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Search Results to Lorna Grindlay Moore

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One or more keywords matched the following properties of Moore, Lorna

overview My research centers on the physiological mechanisms underlying the normal maternal physiological responses to pregnancy and the pregnancy complications of fetal growth restriction and preeclampsia. I use the chronic hypoxia of residence at high altitude (>2500 m or 8000 ft) as a natural laboratory for studying these mechanisms since high altitude exerts one of the strongest influences on fetal growth (being second in magnitude only to gestational age) and triples the frequency of preeclampsia. With students, fellows and faculty colleagues from obstetrics & gynecology and other disciplines (anesthesiology, anthropology, cancer biology, genetics, medicine, pediatrics, physiology, and public health) and the aid of NIH, NSF or other federal funding, we have published more than 200 articles documenting the effects of chronic hypoxia on maternal and fetal well being. In particular our human studies have shown that altitude lowers birth weight an average of 102 g/1000 m and is associated with less pregnancy-associated rise in uterine artery blood flow, due in turn to smaller uterine artery diameters. Experimental animal studies have shown that chronic hypoxia vs. normoxia reduces uterine artery nitric oxide production, vasodilator response to flow, growth and remodeling, suggesting that chronic hypoxia interferes with the normal maternal uterine vascular responses to pregnancy. Multigenerational populations (Andeans, Tibetans) are largely protected from hypoxia-associated fetal growth restriction, due in part to being able to attain greater uterine artery diameter and blood flow than shorter-term residents (Europeans, Chinese). Our recent whole-genome scan and gene-expression studies have identified several genes likely involved. Current work is aimed at identifying the specific gene variants and physiological mechanisms by which they exert their effects with hopes that such studies will aid not only in understanding processes of evolutionary adaptation but also our ability to identify persons at risk for pregnancy complications and/or design more effective therapies for their treatment or prevention.

One or more keywords matched the following items that are connected to Moore, Lorna

Item TypeName
Academic Article Chronic hypoxia diminishes the proliferative response of Guinea pig uterine artery vascular smooth muscle cells in vitro.
Academic Article Lower uterine artery blood flow and higher endothelin relative to nitric oxide metabolite levels are associated with reductions in birth weight at high altitude.
Academic Article Do cytokines contribute to the Andean-associated protection from reduced fetal growth at high altitude?
Academic Article Potential role for elevated maternal enzymatic antioxidant status in Andean protection against altitude-associated SGA.
Academic Article High-altitude ancestry protects against hypoxia-associated reductions in fetal growth.
Academic Article Do anti-angiogenic or angiogenic factors contribute to the protection of birth weight at high altitude afforded by Andean ancestry?
Academic Article High-end arteriolar resistance limits uterine artery blood flow and restricts fetal growth in preeclampsia and gestational hypertension at high altitude.
Academic Article Little effect of gestation at 3,100 m on fetal fat accretion or the fetal circulation.
Concept Gestational Age
Concept Infant, Small for Gestational Age
Academic Article Maternal PRKAA1 and EDNRA genotypes are associated with birth weight, and PRKAA1 with uterine artery diameter and metabolic homeostasis at high altitude.
Academic Article Hypoxia causes reductions in birth weight by altering maternal glucose and lipid metabolism.
Academic Article Hypoxia-induced inhibition of mTORC1 activity in the developing lung: a possible mechanism for the developmental programming of pulmonary hypertension.

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