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overview Dr. Kenneth Liechty is a Pediatric and Fetal Surgeon. His research has been focused primarily in the field of wound healing and regenerative medicine, with an emphasis on elucidating the mechanisms involved in the regenerative response to injury in the fetus, the role of stem cells in tissue repair, and the correction of abnormal healing in the adult. His team has contributed significantly to the understanding of regenerative healing in the skin and tendon, as well as the correction of impaired healing in diabetics. Dr. Liechty’s research team has pioneered the role of dysregulation of microRNAs in the diabetic wound healing impairment and the mechanisms of stem cell and gene therapy in the correction of this impairment. He and his team are developing novel treatment paradigms using stem cells and gene therapy strategies to promote healing and tissue regeneration in multiple tissues by modulating the inflammatory response, angiogenesis, the composition of the extracellular matrix, and the progenitor cell content. The goal of this regenerative medicine approach is to restore normal tissue architecture and function and to prevent the complications of impaired healing or scar formation following injury.

One or more keywords matched the following items that are connected to Liechty, Ken

Item TypeName
Concept Hematopoietic Stem Cells
Concept Hematopoietic Stem Cell Transplantation
Concept Stem Cell Factor
Concept Mesenchymal Stem Cell Transplantation
Concept Stem Cell Transplantation
Concept Adult Stem Cells
Concept Multipotent Stem Cells
Concept Stem Cells
Academic Article Production of granulocyte colony-stimulating factor in vitro by monocytes from preterm and term neonates.
Academic Article Human mesenchymal stem cells engraft and demonstrate site-specific differentiation after in utero transplantation in sheep.
Academic Article Stromal progenitor cell therapy corrects the wound-healing defect in the ischemic rabbit ear model of chronic wound repair.
Academic Article Prenatal transplantation of cytokine-stimulated marrow improves early chimerism in a resistant strain combination but results in poor long-term engraftment.
Academic Article Administration of erythropoietin to newborn rats results in diminished neutrophil production.
Academic Article The role of microRNA-146a in the pathogenesis of the diabetic wound-healing impairment: correction with mesenchymal stem cell treatment.
Academic Article Mammalian cardiac regeneration after fetal myocardial infarction requires cardiac progenitor cell recruitment.
Academic Article Stromal progenitor cells promote leukocyte migration through production of stromal-derived growth factor 1alpha: a potential mechanism for stromal progenitor cell-mediated enhancement of cellular recruitment to wounds.
Academic Article Effects of interleukin-6 on fetal hematopoietic progenitors.
Academic Article Multiple strategies must be pursued in the development of cellular therapies.
Academic Article Multipotent adult progenitor cells: their role in wound healing and the treatment of dermal wounds.
Academic Article Effect of recombinant stem cell factor on clonogenic maturation and cycle status of human fetal hematopoietic progenitors.
Academic Article Possible mechanisms accounting for the growth factor independence of hematopoietic progenitors from umbilical cord blood.
Academic Article The role of microRNA-15b in the impaired angiogenesis in diabetic wounds.
Academic Article SCF increases in utero-labeled stem cells migration and improves wound healing.
Academic Article Mechanisms of mesenchymal stem cell correction of the impaired biomechanical properties of diabetic skin: The role of miR-29a.
Academic Article Cardiac Progenitor Cell Recruitment Drives Fetal Cardiac Regeneration by Enhanced Angiogenesis.
Academic Article Mesenchymal stem cells correct impaired diabetic wound healing by decreasing ECM proteolysis.
Academic Article Mesenchymal stromal cells contract collagen more efficiently than dermal fibroblasts: Implications for cytotherapy.

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