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Search Results to Linda R Watkins

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Watkins, Linda

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Item Type	Name
Academic Article	Cytokine-to-brain communication: a review & analysis of alternative mechanisms.
Academic Article	8-OH-DPAT microinjected in the region of the dorsal raphe nucleus blocks and reverses the enhancement of fear conditioning and interference with escape produced by exposure to inescapable shock.
Academic Article	Interleukin-1 beta induced corticosterone elevation and hypothalamic NE depletion is vagally mediated.
Academic Article	Blockade of cytokine induced conditioned taste aversion by subdiaphragmatic vagotomy: further evidence for vagal mediation of immune-brain communication.
Academic Article	Psychoneuroimmunology. The interface between behavior, brain, and immunity.
Academic Article	A permissive role of corticosterone in an opioid form of stress-induced analgesia: blockade of opiate analgesia is not due to stress-induced hormone release.
Academic Article	Morphine-induced decreases in in vivo antibody responses.
Academic Article	A horseradish peroxidase study of parallel thalamocortical projections responsible for the generation of mid-latency auditory-evoked potentials.
Academic Article	Delta opiate receptors mediate tail-shock induced antinociception at supraspinal levels.
Academic Article	The role of the amygdala and dorsal raphe nucleus in mediating the behavioral consequences of inescapable shock.
Academic Article	Mechanisms of tumor necrosis factor-alpha (TNF-alpha) hyperalgesia.
Academic Article	A 9L gliosarcoma transplantation model for studying adoptive immunotherapy into the brains of conscious rats.
Academic Article	Kappa opiate receptors mediate tail-shock induced antinociception at spinal levels.
Academic Article	Inescapable shock-induced potentiation of morphine analgesia in rats: involvement of opioid, GABAergic, and serotonergic mechanisms in the dorsal raphe nucleus.
Academic Article	TNF-alpha-induced corticosterone elevation but not serum protein or corticosteroid binding globulin reduction is vagally mediated.
Academic Article	Exposure to acute stress induces brain interleukin-1beta protein in the rat.
Academic Article	Cytokines for psychologists: implications of bidirectional immune-to-brain communication for understanding behavior, mood, and cognition.
Academic Article	Selective effects of peripheral lipopolysaccharide administration on contextual and auditory-cue fear conditioning.
Academic Article	Blockade of interleukin-1 induced hyperthermia by subdiaphragmatic vagotomy: evidence for vagal mediation of immune-brain communication.
Academic Article	Interleukin-1 induces c-Fos immunoreactivity in primary afferent neurons of the vagus nerve.
Academic Article	Interleukin-1 mediates the behavioral hyperalgesia produced by lithium chloride and endotoxin.
Academic Article	Implications of immune-to-brain communication for sickness and pain.
Academic Article	Parallel activation of multiple spinal opiate systems appears to mediate 'non-opiate' stress-induced analgesias.
Academic Article	Stress, learned helplessness, and brain interleukin-1 beta.
Academic Article	Opioid-dependent effects of inescapable shock on escape behavior and conditioned fear responding are mediated by the dorsal raphe nucleus.
Academic Article	Long-term changes in mineralocorticoid and glucocorticoid receptor occupancy following exposure to an acute stressor.
Academic Article	The amygdala is necessary for the expression of conditioned but not unconditioned analgesia.
Academic Article	The pain of being sick: implications of immune-to-brain communication for understanding pain.
Academic Article	The contribution of the vagus nerve in interleukin-1beta-induced fever is dependent on dose.
Academic Article	The role of the vagus nerve in cytokine-to-brain communication.
Academic Article	Peripheral and central proinflammatory cytokine response to a severe acute stressor.
Academic Article	Brain-derived neurotrophic factor mRNA downregulation produced by social isolation is blocked by intrahippocampal interleukin-1 receptor antagonist.
Academic Article	Circulating cytokines and endotoxin are not necessary for the activation of the sickness or corticosterone response produced by peripheral E. coli challenge.
Academic Article	BDNF mRNA expression in rat hippocampus following contextual learning is blocked by intrahippocampal IL-1beta administration.
Academic Article	Activation of serotonin-immunoreactive cells in the dorsal raphe nucleus in rats exposed to an uncontrollable stressor.
Academic Article	Glia: novel counter-regulators of opioid analgesia.
Academic Article	Expression of c-fos and BDNF mRNA in subregions of the prefrontal cortex of male and female rats after acute uncontrollable stress.
Academic Article	Microglia serve as a neuroimmune substrate for stress-induced potentiation of CNS pro-inflammatory cytokine responses.
Academic Article	A behavioural characterization of neonatal infection-facilitated memory impairment in adult rats.
Academic Article	Norman Cousins Lecture. Glia as the "bad guys": implications for improving clinical pain control and the clinical utility of opioids.
Academic Article	Expression of fibroblast growth factor-2 and brain-derived neurotrophic factor mRNA in the medial prefrontal cortex and hippocampus after uncontrollable or controllable stress.
Academic Article	"Listening" and "talking" to neurons: implications of immune activation for pain control and increasing the efficacy of opioids.
Academic Article	Phenylephrine-induced antinociception: investigations of potential neural and endocrine bases.
Academic Article	Proinflammatory cytokines oppose opioid-induced acute and chronic analgesia.
Academic Article	Time course of hippocampal IL-1 beta and memory consolidation impairments in aging rats following peripheral infection.
Academic Article	Minocycline suppresses morphine-induced respiratory depression, suppresses morphine-induced reward, and enhances systemic morphine-induced analgesia.
Academic Article	Characterization of the sickness response in young and aging rats following E. coli infection.
Academic Article	The glial activation inhibitor AV411 reduces morphine-induced nucleus accumbens dopamine release.
Academic Article	The cortical innate immune response increases local neuronal excitability leading to seizures.
Academic Article	Enduring consequences of early-life infection on glial and neural cell genesis within cognitive regions of the brain.
Academic Article	IL-1RA blocks E. coli-induced suppression of Arc and long-term memory in aged F344xBN F1 rats.
Academic Article	A novel method for modeling facial allodynia associated with migraine in awake and freely moving rats.
Academic Article	Toll-like receptor 4 in CNS pathologies.
Academic Article	Human immunodeficiency virus-1 coat protein gp120 impairs contextual fear conditioning: a potential role in AIDS related learning and memory impairments.
Academic Article	Thermal hyperalgesia and mechanical allodynia produced by intrathecal administration of the human immunodeficiency virus-1 (HIV-1) envelope glycoprotein, gp120.
Academic Article	Caudal granular insular cortex is sufficient and necessary for the long-term maintenance of allodynic behavior in the rat attributable to mononeuropathy.
Academic Article	Effects of vagotomy on lipopolysaccharide-induced brain interleukin-1beta protein in rats.
Academic Article	Safety signals mitigate the consequences of uncontrollable stress via a circuit involving the sensory insular cortex and bed nucleus of the stria terminalis.
Academic Article	Post-conditioning experience with acute or chronic inflammatory pain reduces contextual fear conditioning in the rat.
Academic Article	Glucocorticoids mediate stress-induced priming of microglial pro-inflammatory responses.
Academic Article	Acute neuroimmune modulation attenuates the development of anxiety-like freezing behavior in an animal model of traumatic brain injury.
Academic Article	Prior stressor exposure sensitizes LPS-induced cytokine production.
Academic Article	Prior exposure to repeated morphine potentiates mechanical allodynia induced by peripheral inflammation and neuropathy.
Academic Article	Blocking toll-like receptor 2 and 4 signaling during a stressor prevents stress-induced priming of neuroinflammatory responses to a subsequent immune challenge.
Academic Article	Immune-to-central nervous system communication and its role in modulating pain and cognition: Implications for cancer and cancer treatment.
Academic Article	Glial proinflammatory cytokines mediate exaggerated pain states: implications for clinical pain.
Academic Article	Illness-induced hyperalgesia is mediated by spinal neuropeptides and excitatory amino acids.
Academic Article	Stressed rats fail to expand the CD45RC+CD4+ (Th1-like) T cell subset in response to KLH: possible involvement of IFN-gamma.
Academic Article	Characterization of cytokine-induced hyperalgesia.
Academic Article	Neurocircuitry of illness-induced hyperalgesia.
Academic Article	Intracerebroventricular interleukin-1 receptor antagonist blocks the enhancement of fear conditioning and interference with escape produced by inescapable shock.
Academic Article	Vagal paraganglia bind biotinylated interleukin-1 receptor antagonist: a possible mechanism for immune-to-brain communication.
Academic Article	Prefrontal cortex serotonin, stress, and morphine-induced nucleus accumbens dopamine.
Academic Article	Immune-to-brain communication dynamically modulates pain: physiological and pathological consequences.
Academic Article	Subdiaphragmatic vagotomy does not prevent fever following intracerebroventricular prostaglandin E2: further evidence for the importance of vagal afferents in immune-to-brain communication.
Academic Article	mRNA up-regulation of MHC II and pivotal pro-inflammatory genes in normal brain aging.
Academic Article	Effect of number of tailshocks on learned helplessness and activation of serotonergic and noradrenergic neurons in the rat.
Academic Article	Exposure to inescapable but not escapable shock increases extracellular levels of 5-HT in the dorsal raphe nucleus of the rat.
Academic Article	The long term acute phase-like responses that follow acute stressor exposure are blocked by alpha-melanocyte stimulating hormone.
Academic Article	Timecourse and corticosterone sensitivity of the brain, pituitary, and serum interleukin-1beta protein response to acute stress.
Academic Article	Subdiaphragmatic vagotomy does not block intraperitoneal lipopolysaccharide-induced fever.
Academic Article	A novel immune-to-CNS communication pathway: cells of the meninges surrounding the spinal cord CSF space produce proinflammatory cytokines in response to an inflammatory stimulus.
Academic Article	Interleukin-6 mediates low-threshold mechanical allodynia induced by intrathecal HIV-1 envelope glycoprotein gp120.
Academic Article	Low doses of corticotropin-releasing hormone injected into the dorsal raphe nucleus block the behavioral consequences of uncontrollable stress.
Academic Article	A method for measuring multiple cytokines from small samples.
Academic Article	Glial activation and pathological pain.
Academic Article	Inescapable shock activates serotonergic neurons in all raphe nuclei of rat.
Academic Article	Early-life infection leads to altered BDNF and IL-1beta mRNA expression in rat hippocampus following learning in adulthood.
Academic Article	Anti-inflammatory cytokine gene therapy decreases sensory and motor dysfunction in experimental Multiple Sclerosis: MOG-EAE behavioral and anatomical symptom treatment with cytokine gene therapy.
Academic Article	Reduction of opioid withdrawal and potentiation of acute opioid analgesia by systemic AV411 (ibudilast).
Academic Article	Differential effects of neonatal handling on early life infection-induced alterations in cognition in adulthood.
Academic Article	Intrathecal interleukin-10 gene therapy attenuates paclitaxel-induced mechanical allodynia and proinflammatory cytokine expression in dorsal root ganglia in rats.
Academic Article	Intrathecal injection of an alpha seven nicotinic acetylcholine receptor agonist attenuates gp120-induced mechanical allodynia and spinal pro-inflammatory cytokine profiles in rats.
Academic Article	The role of prior stressor controllability and the dorsal raph? nucleus in sucrose preference and social exploration.
Academic Article	PEGylation of brain-derived neurotrophic factor for preserved biological activity and enhanced spinal cord distribution.
Academic Article	Prior exposure to glucocorticoids sensitizes the neuroinflammatory and peripheral inflammatory responses to E. coli lipopolysaccharide.
Academic Article	Evidence that opioids may have toll-like receptor 4 and MD-2 effects.
Academic Article	Role of the medial prefrontal cortex in coping and resilience.
Academic Article	Stress- and glucocorticoid-induced priming of neuroinflammatory responses: potential mechanisms of stress-induced vulnerability to drugs of abuse.
Academic Article	Voluntary wheel running produces resistance to inescapable stress-induced potentiation of morphine conditioned place preference.
Academic Article	Attenuation of microglial and IL-1 signaling protects mice from acute alcohol-induced sedation and/or motor impairment.
Academic Article	Naloxone-precipitated morphine withdrawal behavior and brain IL-1? expression: comparison of different mouse strains.
Academic Article	Prior exposure to glucocorticoids potentiates lipopolysaccharide induced mechanical allodynia and spinal neuroinflammation.
Academic Article	Glucuronic acid and the ethanol metabolite ethyl-glucuronide cause toll-like receptor 4 activation and enhanced pain.
Academic Article	Short- and long-term consequences of stressor controllability in adolescent rats.
Concept	Brain Ischemia
Concept	Brain Neoplasms
Concept	Blood-Brain Barrier
Concept	Brain
Concept	Brain Injuries
Concept	Brain Stem
Concept	Brain Chemistry
Concept	Brain-Derived Neurotrophic Factor
Concept	Brain Mapping
Academic Article	Intrathecal injection of adenosine 2A receptor agonists reversed neuropathic allodynia through protein kinase (PK)A/PKC signaling.
Academic Article	Stress-induced glucocorticoids as a neuroendocrine alarm signal of danger.
Academic Article	Reversal of established traumatic brain injury-induced, anxiety-like behavior in rats after delayed, post-injury neuroimmune suppression.
Academic Article	High-fat diet consumption disrupts memory and primes elevations in hippocampal IL-1?, an effect that can be prevented with dietary reversal or IL-1 receptor antagonism.
Academic Article	The role of hepatic and splenic macrophages in E. coli-induced memory impairments in aged rats.
Academic Article	Select steroid hormone glucuronide metabolites can cause toll-like receptor 4 activation and enhanced pain.
Academic Article	Microglia inflammatory responses are controlled by an intrinsic circadian clock.
Academic Article	Alcohol-induced sedation and synergistic interactions between alcohol and morphine: a key mechanistic role for Toll-like receptors and MyD88-dependent signaling.
Academic Article	Adenosine 2A receptor agonism: A single intrathecal administration attenuates motor paralysis in experimental autoimmune encephalopathy in rats.
Academic Article	The permissive role of glucocorticoids in neuroinflammatory priming: mechanisms and insights.
Academic Article	(+)-Naltrexone is neuroprotective and promotes alternative activation in the mouse hippocampus after cardiac arrest/cardiopulmonary resuscitation.
Academic Article	Stress sounds the alarmin: The role of the danger-associated molecular pattern HMGB1 in stress-induced neuroinflammatory priming.
Academic Article	The danger-associated molecular pattern HMGB1 mediates the neuroinflammatory effects of methamphetamine.
Academic Article	The redox state of the alarmin HMGB1 is a pivotal factor in neuroinflammatory and microglial priming: A role for the NLRP3 inflammasome.
Academic Article	Morphine amplifies mechanical allodynia via TLR4 in a rat model of spinal cord injury.
Academic Article	Behavioral assessment of neuropathic pain, fatigue, and anxiety in experimental autoimmune encephalomyelitis (EAE) and attenuation by interleukin-10 gene therapy.
Academic Article	Constriction of the buccal branch of the facial nerve produces unilateral craniofacial allodynia.
Academic Article	Supradural inflammatory soup in awake and freely moving rats induces facial allodynia that is blocked by putative immune modulators.
Grant	CYTOKINE TO BRAIN COMMUNICATION--ROLE OF THE VAGUS
Grant	CYTOKINE-TO-BRAIN COMMUNICATION--ROLE OF THE VAGUS
Grant	Pain control via spinal interleukin-10 gene therapy
Grant	Immune and Gilia Regulation of Pain & Analgesic Actions
Grant	Preventing Transition of Acute-to-Chronic Neuropathic Pain: Models, Mechanisms &
Grant	Targeting toll like receptor 4 (TLR4) and TLR2 to resolve EAE-associated paralysis, pain and cognitive deficits: efficacy of a clinically-relevant blood brain barrier permeable TLR4/TLR2 antagonist
Grant	Models and mechanisms for the transition of acute-to-chronic orofacial pain
Grant	Spinal glia activation in human chronic pain
Grant	Exploring the Potential of Glia for Regulating Clinically Relevant Opiod Actions
Academic Article	Innate immune signaling in the ventral tegmental area contributes to drug-primed reinstatement of cocaine seeking.
Academic Article	Protraction of neuropathic pain by morphine is mediated by spinal damage associated molecular patterns (DAMPs) in male rats.
Academic Article	Stress disinhibits microglia via down-regulation of CD200R: A mechanism of neuroinflammatory priming.
Academic Article	Neuroinflammatory priming to stress is differentially regulated in male and female rats.
Academic Article	Sustained reversal of central neuropathic pain induced by a single intrathecal injection of adenosine A2A receptor agonists.
Academic Article	A novel platform for in vivo detection of cytokine release within discrete brain regions.
Academic Article	MicroRNA-124 and microRNA-146a both attenuate persistent neuropathic pain induced by morphine in male rats.
Academic Article	Post-stroke Intranasal (+)-Naloxone Delivery Reduces Microglial Activation and Improves Behavioral Recovery from Ischemic Injury.
Academic Article	Immunization with Mycobacterium vaccae induces an anti-inflammatory milieu in the CNS: Attenuation of stress-induced microglial priming, alarmins and anxiety-like behavior.
Academic Article	Could Probiotics Be Used to Mitigate Neuroinflammation?
Academic Article	Circadian misalignment has differential effects on affective behavior following exposure to controllable or uncontrollable stress.
Academic Article	A single peri-sciatic nerve administration of the adenosine 2A receptor agonist ATL313 produces long-lasting anti-allodynia and anti-inflammatory effects in male rats.
Academic Article	Glucocorticoids mediate stress induction of the alarmin HMGB1 and reduction of the microglia checkpoint receptor CD200R1 in limbic brain structures.
Academic Article	Lovastatin inhibits Toll-like receptor 4 signaling in microglia by targeting its co-receptor myeloid differentiation protein 2 and attenuates neuropathic pain.
Academic Article	Acute stress induces chronic neuroinflammatory, microglial and behavioral priming: A role for potentiated NLRP3 inflammasome activation.
Academic Article	Acute stress induces the rapid and transient induction of caspase-1, gasdermin D and release of constitutive IL-1? protein in dorsal hippocampus.
Academic Article	Targeted interleukin-10 plasmid DNA therapy in the treatment of osteoarthritis: Toxicology and pain efficacy assessments.
Academic Article	Experimental autoimmune encephalopathy (EAE)-induced hippocampal neuroinflammation and memory deficits are prevented with the non-opioid TLR2/TLR4 antagonist (+)-naltrexone.
Academic Article	Toll-like receptor 2 and 4 antagonism for the treatment of experimental autoimmune encephalomyelitis (EAE)-related pain.
Academic Article	Aging and miR-155 in mice influence survival and neuropathic pain after spinal cord injury.
Academic Article	Intrathecal non-viral interleukin-10 gene therapy ameliorates neuropathic pain as measured by both classical static allodynia and a novel supra-spinally mediated pain assay, the Two-Arm Rodent Somatosensory (TARS) task.
Academic Article	Interleukin-1beta and inflammasome expression in spinal cord following chronic constriction injury in male and female rats.
Academic Article	Voluntary wheel running prevents formation of membrane attack complexes and myelin degradation after peripheral nerve injury.

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