Colorado PROFILES, The Colorado Clinical and Translational Sciences Institute (CCTSI)
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Last Name
Institution

Katy E Trinkley

TitleAssociate Professor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-FM General Operations
Phone303/724-6563

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    K23HL161352     (TRINKLEY, KATY E)Sep 1, 2022 - Aug 31, 2027
    NIH
    Personalizing Clinical Decision Support for Heart Failure Treatment to Clinicians' Needs
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Trinkley KE, Simon ST, Rosenberg MA. Impact of an Alert-Based Inpatient Clinical Decision Support Tool to Prevent Drug-Induced Long QT Syndrome: Large-Scale, System-Wide Observational Study. J Med Internet Res. 2025 Apr 14; 27:e68256. PMID: 40228236.
      View in: PubMed
    2. Pittman JOE, Lindamer L, Almklov E, Glasgow RE, Huebschmann AG, Trinkley KE, Huynh B, Rabin BA. Development of a pragmatic measure for the Practical, Robust Implementation and Sustainability Model. Psychol Serv. 2025 Apr 10. PMID: 40208716.
      View in: PubMed
    3. Faro JM, Obermiller E, Obermiller C, Trinkley KE, Wright G, Sadasivam RS, Foley KL, Cutrona SL, Houston TK. Using routinely available electronic health record data elements to develop and validate a digital divide risk score. JAMIA Open. 2025 Feb; 8(1):ooaf004. PMID: 39906363.
      View in: PubMed
    4. Ho PM, Glorioso TJ, Allen LA, Blankenhorn R, Glasgow RE, Grunwald GK, Khanna A, Magid DJ, Marrs JC, Novins-Montague S, Orlando S, Peterson P, Plomondon ME, Sandy LM, Saseen JJ, Trinkley KE, Vaughn S, Waughtal J, Bull S. Personalized Patient Data and Behavioral Nudges to Improve Adherence to Chronic Cardiovascular Medications: A Randomized Pragmatic Trial. JAMA. 2025 01 07; 333(1):49-59. PMID: 39621340.
      View in: PubMed
    5. Sommers SW, Tolle HJ, Trinkley KE, Johnston CG, Dietsche CL, Eldred SV, Wick AT, Hoppe JA. Clinical Decision Support to Increase Emergency Department Naloxone Coprescribing: Implementation Report. JMIR Med Inform. 2024 Nov 06; 12:e58276. PMID: 39504560.
      View in: PubMed
    6. Bosic-Reiniger J, Martin JL, Brown KE, Anderson HD, Blackburn H, Kao DP, Trinkley KE, Woodahl EL, Aquilante CL. Barriers and facilitators of the use of clinical informatics resources to facilitate pharmacogenomic implementation in resource-limited settings. JAMIA Open. 2024 Dec; 7(4):ooae101. PMID: 39399271.
      View in: PubMed
    7. Trinkley KE, Maw AM, Torres CH, Huebschmann AG, Glasgow RE. Applying Implementation Science to Advance Electronic Health Record-Driven Learning Health Systems: Case Studies, Challenges, and Recommendations. J Med Internet Res. 2024 Oct 07; 26:e55472. PMID: 39374069.
      View in: PubMed
    8. Glasgow RE, Trinkley KE, Ford B, Rabin BA. The Application and Evolution of the Practical, Robust Implementation and Sustainability Model (PRISM): History and Innovations. Glob Implement Res Appl. 2024; 4(4):404-420. PMID: 39568619.
      View in: PubMed
    9. Lipsey J, Allen LA, Page RL, Helmkamp LJ, Venechuk G, Trinkley KE, Matlock DD, McIlvennan CK. Association of multimorbidity with guideline-directed medical therapy intensification in heart failure: Findings from the EPIC-HF trial. Heliyon. 2024 Jul 15; 10(13):e34178. PMID: 39071594.
      View in: PubMed
    10. Johnson JK, Sullivan JL, Trinkley KE, Lapin B, Passek S, Asp V, Ford B, Rabin BA. Use of the iPRISM webtool in a learning community to assess implementation context and fit of a novel clinical decision support tool for physical therapy triage in acute care hospitals. PM R. 2024 Jun 27. PMID: 38934486.
      View in: PubMed
    11. Simon ST, Lin M, Trinkley KE, Aleong R, Rafaels N, Crooks KR, Reiter MJ, Gignoux CR, Rosenberg MA. A polygenic risk score for the QT interval is an independent predictor of drug-induced QT prolongation. PLoS One. 2024; 19(6):e0303261. PMID: 38885227.
      View in: PubMed
    12. Aquilante CL, Trinkley KE, Lee YM, Crooks KR, Hearst EC, Heckman SM, Hess KW, Kudron EL, Martin JL, Swartz CT, Kao DP. Implementation of clopidogrel pharmacogenetic clinical decision support for a preemptive return of results program. Am J Health Syst Pharm. 2024 Jun 11; 81(12):555-562. PMID: 38253063.
      View in: PubMed
    13. Trinkley KE, An R, Maw AM, Glasgow RE, Brownson RC. Leveraging artificial intelligence to advance implementation science: potential opportunities and cautions. Implement Sci. 2024 02 21; 19(1):17. PMID: 38383393.
      View in: PubMed
    14. Maw AM, Trinkley KE, Glasgow RE. The Role of Pragmatic Implementation Science Methods in Achieving Equitable and Effective Use of Artificial Intelligence in Healthcare. J Gen Intern Med. 2024 May; 39(7):1242-1244. PMID: 38172408.
      View in: PubMed
    15. Lowe RN, Wright G, Olivas L, Teel C, Suresh K, Macke LB, Sieja A, Rosenberg MA, Trinkley KE. Evaluating the prescribing and monitoring of medications associated with QTc-prolongation in the ambulatory care setting. J Eval Clin Pract. 2024 04; 30(3):385-392. PMID: 38073034.
      View in: PubMed
    16. Trinkley KE, Wright G, Allen LA, Bennett TD, Glasgow RE, Hale G, Heckman S, Huebschmann AG, Kahn MG, Kao DP, Lin CT, Malone DC, Matlock DD, Wells L, Wysocki V, Zhang S, Suresh K. Sustained Effect of Clinical Decision Support for Heart Failure: A Natural Experiment Using Implementation Science. Appl Clin Inform. 2023 10; 14(5):822-832. PMID: 37852249.
      View in: PubMed
    17. Trinkley KE, Glasgow RE, D'Mello S, Fort MP, Ford B, Rabin BA. The iPRISM webtool: an interactive tool to pragmatically guide the iterative use of the Practical, Robust Implementation and Sustainability Model in public health and clinical settings. Implement Sci Commun. 2023 Sep 19; 4(1):116. PMID: 37726860.
      View in: PubMed
    18. Shakowski C, Page Ii RL, Wright G, Lunowa C, Marquez C, Suresh K, Allen LA, Glasgow RE, Lin CT, Wick A, Trinkley KE. Comparative effectiveness of generic commercial versus locally customized clinical decision support tools to reduce prescription of nonsteroidal anti-inflammatory drugs for patients with heart failure. J Am Med Inform Assoc. 2023 08 18; 30(9):1516-1525. PMID: 37352404.
      View in: PubMed
    19. Kim R, Suresh K, Rosenberg MA, Tan MS, Malone DC, Allen LA, Kao DP, Anderson HD, Tiwari P, Trinkley KE. A machine learning evaluation of patient characteristics associated with prescribing of guideline-directed medical therapy for heart failure. Front Cardiovasc Med. 2023; 10:1169574. PMID: 37416920.
      View in: PubMed
    20. Trinkley KE, Dafoe A, Malone DC, Allen LA, Huebschmann A, Khazanie P, Lunowa C, Matlock DC, Suresh K, Rosenberg MA, Swat SA, Sosa A, Morris MA. Clinician challenges to evidence-based prescribing for heart failure and reduced ejection fraction: A qualitative evaluation. J Eval Clin Pract. 2023 12; 29(8):1363-1371. PMID: 37335624.
      View in: PubMed
    21. Callahan TJ, Stefanski AL, Wyrwa JM, Zeng C, Ostropolets A, Banda JM, Baumgartner WA, Boyce RD, Casiraghi E, Coleman BD, Collins JH, Deakyne Davies SJ, Feinstein JA, Lin AY, Martin B, Matentzoglu NA, Meeker D, Reese J, Sinclair J, Taneja SB, Trinkley KE, Vasilevsky NA, Williams AE, Zhang XA, Denny JC, Ryan PB, Hripcsak G, Bennett TD, Haendel MA, Robinson PN, Hunter LE, Kahn MG. Ontologizing health systems data at scale: making translational discovery a reality. NPJ Digit Med. 2023 May 19; 6(1):89. PMID: 37208468.
      View in: PubMed
    22. Simon ST, Trinkley KE, Malone DC, Rosenberg MA. Interpretable Machine Learning Prediction of Drug-Induced QT Prolongation: Electronic Health Record Analysis. J Med Internet Res. 2022 12 01; 24(12):e42163. PMID: 36454608.
      View in: PubMed
    23. Trinkley KE, Ho PM, Glasgow RE, Huebschmann AG. How Dissemination and Implementation Science Can Contribute to the Advancement of Learning Health Systems. Acad Med. 2022 10 01; 97(10):1447-1458. PMID: 35796045.
      View in: PubMed
    24. Kuo GM, Trinkley KE, Rabin B. Research and Scholarly Methods: Implementation Science Studies. J Am Coll Clin Pharm. 2022 Sep; 5(9):995-1004. PMID: 36212610.
      View in: PubMed
    25. Huebschmann AG, Trinkley KE, Gritz M, Glasgow RE. Pragmatic considerations and approaches for measuring staff time as an implementation cost in health systems and clinics: key issues and applied examples. Implement Sci Commun. 2022 Apr 15; 3(1):44. PMID: 35428326.
      View in: PubMed
    26. Maten N, Kroehl ME, Loeb DF, Bhat S, Ota T, Billups SJ, Schilling LM, Heckman S, Reingardt C, Trinkley KE. An evaluation of clinical decision support tools for Patient Health Questionnaire-9 administration. Ment Health Clin. 2021 Sep; 11(5):267-273. PMID: 34621601.
      View in: PubMed
    27. Kluemper A, Heath L, Loeb D, Kroehl M, Trinkley K. Depression-related stigma among primary care providers. Ment Health Clin. 2021 May; 11(3):175-180. PMID: 34026392.
      View in: PubMed
    28. Trinkley KE, Kroehl ME, Kahn MG, Allen LA, Bennett TD, Hale G, Haugen H, Heckman S, Kao DP, Kim J, Matlock DM, Malone DC, Page Nd RL, Stine J, Suresh K, Wells L, Lin CT. Applying Clinical Decision Support Design Best Practices With the Practical Robust Implementation and Sustainability Model Versus Reliance on Commercially Available Clinical Decision Support Tools: Randomized Controlled Trial. JMIR Med Inform. 2021 Mar 22; 9(3):e24359. PMID: 33749610.
      View in: PubMed
    29. Trinkley KE, Pell JM, Martinez DD, Maude NR, Hale G, Rosenberg MA. Assessing Prescriber Behavior with a Clinical Decision Support Tool to Prevent Drug-Induced Long QT Syndrome. Appl Clin Inform. 2021 01; 12(1):190-197. PMID: 33694143.
      View in: PubMed
    30. Derington CG, King JB, Delate T, Botts SR, Kroehl M, Kao DP, Trinkley KE. Twice-daily versus once-daily lisinopril and losartan for hypertension: Real-world effectiveness and safety. PLoS One. 2020; 15(12):e0243371. PMID: 33270787.
      View in: PubMed
    31. Allen LA, Venechuk G, McIlvennan CK, Page RL, Knoepke CE, Helmkamp LJ, Khazanie P, Peterson PN, Pierce K, Harger G, Thompson JS, Dow TJ, Richards L, Huang J, Strader JR, Trinkley KE, Kao DP, Magid DJ, Buttrick PM, Matlock DD. An Electronically Delivered Patient-Activation Tool for Intensification of Medications for Chronic Heart Failure With Reduced Ejection Fraction: The EPIC-HF Trial. Circulation. 2021 02 02; 143(5):427-437. PMID: 33201741.
      View in: PubMed
    32. Trinkley KE, Kahn MG, Allen LA, Haugen H, Kroehl ME, Lin CT, Malone DC, Matlock DD. Patient Treatment Preferences for Heart Failure Medications: A Mixed Methods Study. Patient Prefer Adherence. 2020; 14:2225-2230. PMID: 33204073.
      View in: PubMed
    33. Trinkley KE, Kahn MG, Bennett TD, Glasgow RE, Haugen H, Kao DP, Kroehl ME, Lin CT, Malone DC, Matlock DD. Integrating the Practical Robust Implementation and Sustainability Model With Best Practices in Clinical Decision Support Design: Implementation Science Approach. J Med Internet Res. 2020 10 29; 22(10):e19676. PMID: 33118943.
      View in: PubMed
    34. Venechuk GE, Khazanie P, Page RL, Knoepke CE, Helmkamp LJ, Peterson PN, Pierce K, Thompson JS, Huang J, Strader JR, Dow TJ, Richards L, Trinkley KE, Kao DP, McIlvennan CK, Magid DJ, Buttrick PM, Matlock DD, Allen LA. An Electronically delivered, Patient-activation tool for Intensification of medications for Chronic Heart Failure with reduced ejection fraction: Rationale and design of the EPIC-HF trial. Am Heart J. 2020 11; 229:144-155. PMID: 32866454.
      View in: PubMed
    35. Arbet J, Brokamp C, Meinzen-Derr J, Trinkley KE, Spratt HM. Lessons and tips for designing a machine learning study using EHR data. J Clin Transl Sci. 2020 Jul 24; 5(1):e21. PMID: 33948244.
      View in: PubMed
    36. Bhat S, Derington CG, Trinkley KE. Clinicians' Values and Preferences for Medication Adherence and Cost Clinical Decision Support in Primary Care: A Qualitative Study. Appl Clin Inform. 2020 05; 11(3):405-414. PMID: 32492717.
      View in: PubMed
    37. Aquilante CL, Kao DP, Trinkley KE, Lin CT, Crooks KR, Hearst EC, Hess SJ, Kudron EL, Lee YM, Liko I, Lowery J, Mathias RA, Monte AA, Rafaels N, Rioth MJ, Roberts ER, Taylor MR, Williamson C, Barnes KC. Clinical implementation of pharmacogenomics via a health system-wide research biobank: the University of Colorado experience. Pharmacogenomics. 2020 04; 21(6):375-386. PMID: 32077359.
      View in: PubMed
    38. Kao DP, Trinkley KE, Lin CT. Heart?Failure Management Innovation Enabled by Electronic Health Records. JACC Heart Fail. 2020 03; 8(3):223-233. PMID: 31926853.
      View in: PubMed
    39. Derington CG, Gums TH, Bress AP, Herrick JS, Greene TH, Moran AE, Weintraub WS, Kronish IM, Morisky DE, Trinkley KE, Saseen JJ, Reynolds K, Bates JT, Berlowitz DR, Chang TI, Chonchol M, Cushman WC, Foy CG, Herring CT, Katz LA, Krousel-Wood M, Pajewski NM, Tamariz L, King JB. Association of Total Medication Burden With Intensive and Standard Blood Pressure Control and Clinical Outcomes: A Secondary Analysis of SPRINT. Hypertension. 2019 Aug; 74(2):267-275. PMID: 31256717.
      View in: PubMed
    40. Bhat S, Kroehl M, Maniga B, Navarro A, Thompson AM, Lam HM, Trinkley KE. Patient Outreaches for Clinical Pharmacy Services: A Population Health Management Program Assessment. J Pharm Pract. 2021 Feb; 34(1):58-63. PMID: 31238771.
      View in: PubMed
    41. Bhat S, Kroehl M, Yi WM, Jaeger J, Thompson AM, Lam HM, Loeb D, Trinkley KE. Factors influencing the acceptance of referrals for clinical pharmacist managed disease states in primary care. J Am Pharm Assoc (2003). 2019 May - Jun; 59(3):336-342. PMID: 30948239.
      View in: PubMed
    42. Trinkley KE, Blakeslee WW, Matlock DD, Kao DP, Van Matre AG, Harrison R, Larson CL, Kostman N, Nelson JA, Lin CT, Malone DC. Clinician preferences for computerised clinical decision support for medications in primary care: a focus group study. BMJ Health Care Inform. 2019 Apr; 26(1):0. PMID: 31039120.
      View in: PubMed
    43. Yang M, Loeb DF, Sprowell AJ, Trinkley KE. Design and Implementation of a Depression Registry for Primary Care. Am J Med Qual. 2019 Jan/Feb; 34(1):59-66. PMID: 30008227.
      View in: PubMed
    44. Trinkley KE, Anderson HD, Nair KV, Malone DC, Saseen JJ. Assessing the incidence of acidosis in patients receiving metformin with and without risk factors for lactic acidosis. Ther Adv Chronic Dis. 2018 Sep; 9(9):179-190. PMID: 30181847.
      View in: PubMed
    45. Trinkley KE, Sturm AM, Porter K, Nahata MC. Efficacy and Safety of Atypical Antipsychotics for Behavioral and Psychological Symptoms of Dementia Among Community Dwelling Adults. J Pharm Pract. 2020 Feb; 33(1):7-14. PMID: 29695193.
      View in: PubMed
    46. Bhat S, Kroehl ME, Trinkley KE, Chow Z, Heath LJ, Billups SJ, Loeb DF. Evaluation of a Clinical Pharmacist-Led Multidisciplinary Antidepressant Telemonitoring Service in the Primary Care Setting. Popul Health Manag. 2018 10; 21(5):366-372. PMID: 29211661.
      View in: PubMed
    47. Sturm AS, Trinkley KE, Porter K, Nahata MC. Efficacy and safety of atypical antipsychotics for behavioral symptoms of dementia among patients residing in long-term care. Int J Clin Pharm. 2018 Feb; 40(1):135-142. PMID: 29189977.
      View in: PubMed
    48. Zeleznikar EA, Kroehl ME, Perica KM, Thompson AM, Trinkley KE. Integration of Community Pharmacists in Transition of Care (TOC) Services: Current Trends and Pharmacist Perceptions. J Pharm Pract. 2019 Feb; 32(1):28-35. PMID: 29061080.
      View in: PubMed
    49. Norman JL, Kroehl ME, Lam HM, Lewis CL, Mitchell CN, O'Bryant CL, Trinkley KE. Implementation of a pharmacist-managed clinic for patients with chronic nonmalignant pain. Am J Health Syst Pharm. 2017 Aug 15; 74(16):1229-1235. PMID: 28790075.
      View in: PubMed
    50. Truong H, Kroehl ME, Lewis C, Pettigrew R, Bennett M, Saseen JJ, Trinkley KE. Clinical pharmacists in primary care: Provider satisfaction and perceived impact on quality of care provided. SAGE Open Med. 2017; 5:2050312117713911. PMID: 28638617.
      View in: PubMed
    51. Tsai T, Kroehl ME, Smith SM, Thompson AM, Dai IY, Trinkley KE. Efficacy and safety of twice- vs once-daily dosing of lisinopril for hypertension. J Clin Hypertens (Greenwich). 2017 Sep; 19(9):868-873. PMID: 28439946.
      View in: PubMed
    52. Trinkley KE, Weed HG, Beatty SJ, Porter K, Nahata MC. Identification and Characterization of Adverse Drug Events in Primary Care. Am J Med Qual. 2017 Sep/Oct; 32(5):518-525. PMID: 27561696.
      View in: PubMed
    53. Trinkley KE, Malone DC, Nelson JA, Saseen JJ. Prescribing attitudes, behaviors and opinions regarding metformin for patients with diabetes: a focus group study. Ther Adv Chronic Dis. 2016 Sep; 7(5):220-8. PMID: 27583122.
      View in: PubMed
    54. Furbish SML, Kroehl ME, Loeb DF, Lam HM, Lewis CL, Nelson J, Chow Z, Trinkley KE. A Pharmacist-Physician Collaboration to Optimize Benzodiazepine Use for Anxiety and Sleep Symptom Control in Primary Care. J Pharm Pract. 2017 Aug; 30(4):425-433. PMID: 27480874.
      View in: PubMed
    55. Trinkley KE, Van Matre ET, Mueller SW, Page RL, Nair K. Perceived Benefit of Teaching Patient Safety to Pharmacy Students by Integrating Classroom Teaching With Introductory (IPPE) Visits. J Pharm Pract. 2017 Feb; 30(1):115-120. PMID: 26519253.
      View in: PubMed
    56. Skiba DJ, Barton AJ, Estes K, Gilliam E, Knapfel S, Lee C, Moore G, Trinkley K. Preparing the Next Generation of Advanced Practice Nurses for Connected Care. Stud Health Technol Inform. 2016; 225:307-13. PMID: 27332212.
      View in: PubMed
    57. Trinkley KE, Sill BE, Porter K, Nahata MC. Prescribing Patterns for Outpatient Treatment of Constipation, Irritable Bowel Syndrome-Related Constipation, and Opioid-Induced Constipation: A Retrospective Cross-Sectional Study. J Manag Care Spec Pharm. 2015 Nov; 21(11):1077-87. PMID: 26521119.
      View in: PubMed
    58. Goldberg T, Kroehl ME, Suddarth KH, Trinkley KE. Variations in Metformin Prescribing for Type 2 Diabetes. J Am Board Fam Med. 2015 Nov-Dec; 28(6):777-84. PMID: 26546654.
      View in: PubMed
    59. Smith SM, Hasan M, Huebschmann AG, Penaloza R, Schorr-Ratzlaff W, Sieja A, Roscoe N, Trinkley KE. Physician Acceptance of a Physician-Pharmacist Collaborative Treatment Model for Hypertension Management in Primary Care. J Clin Hypertens (Greenwich). 2015 Sep; 17(9):686-91. PMID: 26032586.
      View in: PubMed
    60. VanderWeide LA, Smith SM, Trinkley KE. A systematic review of the efficacy of venlafaxine for the treatment of fibromyalgia. J Clin Pharm Ther. 2015 Feb; 40(1):1-6. PMID: 25294655.
      View in: PubMed
    61. Trinkley KE, Nahata MC. Medication management of irritable bowel syndrome. Digestion. 2014; 89(4):253-67. PMID: 24992947.
      View in: PubMed
    62. Trinkley KE, Nikels SM, Page RL, Joy MS. Automating and estimating glomerular filtration rate for dosing medications and staging chronic kidney disease. Int J Gen Med. 2014; 7:211-8. PMID: 24833913.
      View in: PubMed
    63. Skiba DJ, Barton AJ, Knapfel S, Moore G, Trinkley K. Infusing informatics into interprofessional education: the iTEAM (Interprofessional Technology Enhanced Advanced practice Model) project. Stud Health Technol Inform. 2014; 201:55-62. PMID: 24943525.
      View in: PubMed
    64. Trinkley KE, Page RL, Lien H, Yamanouye K, Tisdale JE. QT interval prolongation and the risk of torsades de pointes: essentials for clinicians. Curr Med Res Opin. 2013 Dec; 29(12):1719-26. PMID: 24020938.
      View in: PubMed
    65. Smith SM, Meyer M, Trinkley KE. Phentermine/topiramate for the treatment of obesity. Ann Pharmacother. 2013 Mar; 47(3):340-9. PMID: 23482732.
      View in: PubMed
    66. Nuffer W, Smith SM, Trinkley K. Integrating virtual reality to expand the public health role of community pharmacists. J Am Pharm Assoc (2003). 2013 Mar-Apr; 53(2):152-8. PMID: 23571622.
      View in: PubMed
    67. Trinkley KE, Nahata MC. Treatment of irritable bowel syndrome. J Clin Pharm Ther. 2011 Jun; 36(3):275-82. PMID: 21545610.
      View in: PubMed
    68. Nahata MC, Trinkley KE. Opioid doses and increased risk for overdose. Ann Intern Med. 2010 Jul 06; 153(1):59; author reply 59-60. PMID: 20621907.
      View in: PubMed
    69. Trinkley KE, Porter K, Nahata MC. Prescribing patterns for the outpatient treatment of constipation in the United States. Dig Dis Sci. 2010 Dec; 55(12):3514-20. PMID: 20397053.
      View in: PubMed
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