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Search Results to Vernon M Holers

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Holers, Vernon

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Item Type	Name
Academic Article	Complement receptor 3 (CR3, Mac-1, integrin alpha M beta 2, CD11b/CD18) is required for tyrosine phosphorylation of paxillin in adherent and nonadherent neutrophils.
Academic Article	Complement regulation in the rat glomerulus: Crry and CD59 regulate complement in glomerular mesangial and endothelial cells.
Academic Article	Moesin, and not the murine functional homologue (Crry/p65) of human membrane cofactor protein (CD46), is involved in the entry of measles virus (strain Edmonston) into susceptible murine cell lines.
Academic Article	Expression and function of membrane regulators of complement on rat astrocytes in culture.
Academic Article	The evolution of mouse and human complement C3-binding proteins: divergence of form but conservation of function.
Academic Article	Characterization of C3-binding proteins on mouse neutrophils and platelets.
Academic Article	Blockade of antibody-induced glomerulonephritis with Crry-Ig, a soluble murine complement inhibitor.
Academic Article	Epstein-Barr virus/C3d receptor (CR2, CD21) activated by its extracellular ligands regulates pp105 phosphorylation through two distinct pathways.
Academic Article	Genetics of the complement system and rheumatic diseases.
Academic Article	Characterization of rat complement receptors and regulatory proteins. CR2 and Crry are conserved, and the C3b receptor of neutrophils and platelets is distinct from CR1.
Academic Article	Characterization of a complement receptor 2 (CR2, CD21) ligand binding site for C3. An initial model of ligand interaction with two linked short consensus repeat modules.
Academic Article	Gamma-glutamyl transpeptidase, an ecto-enzyme regulator of intracellular redox potential, is a component of TM4 signal transduction complexes.
Academic Article	Renal, central nervous system and pancreatic overexpression of recombinant soluble Crry in transgenic mice. A novel means of protection from complement-mediated injury.
Academic Article	Complement deficiency states, disease susceptibility, and infection risk in systemic lupus erythematosus.
Academic Article	Expression of the murine complement regulatory protein crry by glial cells and neurons.
Academic Article	Regulation of nuclear antigen expression on the cell surface of human monocytes.
Academic Article	Expression of a soluble complement inhibitor protects transgenic mice from antibody-induced acute renal failure.
Academic Article	Inhibiting the complement system does not reduce injury in renal ischemia reperfusion.
Academic Article	Complement inhibitor, complement receptor 1-related gene/protein y-Ig attenuates intestinal damage after the onset of mesenteric ischemia/reperfusion injury in mice.
Academic Article	The serum resistance of malaria-infected erythrocytes.
Academic Article	CR2/CD21 proximal promoter activity is critically dependent on a cell type-specific repressor.
Academic Article	Arthritis critically dependent on innate immune system players.
Academic Article	Administration of a soluble recombinant complement C3 inhibitor protects against renal disease in MRL/lpr mice.
Academic Article	The complement system as a therapeutic target in autoimmunity.
Academic Article	Transgenic mice overexpressing the complement inhibitor crry as a soluble protein are protected from antibody-induced glomerular injury.
Academic Article	Inhibition of complement activation decreases airway inflammation and hyperresponsiveness.
Academic Article	Complement receptor 2-mediated targeting of complement inhibitors to sites of complement activation.
Academic Article	Administration of the soluble complement inhibitor, Crry-Ig, reduces inflammation and aquaporin 4 expression in lupus cerebritis.
Academic Article	Complement activation is critical to airway hyperresponsiveness after acute ozone exposure.
Academic Article	Overexpression of complement inhibitor Crry does not prevent cryoglobulin-associated membranoproliferative glomerulonephritis.
Academic Article	Anti-phospholipid antibodies restore mesenteric ischemia/reperfusion-induced injury in complement receptor 2/complement receptor 1-deficient mice.
Academic Article	Altered renal tubular expression of the complement inhibitor Crry permits complement activation after ischemia/reperfusion.
Academic Article	Pharmacological complement inhibition at the C3 convertase level promotes neuronal survival, neuroprotective intracerebral gene expression, and neurological outcome after traumatic brain injury.
Academic Article	Extended flexible linker structures in the complement chimaeric conjugate CR2-Ig by scattering, analytical ultracentrifugation and constrained modelling: implications for function and therapy.
Academic Article	Factor B of the alternative complement pathway regulates development of airway hyperresponsiveness and inflammation.
Academic Article	Characterization of human complement receptor type 2 (CR2/CD21) as a receptor for IFN-alpha: a potential role in systemic lupus erythematosus.
Academic Article	Alternative complement pathway activation is essential for inflammation and joint destruction in the passive transfer model of collagen-induced arthritis.
Academic Article	Complement is an essential component of the immune response to adeno-associated virus vectors.
Academic Article	Antibodies to citrullinated proteins: pathogenic and diagnostic significance.
Academic Article	The spectrum of complement alternative pathway-mediated diseases.
Academic Article	A novel targeted inhibitor of the alternative pathway of complement and its therapeutic application in ischemia/reperfusion injury.
Academic Article	Cloning and characterization of cDNAs encoding the complete sequence of decay-accelerating factor of human complement.
Academic Article	The gene encoding decay-accelerating factor (DAF) is located in the complement-regulatory locus on the long arm of chromosome 1.
Academic Article	Normal polymorphic variations and transcription of the decay accelerating factor gene in paroxysmal nocturnal hemoglobinuria cells.
Academic Article	Complement activation pathways in murine immune complex-induced arthritis and in C3a and C5a generation in vitro.
Academic Article	Aseptic injury to epithelial cells alters cell surface complement regulation in a tissue specific fashion.
Academic Article	The complement inhibitors Crry and factor H are critical for preventing autologous complement activation on renal tubular epithelial cells.
Academic Article	The regulators of complement activation (RCA) gene cluster.
Academic Article	Structural studies in solution of the recombinant N-terminal pair of short consensus/complement repeat domains of complement receptor type 2 (CR2/CD21) and interactions with its ligand C3dg.
Academic Article	Design and development of TT30, a novel C3d-targeted C3/C5 convertase inhibitor for treatment of human complement alternative pathway-mediated diseases.
Academic Article	CD4+ T cells and complement independently mediate graft ischemia in the rejection of mouse orthotopic tracheal transplants.
Academic Article	Transgenic expression of a soluble complement inhibitor protects against renal disease and promotes survival in MRL/lpr mice.
Academic Article	Characterization of the human complement receptor 2 (CR2, CD21) promoter reveals sequences shared with regulatory regions of other developmentally restricted B cell proteins.
Academic Article	Solution structure of TT30, a novel complement therapeutic agent, provides insight into its joint binding to complement C3b and C3d.
Academic Article	The complement receptor 2/factor H fusion protein TT30 protects paroxysmal nocturnal hemoglobinuria erythrocytes from complement-mediated hemolysis and C3 fragment.
Academic Article	Distinct receptor and regulatory properties of recombinant mouse complement receptor 1 (CR1) and Crry, the two genetic homologues of human CR1.
Academic Article	Herpes simplex virus glycoproteins gC-1 and gC-2 bind to the third component of complement and provide protection against complement-mediated neutralization of viral infectivity.
Academic Article	Rheumatoid arthritis is associated with signaling alterations in naturally occurring autoreactive B-lymphocytes.
Academic Article	Identification of a third component of complement-binding glycoprotein of human platelets.
Academic Article	Prevention of collagen-induced arthritis in mice transgenic for the complement inhibitor complement receptor 1-related gene/protein y.
Academic Article	Excessive matrix accumulation in the kidneys of MRL/lpr lupus mice is dependent on complement activation.
Academic Article	Analysis of C3b/C3d binding sites and factor I cofactor regions within mouse complement receptors 1 and 2.
Academic Article	CD59 homologue regulates complement-dependent cytolysis of rat Schwann cells.
Academic Article	CD21 augments antigen presentation in immune individuals.
Academic Article	Mutational analysis of the complement receptor type 2 (CR2/CD21)-C3d interaction reveals a putative charged SCR1 binding site for C3d.
Academic Article	Solution structure of the complex between CR2 SCR 1-2 and C3d of human complement: an X-ray scattering and sedimentation modelling study.
Academic Article	Targeted complement inhibition by C3d recognition ameliorates tissue injury without apparent increase in susceptibility to infection.
Academic Article	Complement opsonization is required for presentation of immune complexes by resting peripheral blood B cells.
Academic Article	CSMD1 is a novel multiple domain complement-regulatory protein highly expressed in the central nervous system and epithelial tissues.
Academic Article	Complement receptors.
Academic Article	Complement is activated in kidney by endotoxin but does not cause the ensuing acute renal failure.
Academic Article	Reduced neuronal cell death after experimental brain injury in mice lacking a functional alternative pathway of complement activation.
Academic Article	A site in the complement receptor 2 (CR2/CD21) silencer is necessary for lineage specific transcriptional regulation.
Academic Article	Structure of the Epstein-Barr virus major envelope glycoprotein.
Academic Article	A molecular and immunochemical characterization of mouse CR2. Evidence for a single gene model of mouse complement receptors 1 and 2.
Academic Article	Epitope mapping using the X-ray crystallographic structure of complement receptor type 2 (CR2)/CD21: identification of a highly inhibitory monoclonal antibody that directly recognizes the CR2-C3d interface.
Academic Article	The extended multidomain solution structures of the complement protein Crry and its chimeric conjugate Crry-Ig by scattering, analytical ultracentrifugation and constrained modelling: implications for function and therapy.
Academic Article	The alternative pathway of complement in disease: opportunities for therapeutic targeting.
Academic Article	Antibodies against citrullinated proteins enhance tissue injury in experimental autoimmune arthritis.
Academic Article	A complement C3 inhibitor specifically targeted to sites of complement activation effectively ameliorates collagen-induced arthritis in DBA/1J mice.
Academic Article	Molecular basis of the interaction between complement receptor type 2 (CR2/CD21) and Epstein-Barr virus glycoprotein gp350.
Academic Article	Oxidative stress renders retinal pigment epithelial cells susceptible to complement-mediated injury.
Academic Article	Isolating the Epstein-Barr virus gp350/220 binding site on complement receptor type 2 (CR2/CD21).
Academic Article	Analysis of epitope expression and the functional repertoire of recombinant complement receptor 2 (CR2/CD21) in mouse and human cells.
Academic Article	The interrelationship of complement-activation fragments and angiogenesis-related factors in early pregnancy and their association with pre-eclampsia.
Academic Article	A molecular insight into complement evasion by the staphylococcal complement inhibitor protein family.
Academic Article	Targeted inhibition of the complement alternative pathway with complement receptor 2 and factor H attenuates collagen antibody-induced arthritis in mice.
Academic Article	Delineation of the complement receptor type 2-C3d complex by site-directed mutagenesis and molecular docking.
Academic Article	The alternative pathway is required, but not alone sufficient, for retinal pathology in mouse laser-induced choroidal neovascularization.
Academic Article	Systemic human CR2-targeted complement alternative pathway inhibitor ameliorates mouse laser-induced choroidal neovascularization.
Academic Article	CR2-mediated targeting of complement inhibitors: bench-to-bedside using a novel strategy for site-specific complement modulation.
Academic Article	Purification and functional analysis of the polymorphic variants of the C3b/C4b receptor (CR1) and comparison with H, C4b-binding protein (C4bp), and decay accelerating factor (DAF).
Academic Article	Therapeutic inhibition of the alternative complement pathway attenuates chronic EAE.
Academic Article	Oxidative stress sensitizes retinal pigmented epithelial (RPE) cells to complement-mediated injury in a natural antibody-, lectin pathway-, and phospholipid epitope-dependent manner.
Academic Article	Detection of complement activation using monoclonal antibodies against C3d.
Concept	Homeodomain Proteins
Concept	Cytoskeletal Proteins
Concept	Adaptor Proteins, Signal Transducing
Concept	Membrane Proteins
Concept	DNA-Binding Proteins
Concept	Oncogene Proteins, Fusion
Concept	Complement C3b Inactivator Proteins
Concept	ADAM Proteins
Concept	HSP40 Heat-Shock Proteins
Concept	GTP-Binding Proteins
Concept	Recombinant Fusion Proteins
Concept	Opsonin Proteins
Concept	Carrier Proteins
Concept	Proto-Oncogene Proteins c-bcl-2
Concept	Nuclear Proteins
Concept	Recombinant Proteins
Concept	Microfilament Proteins
Concept	Viral Matrix Proteins
Concept	Acute-Phase Proteins
Concept	Mutant Proteins
Concept	Extracellular Matrix Proteins
Concept	Intracellular Signaling Peptides and Proteins
Concept	Complement Inactivator Proteins
Concept	Retroviridae Proteins, Oncogenic
Concept	Blood Proteins
Concept	Viral Envelope Proteins
Concept	Nerve Tissue Proteins
Concept	RNA-Binding Proteins
Concept	Intercellular Signaling Peptides and Proteins
Concept	Repressor Proteins
Concept	Immediate-Early Proteins
Concept	Complement System Proteins
Concept	Proteins
Academic Article	Human C3 glomerulopathy provides unique insights into complement factor H-related protein function.
Academic Article	Complement activation and mortality during an acute episode of thrombotic thrombocytopenic purpura.
Academic Article	Autoimmunity to citrullinated proteins and the initiation of rheumatoid arthritis.
Academic Article	Complement and its receptors: new insights into human disease.
Academic Article	Deficiency of complement receptors CR2/CR1 in Cr2?/? mice reduces the extent of secondary brain damage after closed head injury.
Academic Article	Human C3b- and C4b-regulatory proteins: a new multi-gene family.
Academic Article	Targeting pathogenic postischemic self-recognition by natural IgM to protect against posttransplantation cardiac reperfusion injury.
Academic Article	Analysis of tandem E-box motifs within human Complement receptor 2 (CR2/CD21) promoter reveals cell specific roles for RP58, E2A, USF and localized chromatin accessibility.
Academic Article	Modulatory Role of Surface Coating of Superparamagnetic Iron Oxide Nanoworms in Complement Opsonization and Leukocyte Uptake.
Academic Article	The relationship of circulating proteins in early pregnancy with preterm birth.
Academic Article	Site-targeted complement inhibition by a complement receptor 2-conjugated inhibitor (mTT30) ameliorates post-injury neuropathology in mouse brains.
Academic Article	New therapeutic and diagnostic opportunities for injured tissue-specific targeting of complement inhibitors and imaging modalities.
Academic Article	A molecular signature of preclinical rheumatoid arthritis triggered by dysregulated PTPN22.
Academic Article	Mapping the Complement Factor H-Related Protein 1 (CFHR1):C3b/C3d Interactions.
Academic Article	Complement proteins bind to nanoparticle protein corona and undergo dynamic exchange in vivo.
Grant	Mouse Membrane RCA Proteins in the Immune Response
Grant	C3d/EBV Receptor Ligand Binding Sites
Grant	Disconnecting CR2/CD21 from Its C3d Ligand to Ameliorate Lupus
Grant	Complement in the Pathogenesis of Autoimmune Arthritis
Academic Article	Deconstructing the Lectin Pathway in the Pathogenesis of Experimental Inflammatory Arthritis: Essential Role of the Lectin Ficolin B and Mannose-Binding Protein-Associated Serine Protease 2.
Academic Article	The Evolving Landscape for Complement Therapeutics in Rheumatic and Autoimmune Diseases.
Academic Article	Association of Antibodies to Citrullinated Protein Antigens with Blood Pressure in First-Degree Relatives of Rheumatoid Arthritis Patients: The Studies of the Etiology of Rheumatoid Arthritis.
Academic Article	Modulation of the Alternative Pathway of Complement by Murine Factor H-Related Proteins.
Academic Article	Complement in the Initiation and Evolution of Rheumatoid Arthritis.
Academic Article	Endothelial Microparticles and Systemic Complement Activation in Patients With Chronic Kidney Disease.
Academic Article	Autoantibodies against Neurologic Antigens in Nonneurologic Autoimmunity.
Concept	Ataxia Telangiectasia Mutated Proteins
Concept	Myxovirus Resistance Proteins
Academic Article	Complement therapeutics meets nanomedicine: overcoming human complement activation and leukocyte uptake of nanomedicines with soluble domains of CD55.
Academic Article	Complement and its environmental determinants in the progression of human rheumatoid arthritis.
Academic Article	Heightened Levels of Antimicrobial Response Factors in Patients With Rheumatoid Arthritis.
Academic Article	Complement Activation in the Vitreous of Patients With Proliferative Diabetic Retinopathy.
Grant	Complement in the Pathogenesis of Autoimmune Arthritis
Academic Article	C2 IgM Natural Antibody Enhances Inflammation and Its Use in the Recombinant Single Chain Antibody-Fused Complement Inhibitor C2-Crry to Target Therapeutics to Joints Attenuates Arthritis in Mice.
Academic Article	Natural antibody and complement activation characterize patients with idiopathic nephrotic syndrome.
Academic Article	Insights Into the Structure-Function Relationships of Dimeric C3d Fragments.
Academic Article	Correlation of Complement Activation in Aqueous and Vitreous in Patients With Proliferative Diabetic Retinopathy.
Academic Article	Analysis of Complement Gene Expression, Clinical Associations, and Biodistribution of Complement Proteins in the Synovium of Early Rheumatoid Arthritis Patients Reveals Unique Pathophysiologic Features.
Academic Article	Development and Optimization of Bifunctional Fusion Proteins to Locally Modulate Complement Activation in Diseased Tissue.
Academic Article	Factor H related proteins modulate complement activation on kidney cells.
Academic Article	Complement: The Road Less Traveled.
Academic Article	Contributions of animal models to mechanistic understandings of antibody-dependent disease and roles of the amplification loop.
Academic Article	Systematic review of type 1 diabetes biomarkers reveals regulation in circulating proteins related to complement, lipid metabolism, and immune response.
Academic Article	Complement therapeutics are coming of age in rheumatology.
Academic Article	Systematic review of type 1 diabetes biomarkers reveals regulation in circulating proteins related to complement, lipid metabolism, and immune response.
Academic Article	Inhibition of acute complement responses towards bolus-injected nanoparticles using targeted short-circulating regulatory proteins.
Grant	Role of the Factor H Related Proteins in Kidney Disease

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