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Search Results to Leslie Anne Leinwand

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Leinwand, Leslie

One or more keywords matched the following items that are connected to Leinwand, Leslie

Item Type	Name
Academic Article	Cloning and characterization of a nonmuscle myosin heavy chain cDNA.
Academic Article	Multigene family for sarcomeric myosin heavy chain in mouse and human DNA: localization on a single chromosome.
Academic Article	Cardiac alpha-myosin heavy chains differ in their induction of myocarditis. Identification of pathogenic epitopes.
Academic Article	Fast myosin heavy chains expressed in secondary mammalian muscle fibers at the time of their inception.
Academic Article	Three slow myosin heavy chains sequentially expressed in developing mammalian skeletal muscle.
Academic Article	Antibody-mediated autoimmune myocarditis depends on genetically determined target organ sensitivity.
Academic Article	Diversity of myosin-based motility: multiple genes and functions.
Academic Article	Behavior of genes directly injected into the rat heart in vivo.
Academic Article	Post-transcriptional regulation of rat alpha cardiac myosin heavy chain gene expression.
Academic Article	Rat liver fat-storing cell lines express sarcomeric myosin heavy chain mRNA and protein.
Academic Article	Sarcomeric myosin heavy chain expressed in nonmuscle cells forms thick filaments in the presence of substoichiometric amounts of light chains.
Academic Article	Distinct behavior of cardiac myosin heavy chain gene constructs in vivo. Discordance with in vitro results.
Academic Article	Prospects for gene therapy with direct injection of polynucleotides.
Academic Article	Isolation and characterization of human myosin heavy chain genes.
Academic Article	Mice expressing mutant myosin heavy chains are a model for familial hypertrophic cardiomyopathy.
Academic Article	The mammalian myosin heavy chain gene family.
Academic Article	A 29 residue region of the sarcomeric myosin rod is necessary for filament formation.
Academic Article	The vertebrate myosin heavy chain: genetics and assembly properties.
Academic Article	Direct gene transfer into the mouse heart.
Academic Article	Myosin heavy chains IIa and IId are functionally distinct in the mouse.
Academic Article	Sarcomeric gene expression and contractility in myofibroblasts.
Academic Article	Organization of the human skeletal myosin heavy chain gene cluster.
Academic Article	Functional analysis of a cardiac myosin rod in Dictyostelium discoideum.
Academic Article	Cardiac adaptations to chronic exercise in mice.
Academic Article	Organization of human and mouse skeletal myosin heavy chain gene clusters is highly conserved.
Academic Article	Cardiac myosin heavy chains lacking the light chain binding domain cause hypertrophic cardiomyopathy in mice.
Academic Article	Functional analysis of myosin missense mutations in familial hypertrophic cardiomyopathy.
Academic Article	Myosin heavy chain isoform expression in the failing and nonfailing human heart.
Academic Article	Spatial and temporal changes in myosin heavy chain gene expression in skeletal muscle development.
Academic Article	Inactivation of myosin heavy chain genes in the mouse: diverse and unexpected phenotypes.
Academic Article	Postnatal myosin heavy chain isoform expression in normal mice and mice null for IIb or IId myosin heavy chains.
Academic Article	Mutation of the IIB myosin heavy chain gene results in muscle fiber loss and compensatory hypertrophy.
Academic Article	Animal models of hypertrophic cardiomyopathy.
Academic Article	Modulation of myosin filament organization by C-protein family members.
Academic Article	Four sarcomeric myosin heavy chain genes are expressed by human fetal skeletal muscle cells differentiating in culture.
Academic Article	Progression from hypertrophic to dilated cardiomyopathy in mice that express a mutant myosin transgene.
Academic Article	Expression of connexin43 in the developing rat heart.
Academic Article	Different pathways regulate expression of the skeletal myosin heavy chain genes.
Academic Article	Cardiac and skeletal muscle adaptations to voluntary wheel running in the mouse.
Academic Article	Skeletal muscle adaptations in response to voluntary wheel running in myosin heavy chain null mice.
Academic Article	Growth and muscle defects in mice lacking adult myosin heavy chain genes.
Academic Article	Myosin heavy chain gene expression in human heart failure.
Academic Article	Effect of aging and hypertension on myosin biochemistry and gene expression in the rat heart.
Academic Article	Cell type specific targeted intracellular delivery into muscle of a monoclonal antibody that binds myosin IIb.
Academic Article	Functional analysis of myosin mutations that cause familial hypertrophic cardiomyopathy.
Academic Article	Yin Yang 1 is increased in human heart failure and represses the activity of the human alpha-myosin heavy chain promoter.
Academic Article	Myocyte enhancer factor-2 and serum response factor binding elements regulate fast Myosin heavy chain transcription in vivo.
Academic Article	Yin Yang 1 represses alpha-myosin heavy chain gene expression in pathologic cardiac hypertrophy.
Academic Article	Soy diet worsens heart disease in mice.
Academic Article	Exercise can prevent and reverse the severity of hypertrophic cardiomyopathy.
Academic Article	Expression of myosin and actin in Escherichia coli.
Academic Article	Diversity in transcriptional start site selection and alternative splicing affects the 5'-UTR of mouse striated muscle myosin transcripts.
Academic Article	Estimate of the abundance of cardiomyopathic mutations in the ?-myosin gene.
Academic Article	Mutations in the beta-myosin rod cause myosin storage myopathy via multiple mechanisms.
Academic Article	Mutations at the same amino acid in myosin that cause either skeletal or cardiac myopathy have distinct molecular phenotypes.
Academic Article	A mutation in the beta-myosin rod associated with hypertrophic cardiomyopathy has an unexpected molecular phenotype.
Academic Article	Functional diversity among a family of human skeletal muscle myosin motors.
Academic Article	Insights into human beta-cardiac myosin function from single molecule and single cell studies.
Academic Article	The role of MEKK1 in hypertrophic cardiomyopathy.
Academic Article	Expression of the beta (slow)-isoform of MHC in the adult mouse heart causes dominant-negative functional effects.
Academic Article	Full-length rat alpha and beta cardiac myosin heavy chain sequences. Comparisons suggest a molecular basis for functional differences.
Academic Article	Gender and aging in a transgenic mouse model of hypertrophic cardiomyopathy.
Academic Article	IIb or not IIb? Regulation of myosin heavy chain gene expression in mice and men.
Academic Article	Bacterial expression of eukaryotic contractile proteins.
Academic Article	Low sequence variation in the gene encoding the human beta-myosin heavy chain.
Academic Article	Ventricular myosin light chain 1 is developmentally regulated and does not change in hypertension.
Academic Article	The use of sarkosyl in generating soluble protein after bacterial expression.
Academic Article	Identification of functional differences between recombinant human a and ? cardiac myosin motors.
Academic Article	Expression and DNA sequence analysis of a human embryonic skeletal muscle myosin heavy chain gene.
Academic Article	Intracellular calcium and myosin isoform transitions. Calcineurin and calcium-calmodulin kinase pathways regulate preferential activation of the IIa myosin heavy chain promoter.
Academic Article	Myosin filament assembly requires a cluster of four positive residues located in the rod domain.
Academic Article	Complete nucleotide sequence of full length cDNA for rat alpha cardiac myosin heavy chain.
Academic Article	Complete nucleotide sequence of full length cDNA for rat beta cardiac myosin heavy chain.
Academic Article	Understanding cardiomyopathy phenotypes based on the functional impact of mutations in the myosin motor.
Academic Article	A polymorphic human myosin heavy chain locus is linked to an anonymous single copy locus (D17S1) at 17p13.
Academic Article	Coexpression and assembly of myosin heavy chain and myosin light chain in Escherichia coli.
Academic Article	Expression in Escherichia coli of a functional Dictyostelium myosin tail fragment.
Academic Article	Skeletal muscle adaptations to microgravity exposure in the mouse.
Academic Article	Type IIx myosin heavy chain transcripts are expressed in type IIb fibers of human skeletal muscle.
Academic Article	Skeletal myosin heavy chain function in cultured lung myofibroblasts.
Academic Article	Expression of cardiac troponin T with COOH-terminal truncation accelerates cross-bridge interaction kinetics in mouse myocardium.
Academic Article	Heterologous expression of a cardiomyopathic myosin that is defective in its actin interaction.
Academic Article	A murine model for hypertrophic cardiomyopathy.
Academic Article	The Ku protein complex interacts with YY1, is up-regulated in human heart failure, and represses alpha myosin heavy-chain gene expression.
Academic Article	Comparative sequence analysis of the complete human sarcomeric myosin heavy chain family: implications for functional diversity.
Academic Article	MyoD, Myf5, and the calcineurin pathway activate the developmental myosin heavy chain genes.
Academic Article	Cardiac troponin T mutations result in allele-specific phenotypes in a mouse model for hypertrophic cardiomyopathy.
Academic Article	COOH-terminal truncated human cardiac MyBP-C alters myosin filament organization.
Academic Article	Alterations in cardiac adrenergic signaling and calcium cycling differentially affect the progression of cardiomyopathy.
Academic Article	Blocking cardiac growth in hypertrophic cardiomyopathy induces cardiac dysfunction and decreased survival only in males.
Academic Article	Regulation of scallop myosin by mutant regulatory light chains.
Academic Article	Morphological and functional alterations in ventricular myocytes from male transgenic mice with hypertrophic cardiomyopathy.
Academic Article	Human nonmuscle myosin heavy chain mRNA: generation of diversity through alternative polyadenylylation.
Academic Article	Identification of sequences necessary for the association of cardiac myosin subunits.
Academic Article	Hormonal modulation of a gene injected into rat heart in vivo.
Academic Article	A beta1-adrenergic receptor CaM kinase II-dependent pathway mediates cardiac myocyte fetal gene induction.
Academic Article	GFP fails to inhibit actin-myosin interactions in vitro.
Academic Article	Thyroid hormone regulates expression of a transfected human alpha-myosin heavy-chain fusion gene in fetal rat heart cells.
Academic Article	Complete cDNA sequence of rat atrial myosin light chain 1: patterns of expression during development and with hypertension.
Academic Article	Generation of a full-length human perinatal myosin heavy-chain-encoding cDNA.
Academic Article	Characterization of diverse forms of myosin heavy chain expressed in adult human skeletal muscle.
Academic Article	Expression of actin in Escherichia coli. Aggregation, solubilization, and functional analysis.
Academic Article	Bioinformatics assessment of beta-myosin mutations reveals myosin's high sensitivity to mutations.
Academic Article	Cloning and characterization of the scallop essential and regulatory myosin light chain cDNAs.
Academic Article	Uncoupling of expression of an intronic microRNA and its myosin host gene by exon skipping.
Academic Article	Medicine. Chemically tuned myosin motors.
Academic Article	Molecular genetic characterization of a developmentally regulated human perinatal myosin heavy chain.
Academic Article	Interferon-? causes cardiac myocyte atrophy via selective degradation of myosin heavy chain in a model of chronic myocarditis.
Academic Article	Human cardiac myosin heavy chain genes and their linkage in the genome.
Academic Article	Myosin heavy chain is not selectively decreased in murine cancer cachexia.
Academic Article	Effects of pathogenic proline mutations on myosin assembly.
Academic Article	Myh7b/miR-499 gene expression is transcriptionally regulated by MRFs and Eos.
Academic Article	Erratum to: Identification of functional differences between recombinant human a and ? cardiac myosin motors.
Academic Article	Conserved protein domains in a myosin heavy chain gene from Dictyostelium discoideum.
Concept	Myosin Subfragments
Concept	Myosin-Light-Chain Kinase
Concept	Myosins
Concept	Ventricular Myosins
Concept	Myosin Heavy Chains
Concept	Myosin Light Chains
Concept	Skeletal Muscle Myosins
Concept	Myosin Type II
Concept	Cardiac Myosins
Concept	Nonmuscle Myosin Type IIB
Academic Article	Molecular consequences of the R453C hypertrophic cardiomyopathy mutation on human ?-cardiac myosin motor function.
Academic Article	The superfast human extraocular myosin is kinetically distinct from the fast skeletal IIa, IIb, and IId isoforms.
Academic Article	The hypertrophic cardiomyopathy myosin mutation R453C alters ATP binding and hydrolysis of human cardiac ?-myosin.
Academic Article	Sex-based differences in skeletal muscle kinetics and fiber-type composition.
Academic Article	Developmental myosins: expression patterns and functional significance.
Academic Article	Skip residues modulate the structural properties of the myosin rod and guide thick filament assembly.
Academic Article	Prolonged Cre expression driven by the a-myosin heavy chain promoter can be cardiotoxic.
Academic Article	Contractility parameters of human ?-cardiac myosin with the hypertrophic cardiomyopathy mutation R403Q show loss of motor function.
Academic Article	A small-molecule inhibitor of sarcomere contractility suppresses hypertrophic cardiomyopathy in mice.
Academic Article	The Most Prevalent Freeman-Sheldon Syndrome Mutations in the Embryonic Myosin Motor Share Functional Defects.
Academic Article	Two novel MYH7 proline substitutions cause Laing Distal Myopathy-like phenotypes with variable expressivity and neck extensor contracture.
Academic Article	Letter to the editor: Comments on Stuart et al. (2016): "Myosin content of individual human muscle fibers isolated by laser capture microdissection".
Grant	Molecular characterization of cardiomyopathy mutations in human cardiac myosin
Grant	Myosin Gene Diversity and Function
Grant	Developmental Myosin Heavy Chain Regulation and Function
Grant	IN VIVO MODELS OF CARDIAC GENE REGULATION
Grant	Mechanisms of myopathy caused by mutations in the myosin rod
Academic Article	Dilated cardiomyopathy myosin mutants have reduced force-generating capacity.
Academic Article	The ancient sarcomeric myosins found in specialized muscles.
Academic Article	Expression of Normally Repressed Myosin Heavy Chain 7b in the Mammalian Heart Induces Dilated Cardiomyopathy.
Academic Article	The ATPase cycle of human muscle myosin II isoforms: Adaptation of a single mechanochemical cycle for different physiological roles.
Academic Article	Myosin motor domains carrying mutations implicated in early or late onset hypertrophic cardiomyopathy have similar properties.
Academic Article	Associations Between Female Sex, Sarcomere Variants, and Clinical Outcomes in Hypertrophic Cardiomyopathy.
Academic Article	Myosin 7b is a regulatory long noncoding RNA (lncMYH7b) in the human heart.
Academic Article	Identification of sequence changes in myosin II that adjust muscle contraction velocity.
Academic Article	Nonproductive Splicing Prevents Expression of MYH7b Protein in the Mammalian Heart.
Academic Article	Targeting the sarcomere in inherited cardiomyopathies.
Academic Article	Drug specificity and affinity are encoded in the probability of cryptic pocket opening in myosin motor domains.
Academic Article	Functional divergence of the sarcomeric myosin, MYH7b, supports species-specific biological roles.
Academic Article	Distinct effects of two hearing loss-associated mutations in?the sarcomeric myosin MYH7b.
Academic Article	Homologous mutations in ?, embryonic, and perinatal muscle myosins have divergent effects on molecular power generation.
Academic Article	Divergent Molecular Phenotypes in Point Mutations at the Same Residue in Beta-Myosin Heavy Chain Lead to Distinct Cardiomyopathies.

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Myosins