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Search Results to Thomas R Cech

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Cech, Thomas

One or more keywords matched the following items that are connected to Cech, Thomas

Item Type	Name
Academic Article	Telomerase RNA localized in the replication band and spherical subnuclear organelles in hypotrichous ciliates.
Academic Article	Telomerase RNAs of different ciliates have a common secondary structure and a permuted template.
Academic Article	Polyadenylation of telomerase RNA in budding yeast.
Academic Article	Euplotes telomerase: evidence for limited base-pairing during primer elongation and dGTP as an effector of translocation.
Academic Article	Reversing time: origin of telomerase.
Academic Article	Telomerase and chromosome end maintenance.
Academic Article	Saccharomyces cerevisiae telomerase is an Sm small nuclear ribonucleoprotein particle.
Academic Article	Purification of telomerase from Euplotes aediculatus: requirement of a primer 3' overhang.
Academic Article	Telomerase and the chromosome end replication problem.
Academic Article	Modulation of telomerase activity by telomere DNA-binding proteins in Oxytricha.
Academic Article	The Euplotes La motif protein p43 has properties of a telomerase-specific subunit.
Academic Article	Human POT1 facilitates telomere elongation by telomerase.
Academic Article	Tetrahymena telomerase is active as a monomer.
Academic Article	A template-proximal RNA paired element contributes to Saccharomyces cerevisiae telomerase activity.
Academic Article	Yeast telomerase RNA: a flexible scaffold for protein subunits.
Academic Article	Structure of human POT1 bound to telomeric single-stranded DNA provides a model for chromosome end-protection.
Academic Article	Expression of a RecQ helicase homolog affects progression through crisis in fission yeast lacking telomerase.
Academic Article	Soluble domains of telomerase reverse transcriptase identified by high-throughput screening.
Academic Article	Switching human telomerase on and off with hPOT1 protein in vitro.
Academic Article	A miniature yeast telomerase RNA functions in vivo and reconstitutes activity in vitro.
Academic Article	Crystal structure of the essential N-terminal domain of telomerase reverse transcriptase.
Academic Article	Low abundance of telomerase in yeast: implications for telomerase haploinsufficiency.
Academic Article	Multiple yeast genes, including Paf1 complex genes, affect telomere length via telomerase RNA abundance.
Academic Article	Mutation in TERT separates processivity from anchor-site function.
Academic Article	Functional interaction between telomere protein TPP1 and telomerase.
Academic Article	Essential functions of amino-terminal domains in the yeast telomerase catalytic subunit revealed by selection for viable mutants.
Academic Article	A mutant of Tetrahymena telomerase reverse transcriptase with increased processivity.
Academic Article	Telomerase RNA bound by protein motifs specific to telomerase reverse transcriptase.
Academic Article	The RNA accordion model for template positioning by telomerase RNA during telomeric DNA synthesis.
Academic Article	Mutually exclusive binding of telomerase RNA and DNA by Ku alters telomerase recruitment model.
Academic Article	The TEL patch of telomere protein TPP1 mediates telomerase recruitment and processivity.
Academic Article	SnapShot: telomeres and telomerase.
Academic Article	Finding the end: recruitment of telomerase to telomeres.
Academic Article	Yeast telomerase is specialized for C/A-rich RNA templates.
Academic Article	Analysis of the structure of Tetrahymena nuclear RNAs in vivo: telomerase RNA, the self-splicing rRNA intron, and U2 snRNA.
Academic Article	Telomerase and DNA end replication: no longer a lagging strand problem?
Academic Article	Beginning to understand the end of the chromosome.
Academic Article	Method for determining RNA 3' ends and application to human telomerase RNA.
Academic Article	The anchor site of telomerase from Euplotes aediculatus revealed by photo-cross-linking to single- and double-stranded DNA primers.
Academic Article	Reverse transcriptase motifs in the catalytic subunit of telomerase.
Academic Article	Telomerase catalytic subunit homologs from fission yeast and human.
Academic Article	dGTP-dependent processivity and possible template switching of euplotes telomerase.
Academic Article	Three Ever Shorter Telomere (EST) genes are dispensable for in vitro yeast telomerase activity.
Academic Article	Telomerase is a true reverse transcriptase. A review.
Academic Article	Telomerase reverse transcriptase genes identified in Tetrahymena thermophila and Oxytricha trifallax.
Academic Article	Two modes of survival of fission yeast without telomerase.
Academic Article	Inhibition of telomerase by G-quartet DNA structures.
Academic Article	Telomerase and the maintenance of chromosome ends.
Academic Article	Analysis of telomerase catalytic subunit mutants in vivo and in vitro in Schizosaccharomycespombe.
Academic Article	Protection of telomeres by the Ku protein in fission yeast.
Academic Article	Euplotes telomerase contains an La motif protein produced by apparent translational frameshifting.
Academic Article	The POT1-TPP1 telomere complex is a telomerase processivity factor.
Academic Article	Effects of nucleotide analogues on Euplotes aediculatus telomerase processivity: evidence for product-assisted translocation.
Academic Article	Essential regions of Saccharomyces cerevisiae telomerase RNA: separate elements for Est1p and Est2p interaction.
Academic Article	N-terminal domain of yeast telomerase reverse transcriptase: recruitment of Est3p to the telomerase complex.
Academic Article	The Euplotes telomerase subunit p43 stimulates enzymatic activity and processivity in vitro.
Academic Article	Global expression changes resulting from loss of telomeric DNA in fission yeast.
Academic Article	RNA as a flexible scaffold for proteins: yeast telomerase and beyond.
Academic Article	Human POT1 disrupts telomeric G-quadruplexes allowing telomerase extension in vitro.
Academic Article	Triple-helix structure in telomerase RNA contributes to catalysis.
Academic Article	Tetrahymena telomerase protein p65 induces conformational changes throughout telomerase RNA (TER) and rescues telomerase reverse transcriptase and TER assembly mutants.
Academic Article	Inhibition of yeast telomerase action by the telomeric ssDNA-binding protein, Cdc13p.
Academic Article	POT1-TPP1 enhances telomerase processivity by slowing primer dissociation and aiding translocation.
Academic Article	Engineering cis-telomerase RNAs that add telomeric repeats to themselves.
Academic Article	Ku can contribute to telomere lengthening in yeast at multiple positions in the telomerase RNP.
Academic Article	Telomere shortening and loss of self-renewal in dyskeratosis congenita induced pluripotent stem cells.
Academic Article	RNA recognition by the DNA end-binding Ku heterodimer.
Concept	Telomerase
Academic Article	Many disease-associated variants of hTERT retain high telomerase enzymatic activity.
Academic Article	3' terminal diversity of MRP RNA and other human noncoding RNAs revealed by deep sequencing.
Academic Article	Inhibition of telomerase recruitment and cancer cell death.
Academic Article	Telomerase in bladder cancer: back to a better future?
Academic Article	Inventory of telomerase components in human cells reveals multiple subpopulations of hTR and hTERT.
Academic Article	Identification of human TERT elements necessary for telomerase recruitment to telomeres.
Academic Article	Disease mutant analysis identifies a new function of DAXX in telomerase regulation and telomere maintenance.
Academic Article	Cancer. TERT promoter mutations and telomerase reactivation in urothelial cancer.
Academic Article	Contributions of the TEL-patch amino acid cluster on TPP1 to telomeric DNA synthesis by human telomerase.
Academic Article	Human telomerase: biogenesis, trafficking, recruitment, and activation.
Academic Article	Mutation of the TERT promoter, switch to active chromatin, and monoallelic TERT expression in multiple cancers.
Academic Article	A novel two-step genome editing strategy with CRISPR-Cas9 provides new insights into telomerase action and TERT gene expression.
Academic Article	Protein-RNA interaction restricts telomerase from running through the stop sign.
Academic Article	Inhibition of telomerase RNA decay rescues telomerase deficiency caused by dyskerin or PARN defects.
Academic Article	Live Cell Imaging Reveals the Dynamics of Telomerase Recruitment to Telomeres.
Grant	TERT Promoter Mutations and Telomerase Reactivation in Cancer Cells
Grant	Telomerase and Telomeres: Structure, Function and Regulation
Academic Article	Reconstitution of human shelterin complexes reveals unexpected stoichiometry and dual pathways to enhance telomerase processivity.
Academic Article	Allele-Specific DNA Methylation and Its Interplay with Repressive Histone Marks at Promoter-Mutant TERT Genes.
Academic Article	Dynamics of human telomerase recruitment depend on template-telomere base pairing.
Academic Article	Single-cell imaging reveals unexpected heterogeneity of telomerase reverse transcriptase expression across human cancer cell lines.
Academic Article	Mesenchymal and MAPK Expression Signatures Associate with Telomerase Promoter Mutations in Multiple Cancers.
Academic Article	Allele-specific proximal promoter hypomethylation of the telomerase reverse transcriptase gene (TERT) associates with TERT expression in multiple cancers.
Academic Article	Shaping human telomeres: from shelterin and CST complexes to telomeric chromatin organization.
Academic Article	Nuclear compartmentalization of TERT mRNA and TUG1 lncRNA is driven by intron retention.
Academic Article	TRIM28 is a transcriptional activator of the mutant TERT promoter in human bladder cancer.
Academic Article	CST does not evict elongating telomerase but prevents initiation by ssDNA binding.
Academic Article	Reconstitution of a telomeric replicon organized by CST.
Academic Article	Dissecting telomerase RNA structural heterogeneity in living human cells with DMS-MaPseq.

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Telomerase