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Search Results to Hatim Sabaawy

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One or more keywords matched the following properties of Sabaawy, Hatim

keywords Gene Therapy
keywords Molecular Targeted Therapy
keywords Targeted Molecular Therapies
keywords Cell Therapy
overview A translation-focused investigator specializing in developmental therapeutics, correlative science, and precision medicine, with 15+ years of continuous NIH and federal funding. Research is focused on identifying novel therapeutic paradigms to enhance self-renewal, in stem cells and organoids for regeneration, and inhibit tumor self-renewal, in cancer stem-like cells (CSCs), for targeting cancer cell plasticity. Our team utilizes genetic reporters to develop first-in-class inhibitors to target CSCs and discover novel immune modulatory activities using organoids, PDXs or genetically engineered mouse models (GEMMs), guided by spacial profiling and single cell-derived organoids. The novel patient derived organoid (PDO) technology has been recently licensed to make it easier for many laboratories to utilize it for developing predictive biomarkers, optimized readouts for drug responses, and effective medical paradigms with personalized medicine. I work with my colleagues at the Cancer Center leadership team to serve as Associate Director for Translational Research, and Director of Personalized Medicine at the Division Medical Oncology. My role is to ensure that translational research relevant to Colorado cancer patients is conducted and facilitate the translation of laboratory findings, including agents, technologies, and treatment strategies, into investigator-initiated trials (IITs), with emphasis on personalized and combined therapy. I am deeply committed to translating basic research to the clinic, translating clinical findings back to basic research, and reducing disparities in cancer outcomes in low-income and under-represented minority patients and patients from rural CO. In a key initiative, I am leading a new precision medicine program for systematic use of tissue biopsies for generation of 1) precision diagnostics (Dx) (with single cell and spacial multiomic assays) to provide unparalleled depth and richness of spatially-intact, scientific- and clinical-grade, single cell signatures from tumor biopsies, and 2) precision therapeutics (Tx) with PDO drug testing and high throughput screening, that promise to offer life-saving treatments and fuel new discoveries for health, diseases, and data science.

One or more keywords matched the following items that are connected to Sabaawy, Hatim

Item TypeName
Concept Exercise Therapy
Concept Genetic Therapy
Concept Treatment Outcome
Concept Combined Modality Therapy
Concept Cell- and Tissue-Based Therapy
Academic Article Effects of MTX-23, a Novel PROTAC of Androgen Receptor Splice Variant-7 and Androgen Receptor, on CRPC Resistant to Second-Line Antiandrogen Therapy.
Academic Article Minimally manipulated autologous adherent bone marrow cells (ABMCs): a promising cell therapy of spinal cord injury.
Academic Article Utility of Glioblastoma Patient-Derived Orthotopic Xenografts in Drug Discovery and Personalized Therapy.
Academic Article Therapeutic compounds
Academic Article JAK/STAT of all trades: linking inflammation with cancer development, tumor progression and therapy resistance.
Academic Article Patient derived organoids in prostate cancer: improving therapeutic efficacy in precision medicine.
Award or Honor Receipt Current Awareness in Biomedicine
Grant Sox9 signaling in lung adenocarcinoma
Grant TEL-AML1 Transgenic Zebrafish Model of Human Leukemia
Grant Targeting the BMI1 oncogene mRNA using small molecules
Grant Role of shox2 in zebrafish otic neuron development
Grant The IMPACT of prostate cancer stem cell therapy
Grant Discovery and therapeutic targeting of biological determinants of lung cancer health disparities
Grant Therapeutic role of inhibitors eliminating prostate tumor stem cells
Academic Article Radiosensitization of Primary Human Glioblastoma Stem-like Cells with Low-Dose AKT Inhibition.
Academic Article Genome-wide alterations in gene expression of prostate cancer (PC) cells surviving neo-adjuvant androgen deprivation therapy.
Academic Article Human heme oxygenase-1 gene transfer lowers blood pressure and promotes growth in spontaneously hypertensive rats.
Academic Article Autologous bone marrow-derived cell therapy combined with physical therapy induces functional improvement in chronic spinal cord injury patients.
Academic Article Enhancement of 5-fluorouracil cytotoxicity on human colon cancer cells by retrovirus-mediated interferon-alpha gene transfer.
Academic Article
Academic Article Cartilage regeneration for treatment of osteoarthritis: a paradigm for nonsurgical intervention.
Academic Article Synergetic effects of retrovirus IFN-alpha gene transfer and 5-FU on apoptosis of colon cancer cells.
Academic Article Immunotherapy by autologous dendritic cell vaccine in patients with advanced HCC.

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  • Therapeutics

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