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Moore, Lorna

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My research centers on the physiological mechanisms underlying the normal maternal physiological responses to pregnancy and the pregnancy complications of fetal growth restriction and preeclampsia. I use the chronic hypoxia of residence at high altitude (>2500 m or 8000 ft) as a natural laboratory for studying these mechanisms since high altitude exerts one of the strongest influences on fetal growth (being second in magnitude only to gestational age) and triples the frequency of preeclampsia. With students, fellows and faculty colleagues from obstetrics & gynecology and other disciplines (anesthesiology, anthropology, cancer biology, genetics, medicine, pediatrics, physiology, and public health) and the aid of NIH, NSF or other federal funding, we have published more than 200 articles documenting the effects of chronic hypoxia on maternal and fetal well being. In particular our human studies have shown that altitude lowers birth weight an average of 102 g/1000 m and is associated with less pregnancy-associated rise in uterine artery blood flow, due in turn to smaller uterine artery diameters. Experimental animal studies have shown that chronic hypoxia vs. normoxia reduces uterine artery nitric oxide production, vasodilator response to flow, growth and remodeling, suggesting that chronic hypoxia interferes with the normal maternal uterine vascular responses to pregnancy. Multigenerational populations (Andeans, Tibetans) are largely protected from hypoxia-associated fetal growth restriction, due in part to being able to attain greater uterine artery diameter and blood flow than shorter-term residents (Europeans, Chinese). Our recent whole-genome scan and gene-expression studies have identified several genes likely involved. Current work is aimed at identifying the specific gene variants and physiological mechanisms by which they exert their effects with hopes that such studies will aid not only in understanding processes of evolutionary adaptation but also our ability to identify persons at risk for pregnancy complications and/or design more effective therapies for their treatment or prevention.

One or more keywords matched the following items that are connected to Moore, Lorna

Item Type	Name
Academic Article	Catecholamine response during 12 days of high-altitude exposure (4, 300 m) in women.
Academic Article	Hypoxic responses in infants. No known mechanism links hypoxia and sudden infant death syndrome.
Academic Article	Superior exercise performance in lifelong Tibetan residents of 4,400 m compared with Tibetan residents of 3,658 m.
Academic Article	Human adaptation to high altitude: regional and life-cycle perspectives.
Academic Article	Women at altitude: changes in carbohydrate metabolism at 4,300-m elevation and across the menstrual cycle.
Academic Article	Altered blood pressure course during normal pregnancy and increased preeclampsia at high altitude (3100 meters) in Colorado.
Academic Article	Women at altitude: carbohydrate utilization during exercise at 4,300 m.
Academic Article	Comparative aspects of high-altitude adaptation in human populations.
Academic Article	Chronic hypoxia, pregnancy, and endothelium-mediated relaxation in guinea pig uterine and thoracic arteries.
Academic Article	Altitude and fetal growth: current knowledge and future directions.
Academic Article	Intraocular pressure and acclimatization to 4300 M altitude.
Academic Article	Oxygen transport in tibetan women during pregnancy at 3,658 m.
Academic Article	Women at altitude: forearm hemodynamics during acclimatization to 4,300 m with alpha(1)-adrenergic blockade.
Academic Article	Human genetic adaptation to high altitude.
Academic Article	Circulatory responses to orthostasis during alpha1-adrenergic receptor blockade at high altitude.
Academic Article	Erythropoiesis in women during 11 days at 4,300 m is not affected by menstrual cycle phase.
Academic Article	Analysis of the myoglobin gene in Tibetans living at high altitude.
Academic Article	Intrauterine growth restriction, preeclampsia, and intrauterine mortality at high altitude in Bolivia.
Academic Article	Fetal growth restriction and maternal oxygen transport during high altitude pregnancy.
Academic Article	Influence of alpha-adrenergic blockade on the catecholamine response to exercise at 4,300 meters.
Academic Article	Maternal adaptation to high-altitude pregnancy: an experiment of nature--a review.
Academic Article	Consensus statement on chronic and subacute high altitude diseases.
Academic Article	Greater uterine artery blood flow during pregnancy in multigenerational (Andean) than shorter-term (European) high-altitude residents.
Academic Article	Does chronic mountain sickness (CMS) have perinatal origins?
Academic Article	Evidence that parent-of-origin affects birth-weight reductions at high altitude.
Academic Article	Lower uterine artery blood flow and higher endothelin relative to nitric oxide metabolite levels are associated with reductions in birth weight at high altitude.
Academic Article	Augmented uterine artery blood flow and oxygen delivery protect Andeans from altitude-associated reductions in fetal growth.
Academic Article	Evolutionary adaptation to high altitude: a view from in utero.
Academic Article	Identifying signatures of natural selection in Tibetan and Andean populations using dense genome scan data.
Academic Article	Do cytokines contribute to the Andean-associated protection from reduced fetal growth at high altitude?
Academic Article	Comparative human ventilatory adaptation to high altitude.
Academic Article	Humans at high altitude: hypoxia and fetal growth.
Academic Article	Lowland origin women raised at high altitude are not protected against lower uteroplacental O2 delivery during pregnancy or reduced birth weight.
Academic Article	Tibetan protection from intrauterine growth restriction (IUGR) and reproductive loss at high altitude.
Academic Article	Women at altitude: ventilatory acclimatization at 4,300 m.
Academic Article	Potential role for elevated maternal enzymatic antioxidant status in Andean protection against altitude-associated SGA.
Academic Article	Role of cytokines in altitude-associated preeclampsia.
Academic Article	Speech motor control and acute mountain sickness.
Academic Article	Travel to high altitude during pregnancy: frequently asked questions and recommendations for clinicians.
Academic Article	Andean and Tibetan patterns of adaptation to high altitude.
Academic Article	High altitude residence during pregnancy alters cytokine and catecholamine levels.
Academic Article	Human physiological adaptation to pregnancy: inter- and intraspecific perspectives.
Academic Article	The quest for riches, or how mining silver in Bolivia has enriched our knowledge of the mechanisms underlying reproductive success.
Academic Article	Ventilation and hypoxic ventilatory responsiveness in Chinese-Tibetan residents at 3,658 m.
Academic Article	ECG observations in Tibetan and Han residents of Lhasa.
Academic Article	Effects of pregnancy and chronic hypoxia on contractile responsiveness to alpha1-adrenergic stimulation.
Academic Article	Women at altitude: energy requirement at 4,300 m.
Academic Article	Catecholamine responses to alpha-adrenergic blockade during exercise in women acutely exposed to altitude.
Academic Article	Women at altitude: short-term exposure to hypoxia and/or alpha(1)-adrenergic blockade reduces insulin sensitivity.
Academic Article	Finding the genes underlying adaptation to hypoxia using genomic scans for genetic adaptation and admixture mapping.
Academic Article	Interleukin-6 response to exercise and high-altitude exposure: influence of alpha-adrenergic blockade.
Academic Article	High-altitude ancestry protects against hypoxia-associated reductions in fetal growth.
Academic Article	Medical recommendations for women going to altitude.
Academic Article	Determinants of blood oxygenation during pregnancy in Andean and European residents of high altitude.
Academic Article	An evolutionary model for identifying genetic adaptation to high altitude.
Academic Article	Do anti-angiogenic or angiogenic factors contribute to the protection of birth weight at high altitude afforded by Andean ancestry?
Academic Article	Identifying positive selection candidate loci for high-altitude adaptation in Andean populations.
Academic Article	High-end arteriolar resistance limits uterine artery blood flow and restricts fetal growth in preeclampsia and gestational hypertension at high altitude.
Academic Article	Sleep-disordered breathing and oxidative stress in preclinical chronic mountain sickness (excessive erythrocytosis).
Academic Article	Little effect of gestation at 3,100 m on fetal fat accretion or the fetal circulation.
Academic Article	Mitochondrial DNA variant associated with Leber hereditary optic neuropathy and high-altitude Tibetans.
Concept	Altitude
Concept	Altitude Sickness
Academic Article	Higher estrogen levels during pregnancy in Andean than European residents of high altitude suggest differences in aromatase activity.
Academic Article	Maternal PRKAA1 and EDNRA genotypes are associated with birth weight, and PRKAA1 with uterine artery diameter and metabolic homeostasis at high altitude.
Academic Article	Graduated effects of high-altitude hypoxia and highland ancestry on birth size.
Academic Article	Uterine artery blood flow, fetal hypoxia and fetal growth.
Academic Article	Neonatal oxygenation, pulmonary hypertension, and evolutionary adaptation to high altitude (2013 Grover Conference series).
Academic Article	Perinatal hypoxia increases susceptibility to high-altitude polycythemia and attendant pulmonary vascular dysfunction.
Academic Article	Erythropoietin and Soluble Erythropoietin Receptor: A Role for Maternal Vascular Adaptation to High-Altitude Pregnancy.
Academic Article	Gain-of-function EGLN1 prolyl hydroxylase (PHD2 D4E:C127S) in combination with EPAS1 (HIF-2a) polymorphism lowers hemoglobin concentration in Tibetan highlanders.
Grant	Genetic Regulation of Hypoxia-Induced IUGR
Grant	MATERNAL VENTILATORY ADAPTATION TO PREGNANCY
Grant	INTRAUTERINE GROWTH RESTRICTION AT HIGH ALTITUDES
Grant	Chronic hypoxia, AMPK activation and uterine artery blood flow
Grant	Perinatal Origins of Chronic Mountain Sickness
Grant	CHRONIC HYPOXIA, UTERINE ARTERY VASOREGULATION &GROWTH
Academic Article	Maternal O2 transport and fetal growth in Colorado, Peru, and Tibet high-altitude residents.
Academic Article	Surname-inferred Andean ancestry is associated with child stature and limb lengths at high altitude in Peru, but not at sea level.
Academic Article	High altitude and hypertension during pregnancy.
Academic Article	Measuring high-altitude adaptation.
Grant	Antenatal Exposures and Non-Communicable Disease(ANDES): Building research capacity to identify and treat causes of NCD in Bolivia
Academic Article	Natural Selection on Genes Related to Cardiovascular Health in High-Altitude Adapted Andeans.
Academic Article	Human Genetic Adaptation to High Altitudes: Current Status and Future Prospects.
Academic Article	Gestational Diabetes Prevalence at Moderate and High Altitude.
Academic Article	Human Genetic Adaptation to High Altitude: Evidence from the Andes.
Academic Article	High Altitude Reduces NO-Dependent Myometrial Artery Vasodilator Response During Pregnancy.
Academic Article	Pharmacological activation of peroxisome proliferator-activated receptor ? (PPAR-?) protects against hypoxia-associated fetal growth restriction.
Academic Article	High Altitude Continues to Reduce Birth Weights in Colorado.
Academic Article	Effect of high altitude on human placental amino acid transport.
Academic Article	Uteroplacental Ischemia Is Associated with Increased PAPP-A2.
Academic Article	Peroxisome proliferator-activated receptor gamma blunts endothelin-1-mediated contraction of the uterine artery in a murine model of high-altitude pregnancy.
Academic Article	High-altitude residence alters blood-pressure course and increases hypertensive disorders of pregnancy.
Academic Article	AMPK activation in pregnant human myometrial arteries from high-altitude and intrauterine growth-restricted pregnancies.
Academic Article	HYPOXIA AND REPRODUCTIVE HEALTH: Reproductive challenges at high altitude: fertility, pregnancy and neonatal well-being.
Academic Article	High altitude regulates the expression of AMPK pathways in human placenta.
Academic Article	How hypoxia slows fetal growth: insights from high altitude.
Academic Article	Vascular Disorders of Pregnancy Increase Susceptibility to Neonatal Pulmonary Hypertension in High-Altitude Populations.
Academic Article	High altitude differentially modulates potassium channel-evoked vasodilatation in pregnant human myometrial arteries.
Academic Article	Is Maternal Cardiovascular Performance Impaired in Altitude-Associated Fetal Growth Restriction?
Academic Article	Altered placental ion channel gene expression in preeclamptic high-altitude pregnancies.

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