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Search Results to Paul Buehler

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Buehler, Paul

One or more keywords matched the following items that are connected to Buehler, Paul

Item Type	Name
Academic Article	Free hemoglobin induction of pulmonary vascular disease: evidence for an inflammatory mechanism.
Academic Article	Mixed S-nitrosylated polymerized bovine hemoglobin species moderate hemodynamic effects in acutely hypoxic rats.
Concept	Hemoglobin A
Concept	Hemoglobins
Academic Article	Structural and functional characterization of glutaraldehyde-polymerized bovine hemoglobin and its isolated fractions.
Academic Article	Hemoglobin-based oxygen carriers: From mechanisms of toxicity and clearance to rational drug design.
Academic Article	Structural basis of peroxide-mediated changes in human hemoglobin: a novel oxidative pathway.
Academic Article	Sequestration of extracellular hemoglobin within a haptoglobin complex decreases its hypertensive and oxidative effects in dogs and guinea pigs.
Academic Article	Peroxidase activity of hemoglobin towards ascorbate and urate: a synergistic protective strategy against toxicity of Hemoglobin-Based Oxygen Carriers (HBOC).
Academic Article	Differential induction of renal heme oxygenase and ferritin in ascorbate and nonascorbate producing species transfused with modified cell-free hemoglobin.
Academic Article	Synthesis and characterization of a novel DTPA polymerized hemoglobin based oxygen carrier.
Academic Article	Acellular haemoglobin attenuates hypoxia-inducible factor-1alpha (HIF-1alpha) and its target genes in haemodiluted rats.
Academic Article	Blood aging, safety, and transfusion: capturing the "radical" menace.
Academic Article	Structural stabilization in tetrameric or polymeric hemoglobin determines its interaction with endogenous antioxidant scavenger pathways.
Academic Article	CD163 is the macrophage scavenger receptor for native and chemically modified hemoglobins in the absence of haptoglobin.
Academic Article	The reaction of hydrogen peroxide with hemoglobin induces extensive alpha-globin crosslinking and impairs the interaction of hemoglobin with endogenous scavenger pathways.
Academic Article	First-generation blood substitutes: what have we learned? Biochemical and physiological perspectives.
Academic Article	Gating the radical hemoglobin to macrophages: the anti-inflammatory role of CD163, a scavenger receptor.
Academic Article	Effects of endogenous ascorbate on oxidation, oxygenation, and toxicokinetics of cell-free modified hemoglobin after exchange transfusion in rat and guinea pig.
Academic Article	Functional comparison of hemoglobin purified by different methods and their biophysical implications.
Academic Article	Hemolysis and free hemoglobin revisited: exploring hemoglobin and hemin scavengers as a novel class of therapeutic proteins.
Academic Article	Toxicities of hemoglobin solutions: in search of in-vitro and in-vivo model systems.
Academic Article	Synthesis, biophysical properties and pharmacokinetics of ultrahigh molecular weight tense and relaxed state polymerized bovine hemoglobins.
Academic Article	Down selection of polymerized bovine hemoglobins for use as oxygen releasing therapeutics in a guinea pig model.
Academic Article	Haptoglobin preserves the CD163 hemoglobin scavenger pathway by shielding hemoglobin from peroxidative modification.
Academic Article	Oxygen sensing in the circulation: "cross talk" between red blood cells and the vasculature.
Academic Article	Hemoglobin-driven pathophysiology is an in vivo consequence of the red blood cell storage lesion that can be attenuated in guinea pigs by haptoglobin therapy.
Academic Article	Synthesis, biophysical properties, and oxygenation potential of variable molecular weight glutaraldehyde-polymerized bovine hemoglobins with low and high oxygen affinity.
Academic Article	Chemical characterization of diaspirin cross-linked hemoglobin polymerized with poly(ethylene glycol).
Academic Article	Ascorbate removes key precursors to oxidative damage by cell-free haemoglobin in vitro and in vivo.
Academic Article	Haptoglobin preferentially binds ? but not a subunits cross-linked hemoglobin tetramers with minimal effects on ligand and redox reactions.
Academic Article	All hemoglobin-based oxygen carriers are not created equally.
Academic Article	O-raffinose crosslinked hemoglobin lacks site-specific chemistry in the central cavity: structural and functional consequences of beta93Cys modification.
Academic Article	Haptoglobin binding stabilizes hemoglobin ferryl iron and the globin radical on tyrosine ?145.
Academic Article	Modeling hemoglobin and hemoglobin:haptoglobin complex clearance in a non-rodent species-pharmacokinetic and therapeutic implications.
Academic Article	Human Hp1-1 and Hp2-2 phenotype-specific haptoglobin therapeutics are both effective in vitro and in guinea pigs to attenuate hemoglobin toxicity.
Academic Article	Quantitative mass spectrometry defines an oxidative hotspot in hemoglobin that is specifically protected by haptoglobin.
Academic Article	Hemoglobin-induced lung vascular oxidation, inflammation, and remodeling contribute to the progression of hypoxic pulmonary hypertension and is attenuated in rats with repeated-dose haptoglobin administration.
Academic Article	Polynitroxyl hemoglobin: a pharmacokinetic study of covalently bound nitroxides to hemoglobin platforms.
Academic Article	Spin trapping combined with quantitative mass spectrometry defines free radical redistribution within the oxidized hemoglobin:haptoglobin complex.
Academic Article	Different target specificities of haptoglobin and hemopexin define a sequential protection system against vascular hemoglobin toxicity.
Academic Article	Hemoglobin can attenuate hydrogen peroxide-induced oxidative stress by acting as an antioxidative peroxidase.
Academic Article	Cell-free hemoglobin and its scavenger proteins: new disease models leading the way to targeted therapies.
Academic Article	Extracellular Hb enhances cardiac toxicity in endotoxemic guinea pigs: protective role of haptoglobin.
Academic Article	Sodium nitrite potentiates renal oxidative stress and injury in hemoglobin exposed guinea pigs.
Academic Article	Hemoglobin induced cell trauma indirectly influences endothelial TLR9 activity resulting in pulmonary vascular smooth muscle cell activation.
Academic Article	Transcriptional Suppression of Renal Antioxidant Enzyme Systems in Guinea Pigs Exposed to Polymerized Cell-Free Hemoglobin.
Academic Article	The quaternary state of polymerized human hemoglobin regulates oxygenation of breast cancer solid tumors: A theoretical and experimental study.
Academic Article	Phenotype-specific recombinant haptoglobin polymers co-expressed with C1r-like protein as optimized hemoglobin-binding therapeutics.
Academic Article	Impact of cell-free hemoglobin on contracting skeletal muscle microvascular oxygen pressure dynamics.
Academic Article	Iron accelerates hemoglobin oxidation increasing mortality in vascular diseased guinea pigs following transfusion of stored blood.
Academic Article	Depletion of haptoglobin and hemopexin promote hemoglobin-mediated lipoprotein oxidation in sickle cell disease.
Academic Article	Renal Toxicodynamic Effects of Extracellular Hemoglobin After Acute Exposure.
Academic Article	Redox states of hemoglobin determine left ventricle pressure recovery and activity of mitochondrial complex IV in hypoxic rat hearts.
Academic Article	An Hb-mediated circulating macrophage contributing to pulmonary vascular remodeling in sickle cell disease.
Academic Article	Haptoglobin administration into the subarachnoid space prevents hemoglobin-induced cerebral vasospasm.
Academic Article	Novel manufacturing method for producing apohemoglobin and its biophysical properties.

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Hemoglobins