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Search Results to James Veblen DeGregori

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DeGregori, James

One or more keywords matched the following items that are connected to DeGregori, James

Item Type	Name
Academic Article	E2F-1 accumulation bypasses a G1 arrest resulting from the inhibition of G1 cyclin-dependent kinase activity.
Academic Article	E2F1 overexpression in quiescent fibroblasts leads to induction of cellular DNA synthesis and apoptosis.
Academic Article	Selective disruption of genes expressed in totipotent embryonal stem cells.
Academic Article	A murine homolog of the yeast RNA1 gene is required for postimplantation development.
Academic Article	Inhibition of cyclin D-CDK4/CDK6 activity is associated with an E2F-mediated induction of cyclin kinase inhibitor activity.
Academic Article	Myc and Ras collaborate in inducing accumulation of active cyclin E/Cdk2 and E2F.
Academic Article	E2F1-specific induction of apoptosis and p53 accumulation, which is blocked by Mdm2.
Academic Article	Distinct roles for E2F proteins in cell growth control and apoptosis.
Academic Article	Cellular targets for activation by the E2F1 transcription factor include DNA synthesis- and G1/S-regulatory genes.
Academic Article	Adenoviral-mediated gene transfer in lymphocytes.
Academic Article	Collaborative role of E2F transcriptional activity and G1 cyclindependent kinase activity in the induction of S phase.
Academic Article	A role for E2F1 in the induction of ARF, p53, and apoptosis during thymic negative selection.
Academic Article	hnRNP C is required for postimplantation mouse development but Is dispensable for cell viability.
Academic Article	Induction of DNA replication in adult rat neurons by deregulation of the retinoblastoma/E2F G1 cell cycle pathway.
Academic Article	Fiber knob modifications overcome low, heterogeneous expression of the coxsackievirus-adenovirus receptor that limits adenovirus gene transfer and oncolysis for human rhabdomyosarcoma cells.
Academic Article	The accumulation of an E2F-p130 transcriptional repressor distinguishes a G0 cell state from a G1 cell state.
Academic Article	Expression of the HsOrc1 gene, a human ORC1 homolog, is regulated by cell proliferation via the E2F transcription factor.
Academic Article	E2F1 and E2F2 determine thresholds for antigen-induced T-cell proliferation and suppress tumorigenesis.
Academic Article	Retrovirus promoter-trap vector to induce lacZ gene fusions in mammalian cells.
Academic Article	The genetics of the E2F family of transcription factors: shared functions and unique roles.
Academic Article	Functional analysis of E2F transcription factor.
Academic Article	Analysis of Cdc6 function in the assembly of mammalian prereplication complexes.
Academic Article	Role of the Rb/E2F pathway in cell growth control.
Academic Article	Identification of gene function by cyclical packaging rescue of retroviral cDNA libraries.
Academic Article	CUSP/p63 expression in basal cell carcinoma.
Academic Article	Characterization of transcriptional regulation during negative selection in vivo.
Academic Article	E2F3 activity is regulated during the cell cycle and is required for the induction of S phase.
Academic Article	Gene trap mutagenesis of hnRNP A2/B1: a cryptic 3' splice site in the neomycin resistance gene allows continued expression of the disrupted cellular gene.
Academic Article	Mechanisms of oncogene cooperation: activation and inactivation of a growth antagonist.
Academic Article	The survival of antigen-stimulated T cells requires NFkappaB-mediated inhibition of p73 expression.
Academic Article	Defective gene expression, S phase progression, and maturation during hematopoiesis in E2F1/E2F2 mutant mice.
Academic Article	Roles for bone-marrow-derived cells in beta-cell maintenance.
Academic Article	E2F and cell survival: context really is key.
Academic Article	Impaired DNA replication within progenitor cell pools promotes leukemogenesis.
Academic Article	Putting the Oncogenic and Tumor Suppressive Activities of E2F into Context.
Academic Article	Building a better model of cancer.
Academic Article	p53 mediates senescence-like arrest induced by chronic replicational stress.
Academic Article	The pRb/E2F cell-cycle pathway mediates cell death in Parkinson's disease.
Academic Article	Replicational stress selects for p53 mutation.
Academic Article	Declining cellular fitness with age promotes cancer initiation by selecting for adaptive oncogenic mutations.
Academic Article	Interfering RNA-mediated purine analog resistance for in vitro and in vivo cell selection.
Academic Article	Publishing flow cytometry data.
Academic Article	Irradiation selects for p53-deficient hematopoietic progenitors.
Academic Article	Wnt/Ca2+/NFAT signaling maintains survival of Ph+ leukemia cells upon inhibition of Bcr-Abl.
Academic Article	Declining lymphoid progenitor fitness promotes aging-associated leukemogenesis.
Academic Article	Prolactin stimulates activation of c-jun N-terminal kinase (JNK).
Academic Article	A new role for E2F1 in DNA repair: all for the greater good.
Academic Article	Integrated genomic analyses identify WEE1 as a critical mediator of cell fate and a novel therapeutic target in acute myeloid leukemia.
Academic Article	Active RB elicits late G1/S inhibition.
Academic Article	ATM and MET kinases are synthetic lethal with nongenotoxic activation of p53.
Academic Article	Tankyrase and the canonical Wnt pathway protect lung cancer cells from EGFR inhibition.
Academic Article	Essential role of GATA3 for the maintenance of type 2 helper T (Th2) cytokine production and chromatin remodeling at the Th2 cytokine gene loci.
Academic Article	The Rb network.
Academic Article	Regulation of the cyclin E gene by transcription factor E2F1.
Academic Article	Cdc6 is regulated by E2F and is essential for DNA replication in mammalian cells.
Academic Article	Ras enhances Myc protein stability.
Academic Article	Surprising dependency for retinoblastoma protein in ras-mediated tumorigenesis.
Academic Article	Transgenic expression of the coxsackie/adenovirus receptor enables adenoviral-mediated gene delivery in naive T cells.
Academic Article	Construction of stable coxsackievirus and adenovirus receptor-expressing 3T3-L1 cells.
Academic Article	The development of diabetes in E2f1/E2f2 mutant mice reveals important roles for bone marrow-derived cells in preventing islet cell loss.
Academic Article	Tumor necrosis factor alpha-induced apoptosis requires p73 and c-ABL activation downstream of RB degradation.
Academic Article	Prolonged skin allograft survival by IL-10 gene-introduced CD4 T cell administration.
Academic Article	Human aldehyde dehydrogenase 3A1 inhibits proliferation and promotes survival of human corneal epithelial cells.
Academic Article	E2F1 and E2F2 are differentially required for homeostasis-driven and antigen-induced T cell proliferation in vivo.
Academic Article	Distinct and Overlapping Roles for E2F Family Members in Transcription, Proliferation and Apoptosis.
Academic Article	Ionizing radiation-induced long-term expression of senescence markers in mice is independent of p53 and immune status.
Academic Article	Irradiation alters selection for oncogenic mutations in hematopoietic progenitors.
Academic Article	Ionizing radiation and hematopoietic malignancies: altering the adaptive landscape.
Academic Article	Relative fitness of hematopoietic progenitors influences leukemia progression.
Academic Article	Evolved tumor suppression: why are we so good at not getting cancer?
Academic Article	Extracellular cyclophilin-A stimulates ERK1/2 phosphorylation in a cell-dependent manner but broadly stimulates nuclear factor kappa B.
Academic Article	Aging-associated changes in hematopoiesis and leukemogenesis: what's the connection?
Academic Article	Challenging the axiom: does the occurrence of oncogenic mutations truly limit cancer development with age?
Academic Article	A receptor tyrosine kinase network composed of fibroblast growth factor receptors, epidermal growth factor receptor, v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, and hepatocyte growth factor receptor drives growth and survival of head and neck squamous carcinoma cell lines.
Concept	Jurkat Cells
Concept	Cell Movement
Concept	Hematopoietic Stem Cells
Concept	Precursor Cells, B-Lymphoid
Concept	Active Transport, Cell Nucleus
Concept	Carcinoma, Non-Small-Cell Lung
Concept	Epithelial Cells
Concept	Alveolar Epithelial Cells
Concept	Hybrid Cells
Concept	Cell Lineage
Concept	Cell Physiological Phenomena
Concept	Receptors, Antigen, T-Cell
Concept	Neoplastic Stem Cells
Concept	Hematopoietic Stem Cell Transplantation
Concept	HeLa Cells
Concept	Cell Nucleus
Concept	Cell Division
Concept	Basal Cell Nevus Syndrome
Concept	Carcinoma, Basal Cell
Concept	Cell Survival
Concept	Cell Cycle
Concept	Cell Culture Techniques
Concept	Eukaryotic Cells
Concept	Clone Cells
Concept	Cell Transformation, Neoplastic
Concept	Cell Cycle Proteins
Concept	Resting Phase, Cell Cycle
Concept	Cell Respiration
Concept	Induced Pluripotent Stem Cells
Concept	Proliferating Cell Nuclear Antigen
Concept	Cell Transformation, Viral
Concept	Th2 Cells
Concept	Cell Line
Concept	3T3 Cells
Concept	Tumor Cells, Cultured
Concept	Multipotent Stem Cells
Concept	Cell Differentiation
Concept	Cell Line, Transformed
Concept	Bone Marrow Cells
Concept	Myeloid Cells
Concept	Killer Cells, Natural
Concept	Cell Line, Tumor
Concept	Cell Fractionation
Concept	Cells, Cultured
Concept	Stem Cells
Concept	Cell Separation
Concept	Cell Proliferation
Concept	Stem Cell Niche
Academic Article	Rational combination of a MEK inhibitor, selumetinib, and the Wnt/calcium pathway modulator, cyclosporin A, in preclinical models of colorectal cancer.
Academic Article	Inhibiting tyrosine phosphorylation of protein kinase Cd (PKCd) protects the salivary gland from radiation damage.
Academic Article	Patterns of somatically acquired amplifications and deletions in apparently normal tissues of ovarian cancer patients.
Academic Article	Inhibition of calcineurin combined with dasatinib has direct and indirect anti-leukemia effects against BCR-ABL1(+) leukemia.
Academic Article	Stochastic modeling indicates that aging and somatic evolution in the hematopoetic system are driven by non-cell-autonomous processes.
Academic Article	Personalized one-two punches for lung cancer.
Academic Article	Tyrosine kinase inhibition in leukemia induces an altered metabolic state sensitive to mitochondrial perturbations.
Academic Article	Contrasting roles for C/EBPa and Notch in irradiation-induced multipotent hematopoietic progenitor cell defects.
Academic Article	PRMT1 Is a Novel Regulator of Epithelial-Mesenchymal-Transition in Non-small Cell Lung Cancer.
Academic Article	Toward an evolutionary model of cancer: Considering the mechanisms that govern the fate of somatic mutations.
Academic Article	A Critical Examination of the "Bad Luck" Explanation of Cancer Risk.
Academic Article	Aging-associated inflammation promotes selection for adaptive oncogenic events in B cell progenitors.
Academic Article	Stochastic modeling reveals an evolutionary mechanism underlying elevated rates of childhood leukemia.
Academic Article	The landscape of somatic mutations in protein coding genes in apparently benign human tissues carries signatures of relaxed purifying selection.
Academic Article	Trisomy 21 consistently activates the interferon response.
Academic Article	ATM/G6PD-driven redox metabolism promotes FLT3 inhibitor resistance in acute myeloid leukemia.
Academic Article	AZ1366: An Inhibitor of Tankyrase and the Canonical Wnt Pathway that Limits the Persistence of Non-Small Cell Lung Cancer Cells Following EGFR Inhibition.
Academic Article	Changing mutational and adaptive landscapes and the genesis of cancer.
Academic Article	Coupling an EML4-ALK-centric interactome with RNA interference identifies sensitizers to ALK inhibitors.
Grant	Rationally designed targeted therapeutic approaches for NSCLC
Grant	Diet-Induced Adaptive Leukemogenesis: BCR-Abl dependent upregulation of folate re
Grant	Noncell autonomous control of Beta islet cells
Grant	Nrf2-mediated impaired hematopoietic stem cell fitness following irradiation
Grant	Regulation of the Lymphocytic cell cycle by E2F
Grant	Predoctoral Training Program in Molecular Biology
Grant	E2F FACTOR AND CELL CYCLE REGULATION
Grant	Poor competition in hematopoietic stem/progenitor pools favors tumorigenesis
Grant	Aging-associated alterations in adaptive landscapes and the evolution of leukemia
Academic Article	Connecting Cancer to Its Causes Requires Incorporation of Effects on Tissue Microenvironments.
Academic Article	Glutaminase inhibition improves FLT3 inhibitor therapy for acute myeloid leukemia.
Academic Article	Folate dietary insufficiency and folic acid supplementation similarly impair metabolism and compromise hematopoiesis.
Grant	Targeting MCJ/DNAJC15 and the mitochondrial electron transport chain in acute myeloid leukemia
Academic Article	Inhibition of Amino Acid Metabolism Selectively Targets Human Leukemia Stem Cells.
Academic Article	SIX2 Mediates Late-Stage Metastasis via Direct Regulation of SOX2 and Induction of a Cancer Stem Cell Program.
Academic Article	Inhibition of Amino Acid Metabolism Selectively Targets Human Leukemia Stem Cells.
Academic Article	Urea Cycle Sustains Cellular Energetics upon EGFR Inhibition in EGFR-Mutant NSCLC.
Academic Article	Decoy fitness peaks, tumor suppression, and aging.
Concept	Cell- and Tissue-Based Therapy
Concept	Myeloid-Derived Suppressor Cells
Concept	HEK293 Cells
Academic Article	Targeting Glutamine Metabolism and Redox State for Leukemia Therapy.
Academic Article	Elimination of unfit cells in young and ageing skin.
Academic Article	A generalized theory of age-dependent carcinogenesis.
Academic Article	Cysteine depletion targets leukemia stem cells through inhibition of electron transport complex II.
Grant	Understanding and circumventing aging-dependent changes in the bone marrow microenvironment that promote leukemogenesis
Academic Article	Molecular Biology and Evolution of Cancer: From Discovery to Action.
Academic Article	Of mice, genes and aging.
Academic Article	Aging, inflammation, and HSC.
Academic Article	A somatic evolutionary model of the dynamics of aneuploid cells during hematopoietic reconstitution.
Academic Article	Nicotinamide Metabolism Mediates Resistance to Venetoclax in Relapsed Acute Myeloid Leukemia Stem Cells.
Academic Article	Cancer Screening, Surrogates of Survival, and the Soma.
Academic Article	Interleukin-37 improves T-cell-mediated immunity and chimeric antigen receptor T-cell therapy in aged backgrounds.
Academic Article	Shedding Light on Mutant Clonal Dynamics and Cancer Risk in the Skin.
Academic Article	Targeting tumor-derived NLRP3 reduces melanoma progression by limiting MDSCs expansion.
Academic Article	PU.1 enforces quiescence and limits hematopoietic stem cell expansion during inflammatory stress.
Academic Article	Chronic interleukin-1 exposure triggers selection for Cebpa-knockout multipotent hematopoietic progenitors.
Academic Article	Cancer stem cells in the gut have a bad influence on neighbouring cells.
Academic Article	Cells with Cancer-associated Mutations Overtake Our Tissues as We Age.
Academic Article	Dnmt3a-Mutant Hematopoietic Stem Cell Rewire IFN? Signaling to Gain Clonal Advantage.
Academic Article	Clonal hematopoiesis: Mutation-specific adaptation to environmental change.
Academic Article	The sculpting of somatic mutational landscapes by evolutionary forces and their impacts on aging-related disease.
Academic Article	Dissecting stepwise mutational impairment of megakaryopoiesis in a model of Down syndrome-associated leukemia.
Academic Article	Therapeutic resistance in acute myeloid leukemia cells is mediated by a novel ATM/mTOR pathway regulating oxidative phosphorylation.
Academic Article	Lung adenocarcinoma promotion by air pollutants.
Academic Article	The paradox of cooperation among selfish cancer cells.
Academic Article	Our ancestry dictates clonal architecture and skin cancer susceptibility.

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