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Search Results to Robert Charles Doebele

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One or more keywords matched the following items that are connected to Doebele, Robert

Item TypeName
Academic Article Mechanisms of resistance to crizotinib in patients with ALK gene rearranged non-small cell lung cancer.
Academic Article Oncogenic fusions involving exon 19 of ALK.
Academic Article Anaplastic lymphoma kinase gene rearrangements in non-small cell lung cancer are associated with prolonged progression-free survival on pemetrexed.
Academic Article Genetic testing for lung cancer: reflex versus clinical selection.
Academic Article Oncogene status predicts patterns of metastatic spread in treatment-naive nonsmall cell lung cancer.
Academic Article Identifying and targeting ROS1 gene fusions in non-small cell lung cancer.
Academic Article Targeting ALK, ROS1, and BRAF kinases.
Academic Article Crizotinib for the treatment of patients with advanced non-small cell lung cancer.
Academic Article Local ablative therapy of oligoprogressive disease prolongs disease control by tyrosine kinase inhibitors in oncogene-addicted non-small-cell lung cancer.
Concept Oncogene Fusion
Concept Oncogene Proteins, Fusion
Concept Oncogenes
Concept Proto-Oncogene Proteins B-raf
Concept Oncogene Proteins
Concept Proto-Oncogene Proteins p21(ras)
Concept Proto-Oncogene Proteins c-ret
Concept Proto-Oncogene Proteins c-met
Concept Proto-Oncogene Proteins
Concept Proto-Oncogene Proteins c-kit
Academic Article Molecular pathways: ROS1 fusion proteins in cancer.
Academic Article Targeted therapies: Time to shift the burden of proof for oncogene-positive cancer?
Academic Article Oncogenic and drug-sensitive NTRK1 rearrangements in lung cancer.
Academic Article Resistance to ROS1 inhibition mediated by EGFR pathway activation in non-small cell lung cancer.
Academic Article ROS1 and ALK fusions in colorectal cancer, with evidence of intratumoral heterogeneity for molecular drivers.
Academic Article Targeted therapies in non-small cell lung cancer: emerging oncogene targets following the success of epidermal growth factor receptor.
Academic Article The democratization of the oncogene.
Academic Article The minority report: targeting the rare oncogenes in NSCLC.
Academic Article Crizotinib in ROS1-rearranged non-small-cell lung cancer.
Academic Article TRKing down an old oncogene in a new era of targeted therapy.
Academic Article Activation of RAS family members confers resistance to ROS1 targeting drugs.
Academic Article Rearranging Detection of Gene Rearrangements.
Academic Article RAS-MAPK dependence underlies a rational polytherapy strategy in EML4-ALK-positive lung cancer.
Academic Article An Oncogenic NTRK Fusion in a Patient with Soft-Tissue Sarcoma with Response to the Tropomyosin-Related Kinase Inhibitor LOXO-101.
Academic Article Malignant pleural disease is highly associated with subsequent peritoneal metastasis in patients with stage IV non-small cell lung cancer independent of oncogene status.
Academic Article A framework for understanding and targeting residual disease in oncogene-driven solid cancers.
Academic Article An Activating KIT Mutation Induces Crizotinib Resistance in ROS1-Positive Lung Cancer.
Academic Article Identifying the Appropriate FISH Criteria for Defining MET Copy Number-Driven Lung Adenocarcinoma through Oncogene Overlap Analysis.
Academic Article Neoadjuvant Oncogene-Targeted Therapy in Early Stage Non-Small-Cell Lung Cancer as a Strategy to Improve Clinical Outcome and Identify Early Mechanisms of Resistance.
Academic Article Safety and Antitumor Activity of the Multitargeted Pan-TRK, ROS1, and ALK Inhibitor Entrectinib: Combined Results from Two Phase I Trials (ALKA-372-001 and STARTRK-1).
Grant The role of EGFR as a mechanism of therapeutic resistance in gene fusion positive lung cancer.
Academic Article EGFR Mediates Responses to Small-Molecule Drugs Targeting Oncogenic Fusion Kinases.
Academic Article Resistance to RET-Inhibition in RET-Rearranged NSCLC Is Mediated By Reactivation of RAS/MAPK Signaling.
Academic Article Targeting RET in Patients With RET-Rearranged Lung Cancers: Results From the Global, Multicenter RET Registry.
Academic Article Baseline and On-Treatment Characteristics of Serum Tumor Markers in Stage IV Oncogene-Addicted Adenocarcinoma of the Lung.
Academic Article ALK Inhibitor Response in Melanomas Expressing EML4-ALK Fusions and Alternate ALK Isoforms.
Academic Article Triple Angiokinase Inhibitor Nintedanib Directly Inhibits Tumor Cell Growth and Induces Tumor Shrinkage via Blocking Oncogenic Receptor Tyrosine Kinases.
Academic Article Efficacy of Larotrectinib in TRK Fusion-Positive Cancers in Adults and Children.
Academic Article Clinical Utility of Cell-Free DNA for the Detection of ALK Fusions and Genomic Mechanisms of ALK Inhibitor Resistance in Non-Small Cell Lung Cancer.
Academic Article Resistance Mechanisms to Targeted Therapies in ROS1+ and ALK+ Non-small Cell Lung Cancer.
Academic Article Comparison of Molecular Testing Modalities for Detection of ROS1 Rearrangements in a Cohort of Positive Patient Samples.
Academic Article The Incidence of Brain Metastases in Stage IV ROS1-Rearranged Non-Small Cell Lung Cancer and Rate of Central Nervous System Progression on Crizotinib.
Academic Article Repotrectinib (TPX-0005) Is a Next-Generation ROS1/TRK/ALK Inhibitor That Potently Inhibits ROS1/TRK/ALK Solvent- Front Mutations.
Academic Article First-line Chemotherapy Responsiveness and Patterns of Metastatic Spread Identify Clinical Syndromes Present Within Advanced KRAS Mutant Non-Small-cell Lung Cancer With Different Prognostic Significance.
Academic Article A Phase I/Ib Trial of the VEGFR-Sparing Multikinase RET Inhibitor RXDX-105.
Academic Article ROS1 Gene Rearrangements Are Associated With an Elevated Risk of Peridiagnosis Thromboembolic Events.
Academic Article Differential Subcellular Localization Regulates Oncogenic Signaling by ROS1 Kinase Fusion Proteins.
Academic Article Larotrectinib in adult patients with solid tumours: a multi-centre, open-label, phase I dose-escalation study.
Academic Article Comparing and contrasting predictive biomarkers for immunotherapy and targeted therapy of NSCLC.
Academic Article Analysis of Cell-Free DNA from 32,989 Advanced Cancers Reveals Novel Co-occurring Activating RET Alterations and Oncogenic Signaling Pathway Aberrations.
Academic Article Acquired Resistance Is Oncogene and Drug Agnostic.
Academic Article Targeted therapies for ROS1-rearranged non-small cell lung cancer.
Academic Article Entrectinib in ROS1 fusion-positive non-small-cell lung cancer: integrated analysis of three phase 1-2 trials.
Academic Article Granulomatosis with polyangiitis in a patient treated with dabrafenib and trametinib for BRAF V600E positive lung adenocarcinoma.
Academic Article Tarloxotinib Is a Hypoxia-Activated Pan-HER Kinase Inhibitor Active Against a Broad Range of HER-Family Oncogenes.
Academic Article Updated Integrated Analysis of the Efficacy and Safety of Entrectinib in Locally Advanced or Metastatic ROS1 Fusion-Positive Non-Small-Cell Lung Cancer.
Academic Article Novel Human-Derived RET Fusion NSCLC Cell Lines Have Heterogeneous Responses to RET Inhibitors and Differential Regulation of Downstream Signaling.
Academic Article Patient-reported outcomes from STARTRK-2: a global phase II basket study of entrectinib for ROS1 fusion-positive non-small-cell lung cancer and NTRK fusion-positive solid tumours.
Academic Article Clinicopathologic Features and Response to Therapy of NRG1 Fusion-Driven Lung Cancers: The eNRGy1 Global Multicenter Registry.
Academic Article Pralsetinib for RET fusion-positive non-small-cell lung cancer (ARROW): a multi-cohort, open-label, phase 1/2 study.

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