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Search Results to Thomas R Cech

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Cech, Thomas

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Item Type	Name
Academic Article	Sequence requirements for self-splicing of the Tetrahymena thermophila pre-ribosomal RNA.
Academic Article	Sites of circularization of the Tetrahymena rRNA IVS are determined by sequence and influenced by position and secondary structure.
Academic Article	Reactions of the intervening sequence of the Tetrahymena ribosomal ribonucleic acid precursor: pH dependence of cyclization and site-specific hydrolysis.
Academic Article	Self-splicing RNA: implications for evolution.
Academic Article	In vitro splicing of the ribosomal RNA precursor of Tetrahymena: involvement of a guanosine nucleotide in the excision of the intervening sequence.
Academic Article	Autocatalytic cyclization of an excised intervening sequence RNA is a cleavage-ligation reaction.
Academic Article	Self-splicing RNA: autoexcision and autocyclization of the ribosomal RNA intervening sequence of Tetrahymena.
Academic Article	Transcribed and non-transcribed regions of Tetrahymena ribosomal gene chromatin have different accessibilities to micrococcal nuclease.
Academic Article	Different nucleosome spacing in transcribed and non-transcribed regions of the ribosomal RNA gene in Tetrahymena thermophila.
Academic Article	Fate of an intervening sequence ribonucleic acid: excision and cyclization of the Tetrahymena ribosomal ribonucleic acid intervening sequence in vivo.
Academic Article	The intervening sequence excised from the ribosomal RNA precursor of Tetrahymena contains a 5-terminal guanosine residue not encoded by the DNA.
Academic Article	Catalysis of RNA cleavage by a ribozyme derived from the group I intron of Anabaena pre-tRNA(Leu).
Academic Article	Chromatin structure of the ribosomal RNA genes of Tetrahymena thermophila as analyzed by trimethylpsoralen crosslinking in vivo.
Academic Article	Tertiary interactions with the internal guide sequence mediate docking of the P1 helix into the catalytic core of the Tetrahymena ribozyme.
Academic Article	Translocation of an RNA duplex on a ribozyme.
Academic Article	Representation of the secondary and tertiary structure of group I introns.
Academic Article	Relative orientation of RNA helices in a group 1 ribozyme determined by helix extension electron microscopy.
Academic Article	Movement of the guide sequence during RNA catalysis by a group I ribozyme.
Academic Article	The importance of being ribose at the cleavage site in the Tetrahymena ribozyme reaction.
Academic Article	A positive entropy change for guanosine binding and for the chemical step in the Tetrahymena ribozyme reaction.
Academic Article	Two major tertiary folding transitions of the Tetrahymena catalytic RNA.
Academic Article	GAAA tetraloop and conserved bulge stabilize tertiary structure of a group I intron domain.
Academic Article	Coaxially stacked RNA helices in the catalytic center of the Tetrahymena ribozyme.
Academic Article	The efficiency and versatility of catalytic RNA: implications for an RNA world.
Academic Article	Guanosine binding to the Tetrahymena ribozyme: thermodynamic coupling with oligonucleotide binding.
Academic Article	The intervening sequence of the ribosomal RNA precursor is converted to a circular RNA in isolated nuclei of Tetrahymena.
Academic Article	A labile phosphodiester bond at the ligation junction in a circular intervening sequence RNA.
Academic Article	Secondary structure of the Tetrahymena ribosomal RNA intervening sequence: structural homology with fungal mitochondrial intervening sequences.
Academic Article	Mutations in the Tetrahymena ribozyme internal guide sequence: effects on docking of the P1 helix into the catalytic core and correlation with catalytic activity.
Academic Article	RNA splicing: three themes with variations.
Academic Article	Conserved thermochemistry of guanosine nucleophile binding for structurally distinct group I ribozymes.
Academic Article	Mitochondrial import of only one of three nuclear-encoded glutamine tRNAs in Tetrahymena thermophila.
Academic Article	RNA substrate binding site in the catalytic core of the Tetrahymena ribozyme.
Academic Article	The anticodon is the signal sequence for mitochondrial import of glutamine tRNA in Tetrahymena.
Academic Article	Kinetic pathway for folding of the Tetrahymena ribozyme revealed by three UV-inducible crosslinks.
Academic Article	Joining the two domains of a group I ribozyme to form the catalytic core.
Academic Article	Crystal structure of a group I ribozyme domain: principles of RNA packing.
Academic Article	RNA tertiary structure mediation by adenosine platforms.
Academic Article	Effects of divalent metal ions on individual steps of the Tetrahymena ribozyme reaction.
Academic Article	Crystals by design: a strategy for crystallization of a ribozyme derived from the Tetrahymena group I intron.
Academic Article	A second catalytic metal ion in group I ribozyme.
Academic Article	Mutagenesis and comparative sequence analysis of a base triple joining the two domains of group I ribozymes.
Academic Article	Self-assembly of a group I intron active site from its component tertiary structural domains.
Academic Article	Identification of ribozymes within a ribozyme library that efficiently cleave a long substrate RNA.
Academic Article	Visualization of a tertiary structural domain of the Tetrahymena group I intron by electron microscopy.
Academic Article	Thermodynamic stability of the P4-P6 domain RNA tertiary structure measured by temperature gradient gel electrophoresis.
Academic Article	An independently folding domain of RNA tertiary structure within the Tetrahymena ribozyme.
Academic Article	A preorganized active site in the crystal structure of the Tetrahymena ribozyme.
Academic Article	Mutations at the guanosine-binding site of the Tetrahymena ribozyme also affect site-specific hydrolysis.
Academic Article	A tertiary interaction in the Tetrahymena intron contributes to selection of the 5' splice site.
Academic Article	Replacement of the conserved G.U with a G-C pair at the cleavage site of the Tetrahymena ribozyme decreases binding, reactivity, and fidelity.
Academic Article	Energetics and cooperativity of tertiary hydrogen bonds in RNA structure.
Academic Article	Self-splicing of the Tetrahymena intron from mRNA in mammalian cells.
Academic Article	RNA tertiary folding monitored by fluorescence of covalently attached pyrene.
Academic Article	Quantifying the energetic interplay of RNA tertiary and secondary structure interactions.
Academic Article	Multiple folding pathways for the P4-P6 RNA domain.
Academic Article	Structural basis of the enhanced stability of a mutant ribozyme domain and a detailed view of RNA--solvent interactions.
Academic Article	A hammerhead ribozyme allows synthesis of a new form of the Tetrahymena ribozyme homogeneous in length with a 3' end blocked for transesterification.
Academic Article	The intervening sequence RNA of Tetrahymena is an enzyme. 1986.
Academic Article	Ribozyme recognition of RNA by tertiary interactions with specific ribose 2'-OH groups.
Academic Article	The intervening sequence RNA of Tetrahymena is an enzyme.
Academic Article	Folding of group I introns from bacteriophage T4 involves internalization of the catalytic core.
Academic Article	The Euplotes La motif protein p43 has properties of a telomerase-specific subunit.
Academic Article	A self-splicing group I intron in the nuclear pre-rRNA of the green alga, Ankistrodesmus stipitatus.
Academic Article	Tetrahymena telomerase is active as a monomer.
Academic Article	Localization of transcribed regions on extrachromosomal ribosomal RNA genes of Tetrahymena thermophila by R-loop mapping.
Academic Article	Alternative secondary structures in the 5' exon affect both forward and reverse self-splicing of the Tetrahymena intervening sequence RNA.
Academic Article	Soluble domains of telomerase reverse transcriptase identified by high-throughput screening.
Academic Article	Self-splicing and enzymatic activity of an intervening sequence RNA from Tetrahymena.
Academic Article	Visualizing the higher order folding of a catalytic RNA molecule.
Academic Article	Ribozyme-catalyzed and nonenzymatic reactions of phosphate diesters: rate effects upon substitution of sulfur for a nonbridging phosphoryl oxygen atom.
Academic Article	Crystal structure of the essential N-terminal domain of telomerase reverse transcriptase.
Academic Article	Local RNA structural changes induced by crystallization are revealed by SHAPE.
Academic Article	Self-splicing of group I introns.
Academic Article	Direct measurement of oligonucleotide substrate binding to wild-type and mutant ribozymes from Tetrahymena.
Academic Article	Catalysis of RNA cleavage by the Tetrahymena thermophila ribozyme. 2. Kinetic description of the reaction of an RNA substrate that forms a mismatch at the active site.
Academic Article	Mutation in TERT separates processivity from anchor-site function.
Academic Article	Role of conserved sequence elements 9L and 2 in self-splicing of the Tetrahymena ribosomal RNA precursor.
Academic Article	A model for the RNA-catalyzed replication of RNA.
Academic Article	Self-catalyzed cyclization of the intervening sequence RNA of Tetrahymena: inhibition by methidiumpropyl.EDTA and localization of the major dye binding sites.
Academic Article	Biological catalysis by RNA.
Academic Article	The chemistry of self-splicing RNA and RNA enzymes.
Academic Article	RNA as an enzyme.
Academic Article	Specificity for 3',5'-linked substrates in RNA-catalyzed RNA polymerization.
Academic Article	Stereochemistry of RNA cleavage by the Tetrahymena ribozyme and evidence that the chemical step is not rate-limiting.
Academic Article	Defining the inside and outside of a catalytic RNA molecule.
Academic Article	A mutant of Tetrahymena telomerase reverse transcriptase with increased processivity.
Academic Article	Aminoacyl esterase activity of the Tetrahymena ribozyme.
Academic Article	Monovalent cation-induced structure of telomeric DNA: the G-quartet model.
Academic Article	RNA chemistry. Ribozyme self-replication?
Academic Article	A Tetrahymena intron nucleotide connected to the GTP/arginine site.
Academic Article	DNA cleavage catalysed by the ribozyme from Tetrahymena.
Academic Article	The RNA accordion model for template positioning by telomerase RNA during telomeric DNA synthesis.
Academic Article	Nobel lecture. Self-splicing and enzymatic activity of an intervening sequence RNA from Tetrahymena.
Academic Article	In vivo selection of better self-splicing introns in Escherichia coli: the role of the P1 extension helix of the Tetrahymena intron.
Academic Article	The telomeres of the linear mitochondrial DNA of Tetrahymena thermophila consist of 53 bp tandem repeats.
Academic Article	One binding site determines sequence specificity of Tetrahymena pre-rRNA self-splicing, trans-splicing, and RNA enzyme activity.
Academic Article	Sequence-specific endoribonuclease activity of the Tetrahymena ribozyme: enhanced cleavage of certain oligonucleotide substrates that form mismatched ribozyme-substrate complexes.
Academic Article	Mechanism of recognition of the 5' splice site in self-splicing group I introns.
Academic Article	Three-dimensional model of the active site of the self-splicing rRNA precursor of Tetrahymena.
Academic Article	The Tetrahymena ribozyme acts like an RNA restriction endonuclease.
Academic Article	Ribozyme inhibitors: deoxyguanosine and dideoxyguanosine are competitive inhibitors of self-splicing of the Tetrahymena ribosomal ribonucleic acid precursor.
Academic Article	Chromatin structure at the replication origins and transcription-initiation regions of the ribosomal RNA genes of Tetrahymena.
Academic Article	Specific interaction between the self-splicing RNA of Tetrahymena and its guanosine substrate: implications for biological catalysis by RNA.
Academic Article	Electron microscopy of DNA crosslinked with trimethylpsoralen: test of the secondary structure of eukaryotic inverted repeat sequences.
Academic Article	Replication of the extrachromosomal ribosomal RNA genes of Tetrahymena thermophilia.
Academic Article	In vitro splicing of the ribosomal RNA precursor in nuclei of Tetrahymena.
Academic Article	Analysis of the structure of Tetrahymena nuclear RNAs in vivo: telomerase RNA, the self-splicing rRNA intron, and U2 snRNA.
Academic Article	Contributions of 2'-hydroxyl groups of the RNA substrate to binding and catalysis by the Tetrahymena ribozyme. An energetic picture of an active site composed of RNA.
Academic Article	Minor groove recognition of the conserved G.U pair at the Tetrahymena ribozyme reaction site.
Academic Article	Ribozyme-mediated repair of defective mRNA by targeted, trans-splicing.
Academic Article	Beginning to understand the end of the chromosome.
Academic Article	Tertiary structure around the guanosine-binding site of the Tetrahymena ribozyme.
Academic Article	Catalytic RNA: structure and mechanism.
Academic Article	Metal ion catalysis in the Tetrahymena ribozyme reaction.
Academic Article	Exocyclic amine of the conserved G.U pair at the cleavage site of the Tetrahymena ribozyme contributes to 5'-splice site selection and transition state stabilization.
Academic Article	X-ray crystallography of large RNAs: heavy-atom derivatives by RNA engineering.
Academic Article	Mutations in a nonconserved sequence of the Tetrahymena ribozyme increase activity and specificity.
Academic Article	Telomerase reverse transcriptase genes identified in Tetrahymena thermophila and Oxytricha trifallax.
Academic Article	An early transition state for folding of the P4-P6 RNA domain.
Academic Article	Structure of the Tetrahymena ribozyme: base triple sandwich and metal ion at the active site.
Academic Article	Comparison of crystal structure interactions and thermodynamics for stabilizing mutations in the Tetrahymena ribozyme.
Academic Article	Catalysis of RNA cleavage by the Tetrahymena thermophila ribozyme. 1. Kinetic description of the reaction of an RNA substrate complementary to the active site.
Academic Article	The Tetrahymena intervening sequence ribonucleic acid enzyme is a phosphotransferase and an acid phosphatase.
Academic Article	Selection of circularization sites in a group I IVS RNA requires multiple alignments of an internal template-like sequence.
Academic Article	Guanosine binding required for cyclization of the self-splicing intervening sequence ribonucleic acid from Tetrahymena thermophila.
Academic Article	5' exon requirement for self-splicing of the Tetrahymena thermophila pre-ribosomal RNA and identification of a cryptic 5' splice site in the 3' exon.
Academic Article	Self-splicing and enzymatic cleavage of RNA by a group I intervening sequence.
Academic Article	An ultraviolet-inducible adenosine-adenosine cross-link reflects the catalytic structure of the Tetrahymena ribozyme.
Academic Article	Tetrahymena telomerase protein p65 induces conformational changes throughout telomerase RNA (TER) and rescues telomerase reverse transcriptase and TER assembly mutants.
Academic Article	Oligomerization of intervening sequence RNA molecules in the absence of proteins.
Academic Article	Self-catalyzed cyclization of the intervening sequence RNA of Tetrahymena: inhibition by intercalating dyes.
Academic Article	Secondary structure of the circular form of the Tetrahymena rRNA intervening sequence: a technique for RNA structure analysis using chemical probes and reverse transcriptase.
Academic Article	RNA as an enzyme.
Academic Article	New reactions of the ribosomal RNA precursor of Tetrahymena and the mechanism of self-splicing.
Academic Article	RNA as an RNA polymerase: net elongation of an RNA primer catalyzed by the Tetrahymena ribozyme.
Academic Article	Alteration of substrate specificity for the endoribonucleolytic cleavage of RNA by the Tetrahymena ribozyme.
Academic Article	Engineering cis-telomerase RNAs that add telomeric repeats to themselves.
Academic Article	A conserved base pair within helix P4 of the Tetrahymena ribozyme helps to form the tertiary structure required for self-splicing.
Academic Article	The conserved U.G pair in the 5' splice site duplex of a group I intron is required in the first but not the second step of self-splicing.
Academic Article	Phylogenetic relationships and altered genome structures among Tetrahymena mitochondrial DNAs.
Academic Article	Determinants of the 3' splice site for self-splicing of the Tetrahymena pre-rRNA.
Academic Article	Self-splicing RNA and an RNA enzyme in Tetrahymena.
Academic Article	G-strings at chromosome ends.
Academic Article	Deletion of nonconserved helices near the 3' end of the rRNA intron of Tetrahymena thermophila alters self-splicing but not core catalytic activity.
Academic Article	Structures involved in Tetrahymena rRNA self-splicing and RNA enzyme activity.
Academic Article	Metal ion requirements for sequence-specific endoribonuclease activity of the Tetrahymena ribozyme.
Academic Article	Reverse self-splicing of the tetrahymena group I intron: implication for the directionality of splicing and for intron transposition.
Academic Article	Coupling of Tetrahymena ribosomal RNA splicing to beta-galactosidase expression in Escherichia coli.
Academic Article	Mitochondrial telomeres: surprising diversity of repeated telomeric DNA sequences among six species of Tetrahymena.
Academic Article	Telomeric repeats of Tetrahymena malaccensis mitochondrial DNA: a multimodal distribution that fluctuates erratically during growth.
Academic Article	Structural conventions for group I introns.
Academic Article	Reversibility of cyclization of the Tetrahymena rRNA intervening sequence: implication for the mechanism of splice site choice.
Academic Article	Intermolecular exon ligation of the rRNA precursor of Tetrahymena: oligonucleotides can function as 5' exons.
Concept	Tetrahymena thermophila
Concept	Tetrahymena pyriformis
Concept	Tetrahymena
Academic Article	Protein-RNA interaction restricts telomerase from running through the stop sign.
Grant	NUCLEIC ACID STRUCTURE AND REACTIVITY
Grant	CHROMATIN STRUCTURE OF A TRANSCRIPTION UNIT
Academic Article	In Crystallo Selection to Establish New?RNA?Crystal?Contacts.

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