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Search Results to Melanie G. Cree

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Cree, Melanie

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Polycystic Ovary Syndrome

overview

I am interested in how insulin resistance affects the reproductive axis, risk for diabetes and liver health. As an MD, PhD with clinical training in pediatric endocrinology and research training in human physiology, I perform translational work in youth with endocrine disorders using stable isotope tracers, magnetic resonance spectroscopy and mathematical modeling. In particular, I am challenged by the extent of insulin resistance-related co-morbidities in girls with polycystic ovary syndrome, including a 21 fold increased risk of type 2 diabetes, common pre-diabetes and >50% with elevated liver fat. My overall goal is to improve the long term health for adolescents with polycystic ovary syndrome or type 2 diabetes and to perform work to inform clinical trials for new therapeutic strategies.

One or more keywords matched the following items that are connected to Cree, Melanie

Item Type	Name
Academic Article	Peripheral insulin resistance in obese girls with hyperandrogenism is related to oxidative phosphorylation and elevated serum free fatty acids.
Academic Article	Hepatic Steatosis is Common in Adolescents with Obesity and PCOS and Relates to De Novo Lipogenesis but not Insulin Resistance.
Academic Article	Obese adolescents with polycystic ovarian syndrome have elevated cardiovascular disease risk markers.
Academic Article	Worldwide Dissatisfaction With the Diagnostic Process and Initial Treatment of PCOS.
Academic Article	Using simple clinical measures to predict insulin resistance or hyperglycemia in girls with polycystic ovarian syndrome.
Grant	Influence of peripheral insulin resistance and hepatic lipogenesis on liver fat in obese PCOS girls
Academic Article	Amino acid and fatty acid metabolomic profile during fasting and hyperinsulinemia in girls with polycystic ovarian syndrome.
Academic Article	Morning Circadian Misalignment Is Associated With Insulin Resistance in Girls With Obesity and Polycystic Ovarian Syndrome.
Academic Article	A simple method to monitor hepatic gluconeogenesis and triglyceride synthesis following oral sugar tolerance test in obese adolescents.
Academic Article	Use of Successive Pharmacologic Hormone Suppression Testing for a Severe Presentation of Adolescent Polycystic Ovarian Syndrome: A Case Report.
Grant	Mechanism of insulin resistance in girls with polycystic ovary disease
Academic Article	Clinical prediction score of nonalcoholic fatty liver disease in adolescent girls with polycystic ovary syndrome (PCOS-HS index).
Academic Article	Editoral commentary: Understanding cardiovascular disease risk in women with polycystic ovary syndrome.
Academic Article	Poor Sleep Is Related to Metabolic Syndrome Severity in Adolescents With PCOS and Obesity.
Academic Article	Obese Adolescents With PCOS Have Altered Biodiversity and Relative Abundance in Gastrointestinal Microbiota.
Academic Article	Obesity and Insulin Resistance, Not Polycystic Ovary Syndrome, Are Independent Predictors of Bone Mineral Density in Adolescents and Young Women.
Academic Article	Good agreement between hyperinsulinemic-euglycemic clamp and 2 hours oral minimal model assessed insulin sensitivity in adolescents.
Academic Article	Depression in Girls With Obesity and Polycystic Ovary Syndrome and/or Type 2 Diabetes.
Academic Article	Application of a Standard Cross-Specialty Workup for Diagnosis and Metabolic Screening of Obese Adolescents With Polycystic Ovary Syndrome.
Academic Article	Twelve-month Continuation of the Etonogestrel Implant in Adolescents With Polycystic Ovary Syndrome.
Grant	Impact of GLP-1 on Hepatic Fat and Energy Utilization in Obese Girls with Polycystic Ovarian Syndrome
Academic Article	Hepatic steatosis relates to gastrointestinal microbiota changes in obese girls with polycystic ovary syndrome.
Academic Article	Racial and Ethnic Differences in Metabolic Disease in Adolescents With Obesity and Polycystic Ovary Syndrome.
Academic Article	Care for Adolescents With Polycystic Ovary Syndrome: Development and Prescribing Patterns of a Multidisciplinary Clinic.
Academic Article	Development of type 2 diabetes in adolescent girls with polycystic ovary syndrome and obesity.
Academic Article	Weight Management in Adolescents with Polycystic Ovary Syndrome.
Academic Article	Pancreatic fat relates to fasting insulin and postprandial lipids but not polycystic ovary syndrome in adolescents with obesity.
Academic Article	11-Oxyandrogens in Adolescents With Polycystic Ovary Syndrome.
Academic Article	Combined Oral Contraceptive Treatment Does Not Alter the Gut Microbiome but Affects Amino Acid Metabolism in Sera of Obese Girls With Polycystic Ovary Syndrome.
Grant	Role of semaglutide in restoring ovulation in youth and adults with polycystic ovary syndrome
Academic Article	Metabolic effects of an essential amino acid supplement in adolescents with PCOS and obesity.
Academic Article	Distinct Reproductive Phenotypes Segregate With Differences in Body Weight in Adolescent Polycystic Ovary Syndrome.
Academic Article	Comprehensive transition of care for polycystic ovary syndrome from adolescence to adulthood.

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Ovary