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Search Results to Lorna Grindlay Moore

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overview My research centers on the physiological mechanisms underlying the normal maternal physiological responses to pregnancy and the pregnancy complications of fetal growth restriction and preeclampsia. I use the chronic hypoxia of residence at high altitude (>2500 m or 8000 ft) as a natural laboratory for studying these mechanisms since high altitude exerts one of the strongest influences on fetal growth (being second in magnitude only to gestational age) and triples the frequency of preeclampsia. With students, fellows and faculty colleagues from obstetrics & gynecology and other disciplines (anesthesiology, anthropology, cancer biology, genetics, medicine, pediatrics, physiology, and public health) and the aid of NIH, NSF or other federal funding, we have published more than 200 articles documenting the effects of chronic hypoxia on maternal and fetal well being. In particular our human studies have shown that altitude lowers birth weight an average of 102 g/1000 m and is associated with less pregnancy-associated rise in uterine artery blood flow, due in turn to smaller uterine artery diameters. Experimental animal studies have shown that chronic hypoxia vs. normoxia reduces uterine artery nitric oxide production, vasodilator response to flow, growth and remodeling, suggesting that chronic hypoxia interferes with the normal maternal uterine vascular responses to pregnancy. Multigenerational populations (Andeans, Tibetans) are largely protected from hypoxia-associated fetal growth restriction, due in part to being able to attain greater uterine artery diameter and blood flow than shorter-term residents (Europeans, Chinese). Our recent whole-genome scan and gene-expression studies have identified several genes likely involved. Current work is aimed at identifying the specific gene variants and physiological mechanisms by which they exert their effects with hopes that such studies will aid not only in understanding processes of evolutionary adaptation but also our ability to identify persons at risk for pregnancy complications and/or design more effective therapies for their treatment or prevention.

One or more keywords matched the following items that are connected to Moore, Lorna

Item TypeName
Academic Article Systemic and renal hemodynamic changes in the luteal phase of the menstrual cycle mimic early pregnancy.
Academic Article Human adaptation to high altitude: regional and life-cycle perspectives.
Academic Article Effect of K+ATP channel inhibition on total and regional vascular resistance in guinea pig pregnancy.
Academic Article Altered blood pressure course during normal pregnancy and increased preeclampsia at high altitude (3100 meters) in Colorado.
Academic Article Comparative aspects of high-altitude adaptation in human populations.
Academic Article Chronic hypoxia diminishes pregnancy-associated DNA synthesis in guinea pig uteroplacental arteries.
Academic Article Chronic hypoxia, pregnancy, and endothelium-mediated relaxation in guinea pig uterine and thoracic arteries.
Academic Article Oxygen transport in tibetan women during pregnancy at 3,658 m.
Academic Article Intrauterine growth restriction, preeclampsia, and intrauterine mortality at high altitude in Bolivia.
Academic Article Fetal growth restriction and maternal oxygen transport during high altitude pregnancy.
Academic Article Maternal adaptation to high-altitude pregnancy: an experiment of nature--a review.
Academic Article Chronic hypoxia diminishes the proliferative response of Guinea pig uterine artery vascular smooth muscle cells in vitro.
Academic Article Greater uterine artery blood flow during pregnancy in multigenerational (Andean) than shorter-term (European) high-altitude residents.
Academic Article Evidence that parent-of-origin affects birth-weight reductions at high altitude.
Academic Article Lower uterine artery blood flow and higher endothelin relative to nitric oxide metabolite levels are associated with reductions in birth weight at high altitude.
Academic Article Augmented uterine artery blood flow and oxygen delivery protect Andeans from altitude-associated reductions in fetal growth.
Academic Article Evolutionary adaptation to high altitude: a view from in utero.
Academic Article Do cytokines contribute to the Andean-associated protection from reduced fetal growth at high altitude?
Academic Article Role of the AT2 receptor in modulating the angiotensin II contractile response of the uterine artery at mid-gestation.
Academic Article Humans at high altitude: hypoxia and fetal growth.
Academic Article Lowland origin women raised at high altitude are not protected against lower uteroplacental O2 delivery during pregnancy or reduced birth weight.
Academic Article Potential role for elevated maternal enzymatic antioxidant status in Andean protection against altitude-associated SGA.
Academic Article Role of cytokines in altitude-associated preeclampsia.
Academic Article Travel to high altitude during pregnancy: frequently asked questions and recommendations for clinicians.
Academic Article High altitude residence during pregnancy alters cytokine and catecholamine levels.
Academic Article Human physiological adaptation to pregnancy: inter- and intraspecific perspectives.
Academic Article The quest for riches, or how mining silver in Bolivia has enriched our knowledge of the mechanisms underlying reproductive success.
Academic Article Effects of pregnancy and chronic hypoxia on contractile responsiveness to alpha1-adrenergic stimulation.
Academic Article Temporal relationships between hormonal and hemodynamic changes in early human pregnancy.
Academic Article Chronic hypoxia augments uterine artery distensibility and alters the circumferential wall stress-strain relationship during pregnancy.
Academic Article High-altitude ancestry protects against hypoxia-associated reductions in fetal growth.
Academic Article Medical recommendations for women going to altitude.
Academic Article Determinants of blood oxygenation during pregnancy in Andean and European residents of high altitude.
Academic Article An evolutionary model for identifying genetic adaptation to high altitude.
Academic Article Do anti-angiogenic or angiogenic factors contribute to the protection of birth weight at high altitude afforded by Andean ancestry?
Academic Article High-end arteriolar resistance limits uterine artery blood flow and restricts fetal growth in preeclampsia and gestational hypertension at high altitude.
Academic Article Pregnancy increases myometrial artery myogenic tone via NOS- or COX-independent mechanisms.
Academic Article Little effect of gestation at 3,100 m on fetal fat accretion or the fetal circulation.
Concept Pregnancy, Animal
Concept Pregnancy Outcome
Concept Pregnancy Trimester, First
Concept Pregnancy Proteins
Concept Pregnancy Complications
Concept Pregnancy-Associated Plasma Protein-A
Concept Pregnancy
Concept Pregnancy Trimesters
Concept Pregnancy Complications, Cardiovascular
Concept Hypertension, Pregnancy-Induced
Academic Article Inhibition of peroxisome proliferator-activated receptor ?: a potential link between chronic maternal hypoxia and impaired fetal growth.
Academic Article Higher estrogen levels during pregnancy in Andean than European residents of high altitude suggest differences in aromatase activity.
Academic Article Maternal PRKAA1 and EDNRA genotypes are associated with birth weight, and PRKAA1 with uterine artery diameter and metabolic homeostasis at high altitude.
Academic Article Uterine artery blood flow, fetal hypoxia and fetal growth.
Academic Article Unique DNA Methylation Patterns in Offspring of Hypertensive Pregnancy.
Academic Article Hypoxia, AMPK activation and uterine artery vasoreactivity.
Academic Article Erythropoietin and Soluble Erythropoietin Receptor: A Role for Maternal Vascular Adaptation to High-Altitude Pregnancy.
Grant Genetic Regulation of Hypoxia-Induced IUGR
Grant Perinatal Origins of Chronic Mountain Sickness
Academic Article High altitude and hypertension during pregnancy.
Academic Article Maternal uterine vascular remodeling during pregnancy.
Grant Antenatal Exposures and Non-Communicable Disease(ANDES): Building research capacity to identify and treat causes of NCD in Bolivia
Academic Article Queen of the mountain: successful pregnancy while exercising up to 5,300 m.
Academic Article Hypoxia causes reductions in birth weight by altering maternal glucose and lipid metabolism.
Academic Article Gestational Diabetes Prevalence at Moderate and High Altitude.
Academic Article High Altitude Reduces NO-Dependent Myometrial Artery Vasodilator Response During Pregnancy.
Academic Article Pharmacological activation of peroxisome proliferator-activated receptor ? (PPAR-?) protects against hypoxia-associated fetal growth restriction.
Academic Article Critical barriers for preeclampsia diagnosis and treatment in low-resource settings: An example from Bolivia.
Academic Article High Altitude Continues to Reduce Birth Weights in Colorado.
Academic Article Increased uterine artery blood flow in hypoxic murine pregnancy is not sufficient to prevent fetal growth restriction?.
Academic Article Effect of high altitude on human placental amino acid transport.
Academic Article Uteroplacental Ischemia Is Associated with Increased PAPP-A2.
Academic Article Peroxisome proliferator-activated receptor gamma blunts endothelin-1-mediated contraction of the uterine artery in a murine model of high-altitude pregnancy.
Academic Article High-altitude residence alters blood-pressure course and increases hypertensive disorders of pregnancy.
Academic Article AMPK activation in pregnant human myometrial arteries from high-altitude and intrauterine growth-restricted pregnancies.
Academic Article AMP-activated protein kinase activator AICAR attenuates hypoxia-induced murine fetal growth restriction in part by improving uterine artery blood flow.
Academic Article HYPOXIA AND REPRODUCTIVE HEALTH: Reproductive challenges at high altitude: fertility, pregnancy and neonatal well-being.
Academic Article Hypoxia-induced inhibition of mTORC1 activity in the developing lung: a possible mechanism for the developmental programming of pulmonary hypertension.
Academic Article High altitude regulates the expression of AMPK pathways in human placenta.
Academic Article Uteroplacental nutrient flux and evidence for metabolic reprogramming during sustained hypoxemia.
Academic Article How hypoxia slows fetal growth: insights from high altitude.
Academic Article Vascular Disorders of Pregnancy Increase Susceptibility to Neonatal Pulmonary Hypertension in High-Altitude Populations.
Academic Article ACOG and local diagnostic criteria for hypertensive disorders of pregnancy (HDP) in La Paz-El Alto, Bolivia: A retrospective case-control study.
Academic Article Why is human uterine artery blood flow during pregnancy so high?
Academic Article High altitude differentially modulates potassium channel-evoked vasodilatation in pregnant human myometrial arteries.
Academic Article Is Maternal Cardiovascular Performance Impaired in Altitude-Associated Fetal Growth Restriction?
Academic Article Adaptive responses in uteroplacental metabolism and fetoplacental nutrient shuttling and sensing during placental insufficiency.
Academic Article Altered placental ion channel gene expression in preeclamptic high-altitude pregnancies.
Academic Article Increased adherence to ACOG diagnostic guidelines for HDP following a workshop in Bolivia, a LMIC.
Academic Article Genomic Selection Signals in Andean Highlanders Reveal Adaptive Placental Metabolic Phenotypes That Are Disrupted in Preeclampsia.

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