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Search Results to Linda R Watkins

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Watkins, Linda

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Item Type	Name
Academic Article	A permissive role of corticosterone in an opioid form of stress-induced analgesia: blockade of opiate analgesia is not due to stress-induced hormone release.
Academic Article	Delta opiate receptors mediate tail-shock induced antinociception at supraspinal levels.
Academic Article	Mechanisms of tumor necrosis factor-alpha (TNF-alpha) hyperalgesia.
Academic Article	Kappa opiate receptors mediate tail-shock induced antinociception at spinal levels.
Academic Article	Inescapable shock-induced potentiation of morphine analgesia in rats: involvement of opioid, GABAergic, and serotonergic mechanisms in the dorsal raphe nucleus.
Academic Article	Inescapable shock-induced potentiation of morphine analgesia.
Academic Article	Neurocircuitry of conditioned inhibition of analgesia: effects of amygdala, dorsal raphe, ventral medullary, and spinal cord lesions on antianalgesia in the rat.
Academic Article	Interleukin-1 mediates the behavioral hyperalgesia produced by lithium chloride and endotoxin.
Academic Article	Implications of immune-to-brain communication for sickness and pain.
Academic Article	The amygdala is necessary for the expression of conditioned but not unconditioned analgesia.
Academic Article	The pain of being sick: implications of immune-to-brain communication for understanding pain.
Academic Article	Cholecystokinin antianalgesia: safety cues abolish morphine analgesia.
Academic Article	Immune activation: the role of pro-inflammatory cytokines in inflammation, illness responses and pathological pain states.
Academic Article	A new model of sciatic inflammatory neuritis (SIN): induction of unilateral and bilateral mechanical allodynia following acute unilateral peri-sciatic immune activation in rats.
Academic Article	Evidence for the involvement of spinal cord glia in subcutaneous formalin induced hyperalgesia in the rat.
Academic Article	Reversal of spinal cord non-opiate analgesia by conditioned anti-analgesia in the rat.
Academic Article	Sciatic inflammatory neuritis (SIN): behavioral allodynia is paralleled by peri-sciatic proinflammatory cytokine and superoxide production.
Academic Article	Sciatic inflammatory neuropathy in the rat: surgical procedures, induction of inflammation, and behavioral testing.
Academic Article	HIV-1 gp120 stimulates proinflammatory cytokine-mediated pain facilitation via activation of nitric oxide synthase-I (nNOS).
Academic Article	Snake venom phospholipase A2s (Asp49 and Lys49) induce mechanical allodynia upon peri-sciatic administration: involvement of spinal cord glia, proinflammatory cytokines and nitric oxide.
Academic Article	Activation of the spinal cord complement cascade might contribute to mechanical allodynia induced by three animal models of spinal sensitization.
Academic Article	Snake venom components enhance pain upon subcutaneous injection: an initial examination of spinal cord mediators.
Academic Article	Fractalkine (CX3CL1) and fractalkine receptor (CX3CR1) distribution in spinal cord and dorsal root ganglia under basal and neuropathic pain conditions.
Academic Article	Minocycline attenuates mechanical allodynia and proinflammatory cytokine expression in rat models of pain facilitation.
Academic Article	Controlling neuropathic pain by adeno-associated virus driven production of the anti-inflammatory cytokine, interleukin-10.
Academic Article	Glia: novel counter-regulators of opioid analgesia.
Academic Article	Controlling pathological pain by adenovirally driven spinal production of the anti-inflammatory cytokine, interleukin-10.
Academic Article	Involvement of spinal cord nuclear factor kappaB activation in rat models of proinflammatory cytokine-mediated pain facilitation.
Academic Article	Mediation of chronic pain: not by neurons alone.
Academic Article	Repeated intrathecal injections of plasmid DNA encoding interleukin-10 produce prolonged reversal of neuropathic pain.
Academic Article	Norman Cousins Lecture. Glia as the "bad guys": implications for improving clinical pain control and the clinical utility of opioids.
Academic Article	A role for G protein-coupled receptor kinase 2 in mechanical allodynia.
Academic Article	Opioid-induced glial activation: mechanisms of activation and implications for opioid analgesia, dependence, and reward.
Academic Article	"Listening" and "talking" to neurons: implications of immune activation for pain control and increasing the efficacy of opioids.
Academic Article	Proinflammatory cytokines oppose opioid-induced acute and chronic analgesia.
Academic Article	Minocycline suppresses morphine-induced respiratory depression, suppresses morphine-induced reward, and enhances systemic morphine-induced analgesia.
Academic Article	Pathological and protective roles of glia in chronic pain.
Academic Article	PEGylation of interleukin-10 for the mitigation of enhanced pain states.
Academic Article	Evidence that intrathecal morphine-3-glucuronide may cause pain enhancement via toll-like receptor 4/MD-2 and interleukin-1beta.
Academic Article	The "toll" of opioid-induced glial activation: improving the clinical efficacy of opioids by targeting glia.
Academic Article	Evidence for a role of heat shock protein-90 in toll like receptor 4 mediated pain enhancement in rats.
Academic Article	A novel method for modeling facial allodynia associated with migraine in awake and freely moving rats.
Academic Article	Pain intensity and duration can be enhanced by prior challenge: initial evidence suggestive of a role of microglial priming.
Academic Article	Release of plasmid DNA-encoding IL-10 from PLGA microparticles facilitates long-term reversal of neuropathic pain following a single intrathecal administration.
Academic Article	Evidence that tricyclic small molecules may possess toll-like receptor and myeloid differentiation protein 2 activity.
Academic Article	Toll-like receptor 4 in CNS pathologies.
Academic Article	Spinal upregulation of glutamate transporter GLT-1 by ceftriaxone: therapeutic efficacy in a range of experimental nervous system disorders.
Academic Article	Below level central pain induced by discrete dorsal spinal cord injury.
Academic Article	Counter-regulation of opioid analgesia by glial-derived bioactive sphingolipids.
Academic Article	Caudal granular insular cortex is sufficient and necessary for the long-term maintenance of allodynic behavior in the rat attributable to mononeuropathy.
Academic Article	Prior laparotomy or corticosterone potentiates lipopolysaccharide-induced fever and sickness behaviors.
Academic Article	Post-conditioning experience with acute or chronic inflammatory pain reduces contextual fear conditioning in the rat.
Academic Article	Unilateral T13 and L1 dorsal root avulsion: methods for a novel model of central neuropathic pain.
Academic Article	(+)-naloxone, an opioid-inactive toll-like receptor 4 signaling inhibitor, reverses multiple models of chronic neuropathic pain in rats.
Academic Article	Understanding chronic inflammatory and neuropathic pain.
Academic Article	Prior exposure to repeated morphine potentiates mechanical allodynia induced by peripheral inflammation and neuropathy.
Academic Article	Opioid activation of toll-like receptor 4 contributes to drug reinforcement.
Academic Article	Spinal glia and proinflammatory cytokines mediate mirror-image neuropathic pain in rats.
Academic Article	Immune-to-central nervous system communication and its role in modulating pain and cognition: Implications for cancer and cancer treatment.
Academic Article	Glial proinflammatory cytokines mediate exaggerated pain states: implications for clinical pain.
Academic Article	Acute and conditioned hyperalgesic responses to illness.
Academic Article	Peri-sciatic proinflammatory cytokines, reactive oxygen species, and complement induce mirror-image neuropathic pain in rats.
Academic Article	Neurocircuitry of illness-induced hyperalgesia.
Academic Article	Immune regulation of central nervous system functions: from sickness responses to pathological pain.
Academic Article	Immune-to-brain communication dynamically modulates pain: physiological and pathological consequences.
Academic Article	Central proinflammatory cytokines and pain enhancement.
Academic Article	Intrathecal HIV-1 envelope glycoprotein gp120 induces enhanced pain states mediated by spinal cord proinflammatory cytokines.
Academic Article	A novel immune-to-CNS communication pathway: cells of the meninges surrounding the spinal cord CSF space produce proinflammatory cytokines in response to an inflammatory stimulus.
Academic Article	Interleukin-6 mediates low-threshold mechanical allodynia induced by intrathecal HIV-1 envelope glycoprotein gp120.
Academic Article	Systemic administration of CNI-1493, a p38 mitogen-activated protein kinase inhibitor, blocks intrathecal human immunodeficiency virus-1 gp120-induced enhanced pain states in rats.
Academic Article	Glia: a novel drug discovery target for clinical pain.
Academic Article	Glial activation and pathological pain.
Academic Article	A role for proinflammatory cytokines and fractalkine in analgesia, tolerance, and subsequent pain facilitation induced by chronic intrathecal morphine.
Academic Article	Spinal gap junctions: potential involvement in pain facilitation.
Academic Article	Evidence that exogenous and endogenous fractalkine can induce spinal nociceptive facilitation in rats.
Academic Article	An initial investigation of spinal mechanisms underlying pain enhancement induced by fractalkine, a neuronally released chemokine.
Academic Article	Spinal cord glia and interleukin-1 do not appear to mediate persistent allodynia induced by intramuscular acidic saline in rats.
Academic Article	Non-stereoselective reversal of neuropathic pain by naloxone and naltrexone: involvement of toll-like receptor 4 (TLR4).
Academic Article	Chapter 22 Contribution of glia to pain processing in health and disease.
Academic Article	Reduction of opioid withdrawal and potentiation of acute opioid analgesia by systemic AV411 (ibudilast).
Academic Article	Intrathecal interleukin-10 gene therapy attenuates paclitaxel-induced mechanical allodynia and proinflammatory cytokine expression in dorsal root ganglia in rats.
Academic Article	Ibudilast (AV-411). A new class therapeutic candidate for neuropathic pain and opioid withdrawal syndromes.
Academic Article	Enduring reversal of neuropathic pain by a single intrathecal injection of adenosine 2A receptor agonists: a novel therapy for neuropathic pain.
Academic Article	Intrathecal polymer-based interleukin-10 gene delivery for neuropathic pain.
Academic Article	The glial modulatory drug AV411 attenuates mechanical allodynia in rat models of neuropathic pain.
Academic Article	Intrathecal injection of an alpha seven nicotinic acetylcholine receptor agonist attenuates gp120-induced mechanical allodynia and spinal pro-inflammatory cytokine profiles in rats.
Academic Article	Long-term control of neuropathic pain in a non-viral gene therapy paradigm.
Academic Article	Comment on: excessive opioid use and the development of chronic migraine.
Academic Article	Immunological priming potentiates non-viral anti-inflammatory gene therapy treatment of neuropathic pain.
Academic Article	Evidence that opioids may have toll-like receptor 4 and MD-2 effects.
Academic Article	Prior exposure to glucocorticoids potentiates lipopolysaccharide induced mechanical allodynia and spinal neuroinflammation.
Academic Article	An MD2 hot-spot-mimicking peptide that suppresses TLR4-mediated inflammatory response in vitro and in vivo.
Academic Article	Commentary on Landry et al.: "Propentofylline, a CNS glial modulator, does not decrease pain in post-herpetic neuralgia patients: in vitro evidence for differential responses in human and rodent microglia and macrophages".
Academic Article	Harnessing pain heterogeneity and RNA transcriptome to identify blood-based pain biomarkers: a novel correlational study design and bioinformatics approach in a graded chronic constriction injury model.
Academic Article	Glucuronic acid and the ethanol metabolite ethyl-glucuronide cause toll-like receptor 4 activation and enhanced pain.
Academic Article	Toll-like receptors in chronic pain.
Academic Article	Tetracyclines and pain.
Academic Article	Indwelling supradural catheters for induction of facial allodynia: surgical procedures, application of inflammatory stimuli, and behavioral testing.
Academic Article	Systemic administration of an alpha-7 nicotinic acetylcholine agonist reverses neuropathic pain in male Sprague Dawley rats.
Concept	Facial Pain
Concept	Pain Measurement
Concept	Pain
Concept	Pain Threshold
Concept	Pain, Intractable
Concept	Pain, Postoperative
Academic Article	Rifampin inhibits Toll-like receptor 4 signaling by targeting myeloid differentiation protein 2 and attenuates neuropathic pain.
Academic Article	Suppression of voluntary wheel running in rats is dependent on the site of inflammation: evidence for voluntary running as a measure of hind paw-evoked pain.
Academic Article	Systemic administration of propentofylline, ibudilast, and (+)-naltrexone each reverses mechanical allodynia in a novel rat model of central neuropathic pain.
Academic Article	Pathological pain and the neuroimmune interface.
Academic Article	Select steroid hormone glucuronide metabolites can cause toll-like receptor 4 activation and enhanced pain.
Academic Article	Advances in neuropathic pain: diagnosis, mechanisms, and treatment recommendations.
Academic Article	Pioglitazone rapidly reduces neuropathic pain through astrocyte and nongenomic PPAR? mechanisms.
Academic Article	Morphine paradoxically prolongs neuropathic pain in rats by amplifying spinal NLRP3 inflammasome activation.
Academic Article	Prior voluntary wheel running attenuates neuropathic pain.
Academic Article	Nitroxidative Signaling Mechanisms in Pathological Pain.
Academic Article	Behavioral assessment of neuropathic pain, fatigue, and anxiety in experimental autoimmune encephalomyelitis (EAE) and attenuation by interleukin-10 gene therapy.
Grant	PAIN FACILITATION BY GP120 AND HIV ENVELOPE PROTEIN
Grant	ALLODYNIC EFFECTS OF SCIATIC INFLAMMATORY NEURITIS
Grant	Pain facilitation via neuron-to-glia signaling
Grant	Pain control via spinal interleukin-10 gene therapy
Grant	Immune and Gilia Regulation of Pain & Analgesic Actions
Grant	Preventing Transition of Acute-to-Chronic Neuropathic Pain: Models, Mechanisms &
Grant	Spinal adenosine modulator: enduring anti-inflammatory action in neuropathic pain
Grant	Optoid Analgesics: Modulation of Trigeminal &Spinal Glial Activation
Grant	Targeting toll like receptor 4 (TLR4) and TLR2 to resolve EAE-associated paralysis, pain and cognitive deficits: efficacy of a clinically-relevant blood brain barrier permeable TLR4/TLR2 antagonist
Grant	Models and mechanisms for the transition of acute-to-chronic orofacial pain
Grant	Spinal glia activation in human chronic pain
Grant	Targeting neuropathic pain prevention: Modulating the neuroimmunology of peripheral nerve injury
Grant	Immune /Glial Mediation of Exaggerated Pain States
Grant	Methods Development for Studying Dorsal Spinal Cord Glia
Grant	Exploring the Potential of Glia for Regulating Clinically Relevant Opiod Actions
Academic Article	Exploring acute-to-chronic neuropathic pain in rats after contusion spinal cord injury.
Academic Article	Protraction of neuropathic pain by morphine is mediated by spinal damage associated molecular patterns (DAMPs) in male rats.
Academic Article	Toll-like receptors and their role in persistent pain.
Academic Article	DREADDed microglia in pain: Implications for spinal inflammatory signaling in male rats.
Academic Article	Sustained reversal of central neuropathic pain induced by a single intrathecal injection of adenosine A2A receptor agonists.
Academic Article	Repeated Morphine Prolongs Postoperative Pain in Male Rats.
Academic Article	MicroRNA-124 and microRNA-146a both attenuate persistent neuropathic pain induced by morphine in male rats.
Grant	Enduring reversal of chronic pain by adenosine 2a agonism
Grant	Enduring enhancement of neuropathic pain by early post-trauma morphine
Concept	Chronic Pain
Concept	Pain Management
Academic Article	Oxycodone, fentanyl, and morphine amplify established neuropathic pain in male rats.
Academic Article	Lovastatin inhibits Toll-like receptor 4 signaling in microglia by targeting its co-receptor myeloid differentiation protein 2 and attenuates neuropathic pain.
Academic Article	Activation of sphingosine-1-phosphate receptor subtype 1 in the central nervous system contributes to morphine-induced hyperalgesia and antinociceptive tolerance in rodents.
Academic Article	Targeted interleukin-10 plasmid DNA therapy in the treatment of osteoarthritis: Toxicology and pain efficacy assessments.
Academic Article	Toll-like receptor 2 and 4 antagonism for the treatment of experimental autoimmune encephalomyelitis (EAE)-related pain.
Academic Article	Spatial summation in human thermal pain perception: comparison within and between dermatomes.
Academic Article	Comparison of human pain sensation and flexion withdrawal evoked by noxious radiant heat.
Academic Article	Autoimmune regulation of chronic pain.
Academic Article	Aging and miR-155 in mice influence survival and neuropathic pain after spinal cord injury.
Academic Article	Preconditioning by voluntary wheel running attenuates later neuropathic pain via nuclear factor E2-related factor 2 antioxidant signaling in rats.
Academic Article	Involvement of TLR2-TLR4, NLRP3, and IL-17 in pain induced by a novel Sprague-Dawley rat model of experimental autoimmune encephalomyelitis.
Academic Article	Intrathecal non-viral interleukin-10 gene therapy ameliorates neuropathic pain as measured by both classical static allodynia and a novel supra-spinally mediated pain assay, the Two-Arm Rodent Somatosensory (TARS) task.
Academic Article	Interleukin-1beta and inflammasome expression in spinal cord following chronic constriction injury in male and female rats.

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Pain