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Search Results to Thomas R Cech

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Cech, Thomas

One or more keywords matched the following items that are connected to Cech, Thomas

Item Type	Name
Academic Article	Organization of highly repeated sequences in mouse main-band DNA.
Academic Article	Reactions of the intervening sequence of the Tetrahymena ribosomal ribonucleic acid precursor: pH dependence of cyclization and site-specific hydrolysis.
Academic Article	Characterization of the most rapidly renaturing sequences in mouse main-band DNA.
Academic Article	Transcribed and non-transcribed regions of Tetrahymena ribosomal gene chromatin have different accessibilities to micrococcal nuclease.
Academic Article	Fate of an intervening sequence ribonucleic acid: excision and cyclization of the Tetrahymena ribosomal ribonucleic acid intervening sequence in vivo.
Academic Article	Catalysis of RNA cleavage by a ribozyme derived from the group I intron of Anabaena pre-tRNA(Leu).
Academic Article	Efficient protein-facilitated splicing of the yeast mitochondrial bI5 intron.
Academic Article	Tertiary interactions with the internal guide sequence mediate docking of the P1 helix into the catalytic core of the Tetrahymena ribozyme.
Academic Article	Relative orientation of RNA helices in a group 1 ribozyme determined by helix extension electron microscopy.
Academic Article	Protein facilitation of group I intron splicing by assembly of the catalytic core and the 5' splice site domain.
Academic Article	A positive entropy change for guanosine binding and for the chemical step in the Tetrahymena ribozyme reaction.
Academic Article	Two major tertiary folding transitions of the Tetrahymena catalytic RNA.
Academic Article	Telomeric protein-DNA point contacts identified by photo-cross-linking using 5-bromodeoxyuridine.
Academic Article	Guanosine binding to the Tetrahymena ribozyme: thermodynamic coupling with oligonucleotide binding.
Academic Article	Minor-groove recognition of double-stranded RNA by the double-stranded RNA-binding domain from the RNA-activated protein kinase PKR.
Academic Article	Mutations in the Tetrahymena ribozyme internal guide sequence: effects on docking of the P1 helix into the catalytic core and correlation with catalytic activity.
Academic Article	Conformational switches involved in orchestrating the successive steps of group I RNA splicing.
Academic Article	Conserved thermochemistry of guanosine nucleophile binding for structurally distinct group I ribozymes.
Academic Article	Effects of divalent metal ions on individual steps of the Tetrahymena ribozyme reaction.
Academic Article	An RNA internal loop acts as a hinge to facilitate ribozyme folding and catalysis.
Academic Article	Peptide bond formation by in vitro selected ribozymes.
Academic Article	Mutations at the guanosine-binding site of the Tetrahymena ribozyme also affect site-specific hydrolysis.
Academic Article	Replacement of the conserved G.U with a G-C pair at the cleavage site of the Tetrahymena ribozyme decreases binding, reactivity, and fidelity.
Academic Article	Characterization of a G-quartet formation reaction promoted by the beta-subunit of the Oxytricha telomere-binding protein.
Academic Article	Energetics and cooperativity of tertiary hydrogen bonds in RNA structure.
Academic Article	Self-splicing of the group I intron from Anabaena pre-tRNA: requirement for base-pairing of the exons in the anticodon stem.
Academic Article	RNA tertiary folding monitored by fluorescence of covalently attached pyrene.
Academic Article	Assembly of a ribonucleoprotein catalyst by tertiary structure capture.
Academic Article	Multiple folding pathways for the P4-P6 RNA domain.
Academic Article	Ribozyme recognition of RNA by tertiary interactions with specific ribose 2'-OH groups.
Academic Article	Kinetic and secondary structure analysis of Naegleria andersoni GIR1, a group I ribozyme whose putative biological function is site-specific hydrolysis.
Academic Article	The intervening sequence RNA of Tetrahymena is an enzyme.
Academic Article	A self-splicing group I intron in the nuclear pre-rRNA of the green alga, Ankistrodesmus stipitatus.
Academic Article	Binding of the CBP2 protein to a yeast mitochondrial group I intron requires the catalytic core of the RNA.
Academic Article	Alternative secondary structures in the 5' exon affect both forward and reverse self-splicing of the Tetrahymena intervening sequence RNA.
Academic Article	Visualizing the higher order folding of a catalytic RNA molecule.
Academic Article	POT1 stimulates RecQ helicases WRN and BLM to unwind telomeric DNA substrates.
Academic Article	Ribozyme-catalyzed and nonenzymatic reactions of phosphate diesters: rate effects upon substitution of sulfur for a nonbridging phosphoryl oxygen atom.
Academic Article	Direct measurement of oligonucleotide substrate binding to wild-type and mutant ribozymes from Tetrahymena.
Academic Article	Catalysis of RNA cleavage by the Tetrahymena thermophila ribozyme. 2. Kinetic description of the reaction of an RNA substrate that forms a mismatch at the active site.
Academic Article	Mutation in TERT separates processivity from anchor-site function.
Academic Article	Effect of monovalent cation-induced telomeric DNA structure on the binding of Oxytricha telomeric protein.
Academic Article	Self-catalyzed cyclization of the intervening sequence RNA of Tetrahymena: inhibition by methidiumpropyl.EDTA and localization of the major dye binding sites.
Academic Article	Biological catalysis by RNA.
Academic Article	Stereochemistry of RNA cleavage by the Tetrahymena ribozyme and evidence that the chemical step is not rate-limiting.
Academic Article	Aminoacyl esterase activity of the Tetrahymena ribozyme.
Academic Article	DNA cleavage catalysed by the ribozyme from Tetrahymena.
Academic Article	In vivo selection of better self-splicing introns in Escherichia coli: the role of the P1 extension helix of the Tetrahymena intron.
Academic Article	Sequence-specific endoribonuclease activity of the Tetrahymena ribozyme: enhanced cleavage of certain oligonucleotide substrates that form mismatched ribozyme-substrate complexes.
Academic Article	The Tetrahymena ribozyme acts like an RNA restriction endonuclease.
Academic Article	Ribozyme inhibitors: deoxyguanosine and dideoxyguanosine are competitive inhibitors of self-splicing of the Tetrahymena ribosomal ribonucleic acid precursor.
Academic Article	Specific interaction between the self-splicing RNA of Tetrahymena and its guanosine substrate: implications for biological catalysis by RNA.
Academic Article	Replication of the extrachromosomal ribosomal RNA genes of Tetrahymena thermophilia.
Academic Article	Contributions of 2'-hydroxyl groups of the RNA substrate to binding and catalysis by the Tetrahymena ribozyme. An energetic picture of an active site composed of RNA.
Academic Article	Tertiary structure around the guanosine-binding site of the Tetrahymena ribozyme.
Academic Article	Exocyclic amine of the conserved G.U pair at the cleavage site of the Tetrahymena ribozyme contributes to 5'-splice site selection and transition state stabilization.
Academic Article	Mutations in a nonconserved sequence of the Tetrahymena ribozyme increase activity and specificity.
Academic Article	Inhibition of telomerase by G-quartet DNA structures.
Academic Article	An early transition state for folding of the P4-P6 RNA domain.
Academic Article	The Euplotes telomerase subunit p43 stimulates enzymatic activity and processivity in vitro.
Academic Article	Catalysis of RNA cleavage by the Tetrahymena thermophila ribozyme. 1. Kinetic description of the reaction of an RNA substrate complementary to the active site.
Academic Article	The Tetrahymena intervening sequence ribonucleic acid enzyme is a phosphotransferase and an acid phosphatase.
Academic Article	Guanosine binding required for cyclization of the self-splicing intervening sequence ribonucleic acid from Tetrahymena thermophila.
Academic Article	Oxytricha telomeric nucleoprotein complexes reconstituted with synthetic DNA.
Academic Article	Self-catalyzed cyclization of the intervening sequence RNA of Tetrahymena: inhibition by intercalating dyes.
Academic Article	Alteration of substrate specificity for the endoribonucleolytic cleavage of RNA by the Tetrahymena ribozyme.
Academic Article	Ku can contribute to telomere lengthening in yeast at multiple positions in the telomerase RNP.
Academic Article	A conserved base pair within helix P4 of the Tetrahymena ribozyme helps to form the tertiary structure required for self-splicing.
Academic Article	The conserved U.G pair in the 5' splice site duplex of a group I intron is required in the first but not the second step of self-splicing.
Academic Article	Metal ion requirements for sequence-specific endoribonuclease activity of the Tetrahymena ribozyme.
Concept	Kinetics

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Kinetics