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Search Results to Melanie G. Cree

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Cree, Melanie

One or more keywords matched the following properties of Cree, Melanie

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non-alcoholic fatty liver disease

overview

I am interested in how insulin resistance affects the reproductive axis, risk for diabetes and liver health. As an MD, PhD with clinical training in pediatric endocrinology and research training in human physiology, I perform translational work in youth with endocrine disorders using stable isotope tracers, magnetic resonance spectroscopy and mathematical modeling. In particular, I am challenged by the extent of insulin resistance-related co-morbidities in girls with polycystic ovary syndrome, including a 21 fold increased risk of type 2 diabetes, common pre-diabetes and >50% with elevated liver fat. My overall goal is to improve the long term health for adolescents with polycystic ovary syndrome or type 2 diabetes and to perform work to inform clinical trials for new therapeutic strategies.

One or more keywords matched the following items that are connected to Cree, Melanie

Item Type	Name
Academic Article	Intrahepatic fat is increased in the neonatal offspring of obese women with gestational diabetes.
Concept	Liver
Concept	Fatty Liver
Academic Article	Hepatic Steatosis is Common in Adolescents with Obesity and PCOS and Relates to De Novo Lipogenesis but not Insulin Resistance.
Academic Article	Clinical workup of fatty liver for the primary care provider.
Academic Article	Youth with type 2 diabetes have hepatic, peripheral, and adipose insulin resistance.
Grant	Influence of peripheral insulin resistance and hepatic lipogenesis on liver fat in obese PCOS girls
Academic Article	Intramuscular and liver triglycerides are increased in the elderly.
Academic Article	Amino acid supplementation decreases plasma and liver triacylglycerols in elderly.
Academic Article	Mixed muscle and hepatic derived plasma protein metabolism is differentially regulated in older and younger men following resistance exercise.
Academic Article	Insulin sensitivity and mitochondrial function are improved in children with burn injury during a randomized controlled trial of fenofibrate.
Academic Article	Amino acid and fatty acid metabolomic profile during fasting and hyperinsulinemia in girls with polycystic ovarian syndrome.
Concept	Non-alcoholic Fatty Liver Disease
Academic Article	Metformin Improves Peripheral Insulin Sensitivity in Youth With Type 1 Diabetes.
Academic Article	A simple method to monitor hepatic gluconeogenesis and triglyceride synthesis following oral sugar tolerance test in obese adolescents.
Grant	Comparison of in-vivo and ex-vivo measures of mitochondrial flux in non-alcoholic fatty liver disease across the lifespan
Grant	Non-invasive assessment of liver glucose metabolism in obese girls
Academic Article	Clinical prediction score of nonalcoholic fatty liver disease in adolescent girls with polycystic ovary syndrome (PCOS-HS index).
Academic Article	Advances in stable isotope tracer methodology part 1: hepatic metabolism via isotopomer analysis and postprandial lipolysis modeling.
Academic Article	Nonalcoholic fatty liver disease in obese adolescent females is associated with multi-tissue insulin resistance and visceral adiposity markers.
Grant	Impact of GLP-1 on Hepatic Fat and Energy Utilization in Obese Girls with Polycystic Ovarian Syndrome
Academic Article	Hepatic steatosis relates to gastrointestinal microbiota changes in obese girls with polycystic ovary syndrome.
Academic Article	Liver Fat Reduction After Gastric Banding and Associations with Changes in Insulin Sensitivity and ?-Cell Function.

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Liver