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Search Results to Joseph Falke

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Falke, Joseph

One or more keywords matched the following items that are connected to Falke, Joseph

Item Type	Name
Academic Article	Transmembrane signaling by the aspartate receptor: engineered disulfides reveal static regions of the subunit interface.
Academic Article	Attractant- and disulfide-induced conformational changes in the ligand binding domain of the chemotaxis aspartate receptor: a 19F NMR study.
Academic Article	Novel ion specificity of a carboxylate cluster Mg(II) binding site: strong charge selectivity and weak size selectivity.
Academic Article	Kinetic tuning of the EF-hand calcium binding motif: the gateway residue independently adjusts (i) barrier height and (ii) equilibrium.
Academic Article	Tuning the equilibrium ion affinity and selectivity of the EF-hand calcium binding motif: substitutions at the gateway position.
Academic Article	Identification of a site critical for kinase regulation on the central processing unit (CPU) helix of the aspartate receptor.
Academic Article	Cysteine and disulfide scanning reveals two amphiphilic helices in the linker region of the aspartate chemoreceptor.
Academic Article	Signaling domain of the aspartate receptor is a helical hairpin with a localized kinase docking surface: cysteine and disulfide scanning studies.
Academic Article	Attractant regulation of the aspartate receptor-kinase complex: limited cooperative interactions between receptors and effects of the receptor modification state.
Academic Article	C2 domains from different Ca2+ signaling pathways display functional and mechanistic diversity.
Academic Article	Optimizing the metal binding parameters of an EF-hand-like calcium chelation loop: coordinating side chains play a more important tuning role than chelation loop flexibility.
Academic Article	Ca2+-signaling cycle of a membrane-docking C2 domain.
Academic Article	Membrane orientation and position of the C2 domain from cPLA2 by site-directed spin labeling.
Academic Article	C2 domains of protein kinase C isoforms alpha, beta, and gamma: activation parameters and calcium stoichiometries of the membrane-bound state.
Academic Article	C2 domain of protein kinase C alpha: elucidation of the membrane docking surface by site-directed fluorescence and spin labeling.
Academic Article	19F NMR studies of the D-galactose chemosensory receptor. 2. Ca(II) binding yields a local structural change.
Academic Article	19F NMR studies of the D-galactose chemosensory receptor. 1. Sugar binding yields a global structural change.
Academic Article	Side chains at the membrane-water interface modulate the signaling state of a transmembrane receptor.
Academic Article	Ca2+ activation of the cPLA2 C2 domain: ordered binding of two Ca2+ ions with positive cooperativity.
Academic Article	Adaptation mechanism of the aspartate receptor: electrostatics of the adaptation subdomain play a key role in modulating kinase activity.
Academic Article	Conserved glycine residues in the cytoplasmic domain of the aspartate receptor play essential roles in kinase coupling and on-off switching.
Academic Article	Evidence that the adaptation region of the aspartate receptor is a dynamic four-helix bundle: cysteine and disulfide scanning studies.
Academic Article	Calcium(II) site specificity: effect of size and charge on metal ion binding to an EF-hand-like site.
Academic Article	Use of site-directed cysteine and disulfide chemistry to probe protein structure and dynamics: applications to soluble and transmembrane receptors of bacterial chemotaxis.
Academic Article	The PICM chemical scanning method for identifying domain-domain and protein-protein interfaces: applications to the core signaling complex of E. coli chemotaxis.
Academic Article	Structure of the conserved HAMP domain in an intact, membrane-bound chemoreceptor: a disulfide mapping study.
Academic Article	Effect of PIP2 binding on the membrane docking geometry of PKC alpha C2 domain: an EPR site-directed spin-labeling and relaxation study.
Academic Article	Molecular mechanism of an oncogenic mutation that alters membrane targeting: Glu17Lys modifies the PIP lipid specificity of the AKT1 PH domain.
Academic Article	Thermal domain motions of CheA kinase in solution: Disulfide trapping reveals the motional constraints leading to trans-autophosphorylation.
Academic Article	OS-FRET: a new one-sample method for improved FRET measurements.
Academic Article	Quantitating and engineering the ion specificity of an EF-hand-like Ca2+ binding.
Academic Article	The GRP1 PH domain, like the AKT1 PH domain, possesses a sentry glutamate residue essential for specific targeting to plasma membrane PI(3,4,5)P(3).
Academic Article	Assembly of membrane-bound protein complexes: detection and analysis by single molecule diffusion.
Academic Article	Hydrophobic contributions to the membrane docking of synaptotagmin 7 C2A domain: mechanistic contrast between isoforms 1 and 7.
Academic Article	Molecular mechanisms of band 3 inhibitors. 2. Channel blockers.
Academic Article	Membrane-docking loops of the cPLA2 C2 domain: detailed structural analysis of the protein-membrane interface via site-directed spin-labeling.
Academic Article	Large amplitude twisting motions of an interdomain hinge: a disulfide trapping study of the galactose-glucose binding protein.
Academic Article	Effects of protein stabilizing agents on thermal backbone motions: a disulfide trapping study.
Academic Article	GRP1 pleckstrin homology domain: activation parameters and novel search mechanism for rare target lipid.
Academic Article	Location of the membrane-docking face on the Ca2+-activated C2 domain of cytosolic phospholipase A2.
Academic Article	CheA Kinase of bacterial chemotaxis: chemical mapping of four essential docking sites.
Academic Article	Open conformation of a substrate-binding cleft: 19F NMR studies of cleft angle in the D-galactose chemosensory receptor.
Academic Article	Cation charge and size selectivity of the C2 domain of cytosolic phospholipase A(2).
Academic Article	Mapping out regions on the surface of the aspartate receptor that are essential for kinase activation.
Academic Article	Mechanism of specific membrane targeting by C2 domains: localized pools of target lipids enhance Ca2+ affinity.
Academic Article	The core signaling proteins of bacterial chemotaxis assemble to form an ultrastable complex.
Academic Article	Engineered socket study of signaling through a four-helix bundle: evidence for a yin-yang mechanism in the kinase control module of the aspartate receptor.
Academic Article	Isolated bacterial chemosensory array possesses quasi- and ultrastable components: functional links between array stability, cooperativity, and order.
Academic Article	Molecular mechanisms of band 3 inhibitors. 3. Translocation inhibitors.
Academic Article	Defining a key receptor-CheA kinase contact and elucidating its function in the membrane-bound bacterial chemosensory array: a disulfide mapping and TAM-IDS Study.
Academic Article	The 3.2 Å resolution structure of a receptor: CheA:CheW signaling complex defines overlapping binding sites and key residue interactions within bacterial chemosensory arrays.
Academic Article	Molecular mechanisms of band 3 inhibitors. 1. Transport site inhibitors.
Concept	Biochemistry
Academic Article	Structure, function, and on-off switching of a core unit contact between CheA kinase and CheW adaptor protein in the bacterial chemosensory array: A disulfide mapping and mutagenesis study.
Academic Article	The PH domain of phosphoinositide-dependent kinase-1 exhibits a novel, phospho-regulated monomer-dimer equilibrium with important implications for kinase domain activation: single-molecule and ensemble studies.
Academic Article	Single-molecule studies reveal a hidden key step in the activation mechanism of membrane-bound protein kinase C-a.
Academic Article	New insights into bacterial chemoreceptor array structure and assembly from electron cryotomography.
Academic Article	Increasing and decreasing the ultrastability of bacterial chemotaxis core signaling complexes by modifying protein-protein contacts.
Academic Article	Regulation of a Coupled MARCKS-PI3K Lipid Kinase Circuit by Calmodulin: Single-Molecule Analysis of a Membrane-Bound Signaling Module.
Grant	Interdisciplinary Predoctoral Training in Molecular Biophysics
Grant	Acquisition of a Continuous Wave X-band EPR Spectrometer

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Biochemistry