Item Type | Name |
Academic Article
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The dorsal raphe nucleus is a site of action mediating the behavioral effects of the benzodiazepine receptor inverse agonist DMCM.
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Academic Article
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A long-term increase in basal levels of corticosterone and a decrease in corticosteroid-binding globulin after acute stressor exposure.
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Academic Article
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Cytokine-to-brain communication: a review & analysis of alternative mechanisms.
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Academic Article
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8-OH-DPAT microinjected in the region of the dorsal raphe nucleus blocks and reverses the enhancement of fear conditioning and interference with escape produced by exposure to inescapable shock.
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Academic Article
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Interleukin-1 beta induced corticosterone elevation and hypothalamic NE depletion is vagally mediated.
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Academic Article
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Blockade of cytokine induced conditioned taste aversion by subdiaphragmatic vagotomy: further evidence for vagal mediation of immune-brain communication.
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Academic Article
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Stress-induced reduction in the rat mixed lymphocyte reaction is due to macrophages and not to changes in T cell phenotypes.
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Academic Article
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A permissive role of corticosterone in an opioid form of stress-induced analgesia: blockade of opiate analgesia is not due to stress-induced hormone release.
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Academic Article
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Route of morphine administration modulates conditioned analgesic tolerance and hyperalgesia.
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Academic Article
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Morphine-induced decreases in in vivo antibody responses.
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Academic Article
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A horseradish peroxidase study of parallel thalamocortical projections responsible for the generation of mid-latency auditory-evoked potentials.
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Academic Article
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Anesthesia-induced modulation of in vivo antibody levels: a study of pentobarbital, chloral hydrate, methoxyflurane, halothane, and ketamine/xylazine.
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Academic Article
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Delta opiate receptors mediate tail-shock induced antinociception at supraspinal levels.
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Academic Article
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The role of the amygdala and dorsal raphe nucleus in mediating the behavioral consequences of inescapable shock.
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Academic Article
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The elevated plus-maze is not sensitive to the effect of stressor controllability in rats.
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Academic Article
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The benzodiazepine receptor antagonists flumazenil and CGS8216 block the enhancement of fear conditioning and interference with escape behavior produced by inescapable shock.
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Academic Article
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Mechanisms of tumor necrosis factor-alpha (TNF-alpha) hyperalgesia.
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Academic Article
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Blockade of the hypothalamic-pituitary-adrenal response to stress by intraventricular injection of dexamethasone: a method for studying the stress-induced peripheral effects of glucocorticoids.
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Academic Article
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A 9L gliosarcoma transplantation model for studying adoptive immunotherapy into the brains of conscious rats.
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Academic Article
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Kappa opiate receptors mediate tail-shock induced antinociception at spinal levels.
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Academic Article
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Peripheral beta-adrenoreceptors and stress-induced hypercholesterolemia in rats.
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Academic Article
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Inescapable shock-induced potentiation of morphine analgesia in rats: involvement of opioid, GABAergic, and serotonergic mechanisms in the dorsal raphe nucleus.
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Academic Article
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TNF-alpha-induced corticosterone elevation but not serum protein or corticosteroid binding globulin reduction is vagally mediated.
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Academic Article
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Exposure to acute stress induces brain interleukin-1beta protein in the rat.
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Academic Article
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Thermogenic and corticosterone responses to intravenous cytokines (IL-1beta and TNF-alpha) are attenuated by subdiaphragmatic vagotomy.
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Academic Article
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Inescapable shock-induced potentiation of morphine analgesia.
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Academic Article
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Acute stressor exposure both suppresses acquired immunity and potentiates innate immunity.
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Academic Article
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Selective effects of peripheral lipopolysaccharide administration on contextual and auditory-cue fear conditioning.
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Academic Article
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Blockade of interleukin-1 induced hyperthermia by subdiaphragmatic vagotomy: evidence for vagal mediation of immune-brain communication.
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Academic Article
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Neurocircuitry of conditioned inhibition of analgesia: effects of amygdala, dorsal raphe, ventral medullary, and spinal cord lesions on antianalgesia in the rat.
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Academic Article
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The impact of the nonpeptide corticotropin-releasing hormone antagonist antalarmin on behavioral and endocrine responses to stress.
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Academic Article
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Interleukin-1 induces c-Fos immunoreactivity in primary afferent neurons of the vagus nerve.
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Academic Article
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Interleukin-1 mediates the behavioral hyperalgesia produced by lithium chloride and endotoxin.
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Academic Article
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Implications of immune-to-brain communication for sickness and pain.
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Academic Article
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Total plasma cholesterol levels of rats are increased following only three sessions of tailshock.
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Academic Article
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Parallel activation of multiple spinal opiate systems appears to mediate 'non-opiate' stress-induced analgesias.
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Academic Article
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Stress, learned helplessness, and brain interleukin-1 beta.
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Academic Article
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Dynamic regulation of the proinflammatory cytokine, interleukin-1beta: molecular biology for non-molecular biologists.
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Academic Article
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Opioid-dependent effects of inescapable shock on escape behavior and conditioned fear responding are mediated by the dorsal raphe nucleus.
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Academic Article
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Long-term changes in mineralocorticoid and glucocorticoid receptor occupancy following exposure to an acute stressor.
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Academic Article
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The amygdala is necessary for the expression of conditioned but not unconditioned analgesia.
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Academic Article
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Opioid and nonopioid interactions in two forms of stress-induced analgesia.
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Academic Article
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Cholecystokinin antianalgesia: safety cues abolish morphine analgesia.
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Academic Article
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The contribution of the vagus nerve in interleukin-1beta-induced fever is dependent on dose.
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Academic Article
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Immune activation: the role of pro-inflammatory cytokines in inflammation, illness responses and pathological pain states.
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Academic Article
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RU-486 blocks differentially suppressive effect of stress on in vivo anti-KLH immunoglobulin response.
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Academic Article
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A new model of sciatic inflammatory neuritis (SIN): induction of unilateral and bilateral mechanical allodynia following acute unilateral peri-sciatic immune activation in rats.
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Academic Article
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Prior stressor exposure primes the HPA axis.
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Academic Article
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Evidence for the involvement of spinal cord glia in subcutaneous formalin induced hyperalgesia in the rat.
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Academic Article
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Reversal of spinal cord non-opiate analgesia by conditioned anti-analgesia in the rat.
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Academic Article
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Sciatic inflammatory neuritis (SIN): behavioral allodynia is paralleled by peri-sciatic proinflammatory cytokine and superoxide production.
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Academic Article
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Evidence that brief stress may induce the acute phase response in rats.
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Academic Article
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The role of the vagus nerve in cytokine-to-brain communication.
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Academic Article
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Peripheral and central proinflammatory cytokine response to a severe acute stressor.
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Academic Article
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Brain-derived neurotrophic factor mRNA downregulation produced by social isolation is blocked by intrahippocampal interleukin-1 receptor antagonist.
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Academic Article
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Further characterization of high mobility group box 1 (HMGB1) as a proinflammatory cytokine: central nervous system effects.
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Academic Article
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Stressor controllability modulates stress-induced serotonin but not dopamine efflux in the nucleus accumbens shell.
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Academic Article
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Stressor controllability modulates stress-induced dopamine and serotonin efflux and morphine-induced serotonin efflux in the medial prefrontal cortex.
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Academic Article
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Circulating cytokines and endotoxin are not necessary for the activation of the sickness or corticosterone response produced by peripheral E. coli challenge.
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Academic Article
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Serum cholesterol levels and stressor controllability in rats.
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Academic Article
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Sciatic inflammatory neuropathy in the rat: surgical procedures, induction of inflammation, and behavioral testing.
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Academic Article
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Stress potentiation of morphine-induced dopamine efflux in the nucleus accumbens shell is dependent upon stressor uncontrollability and is mediated by the dorsal raphe nucleus.
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Academic Article
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Stressor exposure produces long-term reductions in antigen-specific T and B cell responses.
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Academic Article
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HIV-1 gp120 stimulates proinflammatory cytokine-mediated pain facilitation via activation of nitric oxide synthase-I (nNOS).
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Academic Article
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Microinjection of urocortin 2 into the dorsal raphe nucleus activates serotonergic neurons and increases extracellular serotonin in the basolateral amygdala.
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Academic Article
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Snake venom phospholipase A2s (Asp49 and Lys49) induce mechanical allodynia upon peri-sciatic administration: involvement of spinal cord glia, proinflammatory cytokines and nitric oxide.
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Academic Article
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Chemical lesion of the bed nucleus of the stria terminalis blocks the behavioral consequences of uncontrollable stress.
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Academic Article
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Stress-induced sensitization of the hypothalamic-pituitary adrenal axis is associated with alterations of hypothalamic and pituitary gene expression.
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Academic Article
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Activation of the spinal cord complement cascade might contribute to mechanical allodynia induced by three animal models of spinal sensitization.
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Academic Article
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Snake venom components enhance pain upon subcutaneous injection: an initial examination of spinal cord mediators.
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Academic Article
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Fractalkine (CX3CL1) and fractalkine receptor (CX3CR1) distribution in spinal cord and dorsal root ganglia under basal and neuropathic pain conditions.
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Academic Article
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BDNF mRNA expression in rat hippocampus following contextual learning is blocked by intrahippocampal IL-1beta administration.
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Academic Article
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Surgical and pharmacological suppression of glucocorticoids prevents the enhancement of morphine conditioned place preference by uncontrollable stress in rats.
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Academic Article
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Minocycline attenuates mechanical allodynia and proinflammatory cytokine expression in rat models of pain facilitation.
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Academic Article
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Rapid isolation of highly enriched and quiescent microglia from adult rat hippocampus: immunophenotypic and functional characteristics.
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Academic Article
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Activation of serotonin-immunoreactive cells in the dorsal raphe nucleus in rats exposed to an uncontrollable stressor.
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Academic Article
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Controlling neuropathic pain by adeno-associated virus driven production of the anti-inflammatory cytokine, interleukin-10.
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Academic Article
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Glia: novel counter-regulators of opioid analgesia.
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Academic Article
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Controlling pathological pain by adenovirally driven spinal production of the anti-inflammatory cytokine, interleukin-10.
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Academic Article
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Stressor controllability and learned helplessness: the roles of the dorsal raphe nucleus, serotonin, and corticotropin-releasing factor.
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Academic Article
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Expression of c-fos and BDNF mRNA in subregions of the prefrontal cortex of male and female rats after acute uncontrollable stress.
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Academic Article
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Involvement of spinal cord nuclear factor kappaB activation in rat models of proinflammatory cytokine-mediated pain facilitation.
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Academic Article
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Mediation of chronic pain: not by neurons alone.
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Academic Article
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Microglia serve as a neuroimmune substrate for stress-induced potentiation of CNS pro-inflammatory cytokine responses.
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Academic Article
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A behavioural characterization of neonatal infection-facilitated memory impairment in adult rats.
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Academic Article
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The role of glucocorticoids in the uncontrollable stress-induced potentiation of nucleus accumbens shell dopamine and conditioned place preference responses to morphine.
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Academic Article
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Repeated intrathecal injections of plasmid DNA encoding interleukin-10 produce prolonged reversal of neuropathic pain.
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Academic Article
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Behavioral control, the medial prefrontal cortex, and resilience.
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Academic Article
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Norman Cousins Lecture. Glia as the "bad guys": implications for improving clinical pain control and the clinical utility of opioids.
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Academic Article
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Previous experience with behavioral control over stress blocks the behavioral and dorsal raphe nucleus activating effects of later uncontrollable stress: role of the ventral medial prefrontal cortex.
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Academic Article
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Expression of fibroblast growth factor-2 and brain-derived neurotrophic factor mRNA in the medial prefrontal cortex and hippocampus after uncontrollable or controllable stress.
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Academic Article
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The effects of a single exposure to uncontrollable stress on the subsequent conditioned place preference responses to oxycodone, cocaine, and ethanol in rats.
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Academic Article
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The effects of a single session of inescapable tailshock on the subsequent locomotor response to brief footshock and cocaine administration in rats.
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Academic Article
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Characterization of the temporo-spatial effects of chronic bilateral intrahippocampal cannulae on interleukin-1beta.
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Academic Article
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A role for G protein-coupled receptor kinase 2 in mechanical allodynia.
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Academic Article
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Controllable versus uncontrollable stressors bi-directionally modulate conditioned but not innate fear.
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Academic Article
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Opioid-induced glial activation: mechanisms of activation and implications for opioid analgesia, dependence, and reward.
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Academic Article
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"Listening" and "talking" to neurons: implications of immune activation for pain control and increasing the efficacy of opioids.
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Academic Article
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Prostaglandins are necessary and sufficient to induce contextual fear learning impairments after interleukin-1 beta injections into the dorsal hippocampus.
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Academic Article
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Role of the ventral medial prefrontal cortex in mediating behavioral control-induced reduction of later conditioned fear.
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Academic Article
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Phenylephrine-induced antinociception: investigations of potential neural and endocrine bases.
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Academic Article
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Bacterial infection early in life protects against stressor-induced depressive-like symptoms in adult rats.
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Academic Article
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The medial prefrontal cortex regulates the differential expression of morphine-conditioned place preference following a single exposure to controllable or uncontrollable stress.
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Academic Article
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Proinflammatory cytokines oppose opioid-induced acute and chronic analgesia.
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Academic Article
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Time course of hippocampal IL-1 beta and memory consolidation impairments in aging rats following peripheral infection.
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Academic Article
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Minocycline suppresses morphine-induced respiratory depression, suppresses morphine-induced reward, and enhances systemic morphine-induced analgesia.
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Academic Article
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Medial prefrontal cortical activation modulates the impact of controllable and uncontrollable stressor exposure on a social exploration test of anxiety in the rat.
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Academic Article
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Pathological and protective roles of glia in chronic pain.
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Academic Article
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A peptide antagonist of the TLR4-MD2 interaction.
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Academic Article
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The sensory insular cortex mediates the stress-buffering effects of safety signals but not behavioral control.
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Academic Article
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Characterization of the sickness response in young and aging rats following E. coli infection.
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Academic Article
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The glial activation inhibitor AV411 reduces morphine-induced nucleus accumbens dopamine release.
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Academic Article
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The cortical innate immune response increases local neuronal excitability leading to seizures.
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Academic Article
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PEGylation of interleukin-10 for the mitigation of enhanced pain states.
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Academic Article
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Enduring consequences of early-life infection on glial and neural cell genesis within cognitive regions of the brain.
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Academic Article
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Evidence that intrathecal morphine-3-glucuronide may cause pain enhancement via toll-like receptor 4/MD-2 and interleukin-1beta.
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Academic Article
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The "toll" of opioid-induced glial activation: improving the clinical efficacy of opioids by targeting glia.
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Academic Article
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Evidence for a role of heat shock protein-90 in toll like receptor 4 mediated pain enhancement in rats.
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Academic Article
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IL-1RA blocks E. coli-induced suppression of Arc and long-term memory in aged F344xBN F1 rats.
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Academic Article
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A novel method for modeling facial allodynia associated with migraine in awake and freely moving rats.
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Academic Article
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Possible involvement of toll-like receptor 4/myeloid differentiation factor-2 activity of opioid inactive isomers causes spinal proinflammation and related behavioral consequences.
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Academic Article
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Pain intensity and duration can be enhanced by prior challenge: initial evidence suggestive of a role of microglial priming.
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Academic Article
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Release of plasmid DNA-encoding IL-10 from PLGA microparticles facilitates long-term reversal of neuropathic pain following a single intrathecal administration.
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Academic Article
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Dynamic regulation of proinflammatory cytokines.
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Academic Article
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Evidence that tricyclic small molecules may possess toll-like receptor and myeloid differentiation protein 2 activity.
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Academic Article
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Acute stress may facilitate recovery from a subcutaneous bacterial challenge.
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Academic Article
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Toll-like receptor 4 in CNS pathologies.
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Academic Article
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A method for increasing the viability of the external portion of lumbar catheters placed in the spinal subarachnoid space of rats.
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Academic Article
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Spinal upregulation of glutamate transporter GLT-1 by ceftriaxone: therapeutic efficacy in a range of experimental nervous system disorders.
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Academic Article
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Below level central pain induced by discrete dorsal spinal cord injury.
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Academic Article
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Application of a novel in silico high-throughput screen to identify selective inhibitors for protein-protein interactions.
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Academic Article
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Counter-regulation of opioid analgesia by glial-derived bioactive sphingolipids.
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Academic Article
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Human immunodeficiency virus-1 coat protein gp120 impairs contextual fear conditioning: a potential role in AIDS related learning and memory impairments.
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Academic Article
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Thermal hyperalgesia and mechanical allodynia produced by intrathecal administration of the human immunodeficiency virus-1 (HIV-1) envelope glycoprotein, gp120.
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Academic Article
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Caudal granular insular cortex is sufficient and necessary for the long-term maintenance of allodynic behavior in the rat attributable to mononeuropathy.
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Academic Article
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The immune system and memory consolidation: a role for the cytokine IL-1beta.
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Academic Article
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Effects of vagotomy on lipopolysaccharide-induced brain interleukin-1beta protein in rats.
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Academic Article
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Endogenous glucocorticoids play a positive regulatory role in the anti-keyhole limpet hemocyanin in vivo antibody response.
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Academic Article
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Safety signals mitigate the consequences of uncontrollable stress via a circuit involving the sensory insular cortex and bed nucleus of the stria terminalis.
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Academic Article
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Little exercise, big effects: reversing aging and infection-induced memory deficits, and underlying processes.
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Academic Article
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Prior laparotomy or corticosterone potentiates lipopolysaccharide-induced fever and sickness behaviors.
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Academic Article
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Post-conditioning experience with acute or chronic inflammatory pain reduces contextual fear conditioning in the rat.
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Academic Article
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Glucocorticoids mediate stress-induced priming of microglial pro-inflammatory responses.
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Academic Article
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Modulation of the locomotor properties of morphine and amphetamine by uncontrollable stress.
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Academic Article
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Intraneural dexamethasone applied simultaneously to rat sciatic nerve constriction delays the development of hyperalgesia and allodynia.
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Academic Article
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Unilateral T13 and L1 dorsal root avulsion: methods for a novel model of central neuropathic pain.
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Academic Article
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Acute neuroimmune modulation attenuates the development of anxiety-like freezing behavior in an animal model of traumatic brain injury.
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Academic Article
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Prior stressor exposure sensitizes LPS-induced cytokine production.
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Academic Article
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Sex and estradiol influence glial pro-inflammatory responses to lipopolysaccharide in rats.
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Academic Article
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(+)-naloxone, an opioid-inactive toll-like receptor 4 signaling inhibitor, reverses multiple models of chronic neuropathic pain in rats.
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Academic Article
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IL-1RA injected intra-cisterna magna confers extended prophylaxis against lipopolysaccharide-induced neuroinflammatory and sickness responses.
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Academic Article
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Prior exposure to repeated morphine potentiates mechanical allodynia induced by peripheral inflammation and neuropathy.
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Academic Article
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Opioid activation of toll-like receptor 4 contributes to drug reinforcement.
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Academic Article
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Intracisternal interleukin-1 receptor antagonist prevents postoperative cognitive decline and neuroinflammatory response in aged rats.
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Academic Article
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Blocking toll-like receptor 2 and 4 signaling during a stressor prevents stress-induced priming of neuroinflammatory responses to a subsequent immune challenge.
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Academic Article
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A minocycline derivative reduces nerve injury-induced allodynia, LPS-induced prostaglandin E2 microglial production and signaling via toll-like receptors 2 and 4.
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Academic Article
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Spinal glia and proinflammatory cytokines mediate mirror-image neuropathic pain in rats.
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Academic Article
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Immune-to-central nervous system communication and its role in modulating pain and cognition: Implications for cancer and cancer treatment.
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Academic Article
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Glial proinflammatory cytokines mediate exaggerated pain states: implications for clinical pain.
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Academic Article
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Inescapable shock induces resistance to the effects of dexamethasone.
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Academic Article
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Illness-induced hyperalgesia is mediated by spinal neuropeptides and excitatory amino acids.
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Academic Article
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Electrolytic lesions and pharmacological inhibition of the dorsal raphe nucleus prevent stressor potentiation of morphine conditioned place preference in rats.
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Academic Article
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Stressed rats fail to expand the CD45RC+CD4+ (Th1-like) T cell subset in response to KLH: possible involvement of IFN-gamma.
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Academic Article
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Characterization of cytokine-induced hyperalgesia.
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Academic Article
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Acute and conditioned hyperalgesic responses to illness.
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Academic Article
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Peri-sciatic proinflammatory cytokines, reactive oxygen species, and complement induce mirror-image neuropathic pain in rats.
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Academic Article
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Neurocircuitry of illness-induced hyperalgesia.
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Academic Article
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Modulation of the in vivo antibody response by a benzodiazepine inverse agonist (DMCM) administered centrally or peripherally.
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Academic Article
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Intracerebroventricular interleukin-1 receptor antagonist blocks the enhancement of fear conditioning and interference with escape produced by inescapable shock.
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Academic Article
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Vagal paraganglia bind biotinylated interleukin-1 receptor antagonist: a possible mechanism for immune-to-brain communication.
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Academic Article
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Prefrontal cortex serotonin, stress, and morphine-induced nucleus accumbens dopamine.
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Academic Article
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Immune-to-brain communication dynamically modulates pain: physiological and pathological consequences.
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Academic Article
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Medial prefrontal cortex determines how stressor controllability affects behavior and dorsal raphe nucleus.
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Academic Article
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Subdiaphragmatic vagotomy does not prevent fever following intracerebroventricular prostaglandin E2: further evidence for the importance of vagal afferents in immune-to-brain communication.
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Academic Article
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mRNA up-regulation of MHC II and pivotal pro-inflammatory genes in normal brain aging.
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Academic Article
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Peripheral infection and aging interact to impair hippocampal memory consolidation.
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Academic Article
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Effect of number of tailshocks on learned helplessness and activation of serotonergic and noradrenergic neurons in the rat.
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Academic Article
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Exposure to inescapable but not escapable shock increases extracellular levels of 5-HT in the dorsal raphe nucleus of the rat.
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Academic Article
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Specific changes in lymphocyte subpopulations: a potential mechanism for stress-induced immunomodulation.
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Academic Article
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Uncontrollable stress potentiates morphine's rewarding properties.
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Academic Article
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Bacterial endotoxin induces fos immunoreactivity in primary afferent neurons of the vagus nerve.
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Academic Article
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Neonatal infection-induced memory impairment after lipopolysaccharide in adulthood is prevented via caspase-1 inhibition.
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Academic Article
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The long term acute phase-like responses that follow acute stressor exposure are blocked by alpha-melanocyte stimulating hormone.
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Academic Article
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Central proinflammatory cytokines and pain enhancement.
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Academic Article
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Interleukin-1beta in immune cells of the abdominal vagus nerve: a link between the immune and nervous systems?
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Academic Article
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Behavioral control of the stressor modulates stress-induced changes in neurogenesis and fibroblast growth factor-2.
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Academic Article
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Effects of vagotomy on serum endotoxin, cytokines, and corticosterone after intraperitoneal lipopolysaccharide.
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Academic Article
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Timecourse and corticosterone sensitivity of the brain, pituitary, and serum interleukin-1beta protein response to acute stress.
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Academic Article
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Subdiaphragmatic vagotomy does not block intraperitoneal lipopolysaccharide-induced fever.
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Academic Article
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Intrathecal HIV-1 envelope glycoprotein gp120 induces enhanced pain states mediated by spinal cord proinflammatory cytokines.
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Academic Article
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A novel immune-to-CNS communication pathway: cells of the meninges surrounding the spinal cord CSF space produce proinflammatory cytokines in response to an inflammatory stimulus.
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Academic Article
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Interleukin-6 mediates low-threshold mechanical allodynia induced by intrathecal HIV-1 envelope glycoprotein gp120.
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Academic Article
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Corticotropin releasing hormone type 2 receptors in the dorsal raphe nucleus mediate the behavioral consequences of uncontrollable stress.
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Academic Article
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Glia: a novel drug discovery target for clinical pain.
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Academic Article
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Low doses of corticotropin-releasing hormone injected into the dorsal raphe nucleus block the behavioral consequences of uncontrollable stress.
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Academic Article
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A method for measuring multiple cytokines from small samples.
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Academic Article
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Glial activation and pathological pain.
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Academic Article
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Differential expression of 5HT-1A, alpha 1b adrenergic, CRF-R1, and CRF-R2 receptor mRNA in serotonergic, gamma-aminobutyric acidergic, and catecholaminergic cells of the rat dorsal raphe nucleus.
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Academic Article
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Inescapable shock activates serotonergic neurons in all raphe nuclei of rat.
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Academic Article
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The role of IL-1beta in stress-induced sensitization of proinflammatory cytokine and corticosterone responses.
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Academic Article
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A role for proinflammatory cytokines and fractalkine in analgesia, tolerance, and subsequent pain facilitation induced by chronic intrathecal morphine.
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Academic Article
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A new function of the leptin receptor: mediation of the recovery from lipopolysaccharide-induced hypothermia.
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Academic Article
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Spinal gap junctions: potential involvement in pain facilitation.
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Academic Article
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Evidence that exogenous and endogenous fractalkine can induce spinal nociceptive facilitation in rats.
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Academic Article
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Neonatal infection induces memory impairments following an immune challenge in adulthood.
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Academic Article
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An initial investigation of spinal mechanisms underlying pain enhancement induced by fractalkine, a neuronally released chemokine.
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Academic Article
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Early-life infection leads to altered BDNF and IL-1beta mRNA expression in rat hippocampus following learning in adulthood.
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Academic Article
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Spinal cord glia and interleukin-1 do not appear to mediate persistent allodynia induced by intramuscular acidic saline in rats.
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Academic Article
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Non-stereoselective reversal of neuropathic pain by naloxone and naltrexone: involvement of toll-like receptor 4 (TLR4).
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Academic Article
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Anti-inflammatory cytokine gene therapy decreases sensory and motor dysfunction in experimental Multiple Sclerosis: MOG-EAE behavioral and anatomical symptom treatment with cytokine gene therapy.
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Academic Article
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Reduction of opioid withdrawal and potentiation of acute opioid analgesia by systemic AV411 (ibudilast).
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Academic Article
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Differential effects of neonatal handling on early life infection-induced alterations in cognition in adulthood.
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Academic Article
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Intrathecal interleukin-10 gene therapy attenuates paclitaxel-induced mechanical allodynia and proinflammatory cytokine expression in dorsal root ganglia in rats.
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Academic Article
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Immunogenicity of intrathecal plasmid gene delivery: cytokine release and effects on transgene expression.
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Academic Article
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Selective activation of dorsal raphe nucleus-projecting neurons in the ventral medial prefrontal cortex by controllable stress.
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Academic Article
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Stress-induced glucocorticoids suppress the antisense molecular regulation of FGF-2 expression.
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Academic Article
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Ibudilast (AV-411). A new class therapeutic candidate for neuropathic pain and opioid withdrawal syndromes.
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Academic Article
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Enduring reversal of neuropathic pain by a single intrathecal injection of adenosine 2A receptor agonists: a novel therapy for neuropathic pain.
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Academic Article
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5-hydroxytryptamine 2C receptors in the basolateral amygdala are involved in the expression of anxiety after uncontrollable traumatic stress.
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Academic Article
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Neonatal Escherichia coli infection alters glial, cytokine, and neuronal gene expression in response to acute amphetamine in adolescent rats.
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Academic Article
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Intrathecal injection of an alpha seven nicotinic acetylcholine receptor agonist attenuates gp120-induced mechanical allodynia and spinal pro-inflammatory cytokine profiles in rats.
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Academic Article
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Activation of the ventral medial prefrontal cortex during an uncontrollable stressor reproduces both the immediate and long-term protective effects of behavioral control.
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Academic Article
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Aging sensitizes rapidly isolated hippocampal microglia to LPS ex vivo.
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Academic Article
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The role of prior stressor controllability and the dorsal raph? nucleus in sucrose preference and social exploration.
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Academic Article
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Activation of the infralimbic cortex in a fear context enhances extinction learning.
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Academic Article
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Intrathecal injection of naked plasmid DNA provides long-term expression of secreted proteins.
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Academic Article
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PEGylation of brain-derived neurotrophic factor for preserved biological activity and enhanced spinal cord distribution.
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Academic Article
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Long-term control of neuropathic pain in a non-viral gene therapy paradigm.
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Academic Article
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Immunological priming potentiates non-viral anti-inflammatory gene therapy treatment of neuropathic pain.
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Academic Article
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Prior exposure to glucocorticoids sensitizes the neuroinflammatory and peripheral inflammatory responses to E. coli lipopolysaccharide.
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Academic Article
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Evidence that opioids may have toll-like receptor 4 and MD-2 effects.
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Academic Article
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Neonatal bacterial infection alters fever to live and simulated infections in adulthood.
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Academic Article
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Behavioral control over shock blocks behavioral and neurochemical effects of later social defeat.
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Academic Article
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Role of the medial prefrontal cortex in coping and resilience.
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Academic Article
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Stress- and glucocorticoid-induced priming of neuroinflammatory responses: potential mechanisms of stress-induced vulnerability to drugs of abuse.
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Academic Article
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Voluntary wheel running produces resistance to inescapable stress-induced potentiation of morphine conditioned place preference.
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Academic Article
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Attenuation of microglial and IL-1 signaling protects mice from acute alcohol-induced sedation and/or motor impairment.
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Academic Article
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Naloxone-precipitated morphine withdrawal behavior and brain IL-1? expression: comparison of different mouse strains.
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Academic Article
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Prior exposure to glucocorticoids potentiates lipopolysaccharide induced mechanical allodynia and spinal neuroinflammation.
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Academic Article
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An MD2 hot-spot-mimicking peptide that suppresses TLR4-mediated inflammatory response in vitro and in vivo.
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Academic Article
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Exploring the neuroimmunopharmacology of opioids: an integrative review of mechanisms of central immune signaling and their implications for opioid analgesia.
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Academic Article
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Inhibiting the TLR4-MyD88 signalling cascade by genetic or pharmacological strategies reduces acute alcohol-induced sedation and motor impairment in mice.
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Academic Article
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Uncontrollable, but not controllable, stress desensitizes 5-HT1A receptors in the dorsal raphe nucleus.
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Academic Article
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Commentary on Landry et al.: "Propentofylline, a CNS glial modulator, does not decrease pain in post-herpetic neuralgia patients: in vitro evidence for differential responses in human and rodent microglia and macrophages".
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Academic Article
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Morphine activates neuroinflammation in a manner parallel to endotoxin.
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Academic Article
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Harnessing pain heterogeneity and RNA transcriptome to identify blood-based pain biomarkers: a novel correlational study design and bioinformatics approach in a graded chronic constriction injury model.
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Academic Article
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Glucuronic acid and the ethanol metabolite ethyl-glucuronide cause toll-like receptor 4 activation and enhanced pain.
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Academic Article
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Anxiogenic effects of brief swim stress are sensitive to stress history.
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Academic Article
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Effect of chronic delivery of the Toll-like receptor 4 antagonist (+)-naltrexone on incubation of heroin craving.
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Academic Article
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Toll-like receptors in chronic pain.
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Academic Article
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Activation of the medial prefrontal cortex by escapable stress is necessary for protection against subsequent inescapable stress-induced potentiation of morphine conditioned place preference.
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Academic Article
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Tetracyclines and pain.
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Academic Article
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Indwelling supradural catheters for induction of facial allodynia: surgical procedures, application of inflammatory stimuli, and behavioral testing.
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Academic Article
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Short- and long-term consequences of stressor controllability in adolescent rats.
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Academic Article
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Systemic administration of an alpha-7 nicotinic acetylcholine agonist reverses neuropathic pain in male Sprague Dawley rats.
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Concept
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Physical Conditioning, Animal
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Concept
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Disease Models, Animal
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Concept
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Animals, Newborn
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Concept
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Models, Animal
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Concept
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Animals
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Concept
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Animal Diseases
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Concept
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Behavior, Animal
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Academic Article
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Rifampin inhibits Toll-like receptor 4 signaling by targeting myeloid differentiation protein 2 and attenuates neuropathic pain.
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Academic Article
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Intrathecal injection of adenosine 2A receptor agonists reversed neuropathic allodynia through protein kinase (PK)A/PKC signaling.
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Academic Article
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Stress-induced glucocorticoids as a neuroendocrine alarm signal of danger.
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Academic Article
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Why is neuroimmunopharmacology crucial for the future of addiction research?
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Academic Article
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Reversal of established traumatic brain injury-induced, anxiety-like behavior in rats after delayed, post-injury neuroimmune suppression.
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Academic Article
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Suppression of voluntary wheel running in rats is dependent on the site of inflammation: evidence for voluntary running as a measure of hind paw-evoked pain.
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Academic Article
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Systemic administration of propentofylline, ibudilast, and (+)-naltrexone each reverses mechanical allodynia in a novel rat model of central neuropathic pain.
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Academic Article
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Chronic exposure to exogenous glucocorticoids primes microglia to pro-inflammatory stimuli and induces NLRP3 mRNA in the hippocampus.
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Academic Article
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Pathological pain and the neuroimmune interface.
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Academic Article
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A concern on comparing 'apples' and 'oranges' when differences between microglia used in human and rodent studies go far, far beyond simply species: comment on Smith and Dragunow.
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Academic Article
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Control over a stressor involves the posterior dorsal striatum and the act/outcome circuit.
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Academic Article
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In vivo veritas: (+)-Naltrexone's actions define translational importance: A letter in response to Skolnick et al. 'Translational potential of naloxone and naltrexone as TLR4 antagonists'.
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Academic Article
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Discovery of a novel site of opioid action at the innate immune pattern-recognition receptor TLR4 and its role in addiction.
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Academic Article
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Glial TLR4 signaling does not contribute to opioid-induced depression of respiration.
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Academic Article
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High-fat diet consumption disrupts memory and primes elevations in hippocampal IL-1?, an effect that can be prevented with dietary reversal or IL-1 receptor antagonism.
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Academic Article
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The role of hepatic and splenic macrophages in E. coli-induced memory impairments in aged rats.
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Academic Article
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Activation of adult rat CNS endothelial cells by opioid-induced toll-like receptor 4 (TLR4) signaling induces proinflammatory, biochemical, morphological, and behavioral sequelae.
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Academic Article
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Select steroid hormone glucuronide metabolites can cause toll-like receptor 4 activation and enhanced pain.
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Academic Article
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Stress induces the danger-associated molecular pattern HMGB-1 in the hippocampus of male Sprague Dawley rats: a priming stimulus of microglia and the NLRP3 inflammasome.
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Academic Article
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Microglia inflammatory responses are controlled by an intrinsic circadian clock.
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Academic Article
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Alcohol-induced sedation and synergistic interactions between alcohol and morphine: a key mechanistic role for Toll-like receptors and MyD88-dependent signaling.
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Academic Article
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Pioglitazone rapidly reduces neuropathic pain through astrocyte and nongenomic PPAR? mechanisms.
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Academic Article
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Greater glucocorticoid receptor activation in hippocampus of aged rats sensitizes microglia.
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Academic Article
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Opioid-induced central immune signaling: implications for opioid analgesia.
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Academic Article
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Adenosine 2A receptor agonism: A single intrathecal administration attenuates motor paralysis in experimental autoimmune encephalopathy in rats.
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Academic Article
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The therapeutic potential of interleukin-10 in neuroimmune diseases.
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Academic Article
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Structure-Activity Relationships of (+)-Naltrexone-Inspired Toll-like Receptor 4 (TLR4) Antagonists.
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Academic Article
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Targeting the Toll of Drug Abuse: The Translational Potential of Toll-Like Receptor 4.
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Academic Article
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(+)-Naltrexone is neuroprotective and promotes alternative activation in the mouse hippocampus after cardiac arrest/cardiopulmonary resuscitation.
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Academic Article
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Stress sounds the alarmin: The role of the danger-associated molecular pattern HMGB1 in stress-induced neuroinflammatory priming.
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Academic Article
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Neuroinflammation in the normal aging hippocampus.
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Academic Article
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DAT isn't all that: cocaine reward and reinforcement require Toll-like receptor 4 signaling.
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Academic Article
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The danger-associated molecular pattern HMGB1 mediates the neuroinflammatory effects of methamphetamine.
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Academic Article
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Previous Ketamine Produces an Enduring Blockade of Neurochemical and Behavioral Effects of Uncontrollable Stress.
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Academic Article
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Stress-induced neuroinflammatory priming is time of day dependent.
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Academic Article
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The redox state of the alarmin HMGB1 is a pivotal factor in neuroinflammatory and microglial priming: A role for the NLRP3 inflammasome.
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Academic Article
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Morphine paradoxically prolongs neuropathic pain in rats by amplifying spinal NLRP3 inflammasome activation.
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Academic Article
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The Alarmin HMGB1 Mediates Age-Induced Neuroinflammatory Priming.
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Academic Article
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Prior voluntary wheel running attenuates neuropathic pain.
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Academic Article
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Glucocorticoids Mediate Short-Term High-Fat Diet Induction of Neuroinflammatory Priming, the NLRP3 Inflammasome, and the Danger Signal HMGB1.
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Academic Article
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Morphine amplifies mechanical allodynia via TLR4 in a rat model of spinal cord injury.
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Academic Article
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Diminished circadian rhythms in hippocampal microglia may contribute to age-related neuroinflammatory sensitization.
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Academic Article
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HMGB1 Activates Proinflammatory Signaling via TLR5 Leading to Allodynia.
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Academic Article
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Activation of a Habenulo-Raphe Circuit Is Critical for the Behavioral and Neurochemical Consequences of Uncontrollable Stress in the Male Rat.
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Academic Article
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Nitroxidative Signaling Mechanisms in Pathological Pain.
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Academic Article
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Behavioral assessment of neuropathic pain, fatigue, and anxiety in experimental autoimmune encephalomyelitis (EAE) and attenuation by interleukin-10 gene therapy.
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Academic Article
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Constriction of the buccal branch of the facial nerve produces unilateral craniofacial allodynia.
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Academic Article
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Stable, long-term, spatial memory in young and aged rats achieved with a one day Morris water maze training protocol.
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Academic Article
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Supradural inflammatory soup in awake and freely moving rats induces facial allodynia that is blocked by putative immune modulators.
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Grant
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ALLODYNIC EFFECTS OF SCIATIC INFLAMMATORY NEURITIS
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Grant
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Immune /Glial Mediation of Exaggerated Pain States
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Academic Article
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Opioid Self-Administration is Attenuated by Early-Life Experience and Gene Therapy for Anti-Inflammatory IL-10 in the Nucleus Accumbens of Male Rats.
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Academic Article
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Exploring acute-to-chronic neuropathic pain in rats after contusion spinal cord injury.
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Academic Article
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High-fat diet and aging interact to produce neuroinflammation and impair hippocampal- and amygdalar-dependent memory.
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Academic Article
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Innate immune signaling in the ventral tegmental area contributes to drug-primed reinstatement of cocaine seeking.
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Academic Article
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Protraction of neuropathic pain by morphine is mediated by spinal damage associated molecular patterns (DAMPs) in male rats.
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Academic Article
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Toll-like receptors and their role in persistent pain.
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Academic Article
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Stress disinhibits microglia via down-regulation of CD200R: A mechanism of neuroinflammatory priming.
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Academic Article
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Behavioural and neural sequelae of stressor exposure are not modulated by controllability in females.
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Academic Article
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Inhibition of a Descending Prefrontal Circuit Prevents Ketamine-Induced Stress Resilience in Females.
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Academic Article
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Neuroinflammatory priming to stress is differentially regulated in male and female rats.
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Academic Article
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DREADDed microglia in pain: Implications for spinal inflammatory signaling in male rats.
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Academic Article
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Sustained reversal of central neuropathic pain induced by a single intrathecal injection of adenosine A2A receptor agonists.
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Academic Article
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Repeated Morphine Prolongs Postoperative Pain in Male Rats.
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Academic Article
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A novel platform for in vivo detection of cytokine release within discrete brain regions.
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Academic Article
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MicroRNA-124 and microRNA-146a both attenuate persistent neuropathic pain induced by morphine in male rats.
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Academic Article
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Post-stroke Intranasal (+)-Naloxone Delivery Reduces Microglial Activation and Improves Behavioral Recovery from Ischemic Injury.
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Academic Article
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MicroRNAs: Roles in Regulating Neuroinflammation.
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Academic Article
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Immunization with Mycobacterium vaccae induces an anti-inflammatory milieu in the CNS: Attenuation of stress-induced microglial priming, alarmins and anxiety-like behavior.
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Academic Article
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Could Probiotics Be Used to Mitigate Neuroinflammation?
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Academic Article
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Mycobacterium vaccae immunization protects aged rats from surgery-elicited neuroinflammation and cognitive dysfunction.
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Academic Article
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Circadian misalignment has differential effects on affective behavior following exposure to controllable or uncontrollable stress.
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Academic Article
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A single peri-sciatic nerve administration of the adenosine 2A receptor agonist ATL313 produces long-lasting anti-allodynia and anti-inflammatory effects in male rats.
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Academic Article
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Spinal Cord Injury in Rats Disrupts the Circadian System.
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Academic Article
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Microglia: Neuroimmune-sensors of stress.
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Academic Article
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Spinal Cord Injury in Rats Dysregulates Diurnal Rhythms of Fecal Output and Liver Metabolic Indicators.
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Academic Article
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Glucocorticoids mediate stress induction of the alarmin HMGB1 and reduction of the microglia checkpoint receptor CD200R1 in limbic brain structures.
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Academic Article
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Stereochemistry and innate immune recognition: (+)-norbinaltorphimine targets myeloid differentiation protein 2 and inhibits toll-like receptor 4 signaling.
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Academic Article
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TDP-43 knockdown causes innate immune activation via protein kinase R in astrocytes.
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Academic Article
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Oxycodone, fentanyl, and morphine amplify established neuropathic pain in male rats.
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Academic Article
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Methamphetamine Activates Toll-Like Receptor 4 to Induce Central Immune Signaling within the Ventral Tegmental Area and Contributes to Extracellular Dopamine Increase in the Nucleus Accumbens Shell.
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Academic Article
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Lovastatin inhibits Toll-like receptor 4 signaling in microglia by targeting its co-receptor myeloid differentiation protein 2 and attenuates neuropathic pain.
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Academic Article
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The behavioral and neurochemical effects of an inescapable stressor are time of day dependent.
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Academic Article
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Activation of sphingosine-1-phosphate receptor subtype 1 in the central nervous system contributes to morphine-induced hyperalgesia and antinociceptive tolerance in rodents.
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Academic Article
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Acute stress induces chronic neuroinflammatory, microglial and behavioral priming: A role for potentiated NLRP3 inflammasome activation.
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Academic Article
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Suppression of active phase voluntary wheel running in male rats by unilateral chronic constriction injury: Enduring therapeutic effects of a brief treatment of morphine combined with TLR4 or P2X7 antagonists.
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Academic Article
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Acute stress induces the rapid and transient induction of caspase-1, gasdermin D and release of constitutive IL-1? protein in dorsal hippocampus.
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Academic Article
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Targeted interleukin-10 plasmid DNA therapy in the treatment of osteoarthritis: Toxicology and pain efficacy assessments.
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Academic Article
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Experimental autoimmune encephalopathy (EAE)-induced hippocampal neuroinflammation and memory deficits are prevented with the non-opioid TLR2/TLR4 antagonist (+)-naltrexone.
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Academic Article
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Toll-like receptor 2 and 4 antagonism for the treatment of experimental autoimmune encephalomyelitis (EAE)-related pain.
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Academic Article
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Postoperative cognitive dysfunction is made persistent with morphine treatment in aged rats.
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Academic Article
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Implantable automatic defibrillators: their potential in prevention of sudden coronary death.
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Academic Article
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Aging and miR-155 in mice influence survival and neuropathic pain after spinal cord injury.
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Academic Article
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Preconditioning by voluntary wheel running attenuates later neuropathic pain via nuclear factor E2-related factor 2 antioxidant signaling in rats.
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Academic Article
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Toll-like receptor 4 antagonists reduce cocaine-primed reinstatement of drug seeking.
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Academic Article
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Interleukin-1beta and inflammasome expression in spinal cord following chronic constriction injury in male and female rats.
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Academic Article
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Voluntary wheel running prevents formation of membrane attack complexes and myelin degradation after peripheral nerve injury.
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