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Search Results to Linda R Watkins

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Watkins, Linda

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Item Type	Name
Academic Article	Minocycline attenuates mechanical allodynia and proinflammatory cytokine expression in rat models of pain facilitation.
Academic Article	Rapid isolation of highly enriched and quiescent microglia from adult rat hippocampus: immunophenotypic and functional characteristics.
Academic Article	Microglia serve as a neuroimmune substrate for stress-induced potentiation of CNS pro-inflammatory cytokine responses.
Academic Article	Norman Cousins Lecture. Glia as the "bad guys": implications for improving clinical pain control and the clinical utility of opioids.
Academic Article	Minocycline suppresses morphine-induced respiratory depression, suppresses morphine-induced reward, and enhances systemic morphine-induced analgesia.
Academic Article	Evidence that intrathecal morphine-3-glucuronide may cause pain enhancement via toll-like receptor 4/MD-2 and interleukin-1beta.
Academic Article	Evidence for a role of heat shock protein-90 in toll like receptor 4 mediated pain enhancement in rats.
Academic Article	Possible involvement of toll-like receptor 4/myeloid differentiation factor-2 activity of opioid inactive isomers causes spinal proinflammation and related behavioral consequences.
Academic Article	Pain intensity and duration can be enhanced by prior challenge: initial evidence suggestive of a role of microglial priming.
Academic Article	Evidence that tricyclic small molecules may possess toll-like receptor and myeloid differentiation protein 2 activity.
Academic Article	Glucocorticoids mediate stress-induced priming of microglial pro-inflammatory responses.
Academic Article	Aging-related changes in neuroimmune-endocrine function: implications for hippocampal-dependent cognition.
Academic Article	Sex and estradiol influence glial pro-inflammatory responses to lipopolysaccharide in rats.
Academic Article	A minocycline derivative reduces nerve injury-induced allodynia, LPS-induced prostaglandin E2 microglial production and signaling via toll-like receptors 2 and 4.
Academic Article	Glial proinflammatory cytokines mediate exaggerated pain states: implications for clinical pain.
Academic Article	Evidence that exogenous and endogenous fractalkine can induce spinal nociceptive facilitation in rats.
Academic Article	An initial investigation of spinal mechanisms underlying pain enhancement induced by fractalkine, a neuronally released chemokine.
Academic Article	Non-stereoselective reversal of neuropathic pain by naloxone and naltrexone: involvement of toll-like receptor 4 (TLR4).
Academic Article	Aging sensitizes rapidly isolated hippocampal microglia to LPS ex vivo.
Academic Article	Prior exposure to glucocorticoids sensitizes the neuroinflammatory and peripheral inflammatory responses to E. coli lipopolysaccharide.
Academic Article	Attenuation of microglial and IL-1 signaling protects mice from acute alcohol-induced sedation and/or motor impairment.
Academic Article	Commentary on Landry et al.: "Propentofylline, a CNS glial modulator, does not decrease pain in post-herpetic neuralgia patients: in vitro evidence for differential responses in human and rodent microglia and macrophages".
Concept	Microglia
Academic Article	Rifampin inhibits Toll-like receptor 4 signaling by targeting myeloid differentiation protein 2 and attenuates neuropathic pain.
Academic Article	Chronic exposure to exogenous glucocorticoids primes microglia to pro-inflammatory stimuli and induces NLRP3 mRNA in the hippocampus.
Academic Article	A concern on comparing 'apples' and 'oranges' when differences between microglia used in human and rodent studies go far, far beyond simply species: comment on Smith and Dragunow.
Academic Article	Discovery of a novel site of opioid action at the innate immune pattern-recognition receptor TLR4 and its role in addiction.
Academic Article	Stress induces the danger-associated molecular pattern HMGB-1 in the hippocampus of male Sprague Dawley rats: a priming stimulus of microglia and the NLRP3 inflammasome.
Academic Article	Microglia inflammatory responses are controlled by an intrinsic circadian clock.
Academic Article	Greater glucocorticoid receptor activation in hippocampus of aged rats sensitizes microglia.
Academic Article	Adenosine 2A receptor agonism: A single intrathecal administration attenuates motor paralysis in experimental autoimmune encephalopathy in rats.
Academic Article	Structure-Activity Relationships of (+)-Naltrexone-Inspired Toll-like Receptor 4 (TLR4) Antagonists.
Academic Article	(+)-Naltrexone is neuroprotective and promotes alternative activation in the mouse hippocampus after cardiac arrest/cardiopulmonary resuscitation.
Academic Article	Neuroinflammation in the normal aging hippocampus.
Academic Article	The danger-associated molecular pattern HMGB1 mediates the neuroinflammatory effects of methamphetamine.
Academic Article	Stress-induced neuroinflammatory priming is time of day dependent.
Academic Article	The redox state of the alarmin HMGB1 is a pivotal factor in neuroinflammatory and microglial priming: A role for the NLRP3 inflammasome.
Academic Article	Morphine paradoxically prolongs neuropathic pain in rats by amplifying spinal NLRP3 inflammasome activation.
Academic Article	Diminished circadian rhythms in hippocampal microglia may contribute to age-related neuroinflammatory sensitization.
Academic Article	Supradural inflammatory soup in awake and freely moving rats induces facial allodynia that is blocked by putative immune modulators.
Grant	PAIN FACILITATION BY GP120 AND HIV ENVELOPE PROTEIN
Grant	Pain facilitation via neuron-to-glia signaling
Grant	Pain control via spinal interleukin-10 gene therapy
Grant	Immune and Gilia Regulation of Pain & Analgesic Actions
Grant	Preventing Transition of Acute-to-Chronic Neuropathic Pain: Models, Mechanisms &
Grant	Spinal adenosine modulator: enduring anti-inflammatory action in neuropathic pain
Grant	Optoid Analgesics: Modulation of Trigeminal &Spinal Glial Activation
Grant	Models and mechanisms for the transition of acute-to-chronic orofacial pain
Grant	Spinal glia activation in human chronic pain
Grant	Immune /Glial Mediation of Exaggerated Pain States
Grant	Methods Development for Studying Dorsal Spinal Cord Glia
Grant	Exploring the Potential of Glia for Regulating Clinically Relevant Opiod Actions
Academic Article	High-fat diet and aging interact to produce neuroinflammation and impair hippocampal- and amygdalar-dependent memory.
Academic Article	Stress disinhibits microglia via down-regulation of CD200R: A mechanism of neuroinflammatory priming.
Academic Article	Neuroinflammatory priming to stress is differentially regulated in male and female rats.
Academic Article	DREADDed microglia in pain: Implications for spinal inflammatory signaling in male rats.
Academic Article	Post-stroke Intranasal (+)-Naloxone Delivery Reduces Microglial Activation and Improves Behavioral Recovery from Ischemic Injury.
Academic Article	Immunization with Mycobacterium vaccae induces an anti-inflammatory milieu in the CNS: Attenuation of stress-induced microglial priming, alarmins and anxiety-like behavior.
Grant	Enduring reversal of chronic pain by adenosine 2a agonism
Academic Article	Mycobacterium vaccae immunization protects aged rats from surgery-elicited neuroinflammation and cognitive dysfunction.
Academic Article	Microglia: Neuroimmune-sensors of stress.
Academic Article	Glucocorticoids mediate stress induction of the alarmin HMGB1 and reduction of the microglia checkpoint receptor CD200R1 in limbic brain structures.
Academic Article	Stereochemistry and innate immune recognition: (+)-norbinaltorphimine targets myeloid differentiation protein 2 and inhibits toll-like receptor 4 signaling.
Academic Article	Methamphetamine Activates Toll-Like Receptor 4 to Induce Central Immune Signaling within the Ventral Tegmental Area and Contributes to Extracellular Dopamine Increase in the Nucleus Accumbens Shell.
Academic Article	Lovastatin inhibits Toll-like receptor 4 signaling in microglia by targeting its co-receptor myeloid differentiation protein 2 and attenuates neuropathic pain.
Academic Article	Acute stress induces chronic neuroinflammatory, microglial and behavioral priming: A role for potentiated NLRP3 inflammasome activation.
Academic Article	Experimental autoimmune encephalopathy (EAE)-induced hippocampal neuroinflammation and memory deficits are prevented with the non-opioid TLR2/TLR4 antagonist (+)-naltrexone.
Academic Article	Mechanisms of microglia-mediated synapse turnover and synaptogenesis.
Academic Article	Combining RNAscope and immunohistochemistry to visualize inflammatory gene products in neurons and microglia.

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Microglia