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Search Results to Douglas R Seals

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Seals, Douglas

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Item Type	Name
Academic Article	Effect of endurance exercise training on ventilatory function in older individuals.
Academic Article	Endurance training in older men and women. I. Cardiovascular responses to exercise.
Academic Article	Endurance training in older men and women II. Blood lactate response to submaximal exercise.
Academic Article	Cardiovascular, plasma norepinephrine, and thermal adjustments to prolonged exercise in young and older healthy humans.
Academic Article	Effects of aging on the responsiveness of the human cardiac sympathetic nerves to stressors.
Academic Article	Endurance exercise training is associated with elevated basal sympathetic nerve activity in healthy older humans.
Academic Article	Effects of aging on epinephrine secretion and regional release of epinephrine from the human heart.
Academic Article	Active forearm blood flow adjustments to handgrip exercise in young and older healthy men.
Academic Article	Exercise and aging: autonomic control of the circulation.
Academic Article	Sympathetic neural reactivity to stress does not increase with age in healthy humans.
Academic Article	Total blood volume in healthy young and older men.
Academic Article	Adiposity and regional body fat distribution in physically active young and middle-aged women.
Academic Article	Sympathoadrenal-circulatory regulation of arterial pressure during orthostatic stress in young and older men.
Academic Article	Age and gender interactions in physiological functional capacity: insight from swimming performance.
Academic Article	Greater rate of decline in maximal aerobic capacity with age in physically active vs. sedentary healthy women.
Academic Article	Augmented forearm vasoconstriction during dynamic exercise in healthy older men.
Academic Article	Physical activity status and adverse age-related differences in coagulation and fibrinolytic factors in women.
Academic Article	Age-related increase in muscle sympathetic nerve activity is associated with abdominal adiposity.
Academic Article	Regular exercise and the age-related decline in resting metabolic rate in women.
Academic Article	Augmented cardiopulmonary and integrative sympathetic baroreflexes but attenuated peripheral vasoconstriction with age.
Academic Article	Reproducibility of a semiautomated acetylene rebreathing technique for measuring cardiac output in humans at rest.
Academic Article	Low-frequency arterial pressure fluctuations do not reflect sympathetic outflow: gender and age differences.
Academic Article	Aging effects on human sympathetic neuronal function.
Academic Article	Smaller differences in total and regional adiposity with age in women who regularly perform endurance exercise.
Academic Article	Enhanced left ventricular performance in endurance trained older men.
Academic Article	Lack of age-associated elevations in 24-h systolic and pulse pressures in women who exercise regularly.
Academic Article	Age and gender influence muscle sympathetic nerve activity at rest in healthy humans.
Academic Article	Age-related increase in femoral intima-media thickness in healthy humans.
Academic Article	Aging, habitual exercise, and dynamic arterial compliance.
Academic Article	Relation of leptin and insulin to adiposity-associated elevations in sympathetic activity with age in humans.
Academic Article	Age-related declines in knee extensor strength and physical performance in healthy Hispanic and Caucasian women.
Academic Article	Carotid artery wall hypertrophy with age is related to local systolic blood pressure in healthy men.
Academic Article	Age-related decreases in basal limb blood flow in humans: time course, determinants and habitual exercise effects.
Academic Article	Tonic sympathetic support of metabolic rate is attenuated with age, sedentary lifestyle, and female sex in healthy adults.
Academic Article	Altered autonomic support of arterial blood pressure with age in healthy men.
Academic Article	Arterial intima-media thickness: site-specific associations with HRT and habitual exercise.
Academic Article	Elevated levels of circulating cell adhesion molecules in uncomplicated essential hypertension.
Academic Article	Lactate threshold and distance-running performance in young and older endurance athletes.
Academic Article	A hemodynamic comparison of young and older endurance athletes during exercise.
Academic Article	Declines in physiological functional capacity with age: a longitudinal study in peak swimming performance.
Academic Article	Use of acetylene breathing to determine cardiac output in young and older adults.
Academic Article	Regular exercise, hormone replacement therapy and the age-related decline in carotid arterial compliance in healthy women.
Academic Article	Baroreflex buffering is reduced with age in healthy men.
Academic Article	Adiposity contributes to differences in left ventricular structure and diastolic function with age in healthy men.
Academic Article	Hemodynamic sequelae of age-related increases in arterial stiffness in healthy women.
Academic Article	Cardiopulmonary baroreflex inhibition of sympathetic nerve activity is preserved with age in healthy humans.
Academic Article	Effect of acute and chronic ascorbic acid on flow-mediated dilatation with sedentary and physically active human ageing.
Academic Article	Ascorbic acid does not affect large elastic artery compliance or central blood pressure in young and older men.
Academic Article	Oxidative stress does not modulate metabolic rate or skeletal muscle sympathetic activity with primary aging in adult humans.
Academic Article	Left ventricular structure and diastolic function with human ageing. Relation to habitual exercise and arterial stiffness.
Academic Article	Ascorbic acid does not affect the age-associated reduction in maximal cardiac output and oxygen consumption in healthy adults.
Academic Article	Increased abdominal-to-peripheral fat distribution contributes to altered autonomic-circulatory control with human aging.
Academic Article	Role of sympathetic neural activation in age- and habitual exercise-related differences in the thermic effect of food.
Academic Article	Tetrahydrobiopterin augments endothelium-dependent dilatation in sedentary but not in habitually exercising older adults.
Academic Article	Decline in large elastic artery compliance with age: a therapeutic target for habitual exercise.
Academic Article	Impaired flow-mediated dilation with age is not explained by L-arginine bioavailability or endothelial asymmetric dimethylarginine protein expression.
Academic Article	Cytochrome P-450 2C9 signaling does not contribute to age-associated vascular endothelial dysfunction in humans.
Academic Article	Thermal adjustments to nonexertional heat stress in mature and senescent Fischer 344 rats.
Academic Article	Nuclear factor-{kappa}B activation contributes to vascular endothelial dysfunction via oxidative stress in overweight/obese middle-aged and older humans.
Academic Article	Voluntary wheel running restores endothelial function in conduit arteries of old mice: direct evidence for reduced oxidative stress, increased superoxide dismutase activity and down-regulation of NADPH oxidase.
Academic Article	Vascular endothelial dysfunction with aging: endothelin-1 and endothelial nitric oxide synthase.
Academic Article	Habitual exercise and vascular ageing.
Academic Article	Vascular endothelial function is related to white blood cell count and myeloperoxidase among healthy middle-aged and older adults.
Academic Article	Limb blood flow and vascular conductance are reduced with age in healthy humans: relation to elevations in sympathetic nerve activity and declines in oxygen demand.
Academic Article	Role of NFkappaB in age-related vascular endothelial dysfunction in humans.
Academic Article	Sex-specific effects of habitual aerobic exercise on brachial artery flow-mediated dilation in middle-aged and older adults.
Academic Article	Life-long caloric restriction elicits pronounced protection of the aged myocardium: a role for AMPK.
Academic Article	Age-associated arterial wall thickening is related to elevations in sympathetic activity in healthy humans.
Academic Article	Regular aerobic exercise prevents and restores age-related declines in endothelium-dependent vasodilation in healthy men.
Academic Article	Regular aerobic exercise modulates age-associated declines in cardiovagal baroreflex sensitivity in healthy men.
Academic Article	Age-predicted maximal heart rate revisited.
Academic Article	Aerobic exercise reverses arterial inflammation with aging in mice.
Academic Article	SIRT-1 and vascular endothelial dysfunction with ageing in mice and humans.
Academic Article	Habitually exercising older men do not demonstrate age-associated vascular endothelial oxidative stress.
Academic Article	MicroRNA changes in human arterial endothelial cells with senescence: relation to apoptosis, eNOS and inflammation.
Academic Article	Vascular health in the ageing athlete.
Academic Article	The aging cardiovascular system: changes in autonomic function at rest and in response to exercise.
Academic Article	Sodium nitrite de-stiffening of large elastic arteries with aging: role of normalization of advanced glycation end-products.
Academic Article	The dependence of FMD% on baseline diameter: a problem solved by allometric scaling - no problem in this case.
Academic Article	Pulmonary function in young and older athletes and untrained men.
Academic Article	Greater rate of decline in maximal aerobic capacity with age in endurance-trained than in sedentary men.
Academic Article	Habitual exercise and the age-associated decline in large artery compliance.
Academic Article	Glucose tolerance in young and older athletes and sedentary men.
Academic Article	Physiological determinants of 10-km performance in highly trained female runners of different ages.
Academic Article	High energy flux mediates the tonically augmented beta-adrenergic support of resting metabolic rate in habitually exercising older adults.
Academic Article	Lesser vagal withdrawal during isometric exercise with age.
Academic Article	Collateral damage: cardiovascular consequences of chronic sympathetic activation with human aging.
Academic Article	Age-related declines in maximal aerobic capacity in regularly exercising vs. sedentary women: a meta-analysis.
Academic Article	Absence of age-related decline in total blood volume in physically active females.
Academic Article	Systemic hemodynamic determinants of blood pressure in women: age, physical activity, and hormone replacement.
Academic Article	Influence of age on the sympathetic neural adjustments to alterations in systemic oxygen levels in humans.
Academic Article	Sympathoadrenal-circulatory regulation during sustained isometric exercise in young and older men.
Academic Article	Physically active women demonstrate less adverse age-related changes in plasma lipids and lipoproteins.
Academic Article	Aortic input impedance increases with age in healthy men and women.
Academic Article	Absence of age-related increase in central arterial stiffness in physically active women.
Academic Article	Influence of age on arterial baroreflex inhibition of sympathetic nerve activity in healthy adult humans.
Academic Article	Elevated heart rate variability in physically active young and older adult women.
Academic Article	Xanthine oxidase does not contribute to impaired peripheral conduit artery endothelium-dependent dilatation with ageing.
Academic Article	Human ageing and the sympathoadrenal system.
Academic Article	Habitual aerobic exercise is associated with smaller femoral artery intima-media thickness with age in healthy men and women.
Academic Article	Regular aerobic exercise and the age-related increase in carotid artery intima-media thickness in healthy men.
Academic Article	Influence of ageing on the sympathetic nervous system and adrenal medulla at rest and during stress.
Academic Article	Basal leg blood flow in healthy women is related to age and hormone replacement therapy status.
Academic Article	Invited Review: Dynamic exercise performance in Masters athletes: insight into the effects of primary human aging on physiological functional capacity.
Academic Article	Chronic sympathetic activation: consequence and cause of age-associated obesity?
Academic Article	Ascorbic acid increases cardiovagal baroreflex sensitivity in healthy older men.
Academic Article	Endurance exercise performance in Masters athletes: age-associated changes and underlying physiological mechanisms.
Academic Article	Modulatory influences on ageing of the vasculature in healthy humans.
Academic Article	Cardiovascular-sympathetic adjustments to nonexertional heat stress in mature and senescent Fischer 344 rats.
Academic Article	Decreased maximal heart rate with aging is related to reduced {beta}-adrenergic responsiveness but is largely explained by a reduction in intrinsic heart rate.
Academic Article	Aging is associated with greater nuclear NF kappa B, reduced I kappa B alpha, and increased expression of proinflammatory cytokines in vascular endothelial cells of healthy humans.
Academic Article	B6D2F1 Mice are a suitable model of oxidative stress-mediated impaired endothelium-dependent dilation with aging.
Academic Article	Direct evidence of endothelial oxidative stress with aging in humans: relation to impaired endothelium-dependent dilation and upregulation of nuclear factor-kappaB.
Academic Article	High-dose ascorbic acid infusion abolishes chronic vasoconstriction and restores resting leg blood flow in healthy older men.
Academic Article	Habitual exercise and arterial aging.
Academic Article	Modulation of vascular endothelial function by low-density lipoprotein cholesterol with aging: influence of habitual exercise.
Academic Article	Nitrite supplementation reverses vascular endothelial dysfunction and large elastic artery stiffness with aging.
Academic Article	Salicylate treatment improves age-associated vascular endothelial dysfunction: potential role of nuclear factor kappaB and forkhead Box O phosphorylation.
Academic Article	Leukocyte telomere length is preserved with aging in endurance exercise-trained adults and related to maximal aerobic capacity.
Academic Article	Short-term calorie restriction reverses vascular endothelial dysfunction in old mice by increasing nitric oxide and reducing oxidative stress.
Academic Article	Arterial stiffening with ageing is associated with transforming growth factor-?1-related changes in adventitial collagen: reversal by aerobic exercise.
Academic Article	Aging and vascular endothelial function in humans.
Academic Article	Plasma norepinephrine is an independent predictor of vascular endothelial function with aging in healthy women.
Academic Article	Regular aerobic exercise protects against impaired fasting plasma glucose-associated vascular endothelial dysfunction with aging.
Academic Article	Replicative aging induces endothelial to mesenchymal transition in human aortic endothelial cells: potential role of inflammation.
Academic Article	Superoxide-lowering therapy with TEMPOL reverses arterial dysfunction with aging in mice.
Academic Article	Sustained activation of AMPK ameliorates age-associated vascular endothelial dysfunction via a nitric oxide-independent mechanism.
Academic Article	Translational evidence that impaired autophagy contributes to arterial ageing.
Academic Article	Curcumin ameliorates arterial dysfunction and oxidative stress with aging.
Academic Article	Metabolic responses to exercise in young and older athletes and sedentary men.
Concept	Cellular Senescence
Concept	Aging
Academic Article	The autophagy enhancer spermidine reverses arterial aging.
Academic Article	Life-long caloric restriction reduces oxidative stress and preserves nitric oxide bioavailability and function in arteries of old mice.
Academic Article	Aging compounds western diet-associated large artery endothelial dysfunction in mice: prevention by voluntary aerobic exercise.
Academic Article	Inorganic nitrite supplementation for healthy arterial aging.
Academic Article	Battery of behavioral tests in mice that models age-associated changes in human motor function.
Academic Article	Superoxide signaling in perivascular adipose tissue promotes age-related artery stiffness.
Academic Article	Mitochondria-targeted antioxidant (MitoQ) ameliorates age-related arterial endothelial dysfunction in mice.
Academic Article	Medical research: treat ageing.
Academic Article	You're only as old as your arteries: translational strategies for preserving vascular endothelial function with aging.
Academic Article	Edward F. Adolph Distinguished Lecture: The remarkable anti-aging effects of aerobic exercise on systemic arteries.
Academic Article	Translational geroscience: emphasizing function to achieve optimal longevity.
Academic Article	Aerobic exercise and other healthy lifestyle factors that influence vascular aging.
Academic Article	Mitochondrial quality control and age-associated arterial stiffening.
Academic Article	The SIRT1 activator SRT1720 reverses vascular endothelial dysfunction, excessive superoxide production, and inflammation with aging in mice.
Academic Article	Sodium nitrite supplementation improves motor function and skeletal muscle inflammatory profile in old male mice.
Academic Article	Reduced large elastic artery stiffness with regular aerobic exercise in middle-aged and older adults: potential role of suppressed nuclear factor ? B signalling.
Academic Article	Improved motor and cognitive performance with sodium nitrite supplementation is related to small metabolite signatures: a pilot trial in middle-aged and older adults.
Academic Article	Nicotinamide mononucleotide supplementation reverses vascular dysfunction and oxidative stress with aging in mice.
Academic Article	Effects of sodium nitrite supplementation on vascular function and related small metabolite signatures in middle-aged and older adults.
Academic Article	Oral trehalose supplementation improves resistance artery endothelial function in healthy middle-aged and older adults.
Academic Article	Adding value to a graduate physiology seminar by focusing on public communication skills.
Academic Article	Estimated aortic stiffness is independently associated with cardiac baroreflex sensitivity in humans: role of ageing and habitual endurance exercise.
Academic Article	Practical alternatives to chronic caloric restriction for optimizing vascular function with ageing.
Academic Article	Comparative Approaches to Understanding the Relation Between Aging and Physical Function.
Academic Article	Nutrition and other lifestyle influences on arterial aging.
Academic Article	Voluntary aerobic exercise increases arterial resilience and mitochondrial health with aging in mice.
Academic Article	Habitual aerobic exercise does not protect against micro- or macrovascular endothelial dysfunction in healthy estrogen-deficient postmenopausal women.
Academic Article	Dietary rapamycin supplementation reverses age-related vascular dysfunction and oxidative stress, while modulating nutrient-sensing, cell cycle, and senescence pathways.
Academic Article	Curcumin supplementation improves vascular endothelial function in healthy middle-aged and older adults by increasing nitric oxide bioavailability and reducing oxidative stress.
Academic Article	Reductions in central arterial compliance with age are related to sympathetic vasoconstrictor nerve activity in healthy men.
Grant	Translational Studies of Interleukin-37, a Novel Anti-inflammatory Cytokine, for Prevention and Treatment of Inflamm-aging and Age-Associated Physiological Dysfunction
Grant	Weight Loss, Inflammation, and Vascular Endothelial Function in Older Adults
Grant	Clinical Translation of Curcumin Therapy to Treat Arterial Aging
Grant	Human Aging and B-adrenergic Modulation of Thermogenesis
Grant	HYPERTENSION IN THE ELDERLY--EFFECTS OF EXERCISE
Grant	Nitrite Supplementation for Improving Physiological Function in Older Adults
Grant	Mechanisms for Reduced Limb Perfusion with Human Aging
Grant	MitoQ Supplementation for Improving Vascular Endothelial Function in Older Adults
Grant	Aging and Arterial Dysfunction with a Western Diet: Exercise and AMPK
Grant	Human Aging, Exercise & FMD: Translational Physiology
Grant	Hormone Replacement Therapy, SERMs &Leg Blood Flow in Postmenopausal Women
Grant	Clinical Translation of Nitrite Therapy to Treat Arterial Aging in Humans
Grant	ENDOTHELIAL FUNCTION--AGING AND PHYSICAL ACTIVITY
Grant	Reduced Inflammatory Suppression of EDD with Habitual Exercise in Older Adults
Academic Article	Trehalose supplementation reduces hepatic endoplasmic reticulum stress and inflammatory signaling in old mice.
Academic Article	A viewpoint on considering physiological principles to study stress resistance and resilience with aging.
Grant	Translational Studies of Age-Associated Arterial Dysfunction, Western Diet and Aerobic Exercise: Role of the Gut Microbiome
Academic Article	Endothelial cell senescence with aging in healthy humans: prevention by habitual exercise and relation to vascular endothelial function.
Academic Article	Strategies for Achieving Healthy Vascular Aging.
Academic Article	Keynote lecture: strategies for optimal cardiovascular aging.
Academic Article	Vascular aging.
Academic Article	Amino acid and lipid associated plasma metabolomic patterns are related to healthspan indicators with ageing.
Grant	Role of cellular senescence in cardiovascular aging
Academic Article	Curcumin supplementation and motor-cognitive function in healthy middle-aged and older adults.
Academic Article	Healthy lifestyle-based approaches for successful vascular aging.
Academic Article	Habitual aerobic exercise and circulating proteomic patterns in healthy adults: relation to indicators of healthspan.
Academic Article	Suppression of the gut microbiome ameliorates age-related arterial dysfunction and oxidative stress in mice.
Grant	Nicotinamide riboside supplementation for treating elevated systolic blood pressure and arterial stiffness in middle-aged and older adults
Grant	Inspiratory muscle strength training for lowering blood pressure in hypertensive mid-life adults
Concept	Healthy Aging
Academic Article	Aerobic exercise training and vascular function with ageing in healthy men and women.
Academic Article	Age-Related Vascular Dysfunction: What Registered Dietitian Nutritionists Need to Know.
Grant	DMB (3,3-dimethyl-1-butanol) as a novel translational strategy for preventing and treating gut dysbiosis-associated arterial aging
Academic Article	The plasma metabolome as a predictor of biological aging in humans.
Academic Article	Short-term interleukin-37 treatment improves vascular endothelial function, endurance exercise capacity, and whole-body glucose metabolism in old mice.
Academic Article	Trimethylamine-N-Oxide Promotes Age-Related Vascular Oxidative Stress and Endothelial Dysfunction in Mice and Healthy Humans.
Academic Article	Targeting mitochondrial fitness as a strategy for healthy vascular aging.
Academic Article	The gut microbiome-derived metabolite trimethylamine N-oxide modulates neuroinflammation and cognitive function with aging.
Academic Article	Healthy Aging Interventions Reduce Repetitive Element Transcripts.
Academic Article	Inorganic Nitrite Supplementation Improves Endothelial Function With Aging: Translational Evidence for Suppression of Mitochondria-Derived Oxidative Stress.
Grant	Mitochondrial-targeted antioxidant supplementation for improving age-related vascular dysfunction in humans
Academic Article	Gut Microbiome-Derived Metabolite Trimethylamine N-Oxide Induces Aortic Stiffening and Increases Systolic Blood Pressure With Aging in Mice and Humans.
Academic Article	Apigenin restores endothelial function by ameliorating oxidative stress, reverses aortic stiffening, and mitigates vascular inflammation with aging.
Academic Article	Accelerated aging of the brain transcriptome by the common chemotherapeutic doxorubicin.
Academic Article	Anthracycline chemotherapy-mediated vascular dysfunction as a model of accelerated vascular aging.
Academic Article	Time-efficient, high-resistance inspiratory muscle strength training for cardiovascular aging.
Academic Article	Associations Between Age and Resting State Connectivity Are Partially Dependent Upon Cardiovascular Fitness.
Academic Article	Circulating interleukin-37 declines with aging in healthy humans: relations to healthspan indicators and IL37 gene SNPs.
Academic Article	Nitric oxide, aging and aerobic exercise: Sedentary individuals to Master's athletes.
Academic Article	Promoting healthy cardiovascular aging: emerging topics.
Academic Article	Initiation of 3,3-dimethyl-1-butanol at midlife prevents endothelial dysfunction and attenuates in vivo aortic stiffening with ageing in mice.
Academic Article	Oral nicotinamide riboside raises NAD+ and lowers biomarkers of neurodegenerative pathology in plasma extracellular vesicles enriched for neuronal origin.
Academic Article	Aging, aerobic exercise, and cardiovascular health: Barriers, alternative strategies and future directions.
Academic Article	Female C57BL/6N mice are a viable model of aortic aging in women.
Academic Article	Dietary Supplementation With NAD+-Boosting Compounds in Humans: Current Knowledge and Future Directions.
Academic Article	Nicotinamide Adenine Dinucleotide in Aging Biology: Potential Applications and Many Unknowns.
Academic Article	Cellular Senescence Contributes to Large Elastic Artery Stiffening and Endothelial Dysfunction With Aging: Amelioration With Senolytic Treatment.
Academic Article	Effects of regular exercise on vascular function with aging: Does sex matter?
Academic Article	Protective effects of apigenin on the brain transcriptome with aging.
Academic Article	Intermittent supplementation with fisetin improves arterial function in old mice by decreasing cellular senescence.
Grant	Targeting cellular senescence to prevent accelerated vascular aging induced by the common chemotherapeutic agent doxorubicin

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