andrade M, Folsom AR. Taller height as a risk factor for venous thromboembolism: a Mendelian randomization meta-analysis. J Thromb Haemost. 2017 07; 15(7):1334-1343. PMID: 28445597.
      View in: PubMed
    34. Strauss DG, Vicente J, Johannesen L, Blinova K, Mason JW, Weeke P, Behr ER, Roden DM, Woosley R, Kosova G, Rosenberg MA, Newton-Cheh C. Common Genetic Variant Risk Score Is Associated With Drug-Induced QT Prolongation and Torsade de Pointes Risk: A Pilot Study. Circulation. 2017 04 04; 135(14):1300-1310. PMID: 28213480.
      View in: PubMed
    35. Karas MG, Yee LM, Biggs ML, Djouss? L, Mukamal KJ, Ix JH, Zieman SJ, Siscovick DS, Gottdiener JS, Rosenberg MA, Kronmal RA, Heckbert SR, Kizer JR. Measures of Body Size and Composition and Risk of Incident Atrial Fibrillation in Older People: The Cardiovascular Health Study. Am J Epidemiol. 2016 06 01; 183(11):998-1007. PMID: 27188936.
      View in: PubMed
    36. Levine YC, Matos J, Rosenberg MA, Manning WJ, Josephson ME, Buxton AE. Left ventricular sphericity independently predicts appropriate implantable cardioverter-defibrillator therapy. Heart Rhythm. 2016 Feb; 13(2):490-7. PMID: 26409099.
      View in: PubMed
    37. Levine YC, Tuttle MK, Rosenberg MA, Goldberg R, Matos J, Samuel M, Kramer DB, Buxton AE. Prevalence and outcomes of patients receiving implantable cardioverter-defibrillators for primary prevention not based on guidelines. Am J Cardiol. 2015 Jun 01; 115(11):1539-44. PMID: 25840578.
      View in: PubMed
    38. Rosenberg MA, Kaplan RC, Siscovick DS, Psaty BM, Heckbert SR, Newton-Cheh C, Mukamal KJ. Genetic variants related to height and risk of atrial fibrillation: the cardiovascular health study. Am J Epidemiol. 2014 Jul 15; 180(2):215-22. PMID: 24944287.
      View in: PubMed
    39. Levine YC, Rosenberg MA, Mittleman M, Samuel M, Methachittiphan N, Link M, Josephson ME, Buxton AE. B-type natriuretic peptide is a major predictor of ventricular tachyarrhythmias. Heart Rhythm. 2014 Jul; 11(7):1109-16. PMID: 24837348.
      View in: PubMed
    40. North BJ, Rosenberg MA, Jeganathan KB, Hafner AV, Michan S, Dai J, Baker DJ, Cen Y, Wu LE, Sauve AA, van Deursen JM, Rosenzweig A, Sinclair DA. SIRT2 induces the checkpoint kinase BubR1 to increase lifespan. EMBO J. 2014 Jul 01; 33(13):1438-53. PMID: 24825348.
      View in: PubMed
    41. Rosenberg MA, Gandhavadi M, Tan AY. To the editor--Spontaneous conversion of a long RP to short RP tachycardia: what is the mechanism? Heart Rhythm. 2014 Jun; 11(6):E5. PMID: 24726976.
      View in: PubMed
    42. Rosenberg MA, Maziarz M, Tan AY, Glazer NL, Zieman SJ, Kizer JR, Ix JH, Djousse L, Siscovick DS, Heckbert SR, Mukamal KJ. Circulating fibrosis biomarkers and risk of atrial fibrillation: The Cardiovascular Health Study (CHS). Am Heart J. 2014 May; 167(5):723-8.e2. PMID: 24766983.
      View in: PubMed
    43. Rosenberg MA, Lopez FL, Bu?kov? P, Adabag S, Chen LY, Sotoodehnia N, Kronmal RA, Siscovick DS, Alonso A, Buxton A, Folsom AR, Mukamal KJ. Height and risk of sudden cardiac death: the Atherosclerosis Risk in Communities and Cardiovascular Health studies. Ann Epidemiol. 2014 Mar; 24(3):174-179.e2. PMID: 24360853.
      View in: PubMed
    44. Tan AY, Rosenberg MA. LOWERING THE RISK FOR THROMBUS AND STROKE IN ATRIAL FIBRILLATION PATIENTS: Will Dabigatran Replace Warfarin? Clin Med Rev Vasc Health. 2013 Jun 20; 5:1-8. PMID: 25253992.
      View in: PubMed
    45. Rosenberg MA, Samuel M, Thosani A, Zimetbaum PJ. Use of a noninvasive continuous monitoring device in the management of atrial fibrillation: a pilot study. Pacing Clin Electrophysiol. 2013 Mar; 36(3):328-33. PMID: 23240827.
      View in: PubMed
    46. Rosenberg MA, Manning WJ. Diastolic dysfunction and risk of atrial fibrillation: a mechanistic appraisal. Circulation. 2012 Nov 06; 126(19):2353-62. PMID: 23129702.
      View in: PubMed
    47. Rosenberg MA, Patton KK, Sotoodehnia N, Karas MG, Kizer JR, Zimetbaum PJ, Chang JD, Siscovick D, Gottdiener JS, Kronmal RA, Heckbert SR, Mukamal KJ. The impact of height on the risk of atrial fibrillation: the Cardiovascular Health Study. Eur Heart J. 2012 Nov; 33(21):2709-17. PMID: 22977225.
      View in: PubMed
    48. Rosenberg MA, Mukamal KJ. The Estimated Risk of Atrial Fibrillation Related to Alcohol Consumption. J Atr Fibrillation. 2012 Jun-Jul; 5(1):424. PMID: 28496744.
      View in: PubMed
    49. Rosenberg MA, Das S, Quintero Pinzon P, Knight AC, Sosnovik DE, Ellinor PT, Rosenzweig A. A Novel Transgenic Mouse Model of Cardiac Hypertrophy and Atrial Fibrillation. J Atr Fibrillation. 2012 Feb-Mar; 4(5):415. PMID: 28496713.
      View in: PubMed
    50. Rosenberg MA, Gottdiener JS, Heckbert SR, Mukamal KJ. Echocardiographic diastolic parameters and risk of atrial fibrillation: the Cardiovascular Health Study. Eur Heart J. 2012 Apr; 33(7):904-12. PMID: 21990265.
      View in: PubMed
    51. Astapova I, Vella KR, Ramadoss P, Holtz KA, Rodwin BA, Liao XH, Weiss RE, Rosenberg MA, Rosenzweig A, Hollenberg AN. The nuclear receptor corepressor (NCoR) controls thyroid hormone sensitivity and the set point of the hypothalamic-pituitary-thyroid axis. Mol Endocrinol. 2011 Feb; 25(2):212-24. PMID: 21239618.
      View in: PubMed
    52. Song X, Kusakari Y, Xiao CY, Kinsella SD, Rosenberg MA, Scherrer-Crosbie M, Hara K, Rosenzweig A, Matsui T. mTOR attenuates the inflammatory response in cardiomyocytes and prevents cardiac dysfunction in pathological hypertrophy. Am J Physiol Cell Physiol. 2010 Dec; 299(6):C1256-66. PMID: 20861467.
      View in: PubMed
    53. Morissette MR, Cook SA, Buranasombati C, Rosenberg MA, Rosenzweig A. Myostatin inhibits IGF-I-induced myotube hypertrophy through Akt. Am J Physiol Cell Physiol. 2009 Nov; 297(5):C1124-32. PMID: 19759331.
      View in: PubMed
    54. Morissette MR, Stricker JC, Rosenberg MA, Buranasombati C, Levitan EB, Mittleman MA, Rosenzweig A. Effects of myostatin deletion in aging mice. Aging Cell. 2009 Sep; 8(5):573-83. PMID: 19663901.
      View in: PubMed
    55. Noseworthy PA, Rosenberg MA, Fifer MA, Palacios IF, Lowry PA, Ruskin JN, Sanborn DM, Picard MH, Vlahakes GJ, Mela T, Das S. Ventricular arrhythmia following alcohol septal ablation for obstructive hypertrophic cardiomyopathy. Am J Cardiol. 2009 Jul 01; 104(1):128-32. PMID: 19576333.
      View in: PubMed
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