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Search Results to Linda R Watkins

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Watkins, Linda

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Item Type	Name
Academic Article	Interleukin-1 beta induced corticosterone elevation and hypothalamic NE depletion is vagally mediated.
Academic Article	Blockade of cytokine induced conditioned taste aversion by subdiaphragmatic vagotomy: further evidence for vagal mediation of immune-brain communication.
Academic Article	Mechanisms of tumor necrosis factor-alpha (TNF-alpha) hyperalgesia.
Academic Article	A 9L gliosarcoma transplantation model for studying adoptive immunotherapy into the brains of conscious rats.
Academic Article	TNF-alpha-induced corticosterone elevation but not serum protein or corticosteroid binding globulin reduction is vagally mediated.
Academic Article	Exposure to acute stress induces brain interleukin-1beta protein in the rat.
Academic Article	Thermogenic and corticosterone responses to intravenous cytokines (IL-1beta and TNF-alpha) are attenuated by subdiaphragmatic vagotomy.
Academic Article	Selective effects of peripheral lipopolysaccharide administration on contextual and auditory-cue fear conditioning.
Academic Article	Blockade of interleukin-1 induced hyperthermia by subdiaphragmatic vagotomy: evidence for vagal mediation of immune-brain communication.
Academic Article	Interleukin-1 induces c-Fos immunoreactivity in primary afferent neurons of the vagus nerve.
Academic Article	Interleukin-1 mediates the behavioral hyperalgesia produced by lithium chloride and endotoxin.
Academic Article	Stress, learned helplessness, and brain interleukin-1 beta.
Academic Article	Dynamic regulation of the proinflammatory cytokine, interleukin-1beta: molecular biology for non-molecular biologists.
Academic Article	The contribution of the vagus nerve in interleukin-1beta-induced fever is dependent on dose.
Academic Article	Evidence for the involvement of spinal cord glia in subcutaneous formalin induced hyperalgesia in the rat.
Academic Article	Sciatic inflammatory neuritis (SIN): behavioral allodynia is paralleled by peri-sciatic proinflammatory cytokine and superoxide production.
Academic Article	Peripheral and central proinflammatory cytokine response to a severe acute stressor.
Academic Article	Brain-derived neurotrophic factor mRNA downregulation produced by social isolation is blocked by intrahippocampal interleukin-1 receptor antagonist.
Academic Article	Further characterization of high mobility group box 1 (HMGB1) as a proinflammatory cytokine: central nervous system effects.
Academic Article	Circulating cytokines and endotoxin are not necessary for the activation of the sickness or corticosterone response produced by peripheral E. coli challenge.
Academic Article	Snake venom phospholipase A2s (Asp49 and Lys49) induce mechanical allodynia upon peri-sciatic administration: involvement of spinal cord glia, proinflammatory cytokines and nitric oxide.
Academic Article	Snake venom components enhance pain upon subcutaneous injection: an initial examination of spinal cord mediators.
Academic Article	BDNF mRNA expression in rat hippocampus following contextual learning is blocked by intrahippocampal IL-1beta administration.
Academic Article	Controlling neuropathic pain by adeno-associated virus driven production of the anti-inflammatory cytokine, interleukin-10.
Academic Article	Controlling pathological pain by adenovirally driven spinal production of the anti-inflammatory cytokine, interleukin-10.
Academic Article	Repeated intrathecal injections of plasmid DNA encoding interleukin-10 produce prolonged reversal of neuropathic pain.
Academic Article	Characterization of the temporo-spatial effects of chronic bilateral intrahippocampal cannulae on interleukin-1beta.
Academic Article	A role for G protein-coupled receptor kinase 2 in mechanical allodynia.
Academic Article	Prostaglandins are necessary and sufficient to induce contextual fear learning impairments after interleukin-1 beta injections into the dorsal hippocampus.
Academic Article	Proinflammatory cytokines oppose opioid-induced acute and chronic analgesia.
Academic Article	Time course of hippocampal IL-1 beta and memory consolidation impairments in aging rats following peripheral infection.
Academic Article	The cortical innate immune response increases local neuronal excitability leading to seizures.
Academic Article	PEGylation of interleukin-10 for the mitigation of enhanced pain states.
Academic Article	Evidence that intrathecal morphine-3-glucuronide may cause pain enhancement via toll-like receptor 4/MD-2 and interleukin-1beta.
Academic Article	Evidence for a role of heat shock protein-90 in toll like receptor 4 mediated pain enhancement in rats.
Academic Article	IL-1RA blocks E. coli-induced suppression of Arc and long-term memory in aged F344xBN F1 rats.
Academic Article	Possible involvement of toll-like receptor 4/myeloid differentiation factor-2 activity of opioid inactive isomers causes spinal proinflammation and related behavioral consequences.
Academic Article	Release of plasmid DNA-encoding IL-10 from PLGA microparticles facilitates long-term reversal of neuropathic pain following a single intrathecal administration.
Academic Article	Dynamic regulation of proinflammatory cytokines.
Academic Article	Evidence that tricyclic small molecules may possess toll-like receptor and myeloid differentiation protein 2 activity.
Academic Article	Human immunodeficiency virus-1 coat protein gp120 impairs contextual fear conditioning: a potential role in AIDS related learning and memory impairments.
Academic Article	The immune system and memory consolidation: a role for the cytokine IL-1beta.
Academic Article	Effects of vagotomy on lipopolysaccharide-induced brain interleukin-1beta protein in rats.
Academic Article	Glucocorticoids mediate stress-induced priming of microglial pro-inflammatory responses.
Academic Article	Prior stressor exposure sensitizes LPS-induced cytokine production.
Academic Article	Sex and estradiol influence glial pro-inflammatory responses to lipopolysaccharide in rats.
Academic Article	IL-1RA injected intra-cisterna magna confers extended prophylaxis against lipopolysaccharide-induced neuroinflammatory and sickness responses.
Academic Article	Intracisternal interleukin-1 receptor antagonist prevents postoperative cognitive decline and neuroinflammatory response in aged rats.
Academic Article	Blocking toll-like receptor 2 and 4 signaling during a stressor prevents stress-induced priming of neuroinflammatory responses to a subsequent immune challenge.
Academic Article	Spinal glia and proinflammatory cytokines mediate mirror-image neuropathic pain in rats.
Academic Article	Inescapable shock induces resistance to the effects of dexamethasone.
Academic Article	Characterization of cytokine-induced hyperalgesia.
Academic Article	Peri-sciatic proinflammatory cytokines, reactive oxygen species, and complement induce mirror-image neuropathic pain in rats.
Academic Article	Intracerebroventricular interleukin-1 receptor antagonist blocks the enhancement of fear conditioning and interference with escape produced by inescapable shock.
Academic Article	Vagal paraganglia bind biotinylated interleukin-1 receptor antagonist: a possible mechanism for immune-to-brain communication.
Academic Article	Peripheral infection and aging interact to impair hippocampal memory consolidation.
Academic Article	Neonatal infection-induced memory impairment after lipopolysaccharide in adulthood is prevented via caspase-1 inhibition.
Academic Article	Interleukin-1beta in immune cells of the abdominal vagus nerve: a link between the immune and nervous systems?
Academic Article	Effects of vagotomy on serum endotoxin, cytokines, and corticosterone after intraperitoneal lipopolysaccharide.
Academic Article	Timecourse and corticosterone sensitivity of the brain, pituitary, and serum interleukin-1beta protein response to acute stress.
Academic Article	Subdiaphragmatic vagotomy does not block intraperitoneal lipopolysaccharide-induced fever.
Academic Article	Intrathecal HIV-1 envelope glycoprotein gp120 induces enhanced pain states mediated by spinal cord proinflammatory cytokines.
Academic Article	A novel immune-to-CNS communication pathway: cells of the meninges surrounding the spinal cord CSF space produce proinflammatory cytokines in response to an inflammatory stimulus.
Academic Article	Interleukin-6 mediates low-threshold mechanical allodynia induced by intrathecal HIV-1 envelope glycoprotein gp120.
Academic Article	A method for measuring multiple cytokines from small samples.
Academic Article	The role of IL-1beta in stress-induced sensitization of proinflammatory cytokine and corticosterone responses.
Academic Article	A role for proinflammatory cytokines and fractalkine in analgesia, tolerance, and subsequent pain facilitation induced by chronic intrathecal morphine.
Academic Article	Spinal gap junctions: potential involvement in pain facilitation.
Academic Article	Neonatal infection induces memory impairments following an immune challenge in adulthood.
Academic Article	An initial investigation of spinal mechanisms underlying pain enhancement induced by fractalkine, a neuronally released chemokine.
Academic Article	Early-life infection leads to altered BDNF and IL-1beta mRNA expression in rat hippocampus following learning in adulthood.
Academic Article	Spinal cord glia and interleukin-1 do not appear to mediate persistent allodynia induced by intramuscular acidic saline in rats.
Academic Article	Anti-inflammatory cytokine gene therapy decreases sensory and motor dysfunction in experimental Multiple Sclerosis: MOG-EAE behavioral and anatomical symptom treatment with cytokine gene therapy.
Academic Article	Differential effects of neonatal handling on early life infection-induced alterations in cognition in adulthood.
Academic Article	Intrathecal interleukin-10 gene therapy attenuates paclitaxel-induced mechanical allodynia and proinflammatory cytokine expression in dorsal root ganglia in rats.
Academic Article	Intrathecal polymer-based interleukin-10 gene delivery for neuropathic pain.
Academic Article	Intrathecal injection of an alpha seven nicotinic acetylcholine receptor agonist attenuates gp120-induced mechanical allodynia and spinal pro-inflammatory cytokine profiles in rats.
Academic Article	Intrathecal injection of naked plasmid DNA provides long-term expression of secreted proteins.
Academic Article	Long-term control of neuropathic pain in a non-viral gene therapy paradigm.
Academic Article	Immunological priming potentiates non-viral anti-inflammatory gene therapy treatment of neuropathic pain.
Academic Article	Attenuation of microglial and IL-1 signaling protects mice from acute alcohol-induced sedation and/or motor impairment.
Academic Article	Naloxone-precipitated morphine withdrawal behavior and brain IL-1? expression: comparison of different mouse strains.
Academic Article	Prior exposure to glucocorticoids potentiates lipopolysaccharide induced mechanical allodynia and spinal neuroinflammation.
Academic Article	Exploring the neuroimmunopharmacology of opioids: an integrative review of mechanisms of central immune signaling and their implications for opioid analgesia.
Academic Article	Morphine activates neuroinflammation in a manner parallel to endotoxin.
Concept	Interleukin-1
Concept	Interleukin 1 Receptor Antagonist Protein
Concept	Interleukin-10
Concept	Receptors, Interleukin-1
Concept	Interleukin-1beta
Concept	Receptors, Interleukin-1 Type I
Concept	Interleukin-6
Concept	Interleukin-2
Academic Article	Rifampin inhibits Toll-like receptor 4 signaling by targeting myeloid differentiation protein 2 and attenuates neuropathic pain.
Academic Article	High-fat diet consumption disrupts memory and primes elevations in hippocampal IL-1?, an effect that can be prevented with dietary reversal or IL-1 receptor antagonism.
Academic Article	Microglia inflammatory responses are controlled by an intrinsic circadian clock.
Academic Article	Alcohol-induced sedation and synergistic interactions between alcohol and morphine: a key mechanistic role for Toll-like receptors and MyD88-dependent signaling.
Academic Article	The therapeutic potential of interleukin-10 in neuroimmune diseases.
Academic Article	(+)-Naltrexone is neuroprotective and promotes alternative activation in the mouse hippocampus after cardiac arrest/cardiopulmonary resuscitation.
Academic Article	DAT isn't all that: cocaine reward and reinforcement require Toll-like receptor 4 signaling.
Academic Article	Morphine paradoxically prolongs neuropathic pain in rats by amplifying spinal NLRP3 inflammasome activation.
Academic Article	Glucocorticoids Mediate Short-Term High-Fat Diet Induction of Neuroinflammatory Priming, the NLRP3 Inflammasome, and the Danger Signal HMGB1.
Academic Article	Diminished circadian rhythms in hippocampal microglia may contribute to age-related neuroinflammatory sensitization.
Academic Article	Behavioral assessment of neuropathic pain, fatigue, and anxiety in experimental autoimmune encephalomyelitis (EAE) and attenuation by interleukin-10 gene therapy.
Academic Article	Constriction of the buccal branch of the facial nerve produces unilateral craniofacial allodynia.
Grant	PAIN FACILITATION BY GP120 AND HIV ENVELOPE PROTEIN
Grant	CYTOKINE TO BRAIN COMMUNICATION--ROLE OF THE VAGUS
Grant	CYTOKINE-TO-BRAIN COMMUNICATION--ROLE OF THE VAGUS
Grant	Pain control via spinal interleukin-10 gene therapy
Grant	Immune and Gilia Regulation of Pain & Analgesic Actions
Grant	Spinal adenosine modulator: enduring anti-inflammatory action in neuropathic pain
Grant	Optoid Analgesics: Modulation of Trigeminal &Spinal Glial Activation
Grant	Immune /Glial Mediation of Exaggerated Pain States
Academic Article	Opioid Self-Administration is Attenuated by Early-Life Experience and Gene Therapy for Anti-Inflammatory IL-10 in the Nucleus Accumbens of Male Rats.
Academic Article	High-fat diet and aging interact to produce neuroinflammation and impair hippocampal- and amygdalar-dependent memory.
Academic Article	Innate immune signaling in the ventral tegmental area contributes to drug-primed reinstatement of cocaine seeking.
Academic Article	Protraction of neuropathic pain by morphine is mediated by spinal damage associated molecular patterns (DAMPs) in male rats.
Academic Article	Neuroinflammatory priming to stress is differentially regulated in male and female rats.
Academic Article	Sustained reversal of central neuropathic pain induced by a single intrathecal injection of adenosine A2A receptor agonists.
Academic Article	A novel platform for in vivo detection of cytokine release within discrete brain regions.
Grant	Enduring reversal of chronic pain by adenosine 2a agonism
Academic Article	Stereochemistry and innate immune recognition: (+)-norbinaltorphimine targets myeloid differentiation protein 2 and inhibits toll-like receptor 4 signaling.
Academic Article	Lovastatin inhibits Toll-like receptor 4 signaling in microglia by targeting its co-receptor myeloid differentiation protein 2 and attenuates neuropathic pain.
Academic Article	Acute stress induces the rapid and transient induction of caspase-1, gasdermin D and release of constitutive IL-1? protein in dorsal hippocampus.
Academic Article	Targeted interleukin-10 plasmid DNA therapy in the treatment of osteoarthritis: Toxicology and pain efficacy assessments.
Academic Article	Involvement of TLR2-TLR4, NLRP3, and IL-17 in pain induced by a novel Sprague-Dawley rat model of experimental autoimmune encephalomyelitis.
Academic Article	Intrathecal non-viral interleukin-10 gene therapy ameliorates neuropathic pain as measured by both classical static allodynia and a novel supra-spinally mediated pain assay, the Two-Arm Rodent Somatosensory (TARS) task.
Academic Article	Interleukin-1beta and inflammasome expression in spinal cord following chronic constriction injury in male and female rats.

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