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Search Results to Linda R Watkins

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Watkins, Linda

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Item Type	Name
Academic Article	Route of morphine administration modulates conditioned analgesic tolerance and hyperalgesia.
Academic Article	Mechanisms of tumor necrosis factor-alpha (TNF-alpha) hyperalgesia.
Academic Article	Interleukin-1 mediates the behavioral hyperalgesia produced by lithium chloride and endotoxin.
Academic Article	Implications of immune-to-brain communication for sickness and pain.
Academic Article	The pain of being sick: implications of immune-to-brain communication for understanding pain.
Academic Article	Immune activation: the role of pro-inflammatory cytokines in inflammation, illness responses and pathological pain states.
Academic Article	A new model of sciatic inflammatory neuritis (SIN): induction of unilateral and bilateral mechanical allodynia following acute unilateral peri-sciatic immune activation in rats.
Academic Article	Evidence for the involvement of spinal cord glia in subcutaneous formalin induced hyperalgesia in the rat.
Academic Article	Sciatic inflammatory neuritis (SIN): behavioral allodynia is paralleled by peri-sciatic proinflammatory cytokine and superoxide production.
Academic Article	Snake venom phospholipase A2s (Asp49 and Lys49) induce mechanical allodynia upon peri-sciatic administration: involvement of spinal cord glia, proinflammatory cytokines and nitric oxide.
Academic Article	Activation of the spinal cord complement cascade might contribute to mechanical allodynia induced by three animal models of spinal sensitization.
Academic Article	Snake venom components enhance pain upon subcutaneous injection: an initial examination of spinal cord mediators.
Academic Article	Minocycline attenuates mechanical allodynia and proinflammatory cytokine expression in rat models of pain facilitation.
Academic Article	A role for G protein-coupled receptor kinase 2 in mechanical allodynia.
Academic Article	Proinflammatory cytokines oppose opioid-induced acute and chronic analgesia.
Academic Article	Evidence that intrathecal morphine-3-glucuronide may cause pain enhancement via toll-like receptor 4/MD-2 and interleukin-1beta.
Academic Article	A novel method for modeling facial allodynia associated with migraine in awake and freely moving rats.
Academic Article	Possible involvement of toll-like receptor 4/myeloid differentiation factor-2 activity of opioid inactive isomers causes spinal proinflammation and related behavioral consequences.
Academic Article	Pain intensity and duration can be enhanced by prior challenge: initial evidence suggestive of a role of microglial priming.
Academic Article	Counter-regulation of opioid analgesia by glial-derived bioactive sphingolipids.
Academic Article	Thermal hyperalgesia and mechanical allodynia produced by intrathecal administration of the human immunodeficiency virus-1 (HIV-1) envelope glycoprotein, gp120.
Academic Article	Caudal granular insular cortex is sufficient and necessary for the long-term maintenance of allodynic behavior in the rat attributable to mononeuropathy.
Academic Article	Post-conditioning experience with acute or chronic inflammatory pain reduces contextual fear conditioning in the rat.
Academic Article	Intraneural dexamethasone applied simultaneously to rat sciatic nerve constriction delays the development of hyperalgesia and allodynia.
Academic Article	Unilateral T13 and L1 dorsal root avulsion: methods for a novel model of central neuropathic pain.
Academic Article	Prior exposure to repeated morphine potentiates mechanical allodynia induced by peripheral inflammation and neuropathy.
Academic Article	Opioid activation of toll-like receptor 4 contributes to drug reinforcement.
Academic Article	A minocycline derivative reduces nerve injury-induced allodynia, LPS-induced prostaglandin E2 microglial production and signaling via toll-like receptors 2 and 4.
Academic Article	Spinal glia and proinflammatory cytokines mediate mirror-image neuropathic pain in rats.
Academic Article	Glial proinflammatory cytokines mediate exaggerated pain states: implications for clinical pain.
Academic Article	Illness-induced hyperalgesia is mediated by spinal neuropeptides and excitatory amino acids.
Academic Article	Characterization of cytokine-induced hyperalgesia.
Academic Article	Acute and conditioned hyperalgesic responses to illness.
Academic Article	Peri-sciatic proinflammatory cytokines, reactive oxygen species, and complement induce mirror-image neuropathic pain in rats.
Academic Article	Neurocircuitry of illness-induced hyperalgesia.
Academic Article	Intrathecal HIV-1 envelope glycoprotein gp120 induces enhanced pain states mediated by spinal cord proinflammatory cytokines.
Academic Article	Interleukin-6 mediates low-threshold mechanical allodynia induced by intrathecal HIV-1 envelope glycoprotein gp120.
Academic Article	A role for proinflammatory cytokines and fractalkine in analgesia, tolerance, and subsequent pain facilitation induced by chronic intrathecal morphine.
Academic Article	Spinal gap junctions: potential involvement in pain facilitation.
Academic Article	Evidence that exogenous and endogenous fractalkine can induce spinal nociceptive facilitation in rats.
Academic Article	An initial investigation of spinal mechanisms underlying pain enhancement induced by fractalkine, a neuronally released chemokine.
Academic Article	Spinal cord glia and interleukin-1 do not appear to mediate persistent allodynia induced by intramuscular acidic saline in rats.
Academic Article	Intrathecal interleukin-10 gene therapy attenuates paclitaxel-induced mechanical allodynia and proinflammatory cytokine expression in dorsal root ganglia in rats.
Academic Article	The glial modulatory drug AV411 attenuates mechanical allodynia in rat models of neuropathic pain.
Academic Article	Intrathecal injection of an alpha seven nicotinic acetylcholine receptor agonist attenuates gp120-induced mechanical allodynia and spinal pro-inflammatory cytokine profiles in rats.
Academic Article	Evidence that opioids may have toll-like receptor 4 and MD-2 effects.
Academic Article	Prior exposure to glucocorticoids potentiates lipopolysaccharide induced mechanical allodynia and spinal neuroinflammation.
Academic Article	Harnessing pain heterogeneity and RNA transcriptome to identify blood-based pain biomarkers: a novel correlational study design and bioinformatics approach in a graded chronic constriction injury model.
Academic Article	Glucuronic acid and the ethanol metabolite ethyl-glucuronide cause toll-like receptor 4 activation and enhanced pain.
Academic Article	Indwelling supradural catheters for induction of facial allodynia: surgical procedures, application of inflammatory stimuli, and behavioral testing.
Concept	Hyperalgesia
Academic Article	Rifampin inhibits Toll-like receptor 4 signaling by targeting myeloid differentiation protein 2 and attenuates neuropathic pain.
Academic Article	Intrathecal injection of adenosine 2A receptor agonists reversed neuropathic allodynia through protein kinase (PK)A/PKC signaling.
Academic Article	Suppression of voluntary wheel running in rats is dependent on the site of inflammation: evidence for voluntary running as a measure of hind paw-evoked pain.
Academic Article	Systemic administration of propentofylline, ibudilast, and (+)-naltrexone each reverses mechanical allodynia in a novel rat model of central neuropathic pain.
Academic Article	Activation of adult rat CNS endothelial cells by opioid-induced toll-like receptor 4 (TLR4) signaling induces proinflammatory, biochemical, morphological, and behavioral sequelae.
Academic Article	Select steroid hormone glucuronide metabolites can cause toll-like receptor 4 activation and enhanced pain.
Academic Article	Pioglitazone rapidly reduces neuropathic pain through astrocyte and nongenomic PPAR? mechanisms.
Academic Article	Opioid-induced central immune signaling: implications for opioid analgesia.
Academic Article	Prior voluntary wheel running attenuates neuropathic pain.
Academic Article	Morphine amplifies mechanical allodynia via TLR4 in a rat model of spinal cord injury.
Academic Article	HMGB1 Activates Proinflammatory Signaling via TLR5 Leading to Allodynia.
Academic Article	Behavioral assessment of neuropathic pain, fatigue, and anxiety in experimental autoimmune encephalomyelitis (EAE) and attenuation by interleukin-10 gene therapy.
Academic Article	Constriction of the buccal branch of the facial nerve produces unilateral craniofacial allodynia.
Academic Article	Supradural inflammatory soup in awake and freely moving rats induces facial allodynia that is blocked by putative immune modulators.
Grant	PAIN FACILITATION BY GP120 AND HIV ENVELOPE PROTEIN
Grant	ALLODYNIC EFFECTS OF SCIATIC INFLAMMATORY NEURITIS
Grant	Pain facilitation via neuron-to-glia signaling
Grant	Optoid Analgesics: Modulation of Trigeminal &Spinal Glial Activation
Grant	Models and mechanisms for the transition of acute-to-chronic orofacial pain
Academic Article	Exploring acute-to-chronic neuropathic pain in rats after contusion spinal cord injury.
Academic Article	Protraction of neuropathic pain by morphine is mediated by spinal damage associated molecular patterns (DAMPs) in male rats.
Academic Article	Sustained reversal of central neuropathic pain induced by a single intrathecal injection of adenosine A2A receptor agonists.
Academic Article	Repeated Morphine Prolongs Postoperative Pain in Male Rats.
Academic Article	MicroRNA-124 and microRNA-146a both attenuate persistent neuropathic pain induced by morphine in male rats.
Academic Article	A single peri-sciatic nerve administration of the adenosine 2A receptor agonist ATL313 produces long-lasting anti-allodynia and anti-inflammatory effects in male rats.
Academic Article	Activation of sphingosine-1-phosphate receptor subtype 1 in the central nervous system contributes to morphine-induced hyperalgesia and antinociceptive tolerance in rodents.
Academic Article	Suppression of active phase voluntary wheel running in male rats by unilateral chronic constriction injury: Enduring therapeutic effects of a brief treatment of morphine combined with TLR4 or P2X7 antagonists.
Academic Article	Aging and miR-155 in mice influence survival and neuropathic pain after spinal cord injury.
Academic Article	Preconditioning by voluntary wheel running attenuates later neuropathic pain via nuclear factor E2-related factor 2 antioxidant signaling in rats.
Academic Article	Intrathecal non-viral interleukin-10 gene therapy ameliorates neuropathic pain as measured by both classical static allodynia and a novel supra-spinally mediated pain assay, the Two-Arm Rodent Somatosensory (TARS) task.
Academic Article	Voluntary wheel running prevents formation of membrane attack complexes and myelin degradation after peripheral nerve injury.

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Hyperalgesia