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Search Results to Joseph Falke

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Falke, Joseph

One or more keywords matched the following items that are connected to Falke, Joseph

Item Type	Name
Academic Article	The minimal structure containing the band 3 anion transport site. A 35Cl NMR study.
Academic Article	Lock on/off disulfides identify the transmembrane signaling helix of the aspartate receptor.
Academic Article	Transmembrane signaling by the aspartate receptor: engineered disulfides reveal static regions of the subunit interface.
Academic Article	Attractant- and disulfide-induced conformational changes in the ligand binding domain of the chemotaxis aspartate receptor: a 19F NMR study.
Academic Article	Novel ion specificity of a carboxylate cluster Mg(II) binding site: strong charge selectivity and weak size selectivity.
Academic Article	Kinetic tuning of the EF-hand calcium binding motif: the gateway residue independently adjusts (i) barrier height and (ii) equilibrium.
Academic Article	Activation of the phosphosignaling protein CheY. II. Analysis of activated mutants by 19F NMR and protein engineering.
Academic Article	Molecular mechanism of transmembrane signaling by the aspartate receptor: a model.
Academic Article	Tuning the equilibrium ion affinity and selectivity of the EF-hand calcium binding motif: substitutions at the gateway position.
Academic Article	Intermolecular tuning of calmodulin by target peptides and proteins: differential effects on Ca2+ binding and implications for kinase activation.
Academic Article	Molecular tuning of an EF-hand-like calcium binding loop. Contributions of the coordinating side chain at loop position 3.
Academic Article	The two-component signaling pathway of bacterial chemotaxis: a molecular view of signal transduction by receptors, kinases, and adaptation enzymes.
Academic Article	Identification of a site critical for kinase regulation on the central processing unit (CPU) helix of the aspartate receptor.
Academic Article	Molecular tuning of ion binding to calcium signaling proteins.
Academic Article	Detection of a conserved alpha-helix in the kinase-docking region of the aspartate receptor by cysteine and disulfide scanning.
Academic Article	Signaling domain of the aspartate receptor is a helical hairpin with a localized kinase docking surface: cysteine and disulfide scanning studies.
Academic Article	Attractant regulation of the aspartate receptor-kinase complex: limited cooperative interactions between receptors and effects of the receptor modification state.
Academic Article	Activation of the phosphosignaling protein CheY. I. Analysis of the phosphorylated conformation by 19F NMR and protein engineering.
Academic Article	BLAST 1995: international conference on bacterial locomotion and signal transduction.
Academic Article	C2 domains from different Ca2+ signaling pathways display functional and mechanistic diversity.
Academic Article	Use of 19F NMR to probe protein structure and conformational changes.
Academic Article	The C2 domain calcium-binding motif: structural and functional diversity.
Academic Article	Optimizing the metal binding parameters of an EF-hand-like calcium chelation loop: coordinating side chains play a more important tuning role than chelation loop flexibility.
Academic Article	Membrane orientation and position of the C2 domain from cPLA2 by site-directed spin labeling.
Academic Article	Cooperativity between bacterial chemotaxis receptors.
Academic Article	C2 domains of protein kinase C isoforms alpha, beta, and gamma: activation parameters and calcium stoichiometries of the membrane-bound state.
Academic Article	C2 domain of protein kinase C alpha: elucidation of the membrane docking surface by site-directed fluorescence and spin labeling.
Academic Article	Quantitative analysis of aspartate receptor signaling complex reveals that the homogeneous two-state model is inadequate: development of a heterogeneous two-state model.
Academic Article	Thermal motions of surface alpha-helices in the D-galactose chemosensory receptor. Detection by disulfide trapping.
Academic Article	Side chains at the membrane-water interface modulate the signaling state of a transmembrane receptor.
Academic Article	Adaptation mechanism of the aspartate receptor: electrostatics of the adaptation subdomain play a key role in modulating kinase activity.
Academic Article	Use of EPR power saturation to analyze the membrane-docking geometries of peripheral proteins: applications to C2 domains.
Academic Article	Conserved glycine residues in the cytoplasmic domain of the aspartate receptor play essential roles in kinase coupling and on-off switching.
Academic Article	Evidence that the adaptation region of the aspartate receptor is a dynamic four-helix bundle: cysteine and disulfide scanning studies.
Academic Article	Self-induced docking site of a deeply embedded peripheral membrane protein.
Academic Article	Calcium(II) site specificity: effect of size and charge on metal ion binding to an EF-hand-like site.
Academic Article	Use of site-directed cysteine and disulfide chemistry to probe protein structure and dynamics: applications to soluble and transmembrane receptors of bacterial chemotaxis.
Academic Article	Chemotaxis receptor complexes: from signaling to assembly.
Academic Article	The PICM chemical scanning method for identifying domain-domain and protein-protein interfaces: applications to the core signaling complex of E. coli chemotaxis.
Academic Article	Structure of the conserved HAMP domain in an intact, membrane-bound chemoreceptor: a disulfide mapping study.
Academic Article	Effect of PIP2 binding on the membrane docking geometry of PKC alpha C2 domain: an EPR site-directed spin-labeling and relaxation study.
Academic Article	Molecular mechanism of an oncogenic mutation that alters membrane targeting: Glu17Lys modifies the PIP lipid specificity of the AKT1 PH domain.
Academic Article	Thermal domain motions of CheA kinase in solution: Disulfide trapping reveals the motional constraints leading to trans-autophosphorylation.
Academic Article	Ion Channels within Ion Transport Proteins: Evidence in the Band 3 System.
Academic Article	The piston rises again.
Academic Article	Single molecule diffusion of membrane-bound proteins: window into lipid contacts and bilayer dynamics.
Academic Article	OS-FRET: a new one-sample method for improved FRET measurements.
Academic Article	Structure of a conserved receptor domain that regulates kinase activity: the cytoplasmic domain of bacterial taxis receptors.
Academic Article	Purification of proteins using polyhistidine affinity tags.
Academic Article	Quantitating and engineering the ion specificity of an EF-hand-like Ca2+ binding.
Academic Article	The GRP1 PH domain, like the AKT1 PH domain, possesses a sentry glutamate residue essential for specific targeting to plasma membrane PI(3,4,5)P(3).
Academic Article	Lipid targeting domain with dual-membrane specificity that expands the diversity of intracellular targeting reactions.
Academic Article	Structure of a bacterial sensory receptor. A site-directed sulfhydryl study.
Academic Article	A proton NMR study of the mechanism of the erythrocyte glucose transporter.
Academic Article	Membrane-docking loops of the cPLA2 C2 domain: detailed structural analysis of the protein-membrane interface via site-directed spin-labeling.
Academic Article	Large amplitude twisting motions of an interdomain hinge: a disulfide trapping study of the galactose-glucose binding protein.
Academic Article	Kinetic control of Ca(II) signaling: tuning the ion dissociation rates of EF-hand Ca(II) binding sites.
Academic Article	Effects of protein stabilizing agents on thermal backbone motions: a disulfide trapping study.
Academic Article	GRP1 pleckstrin homology domain: activation parameters and novel search mechanism for rare target lipid.
Academic Article	The kinetic cycle of cardiac troponin C: calcium binding and dissociation at site II trigger slow conformational rearrangements.
Academic Article	CheA Kinase of bacterial chemotaxis: chemical mapping of four essential docking sites.
Academic Article	Transmembrane signaling in bacterial chemoreceptors.
Academic Article	Mechanism of specific membrane targeting by C2 domains: localized pools of target lipids enhance Ca2+ affinity.
Academic Article	Bacterial chemoreceptors: high-performance signaling in networked arrays.
Academic Article	Single-molecule fluorescence studies of a PH domain: new insights into the membrane docking reaction.
Academic Article	The core signaling proteins of bacterial chemotaxis assemble to form an ultrastable complex.
Academic Article	Engineered socket study of signaling through a four-helix bundle: evidence for a yin-yang mechanism in the kinase control module of the aspartate receptor.
Academic Article	Membrane docking geometry and target lipid stoichiometry of membrane-bound PKCa C2 domain: a combined molecular dynamics and experimental study.
Academic Article	Isolated bacterial chemosensory array possesses quasi- and ultrastable components: functional links between array stability, cooperativity, and order.
Academic Article	Global flexibility in a sensory receptor: a site-directed cross-linking approach.
Academic Article	Defining a key receptor-CheA kinase contact and elucidating its function in the membrane-bound bacterial chemosensory array: a disulfide mapping and TAM-IDS Study.
Academic Article	The 3.2 ? resolution structure of a receptor: CheA:CheW signaling complex defines overlapping binding sites and key residue interactions within bacterial chemosensory arrays.
Concept	Archaeal Proteins
Concept	Adaptor Proteins, Signal Transducing
Concept	Monosaccharide Transport Proteins
Concept	Vesicular Transport Proteins
Concept	Membrane Proteins
Concept	Periplasmic Binding Proteins
Concept	Escherichia coli Proteins
Concept	ras Proteins
Concept	Bacterial Proteins
Concept	Recombinant Fusion Proteins
Concept	Calcium-Binding Proteins
Concept	Bacterial Outer Membrane Proteins
Concept	Carrier Proteins
Concept	Recombinant Proteins
Concept	rab5 GTP-Binding Proteins
Concept	Intracellular Signaling Peptides and Proteins
Concept	Blood Proteins
Concept	Nerve Tissue Proteins
Concept	Proto-Oncogene Proteins c-akt
Concept	Proteins
Academic Article	Lateral diffusion of peripheral membrane proteins on supported lipid bilayers is controlled by the additive frictional drags of (1) bound lipids and (2) protein domains penetrating into the bilayer hydrocarbon core.
Academic Article	Molecular mechanism of membrane binding of the GRP1 PH domain.
Academic Article	Structure, function, and on-off switching of a core unit contact between CheA kinase and CheW adaptor protein in the bacterial chemosensory array: A disulfide mapping and mutagenesis study.
Academic Article	New insights into bacterial chemoreceptor array structure and assembly from electron cryotomography.
Academic Article	Piston versus scissors: chemotaxis receptors versus sensor His-kinase receptors in two-component signaling pathways.
Academic Article	Increasing and decreasing the ultrastability of bacterial chemotaxis core signaling complexes by modifying protein-protein contacts.
Academic Article	Architecture and signal transduction mechanism of the bacterial chemosensory array: progress, controversies, and challenges.
Academic Article	Signaling and sensory adaptation in Escherichia coli chemoreceptors: 2015 update.
Academic Article	Regulation of PI3K by PKC and MARCKS: Single-Molecule Analysis of a Reconstituted Signaling Pathway.
Academic Article	Reprint of: Purification of Proteins Using Polyhistidine Affinity Tags.
Academic Article	Regulation of a Coupled MARCKS-PI3K Lipid Kinase Circuit by Calmodulin: Single-Molecule Analysis of a Membrane-Bound Signaling Module.
Grant	Acquisition of a Continuous Wave X-band EPR Spectrometer
Grant	MOLECULAR STUDIES OF CALCIUM BINDING AND SIGNALING
Grant	Membrane Proteins - Structure and Mechanism
Grant	SCIENTIFIC CONFERENCE--BLAST IV
Grant	Mechanisms of Signaling on Membrane Surfaces
Academic Article	Single-Molecule Study Reveals How Receptor and Ras Synergistically Activate PI3Ka and PIP3 Signaling.
Academic Article	A PKC-MARCKS-PI3K regulatory module links Ca2+ and PIP3 signals at the leading edge of polarized macrophages.
Concept	Methyl-Accepting Chemotaxis Proteins
Academic Article	The G-Protein Rab5A Activates VPS34 Complex II, a Class III PI3K, by a Dual Regulatory Mechanism.
Academic Article	Ras-guanine nucleotide complexes: A UV spectral deconvolution method to analyze protein concentration, nucleotide stoichiometry, and purity.
Academic Article	HPLC method to resolve, identify and quantify guanine nucleotides bound to recombinant ras GTPase.
Academic Article	Binding of active Ras and its mutants to the Ras binding domain of PI-3-kinase: A quantitative approach to KD measurements.

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