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Search Results to Colin Tucker Shearn

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Shearn, Colin

One or more keywords matched the following items that are connected to Shearn, Colin

Item Type	Name
Academic Article	Inhibition of hydrogen peroxide signaling by 4-hydroxynonenal due to differential regulation of Akt1 and Akt2 contributes to decreases in cell survival and proliferation in hepatocellular carcinoma cells.
Academic Article	Characterization of 4-HNE modified L-FABP reveals alterations in structural and functional dynamics.
Academic Article	Susceptibility of L-FABP-/- mice to oxidative stress in early-stage alcoholic liver.
Academic Article	4-Hydroxynonenal inhibits SIRT3 via thiol-specific modification.
Academic Article	Profiling impaired hepatic endoplasmic reticulum glycosylation as a consequence of ethanol ingestion.
Academic Article	Oxidative Stress and the ER Stress Response in a Murine Model for Early-Stage Alcoholic Liver Disease.
Concept	Liver Diseases
Concept	Liver Cirrhosis
Concept	Liver
Concept	Chemical and Drug Induced Liver Injury, Chronic
Concept	Liver Cirrhosis, Alcoholic
Concept	Fatty Liver
Concept	Liver Diseases, Alcoholic
Concept	Fatty Liver, Alcoholic
Concept	Mitochondria, Liver
Concept	Liver Neoplasms
Concept	Microsomes, Liver
Academic Article	Increased dietary fat contributes to dysregulation of the LKB1/AMPK pathway and increased damage in a mouse model of early-stage ethanol-mediated steatosis.
Academic Article	Phosphatase and tensin homolog deleted on chromosome 10 (PTEN) signaling regulates mitochondrial biogenesis and respiration via estrogen-related receptor a (ERRa).
Academic Article	Increased carbonylation of the lipid phosphatase PTEN contributes to Akt2 activation in a murine model of early alcohol-induced steatosis.
Academic Article	Short term feeding of a high fat diet exerts an additive effect on hepatocellular damage and steatosis in liver-specific PTEN knockout mice.
Academic Article	Identification of 5' AMP-activated kinase as a target of reactive aldehydes during chronic ingestion of high concentrations of ethanol.
Academic Article	Oxidative stress-mediated aldehyde adduction of GRP78 in a mouse model of alcoholic liver disease: functional independence of ATPase activity and chaperone function.
Academic Article	Understanding the tumor suppressor PTEN in chronic alcoholism and hepatocellular carcinoma.
Academic Article	Increased 4-hydroxynonenal protein adducts in male GSTA4-4/PPAR-a double knockout mice enhance injury during early stages of alcoholic liver disease.
Academic Article	Increased hepatocellular protein carbonylation in human end-stage alcoholic cirrhosis.
Academic Article	Deletion of GSTA4-4 results in increased mitochondrial post-translational modification of proteins by reactive aldehydes following chronic ethanol consumption in mice.
Academic Article	Liver-Specific Deletion of Phosphatase and Tensin Homolog Deleted on Chromosome 10 Significantly Ameliorates Chronic EtOH-Induced Increases in Hepatocellular Damage.
Academic Article	Aberrant post-translational protein modifications in the pathogenesis of alcohol-induced liver injury.
Academic Article	Nocturnal hypoxia-induced oxidative stress promotes progression of pediatric non-alcoholic fatty liver disease.
Grant	Regulation of PTEN in chronic alcohol mediated liver disease
Academic Article	Global Deletion of Glutathione S-Transferase A4 Exacerbates Developmental Nonalcoholic Steatohepatitis.
Academic Article	Hepatocyte Hyperproliferation upon Liver-Specific Co-disruption of Thioredoxin-1, Thioredoxin Reductase-1, and Glutathione Reductase.
Academic Article	Chronic Ethanol Metabolism Inhibits Hepatic Mitochondrial Superoxide Dismutase via Lysine Acetylation.
Academic Article	Differential carbonylation of proteins in end-stage human fatty and nonfatty NASH.
Academic Article	Taurine treatment prevents derangement of the hepatic ?-glutamyl cycle and methylglyoxal metabolism in a mouse model of classical homocystinuria: regulatory crosstalk between thiol and sulfinic acid metabolism.
Academic Article	Dysregulation of antioxidant responses in patients diagnosed with concomitant Primary Sclerosing Cholangitis/Inflammatory Bowel Disease.
Academic Article	Knockout of the Gsta4 Gene in Male Mice Leads to an Altered Pattern of Hepatic Protein Carbonylation and Enhanced Inflammation Following Chronic Consumption of an Ethanol Diet.
Academic Article	Role of Nutrition in Alcoholic Liver Disease: Summary of the Symposium at the ESBRA 2017 Congress.
Academic Article	Aberrant expression of redox regulatory proteins in patients with concomitant primary Sclerosing cholangitis/inflammatory bowel disease.
Academic Article	Elevated Nrf-2 responses are insufficient to mitigate protein carbonylation in hepatospecific PTEN deletion mice.
Academic Article	Quantifying Competition among Mitochondrial Protein Acylation Events Induced by Ethanol Metabolism.
Concept	End Stage Liver Disease
Concept	Non-alcoholic Fatty Liver Disease
Academic Article	TrxR1, Gsr, and oxidative stress determine hepatocellular carcinoma malignancy.
Academic Article	Lipid peroxidation derived reactive aldehydes in alcoholic liver disease.
Academic Article	Cholestatic liver disease results increased production of reactive aldehydes and an atypical periportal hepatic antioxidant response.
Academic Article	Supplemental Ascorbate Diminishes DNA Damage Yet Depletes Glutathione and Increases Acute Liver Failure in a Mouse Model of Hepatic Antioxidant System Disruption.
Academic Article	Identification of Dose-Dependent DNA Damage and Repair Responses From Subchronic Exposure to 1,4-Dioxane in Mice Using a Systems Analysis Approach.
Academic Article	Pharmacologic activation of hepatic farnesoid X receptor prevents parenteral nutrition-associated cholestasis in mice.
Academic Article	Thioredoxin reductase 1 regulates hepatic inflammation and macrophage activation during acute cholestatic liver injury.
Academic Article	The autophagic protein p62 is a target of reactive aldehydes in human and murine cholestatic liver disease.

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